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Q608N7

- SYL_METCA

UniProt

Q608N7 - SYL_METCA

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Protein
Leucine--tRNA ligase
Gene
leuS, MCA1453
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:MCA1453
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Leucine--tRNA ligaseUniRule annotation
PRO_0000152042Add
BLAST

Proteomic databases

PRIDEiQ608N7.

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA1453.

Structurei

3D structure databases

ProteinModelPortaliQ608N7.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi624 – 6285"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q608N7-1 [UniParc]FASTAAdd to Basket

« Hide

MEETYNPKTV EETAQRIWEE SGVFRAREDS GREKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VIARYQRMRG KNVLQPMGWD AFGLPAENAA MQNGVTPAAW 100
TDANADYMRK QLKSLGLAVD WDREIATCKP EYYRWEQWLF TRLFEKGLIY 150
KKTAPVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPM YFMRITAYAE 200
ELLAELDDLP GWPEQVKTMQ RNWIGKSHGC EVHFPYEDGS DVLKVYTTRP 250
DTLMGATYVA VAAEHPLALE AARDNPELAA FIEECRHGGT AEADLATMEK 300
KGMATGRFVV HPLNGEKLPV WIANYVLWGY GEGAVMAVPA HDERDFEFAN 350
KYGLPIKTVI VSTVGAYETV DTKGGWIDAY AEHGRCTNSG KYDGLAFQQA 400
FDAIAADLEA KGLGQKRTQF RLRDWGISRQ RYWGCPIPII HCLSCGDVPV 450
PAEQLPVVLP EDVTIDVGSP LKKMPEWYST TCPKCGGAAE RETDTMDTFV 500
ESSWYYARYT CPDNTEAMLD RRADYWLPVD QYVGGIEHAI LHLLYARFFH 550
KLMRDAGLVH CDEPFTNLLT QGMVVAPTFY REEGGKKHYF GPTEVELSTD 600
ERGRPLGATL KSDGAPVTVG HIEKMSKSKN NGVDPEALID RYGADTVRLF 650
TMFAAPPDQS LEWSDSGVEG AFRFLKRLWT RAAFSVNTAF SQYGRDELRV 700
TDWALVPLAP NHKEARRMIH ATLKQANFDF VRHQFNTVVS AAMKILNTLA 750
DDKGFWNCDH LPEGDEKDAF RRSAAVVAFE GYSLLTRLLY PIAPHICDAL 800
WRQLMPGTDI LDAGWPEVDE AALAQDEIEL VVQVNGKLRG KITVPADASR 850
ETVEQIALAD AQVLRFVEGK PPKRVIVVPG KLVNVVA 887
Length:887
Mass (Da):99,746
Last modified:November 23, 2004 - v1
Checksum:i72535449F9AD8F20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92547.1.
RefSeqiYP_113910.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92547; AAU92547; MCA1453.
GeneIDi3103369.
KEGGimca:MCA1453.
PATRICi22606742. VBIMetCap22254_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92547.1 .
RefSeqi YP_113910.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q608N7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243233.MCA1453.

Proteomic databases

PRIDEi Q608N7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU92547 ; AAU92547 ; MCA1453 .
GeneIDi 3103369.
KEGGi mca:MCA1453.
PATRICi 22606742. VBIMetCap22254_1483.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiSYL_METCA
AccessioniPrimary (citable) accession number: Q608N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi