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Q60867

- NDF1_MOUSE

UniProt

Q60867 - NDF1_MOUSE

Protein

Neurogenic differentiation factor 1

Gene

Neurod1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.15 Publications

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. DNA binding Source: MGI
    3. double-stranded DNA binding Source: Ensembl
    4. E-box binding Source: UniProtKB
    5. protein binding Source: UniProtKB
    6. protein heterodimerization activity Source: MGI
    7. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    8. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    9. RNA polymerase II transcription coactivator activity Source: Ensembl
    10. sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. amacrine cell differentiation Source: UniProtKB
    2. anterior/posterior pattern specification Source: MGI
    3. camera-type eye development Source: MGI
    4. cell fate commitment Source: MGI
    5. cellular response to glucose stimulus Source: Ensembl
    6. cerebellum development Source: UniProtKB
    7. dentate gyrus development Source: UniProtKB
    8. embryonic organ morphogenesis Source: BHF-UCL
    9. endocrine pancreas development Source: UniProtKB
    10. enteroendocrine cell differentiation Source: UniProtKB
    11. glucose homeostasis Source: BHF-UCL
    12. hindbrain development Source: MGI
    13. inner ear development Source: UniProtKB
    14. insulin secretion Source: Ensembl
    15. negative regulation of JAK-STAT cascade Source: MGI
    16. negative regulation of type B pancreatic cell apoptotic process Source: BHF-UCL
    17. nitric oxide mediated signal transduction Source: Ensembl
    18. nucleocytoplasmic transport Source: Ensembl
    19. pancreatic A cell fate commitment Source: MGI
    20. pancreatic PP cell fate commitment Source: MGI
    21. positive regulation of apoptotic process Source: UniProtKB
    22. positive regulation of cell differentiation Source: UniProtKB
    23. positive regulation of neuron differentiation Source: UniProtKB
    24. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    25. positive regulation of transcription, DNA-templated Source: UniProtKB
    26. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    27. positive regulation of transcription regulatory region DNA binding Source: Ensembl
    28. regulation of cell cycle arrest Source: UniProtKB
    29. regulation of intestinal epithelial structure maintenance Source: UniProtKB
    30. regulation of neuron differentiation Source: MGI
    31. response to drug Source: Ensembl
    32. signal transduction involved in regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_214529. Regulation of gene expression in beta cells.
    REACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogenic differentiation factor 1
    Short name:
    NeuroD1
    Alternative name(s):
    Beta-cell E-box transcriptional activator 2
    Short name:
    Beta2
    Gene namesi
    Name:Neurod1
    Synonyms:Neurod
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1339708. Neurod1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus PROSITE-ProRule annotation
    Note: In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. Colocalizes with NR0B2 in the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. intracellular Source: MGI
    3. nucleoplasm Source: Reactome
    4. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice are deaf and die shortly after birth due to neonatal diabetes that results from developmental and functional defects of the pancreatic endocrine cells. Show a loss of enteroendocrine cells in the small intestine, airway and alveolar epithelial cells in the lung, granular neuronal cells in the cerebellum, hippocampal dentate gyrus and sensory neurons in the inner ear due to extensive cell death that occurs during the early stages of differentiation.5 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi162 – 1621S → A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-259 and A-266. 2 Publications
    Mutagenesisi259 – 2591S → A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-162 and A-266. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-266 and A-274. 3 Publications
    Mutagenesisi266 – 2661S → A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-162 and A-259. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-259 and A-274. 3 Publications
    Mutagenesisi274 – 2741S → A: Reduces strongly phosphorylation. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-259 and A-266. 3 Publications
    Mutagenesisi279 – 2791I → V: Promotes the formation of differentiated late retinal amacrine cells. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Neurogenic differentiation factor 1PRO_0000127383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei162 – 1621Phosphoserine1 Publication
    Modified residuei259 – 2591Phosphoserine2 Publications
    Modified residuei266 – 2661Phosphoserine2 Publications
    Modified residuei274 – 2741Phosphoserine2 Publications
    Modified residuei336 – 3361Phosphoserine; by CaMK2By similarity

    Post-translational modificationi

    In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-336; which promotes dendritic growth By similarity. Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells.By similarity2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ60867.

    PTM databases

    PhosphoSiteiQ60867.

    Expressioni

    Tissue specificityi

    Expressed in pancreatic beta cells, pulmonary neuroendocrine cells and retinal interneurons amacrine cells (at protein level). Expressed in endocrine cells of the pancreas. Expressed in the inner layer of cerebellar external granular layer (EGL). Expressed in the Ammon's horn (AH), which includes the CA1-CA3 pyramidal layer and in granule cells of the dentate gyrus (DG). Expressed in photoreceptors of the outer nuclear layer (ONL), in a subset of cells in the lower half of the inner nuclear layer (INL), and in a subset of cells in the ganglion cell layer (GCL) of the retina. Expressed in cholinergic and AII amacrine cell types. Expressed in differentiating neurons of both the central and peripheral nervous systems.6 Publications

