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Q608N7

- SYL_METCA

UniProt

Q608N7 - SYL_METCA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei627 – 6271ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:MCA1453
    OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
    Taxonomic identifieri243233 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
    ProteomesiUP000006821: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 887887Leucine--tRNA ligasePRO_0000152042Add
    BLAST

    Proteomic databases

    PRIDEiQ608N7.

    Interactioni

    Protein-protein interaction databases

    STRINGi243233.MCA1453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ608N7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi624 – 6285"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q608N7-1 [UniParc]FASTAAdd to Basket

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    MEETYNPKTV EETAQRIWEE SGVFRAREDS GREKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VIARYQRMRG KNVLQPMGWD AFGLPAENAA MQNGVTPAAW 100
    TDANADYMRK QLKSLGLAVD WDREIATCKP EYYRWEQWLF TRLFEKGLIY 150
    KKTAPVNWDP VDQTVLANEQ VIDGRGWRSG ALVEKRDIPM YFMRITAYAE 200
    ELLAELDDLP GWPEQVKTMQ RNWIGKSHGC EVHFPYEDGS DVLKVYTTRP 250
    DTLMGATYVA VAAEHPLALE AARDNPELAA FIEECRHGGT AEADLATMEK 300
    KGMATGRFVV HPLNGEKLPV WIANYVLWGY GEGAVMAVPA HDERDFEFAN 350
    KYGLPIKTVI VSTVGAYETV DTKGGWIDAY AEHGRCTNSG KYDGLAFQQA 400
    FDAIAADLEA KGLGQKRTQF RLRDWGISRQ RYWGCPIPII HCLSCGDVPV 450
    PAEQLPVVLP EDVTIDVGSP LKKMPEWYST TCPKCGGAAE RETDTMDTFV 500
    ESSWYYARYT CPDNTEAMLD RRADYWLPVD QYVGGIEHAI LHLLYARFFH 550
    KLMRDAGLVH CDEPFTNLLT QGMVVAPTFY REEGGKKHYF GPTEVELSTD 600
    ERGRPLGATL KSDGAPVTVG HIEKMSKSKN NGVDPEALID RYGADTVRLF 650
    TMFAAPPDQS LEWSDSGVEG AFRFLKRLWT RAAFSVNTAF SQYGRDELRV 700
    TDWALVPLAP NHKEARRMIH ATLKQANFDF VRHQFNTVVS AAMKILNTLA 750
    DDKGFWNCDH LPEGDEKDAF RRSAAVVAFE GYSLLTRLLY PIAPHICDAL 800
    WRQLMPGTDI LDAGWPEVDE AALAQDEIEL VVQVNGKLRG KITVPADASR 850
    ETVEQIALAD AQVLRFVEGK PPKRVIVVPG KLVNVVA 887
    Length:887
    Mass (Da):99,746
    Last modified:November 23, 2004 - v1
    Checksum:i72535449F9AD8F20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU92547.1.
    RefSeqiYP_113910.1. NC_002977.6.

    Genome annotation databases

    EnsemblBacteriaiAAU92547; AAU92547; MCA1453.
    GeneIDi3103369.
    KEGGimca:MCA1453.
    PATRICi22606742. VBIMetCap22254_1483.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017282 Genomic DNA. Translation: AAU92547.1 .
    RefSeqi YP_113910.1. NC_002977.6.

    3D structure databases

    ProteinModelPortali Q608N7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243233.MCA1453.

    Proteomic databases

    PRIDEi Q608N7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU92547 ; AAU92547 ; MCA1453 .
    GeneIDi 3103369.
    KEGGi mca:MCA1453.
    PATRICi 22606742. VBIMetCap22254_1483.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33009 / NCIMB 11132 / Bath.

    Entry informationi

    Entry nameiSYL_METCA
    AccessioniPrimary (citable) accession number: Q608N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3