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Q608N7

- SYL_METCA

UniProt

Q608N7 - SYL_METCA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei627 – 6271ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:MCA1453
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 887887Leucine--tRNA ligasePRO_0000152042Add
BLAST

Proteomic databases

PRIDEiQ608N7.

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA1453.

Structurei

3D structure databases

ProteinModelPortaliQ608N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi624 – 6285"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q608N7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEETYNPKTV EETAQRIWEE SGVFRAREDS GREKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VIARYQRMRG KNVLQPMGWD AFGLPAENAA MQNGVTPAAW
110 120 130 140 150
TDANADYMRK QLKSLGLAVD WDREIATCKP EYYRWEQWLF TRLFEKGLIY
160 170 180 190 200
KKTAPVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPM YFMRITAYAE
210 220 230 240 250
ELLAELDDLP GWPEQVKTMQ RNWIGKSHGC EVHFPYEDGS DVLKVYTTRP
260 270 280 290 300
DTLMGATYVA VAAEHPLALE AARDNPELAA FIEECRHGGT AEADLATMEK
310 320 330 340 350
KGMATGRFVV HPLNGEKLPV WIANYVLWGY GEGAVMAVPA HDERDFEFAN
360 370 380 390 400
KYGLPIKTVI VSTVGAYETV DTKGGWIDAY AEHGRCTNSG KYDGLAFQQA
410 420 430 440 450
FDAIAADLEA KGLGQKRTQF RLRDWGISRQ RYWGCPIPII HCLSCGDVPV
460 470 480 490 500
PAEQLPVVLP EDVTIDVGSP LKKMPEWYST TCPKCGGAAE RETDTMDTFV
510 520 530 540 550
ESSWYYARYT CPDNTEAMLD RRADYWLPVD QYVGGIEHAI LHLLYARFFH
560 570 580 590 600
KLMRDAGLVH CDEPFTNLLT QGMVVAPTFY REEGGKKHYF GPTEVELSTD
610 620 630 640 650
ERGRPLGATL KSDGAPVTVG HIEKMSKSKN NGVDPEALID RYGADTVRLF
660 670 680 690 700
TMFAAPPDQS LEWSDSGVEG AFRFLKRLWT RAAFSVNTAF SQYGRDELRV
710 720 730 740 750
TDWALVPLAP NHKEARRMIH ATLKQANFDF VRHQFNTVVS AAMKILNTLA
760 770 780 790 800
DDKGFWNCDH LPEGDEKDAF RRSAAVVAFE GYSLLTRLLY PIAPHICDAL
810 820 830 840 850
WRQLMPGTDI LDAGWPEVDE AALAQDEIEL VVQVNGKLRG KITVPADASR
860 870 880
ETVEQIALAD AQVLRFVEGK PPKRVIVVPG KLVNVVA
Length:887
Mass (Da):99,746
Last modified:November 23, 2004 - v1
Checksum:i72535449F9AD8F20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU92547.1.
RefSeqiYP_113910.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92547; AAU92547; MCA1453.
GeneIDi3103369.
KEGGimca:MCA1453.
PATRICi22606742. VBIMetCap22254_1483.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA. Translation: AAU92547.1 .
RefSeqi YP_113910.1. NC_002977.6.

3D structure databases

ProteinModelPortali Q608N7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA1453.

Proteomic databases

PRIDEi Q608N7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU92547 ; AAU92547 ; MCA1453 .
GeneIDi 3103369.
KEGGi mca:MCA1453.
PATRICi 22606742. VBIMetCap22254_1483.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiSYL_METCA
AccessioniPrimary (citable) accession number: Q608N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3