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Protein

ELAV-like protein 2

Gene

Elavl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 2
Alternative name(s):
ELAV-like neuronal protein 1
Hu-antigen B
Short name:
HuB
Nervous system-specific RNA-binding protein Mel-N1
Gene namesi
Name:Elavl2
Synonyms:Hub
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1100887. Elavl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360ELAV-like protein 2PRO_0000081580Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei221 – 2211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60899.
PaxDbiQ60899.
PRIDEiQ60899.

PTM databases

iPTMnetiQ60899.
PhosphoSiteiQ60899.

Expressioni

Tissue specificityi

Brain; neural-specific.1 Publication

Gene expression databases

BgeeiQ60899.
ExpressionAtlasiQ60899. baseline and differential.
GenevisibleiQ60899. MM.

Interactioni

Subunit structurei

Interacts with IGF2BP1.By similarity

Protein-protein interaction databases

BioGridi200483. 1 interaction.
IntActiQ60899. 1 interaction.
MINTiMINT-4094224.
STRINGi10090.ENSMUSP00000099863.

Structurei

3D structure databases

ProteinModelPortaliQ60899.
SMRiQ60899. Positions 37-203, 276-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 11779RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini125 – 20581RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini277 – 35579RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RRM elav family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ60899.
KOiK13208.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQLSNGPT CNNTANGPTT VNNNCSSPVD SGNTEDSKTN LIVNYLPQNM
60 70 80 90 100
TQEELKSLFG SIGEIESCKL VRDKITGQSL GYGFVNYIDP KDAEKAINTL
110 120 130 140 150
NGLRLQTKTI KVSYARPSSA SIRDANLYVS GLPKTMTQKE LEQLFSQYGR
160 170 180 190 200
IITSRILVDQ VTGISRGVGF IRFDKRIEAE EAIKGLNGQK PPGATEPITV
210 220 230 240 250
KFANNPSQKT NQAILSQLYQ SPNRRYPGPL AQQAQRFRLD NLLNMAYGVK
260 270 280 290 300
SRFSPMTIDG MTSLAGINIP GHPGTGWCIF VYNLAPDADE SILWQMFGPF
310 320 330 340 350
GAVTNVKVIR DFNTNKCKGF GFVTMTNYDE AAMAIASLNG YRLGDRVLQV
360
SFKTNKTHKA
Length:360
Mass (Da):39,577
Last modified:November 1, 1996 - v1
Checksum:i780CDD07F2E97D74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29088 mRNA. Translation: AAC52644.1.
CCDSiCCDS18355.1.
PIRiJC6057.
RefSeqiNP_034616.1. NM_010486.2.
XP_006502852.1. XM_006502789.2.
XP_006502853.1. XM_006502790.2.
XP_006502854.1. XM_006502791.2.
UniGeneiMm.318042.

Genome annotation databases

EnsembliENSMUST00000008633; ENSMUSP00000008633; ENSMUSG00000008489.
GeneIDi15569.
KEGGimmu:15569.
UCSCiuc008ton.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29088 mRNA. Translation: AAC52644.1.
CCDSiCCDS18355.1.
PIRiJC6057.
RefSeqiNP_034616.1. NM_010486.2.
XP_006502852.1. XM_006502789.2.
XP_006502853.1. XM_006502790.2.
XP_006502854.1. XM_006502791.2.
UniGeneiMm.318042.

3D structure databases

ProteinModelPortaliQ60899.
SMRiQ60899. Positions 37-203, 276-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200483. 1 interaction.
IntActiQ60899. 1 interaction.
MINTiMINT-4094224.
STRINGi10090.ENSMUSP00000099863.

PTM databases

iPTMnetiQ60899.
PhosphoSiteiQ60899.

Proteomic databases

MaxQBiQ60899.
PaxDbiQ60899.
PRIDEiQ60899.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008633; ENSMUSP00000008633; ENSMUSG00000008489.
GeneIDi15569.
KEGGimmu:15569.
UCSCiuc008ton.2. mouse.

Organism-specific databases

CTDi1993.
MGIiMGI:1100887. Elavl2.

Phylogenomic databases

eggNOGiKOG0145. Eukaryota.
ENOG410XP7S. LUCA.
GeneTreeiENSGT00760000118913.
HOGENOMiHOG000231162.
HOVERGENiHBG002295.
InParanoidiQ60899.
KOiK13208.

Miscellaneous databases

NextBioi288546.
PROiQ60899.
SOURCEiSearch...

Gene expression databases

BgeeiQ60899.
ExpressionAtlasiQ60899. baseline and differential.
GenevisibleiQ60899. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR006548. ELAD_HUD_SF.
IPR002343. Hud_Sxl_RNA.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
PRINTSiPR00961. HUDSXLRNA.
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01661. ELAV_HUD_SF. 1 hit.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Target specificity of neuronal RNA-binding protein, Mel-N1: direct binding to the 3' untranslated region of its own mRNA."
    Abe R., Yamamoto K., Sakamoto H.
    Nucleic Acids Res. 24:2011-2016(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiELAV2_MOUSE
AccessioniPrimary (citable) accession number: Q60899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.