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Q60860

- LTC4S_MOUSE

UniProt

Q60860 - LTC4S_MOUSE

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Protein
Leukotriene C4 synthase
Gene
Ltc4s
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Catalytic activityi

Leukotriene C4 = leukotriene A4 + glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301Glutathione By similarity
Active sitei31 – 311Proton donor By similarity
Active sitei104 – 1041Proton acceptor By similarity

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro
  2. glutathione peroxidase activity Source: RefGenome
  3. glutathione transferase activity Source: RefGenome
  4. leukotriene-C4 synthase activity Source: MGI
  5. lipid binding Source: MGI

GO - Biological processi

  1. leukotriene biosynthetic process Source: RefGenome
  2. leukotriene metabolic process Source: MGI
  3. oxidation-reduction process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Leukotriene biosynthesis

Enzyme and pathway databases

BRENDAi4.4.1.20. 3474.
ReactomeiREACT_196544. Synthesis of Lipoxins (LX).
REACT_206751. Synthesis of 5-eicosatetraenoic acids.
REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene C4 synthase (EC:4.4.1.20)
Short name:
LTC4 synthase
Alternative name(s):
Leukotriene-C(4) synthase
Gene namesi
Name:Ltc4s
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:107498. Ltc4s.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic By similarity
Transmembranei7 – 2721Helical; By similarity
Add
BLAST
Topological domaini28 – 4821Lumenal By similarity
Add
BLAST
Transmembranei49 – 6921Helical; By similarity
Add
BLAST
Topological domaini70 – 734Cytoplasmic By similarity
Transmembranei74 – 9421Helical; By similarity
Add
BLAST
Topological domaini95 – 10410Lumenal By similarity
Transmembranei105 – 12420Helical; By similarity
Add
BLAST
Topological domaini125 – 15026Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: RefGenome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear envelope Source: UniProtKB
  5. nuclear outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Leukotriene C4 synthase
PRO_0000217749Add
BLAST

Proteomic databases

PRIDEiQ60860.

PTM databases

PhosphoSiteiQ60860.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ60860.
BgeeiQ60860.
CleanExiMM_LTC4S.
GenevestigatoriQ60860.

Interactioni

Subunit structurei

Homotrimer. Interacts with ALOX5AP and ALOX5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ60860.
SMRiQ60860. Positions 1-148.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 555Glutathione binding By similarity
Regioni58 – 592Glutathione binding By similarity
Regioni93 – 975Glutathione binding By similarity

Sequence similaritiesi

Belongs to the MAPEG family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00430000030964.
HOGENOMiHOG000116372.
HOVERGENiHBG105513.
InParanoidiQ5SVR7.
KOiK00807.
TreeFamiTF105328.

Family and domain databases

Gene3Di1.20.120.550. 1 hit.
InterProiIPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamiPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSiPR00488. 5LPOXGNASEAP.
PROSITEiPS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60860-1 [UniParc]FASTAAdd to Basket

« Hide

MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF    50
RAQVNCSEYF PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS 100
AQLRLTPLYA SARALWLLVA MAALGLLVHF LPGTLRTALF RWLQMLLPMA 150
Length:150
Mass (Da):16,814
Last modified:November 1, 1996 - v1
Checksum:i120ABC53892189C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27195 mRNA. Translation: AAA75042.1.
AL627187 Genomic DNA. Translation: CAI25121.1.
CCDSiCCDS24631.1.
PIRiS68961.
RefSeqiNP_032547.1. NM_008521.1.
UniGeneiMm.245151.

Genome annotation databases

EnsembliENSMUST00000102772; ENSMUSP00000099833; ENSMUSG00000020377.
GeneIDi17001.
KEGGimmu:17001.
UCSCiuc007isa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U27195 mRNA. Translation: AAA75042.1 .
AL627187 Genomic DNA. Translation: CAI25121.1 .
CCDSi CCDS24631.1.
PIRi S68961.
RefSeqi NP_032547.1. NM_008521.1.
UniGenei Mm.245151.

3D structure databases

ProteinModelPortali Q60860.
SMRi Q60860. Positions 1-148.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q60860.

Proteomic databases

PRIDEi Q60860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102772 ; ENSMUSP00000099833 ; ENSMUSG00000020377 .
GeneIDi 17001.
KEGGi mmu:17001.
UCSCi uc007isa.1. mouse.

Organism-specific databases

CTDi 4056.
MGIi MGI:107498. Ltc4s.

Phylogenomic databases

GeneTreei ENSGT00430000030964.
HOGENOMi HOG000116372.
HOVERGENi HBG105513.
InParanoidi Q5SVR7.
KOi K00807.
TreeFami TF105328.

Enzyme and pathway databases

BRENDAi 4.4.1.20. 3474.
Reactomei REACT_196544. Synthesis of Lipoxins (LX).
REACT_206751. Synthesis of 5-eicosatetraenoic acids.
REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).

Miscellaneous databases

NextBioi 291112.
PROi Q60860.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60860.
Bgeei Q60860.
CleanExi MM_LTC4S.
Genevestigatori Q60860.

Family and domain databases

Gene3Di 1.20.120.550. 1 hit.
InterProi IPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view ]
Pfami PF01124. MAPEG. 1 hit.
[Graphical view ]
PRINTSi PR00488. 5LPOXGNASEAP.
PROSITEi PS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the gene for mouse leukotriene-C4 synthase."
    Penrose J.F., Baldasaro M.H., Webster M., Xu K., Austen K.F., Lam B.K.
    Eur. J. Biochem. 248:807-813(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Two step purification of human and murine leukotriene C4 synthase."
    Goppelt-Struebe M.
    Biochim. Biophys. Acta 1256:257-261(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-27.
    Tissue: Mast cell.
  4. "Molecular cloning, expression and characterization of mouse leukotriene C4 synthase."
    Lam B.K., Penrose J.F., Rokach J., Xu K., Baldasaro M.H., Austen K.F.
    Eur. J. Biochem. 238:606-612(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLTC4S_MOUSE
AccessioniPrimary (citable) accession number: Q60860
Secondary accession number(s): Q5SVR7, Q9QVS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi