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Protein

Caprin-1

Gene

Caprin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of translation Source: UniProtKB
  • positive regulation of dendrite morphogenesis Source: UniProtKB
  • positive regulation of dendritic spine morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-1
Alternative name(s):
Cytoplasmic activation- and proliferation-associated protein 1
GPI-anchored membrane protein 1
GPI-anchored protein p137
Short name:
GPI-p137
Short name:
p137GPI
Membrane component chromosome 11 surface marker 1
RNA granule protein 105
Gene namesi
Name:Caprin1
Synonyms:Gpiap, Gpiap1, Gpip137, M11s1, Rng105
ORF Names:G5E5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1858234. Caprin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000875502 – 707Caprin-1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei113PhosphoserineBy similarity1
Modified residuei163Omega-N-methylarginineCombined sources1
Modified residuei333PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei624Omega-N-methylarginineBy similarity1
Modified residuei631Omega-N-methylarginineCombined sources1
Modified residuei638Omega-N-methylarginineCombined sources1
Modified residuei696Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei696Omega-N-methylarginine; alternateBy similarity1

Post-translational modificationi

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

EPDiQ60865.
MaxQBiQ60865.
PaxDbiQ60865.
PeptideAtlasiQ60865.
PRIDEiQ60865.

PTM databases

iPTMnetiQ60865.
PhosphoSitePlusiQ60865.
SwissPalmiQ60865.

Expressioni

Tissue specificityi

Highest expression in thymus, spleen and brain (at protein level). Lower levels in kidney, muscle and liver (at protein level).2 Publications

Developmental stagei

Up-regulated when resting T- or B-lymphocytes or hemopoietic progenitors are activated. Down-regulated when a monocytic leukemia cell line, M1, is induced to differentiate. Expressed in brain at E17.5 (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000027184.
CleanExiMM_CAPRIN1.
ExpressionAtlasiQ60865. baseline and differential.
GenevisibleiQ60865. MM.

Interactioni

Subunit structurei

May form homomultimers. Directly interacts with G3BP1 in cytoplasmic RNA granules. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity).By similarity

Protein-protein interaction databases

BioGridi207501. 3 interactors.
IntActiQ60865. 10 interactors.
MINTiMINT-1862967.
STRINGi10090.ENSMUSP00000028607.

Structurei

3D structure databases

ProteinModelPortaliQ60865.
SMRiQ60865.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni358 – 379G3BP1-bindingBy similarityAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili58 – 92Sequence analysisAdd BLAST35
Coiled coili123 – 151Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the caprin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEA8. Eukaryota.
ENOG4110M5Q. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000290177.
HOVERGENiHBG051781.
InParanoidiQ60865.
KOiK18743.
OMAiFYKLADP.
OrthoDBiEOG091G0575.
PhylomeDBiQ60865.
TreeFamiTF329471.

Family and domain databases

InterProiIPR028816. Caprin.
IPR022070. Caprin-1_C.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF12287. Caprin-1_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAAAPASQHP ATGTGAVQTE
60 70 80 90 100
AMKQILGVID KKLRNLEKKK GKLDDYQERM NKGERLNQDQ LDAVSKYQEV
110 120 130 140 150
TNNLEFAKEL QRSFMALSQD IQKTIKKTAR REQLMREEAE QKRLKTVLEL
160 170 180 190 200
QYVLDKLGDD DVRTDLKQGL SGVPILSEEE LSLLDEFYKL VDPERDMSLR
210 220 230 240 250
LNEQYEHASI HLWDLLEGKE KPVCGTTYKA LKEIVERVFQ SNYFDSTHNH
260 270 280 290 300
QNGLCEEEEA ASAPTVEDQV AEAEPEPAEE YTEQSEVEST EYVNRQFMAE
310 320 330 340 350
TQFSSGEKEQ VDEWTVETVE VVNSLQQQPQ AASPSVPEPH SLTPVAQSDP
360 370 380 390 400
LVRRQRVQDL MAQMQGPYNF IQDSMLDFEN QTLDPAIVSA QPMNPTQNMD
410 420 430 440 450
MPQLVCPQVH SESRLAQSNQ VPVQPEATQV PLVSSTSEGY TASQPLYQPS
460 470 480 490 500
HATEQRPQKE PMDQIQATIS LNTDQTTASS SLPAASQPQV FQAGTSKPLH
510 520 530 540 550
SSGINVNAAP FQSMQTVFNM NAPVPPANEP ETLKQQSQYQ ATYNQSFSSQ
560 570 580 590 600
PHQVEQTELQ QDQLQTVVGT YHGSQDQPHQ VPGNHQQPPQ QNTGFPRSSQ
610 620 630 640 650
PYYNSRGVSR GGSRGARGLM NGYRGPANGF RGGYDGYRPS FSNTPNSGYS
660 670 680 690 700
QSQFTAPRDY SGYQRDGYQQ NFKRGSGQSG PRGAPRGRGG PPRPNRGMPQ