    Developmental stagei

    Expressed in glucagon- and ghrelin-producing cells of the pancreas at 14.5 dpc. Expressed in each of the hormone-producing cells population of the pancreas, except somatostatin-producing cells at 16.5 dpc (at protein level). Expressed during embryonic development. Expressed in the earliest islet precursor cells of the pancreas at 9.5 dpc. Expressed in neuronal cells in the inner ear between 9.5 and 12.5 dpc. Expressed within the otic epithelium and among the delaminating cells migrating away from the ear to form sensory neurons at E10.5. Expressed in the upper blade of the nascent dentate gyrus at 16.5 dpc.5 Publications

    Inductioni

    Up-regulated by NKX2-2 and NEUROG3.2 Publications

    Gene expression databases

    BgeeiQ60867.
    CleanExiMM_NEUROD1.
    GenevestigatoriQ60867.

    Interactioni

    Subunit structurei

    Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E-box element. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2. Interacts with RREB1 By similarity. Heterodimer with TCF3/E47. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus).By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CCNDBP1O952734EBI-309315,EBI-748961From a different organism.

    Protein-protein interaction databases

    BioGridi201733. 8 interactions.
    IntActiQ60867. 2 interactions.
    MINTiMINT-8396397.

    Structurei

    Secondary structure

    1
    357
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi102 – 12625
    Beta strandi128 – 1303
    Beta strandi133 – 1353
    Helixi139 – 15618

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QL2X-ray2.50B/D102-160[»]
    ProteinModelPortaliQ60867.
    SMRiQ60867. Positions 102-158.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ60867.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 15353bHLHPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi87 – 937Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 7720Glu-rich (acidic)Add
    BLAST
    Compositional biasi58 – 647Poly-Glu
    Compositional biasi67 – 7711Poly-GluAdd
    BLAST
    Compositional biasi87 – 904Poly-Lys

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG287211.
    GeneTreeiENSGT00680000099860.
    HOGENOMiHOG000049256.
    HOVERGENiHBG000250.
    InParanoidiQ60867.
    KOiK08033.
    OMAiMNAQLNA.
    OrthoDBiEOG722J8S.
    PhylomeDBiQ60867.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60867-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSYSESGL MGEPQPQGPP SWTDECLSSQ DEEHEADKKE DELEAMNAEE    50
    DSLRNGGEEE EEDEDLEEEE EEEEEEEDQK PKRRGPKKKK MTKARLERFK 100
    LRRMKANARE RNRMHGLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI 150
    WALSEILRSG KSPDLVSFVQ TLCKGLSQPT TNLVAGCLQL NPRTFLPEQN 200
    PDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF HVKPPPHAYS 250
    AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT 300
    MHYPAATLAG PQSHGSIFSS GAAAPRCEIP IDNIMSFDSH SHHERVMSAQ 350
    LNAIFHD 357
    Length:357
    Mass (Da):39,999
    Last modified:February 1, 1997 - v2
    Checksum:iB6626E1315E31027
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28068 mRNA. Translation: AAC52203.1.
    U28888 Genomic DNA. Translation: AAC52204.1.
    AK005073 mRNA. Translation: BAB23797.1.
    AK018781 mRNA. Translation: BAB31405.1.
    BC018241 mRNA. Translation: AAH18241.1.
    CCDSiCCDS16169.1.
    PIRiI49338.
    RefSeqiNP_035024.1. NM_010894.2.
    UniGeneiMm.4636.

    Genome annotation databases

    EnsembliENSMUST00000041099; ENSMUSP00000040364; ENSMUSG00000034701.
    GeneIDi18012.
    KEGGimmu:18012.
    UCSCiuc008kgt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U28068 mRNA. Translation: AAC52203.1 .
    U28888 Genomic DNA. Translation: AAC52204.1 .
    AK005073 mRNA. Translation: BAB23797.1 .
    AK018781 mRNA. Translation: BAB31405.1 .
    BC018241 mRNA. Translation: AAH18241.1 .
    CCDSi CCDS16169.1.
    PIRi I49338.
    RefSeqi NP_035024.1. NM_010894.2.
    UniGenei Mm.4636.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QL2 X-ray 2.50 B/D 102-160 [» ]
    ProteinModelPortali Q60867.
    SMRi Q60867. Positions 102-158.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201733. 8 interactions.
    IntActi Q60867. 2 interactions.
    MINTi MINT-8396397.

    PTM databases

    PhosphoSitei Q60867.

    Proteomic databases

    PRIDEi Q60867.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041099 ; ENSMUSP00000040364 ; ENSMUSG00000034701 .
    GeneIDi 18012.
    KEGGi mmu:18012.
    UCSCi uc008kgt.1. mouse.

    Organism-specific databases

    CTDi 4760.
    MGIi MGI:1339708. Neurod1.

    Phylogenomic databases

    eggNOGi NOG287211.
    GeneTreei ENSGT00680000099860.
    HOGENOMi HOG000049256.
    HOVERGENi HBG000250.
    InParanoidi Q60867.
    KOi K08033.
    OMAi MNAQLNA.
    OrthoDBi EOG722J8S.
    PhylomeDBi Q60867.
    TreeFami TF315153.

