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Protein

Origin recognition complex subunit 2

Gene

Orc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity).By similarity

GO - Molecular functioni

  • DNA replication origin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68616 Assembly of the ORC complex at the origin of replication
R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867 Assembly of the pre-replicative complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 2
Gene namesi
Name:Orc2
Synonyms:Orc2l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1328306 Orc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270761 – 576Origin recognition complex subunit 2Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116PhosphothreonineBy similarity1
Modified residuei225PhosphothreonineBy similarity1
Modified residuei247PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ60862
MaxQBiQ60862
PaxDbiQ60862
PRIDEiQ60862

PTM databases

iPTMnetiQ60862
PhosphoSitePlusiQ60862

Expressioni

Gene expression databases

BgeeiENSMUSG00000026037
ExpressionAtlasiQ60862 baseline and differential
GenevisibleiQ60862 MM

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (PubMed:12614612). Interacts with MCM10. Interacts with LRWD1 throughout the cell cycle; this interaction, wich occurs only with non-ubiquitinated form of LRWD1, prevents LRWD1 ubiquitination and hence stabilizes the protein. Interacts with POLQ (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi201975, 11 interactors
ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiQ60862
IntActiQ60862, 8 interactors
STRINGi10090.ENSMUSP00000027198

Structurei

3D structure databases

ProteinModelPortaliQ60862
SMRiQ60862
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 100Involved in LRWD1-bindingBy similarityAdd BLAST100

Sequence similaritiesi

Belongs to the ORC2 family.Curated

Phylogenomic databases

eggNOGiKOG2928 Eukaryota
COG5575 LUCA
GeneTreeiENSGT00390000015228
HOGENOMiHOG000045588
HOVERGENiHBG007874
InParanoidiQ60862
KOiK02604
OMAiETAFENS
OrthoDBiEOG091G0H5Q
PhylomeDBiQ60862
TreeFamiTF101092

Family and domain databases

InterProiView protein in InterPro
IPR007220 ORC2
PANTHERiPTHR14052 PTHR14052, 1 hit
PfamiView protein in Pfam
PF04084 ORC2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLQLKETK VPSVQFVGDD DVLSHILDRE GGTKLKKEKA QLLVNPQKVI
60 70 80 90 100
KKADCELEKS DLEVLEDQNY VKVLGRNIQE SLGNGSAKDG RNKVYSFQQR
110 120 130 140 150
KHPEEMTKLA LELAKTSGKK DPLDSNDPEI TKNIAQKSKG HSTSEKAPLV
160 170 180 190 200
NNNKTEFLST QPHNLRKRII ASRSHYDSES EYSASSSEDD EEATKDEEED
210 220 230 240 250
TNVARLSQKS QGQNRLLPAP VSKETLPKKK KRDKASDLVE EYFEAHSSSK
260 270 280 290 300
VLTSDRTLQR LRRARVDQKT LHNLLRKFVP SFSAEIERLN QQHEKLFHKW
310 320 330 340 350
MLQLHLGFNI VLYGLGSKRD LLEKFRTTML QDSIHVVING YFPGVSVKSI
360 370 380 390 400
LNSITEDVLS HVGTFQSVLD QRDWIINRFK EDSSLELFLL IHNLDSQMLR
410 420 430 440 450
GDNSQQILGQ LSSLHNVYLI ASIDHLNAPL MWDHAKQSLY NWLWYETTTY
460 470 480 490 500
SPYTEETSYE NSLLVKQSGS LPLSSLIHVL RSLTPNARGI FRLLMKFQLD
510 520 530 540 550
NQDSPSYIGL SFQDFYQQCR EAFLVNSDLT LRAQLTEFRD HKLIRTKKGT
560 570
DGVEYLLIPV DSGILADFLE KEEEEA
Length:576
Mass (Da):65,893
Last modified:November 1, 1997 - v1
Checksum:iA18BA2D18E72553B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27457 mRNA Translation: AAB33994.1
BC015257 mRNA Translation: AAH15257.1
CCDSiCCDS14975.1
RefSeqiNP_001258455.1, NM_001271526.1
NP_032791.1, NM_008765.3
UniGeneiMm.3411

Genome annotation databases

EnsembliENSMUST00000027198; ENSMUSP00000027198; ENSMUSG00000026037
GeneIDi18393
KEGGimmu:18393
UCSCiuc007bcd.2 mouse

Similar proteinsi

Entry informationi

Entry nameiORC2_MOUSE
AccessioniPrimary (citable) accession number: Q60862
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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