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Protein

Caprin-1

Gene

Caprin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:20516077). Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).By similarity1 Publication

Caution

Was originally thought to be a GPI-anchored membrane protein.Curated

GO - Molecular functioni

GO - Biological processi

  • negative regulation of translation Source: UniProtKB
  • positive regulation of dendrite morphogenesis Source: UniProtKB
  • positive regulation of dendritic spine morphogenesis Source: UniProtKB

Keywordsi

Molecular functionProtein synthesis inhibitor, RNA-binding
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-1
Alternative name(s):
Cytoplasmic activation- and proliferation-associated protein 1
GPI-anchored membrane protein 1
GPI-anchored protein p137
Short name:
GPI-p137
Short name:
p137GPI
Membrane component chromosome 11 surface marker 1
RNA granule protein 105
Gene namesi
Name:Caprin1
Synonyms:Gpiap, Gpiap1, Gpip137, M11s1, Rng105
ORF Names:G5E5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858234 Caprin1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000875502 – 707Caprin-1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei163Omega-N-methylarginineCombined sources1
Modified residuei333PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei624Omega-N-methylarginineBy similarity1
Modified residuei631Omega-N-methylarginineCombined sources1
Modified residuei638Omega-N-methylarginineCombined sources1
Modified residuei696Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei696Omega-N-methylarginine; alternateBy similarity1

Post-translational modificationi

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ60865
MaxQBiQ60865
PaxDbiQ60865
PeptideAtlasiQ60865
PRIDEiQ60865

PTM databases

iPTMnetiQ60865
PhosphoSitePlusiQ60865
SwissPalmiQ60865

Expressioni

Tissue specificityi

Highest expression in thymus, spleen and brain (at protein level). Lower levels in kidney, muscle and liver (at protein level).2 Publications

Developmental stagei

Up-regulated when resting T- or B-lymphocytes or hemopoietic progenitors are activated. Down-regulated when a monocytic leukemia cell line, M1, is induced to differentiate. Expressed in brain at E17.5 (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000027184
CleanExiMM_CAPRIN1
ExpressionAtlasiQ60865 baseline and differential
GenevisibleiQ60865 MM

Interactioni

Subunit structurei

May form homomultimers (PubMed:14764709). Interacts with G3BP1; interaction is direct and takes place in cytoplasmic RNA granules. Interacts with PQBP1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi207501, 9 interactors
IntActiQ60865, 16 interactors
MINTiQ60865
STRINGi10090.ENSMUSP00000028607

Structurei

3D structure databases

ProteinModelPortaliQ60865
SMRiQ60865
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni358 – 379G3BP1-bindingBy similarityAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili58 – 92Sequence analysisAdd BLAST35
Coiled coili123 – 151Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the caprin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA8 Eukaryota
ENOG4110M5Q LUCA
GeneTreeiENSGT00760000119052
HOGENOMiHOG000290177
HOVERGENiHBG051781
InParanoidiQ60865
KOiK18743
OMAiVEQNYFK
OrthoDBiEOG091G0575
PhylomeDBiQ60865
TreeFamiTF329471

Family and domain databases

InterProiView protein in InterPro
IPR028816 Caprin
IPR022070 Caprin-1_C
PANTHERiPTHR22922 PTHR22922, 1 hit
PfamiView protein in Pfam
PF12287 Caprin-1_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAAAPASQHP ATGTGAVQTE
60 70 80 90 100
AMKQILGVID KKLRNLEKKK GKLDDYQERM NKGERLNQDQ LDAVSKYQEV
110 120 130 140 150
TNNLEFAKEL QRSFMALSQD IQKTIKKTAR REQLMREEAE QKRLKTVLEL
160 170 180 190 200
QYVLDKLGDD DVRTDLKQGL SGVPILSEEE LSLLDEFYKL VDPERDMSLR
210 220 230 240 250
LNEQYEHASI HLWDLLEGKE KPVCGTTYKA LKEIVERVFQ SNYFDSTHNH
260 270 280 290 300
QNGLCEEEEA ASAPTVEDQV AEAEPEPAEE YTEQSEVEST EYVNRQFMAE
310 320 330 340 350
TQFSSGEKEQ VDEWTVETVE VVNSLQQQPQ AASPSVPEPH SLTPVAQSDP
360 370 380 390 400
LVRRQRVQDL MAQMQGPYNF IQDSMLDFEN QTLDPAIVSA QPMNPTQNMD
410 420 430 440 450
MPQLVCPQVH SESRLAQSNQ VPVQPEATQV PLVSSTSEGY TASQPLYQPS
460 470 480 490 500
HATEQRPQKE PMDQIQATIS LNTDQTTASS SLPAASQPQV FQAGTSKPLH
510 520 530 540 550
SSGINVNAAP FQSMQTVFNM NAPVPPANEP ETLKQQSQYQ ATYNQSFSSQ
560 570 580 590 600
PHQVEQTELQ QDQLQTVVGT YHGSQDQPHQ VPGNHQQPPQ QNTGFPRSSQ
610 620 630 640 650
PYYNSRGVSR GGSRGARGLM NGYRGPANGF RGGYDGYRPS FSNTPNSGYS
660 670 680 690 700
QSQFTAPRDY SGYQRDGYQQ NFKRGSGQSG PRGAPRGRGG PPRPNRGMPQ

MNTQQVN
Length:707
Mass (Da):78,169
Last modified:April 8, 2008 - v2
Checksum:iAF8812DE013A9081
GO

Sequence cautioni

The sequence AAA68561 differs from that shown. Reason: Frameshift at position 566.Curated
The sequence AAA82599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA61750 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → F in AAA82599 (Ref. 1) Curated1
Sequence conflicti45G → D in AAA82599 (Ref. 1) Curated1
Sequence conflicti105E → G in AAA82599 (Ref. 1) Curated1
Sequence conflicti266V → A in AAA82599 (Ref. 1) Curated1
Sequence conflicti338E → K in AAA82599 (Ref. 1) Curated1
Sequence conflicti402 – 404PQL → ESV in AAA68561 (Ref. 6) Curated3
Sequence conflicti403 – 404QL → HV in AAA82599 (Ref. 1) Curated2
Sequence conflicti603Missing in AAH52427 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27838 mRNA Translation: AAA82599.1 Different initiation.
AB373955 mRNA Translation: BAF96513.1
BX537331 Genomic DNA Translation: CAM21440.1
BC052427 mRNA Translation: AAH52427.2
X89571 Genomic DNA Translation: CAA61750.1 Sequence problems.
U18773 mRNA Translation: AAA68561.1 Frameshift.
BK001105 mRNA Translation: DAA01122.1
CCDSiCCDS16481.1
PIRiS58008
RefSeqiNP_001104759.1, NM_001111289.1
NP_001104760.1, NM_001111290.1
NP_001104761.1, NM_001111291.1
NP_001104762.1, NM_001111292.1
NP_058019.2, NM_016739.3
UniGeneiMm.427589
Mm.488635

Genome annotation databases

EnsembliENSMUST00000028607; ENSMUSP00000028607; ENSMUSG00000027184
ENSMUST00000111147; ENSMUSP00000106777; ENSMUSG00000027184
GeneIDi53872
KEGGimmu:53872
UCSCiuc008ljb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCAPR1_MOUSE
AccessioniPrimary (citable) accession number: Q60865
Secondary accession number(s): Q60758
, Q61620, Q6IMN3, Q7TT26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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