MNTQQVN
Length:707
Mass (Da):78,169
Last modified:April 8, 2008 - v2
Checksum:iAF8812DE013A9081
GO

Sequence cautioni

The sequence AAA68561 differs from that shown. Reason: Frameshift at position 566.Curated
The sequence AAA82599 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA61750 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → F in AAA82599 (Ref. 1) Curated1
Sequence conflicti45G → D in AAA82599 (Ref. 1) Curated1
Sequence conflicti105E → G in AAA82599 (Ref. 1) Curated1
Sequence conflicti266V → A in AAA82599 (Ref. 1) Curated1
Sequence conflicti338E → K in AAA82599 (Ref. 1) Curated1
Sequence conflicti402 – 404PQL → ESV in AAA68561 (Ref. 6) Curated3
Sequence conflicti403 – 404QL → HV in AAA82599 (Ref. 1) Curated2
Sequence conflicti603Missing in AAH52427 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27838 mRNA. Translation: AAA82599.1. Different initiation.
AB373955 mRNA. Translation: BAF96513.1.
BX537331 Genomic DNA. Translation: CAM21440.1.
BC052427 mRNA. Translation: AAH52427.2.
X89571 Genomic DNA. Translation: CAA61750.1. Sequence problems.
U18773 mRNA. Translation: AAA68561.1. Frameshift.
BK001105 mRNA. Translation: DAA01122.1.
CCDSiCCDS16481.1.
PIRiS58008.
RefSeqiNP_001104759.1. NM_001111289.1.
NP_001104760.1. NM_001111290.1.
NP_001104761.1. NM_001111291.1.
NP_001104762.1. NM_001111292.1.
NP_058019.2. NM_016739.3.
UniGeneiMm.427589.
Mm.488635.

Genome annotation databases

EnsembliENSMUST00000028607; ENSMUSP00000028607; ENSMUSG00000027184.
ENSMUST00000111147; ENSMUSP00000106777; ENSMUSG00000027184.
GeneIDi53872.
KEGGimmu:53872.
UCSCiuc008ljb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27838 mRNA. Translation: AAA82599.1. Different initiation.
AB373955 mRNA. Translation: BAF96513.1.
BX537331 Genomic DNA. Translation: CAM21440.1.
BC052427 mRNA. Translation: AAH52427.2.
X89571 Genomic DNA. Translation: CAA61750.1. Sequence problems.
U18773 mRNA. Translation: AAA68561.1. Frameshift.
BK001105 mRNA. Translation: DAA01122.1.
CCDSiCCDS16481.1.
PIRiS58008.
RefSeqiNP_001104759.1. NM_001111289.1.
NP_001104760.1. NM_001111290.1.
NP_001104761.1. NM_001111291.1.
NP_001104762.1. NM_001111292.1.
NP_058019.2. NM_016739.3.
UniGeneiMm.427589.
Mm.488635.

3D structure databases

ProteinModelPortaliQ60865.
SMRiQ60865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207501. 3 interactors.
IntActiQ60865. 10 interactors.
MINTiMINT-1862967.
STRINGi10090.ENSMUSP00000028607.

PTM databases

iPTMnetiQ60865.
PhosphoSitePlusiQ60865.
SwissPalmiQ60865.

Proteomic databases

EPDiQ60865.
MaxQBiQ60865.
PaxDbiQ60865.
PeptideAtlasiQ60865.
PRIDEiQ60865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028607; ENSMUSP00000028607; ENSMUSG00000027184.
ENSMUST00000111147; ENSMUSP00000106777; ENSMUSG00000027184.
GeneIDi53872.
KEGGimmu:53872.
UCSCiuc008ljb.2. mouse.

Organism-specific databases

CTDi4076.
MGIiMGI:1858234. Caprin1.

Phylogenomic databases

eggNOGiENOG410IEA8. Eukaryota.
ENOG4110M5Q. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000290177.
HOVERGENiHBG051781.
InParanoidiQ60865.
KOiK18743.
OMAiFYKLADP.
OrthoDBiEOG091G0575.
PhylomeDBiQ60865.
TreeFamiTF329471.

Miscellaneous databases

ChiTaRSiCaprin1. mouse.
PROiQ60865.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027184.
CleanExiMM_CAPRIN1.
ExpressionAtlasiQ60865. baseline and differential.
GenevisibleiQ60865. MM.

Family and domain databases

InterProiIPR028816. Caprin.
IPR022070. Caprin-1_C.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF12287. Caprin-1_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAPR1_MOUSE
AccessioniPrimary (citable) accession number: Q60865
Secondary accession number(s): Q60758
, Q61620, Q6IMN3, Q7TT26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a GPI-anchored membrane protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.