    Enzyme and pathway databases

    Reactomei REACT_214529. Regulation of gene expression in beta cells.
    REACT_221082. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

    Miscellaneous databases

    EvolutionaryTracei Q60867.
    NextBioi 293037.
    PROi Q60867.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60867.
    CleanExi MM_NEUROD1.
    Genevestigatori Q60867.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR022575. Neurogenic_DUF.
    IPR016637. TF_bHLH_NeuroD.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF12533. Neuro_bHLH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015618. bHLH_NeuroD. 1 hit.
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein."
      Lee J.E., Hollenberg S.M., Snider L., Turner D.L., Lipnick N., Weintraub H.
      Science 268:836-844(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: 129/Sv and MF1.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice."
      Naya F.J., Huang H.P., Qiu Y., Mutoh H., DeMayo F.J., Leiter A.B., Tsai M.J.
      Genes Dev. 11:2323-2334(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells."
      Mutoh H., Naya F.J., Tsai M.J., Leiter A.B.
      Genes Dev. 12:820-830(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EP300, DNA-BINDING.
    6. "NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus."
      Miyata T., Maeda T., Lee J.E.
      Genes Dev. 13:1647-1652(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    7. "Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy."
      Liu M., Pleasure S.J., Collins A.E., Noebels J.L., Naya F.J., Tsai M.J., Lowenstein D.H.
      Proc. Natl. Acad. Sci. U.S.A. 97:865-870(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
    8. "NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development."
      Kim W.Y., Fritzsch B., Serls A., Bakel L.A., Huang E.J., Reichardt L.F., Barth D.S., Lee J.E.
      Development 128:417-426(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
    9. "Math3 and NeuroD regulate amacrine cell fate specification in the retina."
      Inoue T., Hojo M., Bessho Y., Tano Y., Lee J.E., Kageyama R.
      Development 129:831-842(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. "Posttranslational mechanisms control the timing of bHLH function and regulate retinal cell fate."
      Moore K.B., Schneider M.L., Vetter M.L.
      Neuron 34:183-195(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 274-SER--SER-278, DEVELOPMENTAL STAGE.
    11. "Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells."
      Khoo S., Griffen S.C., Xia Y., Baer R.J., German M.S., Cobb M.H.
      J. Biol. Chem. 278:32969-32977(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HETERODIMERIZATION, PHOSPHORYLATION AT SER-162; SER-259; SER-266 AND SER-274, TISSUE SPECIFICITY, MUTAGENESIS OF SER-162; SER-259; SER-266 AND SER-274.
    12. Cited for: FUNCTION, DNA-BINDING.
    13. "Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD."
      Kim J.Y., Chu K., Kim H.J., Seong H.A., Park K.C., Sanyal S., Takeda J., Ha H., Shong M., Tsai M.J., Choi H.S.
      Mol. Endocrinol. 18:776-790(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    14. "Context-dependent regulation of NeuroD activity and protein accumulation."
      Dufton C., Marcora E., Chae J.H., McCullough J., Eby J., Hausburg M., Stein G.H., Khoo S., Cobb M.H., Lee J.E.
      Mol. Cell. Neurosci. 28:727-736(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT SER-259; SER-266 AND SER-274, MUTAGENESIS OF SER-259; SER-266 AND SER-274.
    15. "Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers."
      Seo S., Lim J.W., Yellajoshyula D., Chang L.W., Kroll K.L.
      EMBO J. 26:5093-5108(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, ASSOCIATION WITH CHROMATIN.
    16. "Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung."
      Neptune E.R., Podowski M., Calvi C., Cho J.H., Garcia J.G., Tuder R., Linnoila R.I., Tsai M.J., Dietz H.C.
      J. Biol. Chem. 283:21160-21169(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    17. "Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis."
      Roybon L., Deierborg T., Brundin P., Li J.Y.
      Eur. J. Neurosci. 29:232-243(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    18. "Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3."
      Anderson K.R., Torres C.A., Solomon K., Becker T.C., Newgard C.B., Wright C.V., Hagman J., Sussel L.
      J. Biol. Chem. 284:31236-31248(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    19. "mu-Opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD."
      Zheng H., Zeng Y., Zhang X., Chu J., Loh H.H., Law P.Y.
      Mol. Pharmacol. 77:102-109(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    20. "NeuroD factors regulate cell fate and neurite stratification in the developing retina."
      Cherry T.J., Wang S., Bormuth I., Schwab M., Olson J., Cepko C.L.
      J. Neurosci. 31:7365-7379(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    21. "Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition."
      Longo A., Guanga G.P., Rose R.B.
      Biochemistry 47:218-229(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 102-160 IN COMPLEX WITH TCF3 AND PROMOTER E-BOX DNA SEQUENCE, SUBUNIT.

    Entry informationi

    Entry nameiNDF1_MOUSE
    AccessioniPrimary (citable) accession number: Q60867
    Secondary accession number(s): Q545N9, Q60897
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3