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Protein

Phosphotriesterase-related protein

Gene

Pter

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi28Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi169Divalent metal cation 1By similarity1
Metal bindingi169Divalent metal cation 2By similarity1
Metal bindingi201Divalent metal cation 2; via pros nitrogenBy similarity1
Metal bindingi230Divalent metal cation 2; via tele nitrogenBy similarity1
Metal bindingi298Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphotriesterase-related protein (EC:3.1.-.-)
Alternative name(s):
Parathion hydrolase-related protein
Gene namesi
Name:Pter
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107372. Pter.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053651 – 349Phosphotriesterase-related proteinAdd BLAST349

Proteomic databases

EPDiQ60866.
PaxDbiQ60866.
PeptideAtlasiQ60866.
PRIDEiQ60866.

2D gel databases

REPRODUCTION-2DPAGEQ60866.

PTM databases

iPTMnetiQ60866.
PhosphoSitePlusiQ60866.
SwissPalmiQ60866.

Expressioni

Tissue specificityi

Expressed in kidney and liver.

Gene expression databases

BgeeiENSMUSG00000026730.
CleanExiMM_PTER.
ExpressionAtlasiQ60866. baseline and differential.
GenevisibleiQ60866. MM.

Interactioni

Protein-protein interaction databases

IntActiQ60866. 5 interactors.
MINTiMINT-1855182.
STRINGi10090.ENSMUSP00000117009.

Structurei

3D structure databases

ProteinModelPortaliQ60866.
SMRiQ60866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphotriesterase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ60866.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG091G0D6G.
PhylomeDBiQ60866.
TreeFamiTF323205.

Family and domain databases

CDDicd00530. PTE. 1 hit.
InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLSGKVQT VLGLVEPSQL GRTLTHEHLT MTFDSFYCPP PPCHEVTSKE
60 70 80 90 100
PIMMKNLFWI QKNPYSHREN LQLNQEVGAI REELLYFKAK GGGALVENTT
110 120 130 140 150
TGLSRDVHTL KWLAEQTGVH IIAGAGFYVD ATHSAATRAM SVEQLTDVLI
160 170 180 190 200
NEILHGADGT SIKCGVIGEI GCSWPLTDSE RKILEATAHA QAQLGCPVII
210 220 230 240 250
HPGRNPGAPF QIIRILQEAG ADISKTVMSH LDRTIFDKKE LLEFAQLGCY
260 270 280 290 300
LEYDLFGTEL LNYQLSPDID MPDDNKRIRR VHFLVDEGYE DRILMAHDIH
310 320 330 340
TKHRLMKYGG HGYSHILTNI VPKMLLRGLT ERVLDKILIE NPKQWLTFK
Length:349
Mass (Da):39,218
Last modified:November 1, 1996 - v1
Checksum:iFF602F1887F16B33
GO
Isoform 2 (identifier: Q60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-260: TEL → SIF
     261-349: Missing.

Note: No experimental confirmation available.
Show »
Length:260
Mass (Da):28,618
Checksum:i5B66A274A41715DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197P → S in BAC25353 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038343258 – 260TEL → SIF in isoform 2. 1 Publication3
Alternative sequenceiVSP_038344261 – 349Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28016 mRNA. Translation: AAA68951.1.
AK012076 mRNA. Translation: BAC25353.1.
AL929209 Genomic DNA. Translation: CAM23725.1.
AL929209 Genomic DNA. Translation: CAM23723.1.
CH466542 Genomic DNA. Translation: EDL08046.1.
BC003793 mRNA. Translation: AAH03793.1.
CCDSiCCDS15691.1. [Q60866-1]
RefSeqiNP_001292365.1. NM_001305436.1. [Q60866-2]
NP_001292366.1. NM_001305437.1.
NP_032987.1. NM_008961.3. [Q60866-1]
UniGeneiMm.229322.

Genome annotation databases

EnsembliENSMUST00000028063; ENSMUSP00000028063; ENSMUSG00000026730. [Q60866-2]
ENSMUST00000134794; ENSMUSP00000117009; ENSMUSG00000026730. [Q60866-1]
GeneIDi19212.
KEGGimmu:19212.
UCSCiuc008ijt.2. mouse. [Q60866-1]
uc012bqx.2. mouse. [Q60866-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28016 mRNA. Translation: AAA68951.1.
AK012076 mRNA. Translation: BAC25353.1.
AL929209 Genomic DNA. Translation: CAM23725.1.
AL929209 Genomic DNA. Translation: CAM23723.1.
CH466542 Genomic DNA. Translation: EDL08046.1.
BC003793 mRNA. Translation: AAH03793.1.
CCDSiCCDS15691.1. [Q60866-1]
RefSeqiNP_001292365.1. NM_001305436.1. [Q60866-2]
NP_001292366.1. NM_001305437.1.
NP_032987.1. NM_008961.3. [Q60866-1]
UniGeneiMm.229322.

3D structure databases

ProteinModelPortaliQ60866.
SMRiQ60866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60866. 5 interactors.
MINTiMINT-1855182.
STRINGi10090.ENSMUSP00000117009.

PTM databases

iPTMnetiQ60866.
PhosphoSitePlusiQ60866.
SwissPalmiQ60866.

2D gel databases

REPRODUCTION-2DPAGEQ60866.

Proteomic databases

EPDiQ60866.
PaxDbiQ60866.
PeptideAtlasiQ60866.
PRIDEiQ60866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028063; ENSMUSP00000028063; ENSMUSG00000026730. [Q60866-2]
ENSMUST00000134794; ENSMUSP00000117009; ENSMUSG00000026730. [Q60866-1]
GeneIDi19212.
KEGGimmu:19212.
UCSCiuc008ijt.2. mouse. [Q60866-1]
uc012bqx.2. mouse. [Q60866-2]

Organism-specific databases

CTDi9317.
MGIiMGI:107372. Pter.

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ60866.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG091G0D6G.
PhylomeDBiQ60866.
TreeFamiTF323205.

Miscellaneous databases

PROiQ60866.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026730.
CleanExiMM_PTER.
ExpressionAtlasiQ60866. baseline and differential.
GenevisibleiQ60866. MM.

Family and domain databases

CDDicd00530. PTE. 1 hit.
InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTER_MOUSE
AccessioniPrimary (citable) accession number: Q60866
Secondary accession number(s): A2AUR4, A2AUR6, Q8BTA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.