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Protein

Phosphotriesterase-related protein

Gene

Pter

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi28Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi169Divalent metal cation 1By similarity1
Metal bindingi169Divalent metal cation 2By similarity1
Metal bindingi201Divalent metal cation 2; via pros nitrogenBy similarity1
Metal bindingi230Divalent metal cation 2; via tele nitrogenBy similarity1
Metal bindingi298Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphotriesterase-related protein (EC:3.1.-.-)
Alternative name(s):
Parathion hydrolase-related protein
Gene namesi
Name:Pter
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:107372 Pter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053651 – 349Phosphotriesterase-related proteinAdd BLAST349

Proteomic databases

EPDiQ60866
PaxDbiQ60866
PeptideAtlasiQ60866
PRIDEiQ60866

2D gel databases

REPRODUCTION-2DPAGEQ60866

PTM databases

iPTMnetiQ60866
PhosphoSitePlusiQ60866
SwissPalmiQ60866

Expressioni

Tissue specificityi

Expressed in kidney and liver.

Gene expression databases

BgeeiENSMUSG00000026730
CleanExiMM_PTER
ExpressionAtlasiQ60866 baseline and differential
GenevisibleiQ60866 MM

Interactioni

Protein-protein interaction databases

IntActiQ60866, 5 interactors
MINTiQ60866
STRINGi10090.ENSMUSP00000117009

Structurei

3D structure databases

ProteinModelPortaliQ60866
SMRiQ60866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGM3 Eukaryota
COG1735 LUCA
GeneTreeiENSGT00390000006960
HOGENOMiHOG000081700
HOVERGENiHBG002463
InParanoidiQ60866
KOiK07048
OMAiPFQIIRV
OrthoDBiEOG091G0D6G
PhylomeDBiQ60866
TreeFamiTF323205

Family and domain databases

CDDicd00530 PTE, 1 hit
InterProiView protein in InterPro
IPR017947 AryldialkylPase_Zn-BS
IPR032466 Metal_Hydrolase
IPR001559 Phosphotriesterase
PANTHERiPTHR10819 PTHR10819, 1 hit
PfamiView protein in Pfam
PF02126 PTE, 1 hit
SUPFAMiSSF51556 SSF51556, 2 hits
PROSITEiView protein in PROSITE
PS01322 PHOSPHOTRIESTERASE_1, 1 hit
PS51347 PHOSPHOTRIESTERASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60866-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLSGKVQT VLGLVEPSQL GRTLTHEHLT MTFDSFYCPP PPCHEVTSKE
60 70 80 90 100
PIMMKNLFWI QKNPYSHREN LQLNQEVGAI REELLYFKAK GGGALVENTT
110 120 130 140 150
TGLSRDVHTL KWLAEQTGVH IIAGAGFYVD ATHSAATRAM SVEQLTDVLI
160 170 180 190 200
NEILHGADGT SIKCGVIGEI GCSWPLTDSE RKILEATAHA QAQLGCPVII
210 220 230 240 250
HPGRNPGAPF QIIRILQEAG ADISKTVMSH LDRTIFDKKE LLEFAQLGCY
260 270 280 290 300
LEYDLFGTEL LNYQLSPDID MPDDNKRIRR VHFLVDEGYE DRILMAHDIH
310 320 330 340
TKHRLMKYGG HGYSHILTNI VPKMLLRGLT ERVLDKILIE NPKQWLTFK
Length:349
Mass (Da):39,218
Last modified:November 1, 1996 - v1
Checksum:iFF602F1887F16B33
GO
Isoform 2 (identifier: Q60866-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-260: TEL → SIF
     261-349: Missing.

Note: No experimental confirmation available.
Show »
Length:260
Mass (Da):28,618
Checksum:i5B66A274A41715DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197P → S in BAC25353 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038343258 – 260TEL → SIF in isoform 2. 1 Publication3
Alternative sequenceiVSP_038344261 – 349Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28016 mRNA Translation: AAA68951.1
AK012076 mRNA Translation: BAC25353.1
AL929209 Genomic DNA Translation: CAM23725.1
AL929209 Genomic DNA Translation: CAM23723.1
CH466542 Genomic DNA Translation: EDL08046.1
BC003793 mRNA Translation: AAH03793.1
CCDSiCCDS15691.1 [Q60866-1]
CCDS84471.1 [Q60866-2]
RefSeqiNP_001292365.1, NM_001305436.1 [Q60866-2]
NP_001292366.1, NM_001305437.1
NP_032987.1, NM_008961.3 [Q60866-1]
UniGeneiMm.229322

Genome annotation databases

EnsembliENSMUST00000028063; ENSMUSP00000028063; ENSMUSG00000026730 [Q60866-2]
ENSMUST00000134794; ENSMUSP00000117009; ENSMUSG00000026730 [Q60866-1]
GeneIDi19212
KEGGimmu:19212
UCSCiuc008ijt.2 mouse [Q60866-1]
uc012bqx.2 mouse [Q60866-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTER_MOUSE
AccessioniPrimary (citable) accession number: Q60866
Secondary accession number(s): A2AUR4, A2AUR6, Q8BTA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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