Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphotriesterase-related protein

Gene

Pter

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi26 – 261Divalent metal cation 1; via tele nitrogenBy similarity
Metal bindingi28 – 281Divalent metal cation 1; via tele nitrogenBy similarity
Metal bindingi169 – 1691Divalent metal cation 1By similarity
Metal bindingi169 – 1691Divalent metal cation 2By similarity
Metal bindingi201 – 2011Divalent metal cation 2; via pros nitrogenBy similarity
Metal bindingi230 – 2301Divalent metal cation 2; via tele nitrogenBy similarity
Metal bindingi298 – 2981Divalent metal cation 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphotriesterase-related protein (EC:3.1.-.-)
Alternative name(s):
Parathion hydrolase-related protein
Gene namesi
Name:Pter
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107372. Pter.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Phosphotriesterase-related proteinPRO_0000205365Add
BLAST

Proteomic databases

EPDiQ60866.
MaxQBiQ60866.
PaxDbiQ60866.
PRIDEiQ60866.

2D gel databases

REPRODUCTION-2DPAGEQ60866.

PTM databases

iPTMnetiQ60866.
PhosphoSiteiQ60866.
SwissPalmiQ60866.

Expressioni

Tissue specificityi

Expressed in kidney and liver.

Gene expression databases

BgeeiQ60866.
CleanExiMM_PTER.
ExpressionAtlasiQ60866. baseline and differential.
GenevisibleiQ60866. MM.

Interactioni

Protein-protein interaction databases

IntActiQ60866. 4 interactions.
MINTiMINT-1855182.
STRINGi10090.ENSMUSP00000117009.

Structurei

3D structure databases

ProteinModelPortaliQ60866.
SMRiQ60866. Positions 5-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphotriesterase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ60866.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG7J70FS.
PhylomeDBiQ60866.
TreeFamiTF323205.

Family and domain databases

InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLSGKVQT VLGLVEPSQL GRTLTHEHLT MTFDSFYCPP PPCHEVTSKE
60 70 80 90 100
PIMMKNLFWI QKNPYSHREN LQLNQEVGAI REELLYFKAK GGGALVENTT
110 120 130 140 150
TGLSRDVHTL KWLAEQTGVH IIAGAGFYVD ATHSAATRAM SVEQLTDVLI
160 170 180 190 200
NEILHGADGT SIKCGVIGEI GCSWPLTDSE RKILEATAHA QAQLGCPVII
210 220 230 240 250
HPGRNPGAPF QIIRILQEAG ADISKTVMSH LDRTIFDKKE LLEFAQLGCY
260 270 280 290 300
LEYDLFGTEL LNYQLSPDID MPDDNKRIRR VHFLVDEGYE DRILMAHDIH
310 320 330 340
TKHRLMKYGG HGYSHILTNI VPKMLLRGLT ERVLDKILIE NPKQWLTFK
Length:349
Mass (Da):39,218
Last modified:November 1, 1996 - v1
Checksum:iFF602F1887F16B33
GO
Isoform 2 (identifier: Q60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-260: TEL → SIF
     261-349: Missing.

Note: No experimental confirmation available.
Show »
Length:260
Mass (Da):28,618
Checksum:i5B66A274A41715DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti197 – 1971P → S in BAC25353 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei258 – 2603TEL → SIF in isoform 2. 1 PublicationVSP_038343
Alternative sequencei261 – 34989Missing in isoform 2. 1 PublicationVSP_038344Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28016 mRNA. Translation: AAA68951.1.
AK012076 mRNA. Translation: BAC25353.1.
AL929209 Genomic DNA. Translation: CAM23725.1.
AL929209 Genomic DNA. Translation: CAM23723.1.
CH466542 Genomic DNA. Translation: EDL08046.1.
BC003793 mRNA. Translation: AAH03793.1.
CCDSiCCDS15691.1. [Q60866-1]
RefSeqiNP_001292365.1. NM_001305436.1. [Q60866-2]
NP_001292366.1. NM_001305437.1.
NP_032987.1. NM_008961.3. [Q60866-1]
UniGeneiMm.229322.

Genome annotation databases

EnsembliENSMUST00000028063; ENSMUSP00000028063; ENSMUSG00000026730. [Q60866-2]
ENSMUST00000134794; ENSMUSP00000117009; ENSMUSG00000026730. [Q60866-1]
GeneIDi19212.
KEGGimmu:19212.
UCSCiuc008ijt.2. mouse. [Q60866-1]
uc012bqx.2. mouse. [Q60866-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28016 mRNA. Translation: AAA68951.1.
AK012076 mRNA. Translation: BAC25353.1.
AL929209 Genomic DNA. Translation: CAM23725.1.
AL929209 Genomic DNA. Translation: CAM23723.1.
CH466542 Genomic DNA. Translation: EDL08046.1.
BC003793 mRNA. Translation: AAH03793.1.
CCDSiCCDS15691.1. [Q60866-1]
RefSeqiNP_001292365.1. NM_001305436.1. [Q60866-2]
NP_001292366.1. NM_001305437.1.
NP_032987.1. NM_008961.3. [Q60866-1]
UniGeneiMm.229322.

3D structure databases

ProteinModelPortaliQ60866.
SMRiQ60866. Positions 5-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60866. 4 interactions.
MINTiMINT-1855182.
STRINGi10090.ENSMUSP00000117009.

PTM databases

iPTMnetiQ60866.
PhosphoSiteiQ60866.
SwissPalmiQ60866.

2D gel databases

REPRODUCTION-2DPAGEQ60866.

Proteomic databases

EPDiQ60866.
MaxQBiQ60866.
PaxDbiQ60866.
PRIDEiQ60866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028063; ENSMUSP00000028063; ENSMUSG00000026730. [Q60866-2]
ENSMUST00000134794; ENSMUSP00000117009; ENSMUSG00000026730. [Q60866-1]
GeneIDi19212.
KEGGimmu:19212.
UCSCiuc008ijt.2. mouse. [Q60866-1]
uc012bqx.2. mouse. [Q60866-2]

Organism-specific databases

CTDi9317.
MGIiMGI:107372. Pter.

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ60866.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG7J70FS.
PhylomeDBiQ60866.
TreeFamiTF323205.

Miscellaneous databases

PROiQ60866.
SOURCEiSearch...

Gene expression databases

BgeeiQ60866.
CleanExiMM_PTER.
ExpressionAtlasiQ60866. baseline and differential.
GenevisibleiQ60866. MM.

Family and domain databases

InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene: abnormal expression in injured and polycystic kidneys."
    Hou X., Maser R.L., Magenheimer B.S., Calvet J.P.
    Gene 168:157-163(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver and Pancreas.

Entry informationi

Entry nameiPTER_MOUSE
AccessioniPrimary (citable) accession number: Q60866
Secondary accession number(s): A2AUR4, A2AUR6, Q8BTA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.