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Q60860 (LTC4S_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukotriene C4 synthase

Short name=LTC4 synthase
EC=4.4.1.20
Alternative name(s):
Leukotriene-C(4) synthase
Gene names
Name:Ltc4s
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Catalytic activity

Leukotriene C4 = leukotriene A4 + glutathione.

Subunit structure

Homotrimer. Interacts with ALOX5AP and ALOX5 By similarity.

Subcellular location

Nucleus outer membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.4

Sequence similarities

Belongs to the MAPEG family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 150150Leukotriene C4 synthase
PRO_0000217749

Regions

Topological domain1 – 66Cytoplasmic By similarity
Transmembrane7 – 2721Helical; By similarity
Topological domain28 – 4821Lumenal By similarity
Transmembrane49 – 6921Helical; By similarity
Topological domain70 – 734Cytoplasmic By similarity
Transmembrane74 – 9421Helical; By similarity
Topological domain95 – 10410Lumenal By similarity
Transmembrane105 – 12420Helical; By similarity
Topological domain125 – 15026Cytoplasmic By similarity
Region51 – 555Glutathione binding By similarity
Region58 – 592Glutathione binding By similarity
Region93 – 975Glutathione binding By similarity

Sites

Active site311Proton donor By similarity
Active site1041Proton acceptor By similarity
Binding site301Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60860 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 120ABC53892189C0

FASTA15016,814
        10         20         30         40         50         60 
MKDEVALLAT VTLVGVLLQA YFSLQVISAR RAFHVSPPLT SGPPEFERVF RAQVNCSEYF 

        70         80         90        100        110        120 
PLFLATLWVA GIFFHEGAAA LCGLFYLFAR LRYFQGYARS AQLRLTPLYA SARALWLLVA 

       130        140        150 
MAALGLLVHF LPGTLRTALF RWLQMLLPMA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of the gene for mouse leukotriene-C4 synthase."
Penrose J.F., Baldasaro M.H., Webster M., Xu K., Austen K.F., Lam B.K.
Eur. J. Biochem. 248:807-813(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Two step purification of human and murine leukotriene C4 synthase."
Goppelt-Struebe M.
Biochim. Biophys. Acta 1256:257-261(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-27.
Tissue: Mast cell.
[4]"Molecular cloning, expression and characterization of mouse leukotriene C4 synthase."
Lam B.K., Penrose J.F., Rokach J., Xu K., Baldasaro M.H., Austen K.F.
Eur. J. Biochem. 238:606-612(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U27195 mRNA. Translation: AAA75042.1.
AL627187 Genomic DNA. Translation: CAI25121.1.
CCDSCCDS24631.1.
PIRS68961.
RefSeqNP_032547.1. NM_008521.1.
UniGeneMm.245151.

3D structure databases

ProteinModelPortalQ60860.
SMRQ60860. Positions 1-148.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ60860.

Proteomic databases

PRIDEQ60860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102772; ENSMUSP00000099833; ENSMUSG00000020377.
GeneID17001.
KEGGmmu:17001.
UCSCuc007isa.1. mouse.

Organism-specific databases

CTD4056.
MGIMGI:107498. Ltc4s.

Phylogenomic databases

GeneTreeENSGT00430000030964.
HOGENOMHOG000116372.
HOVERGENHBG105513.
InParanoidQ5SVR7.
KOK00807.
TreeFamTF105328.

Enzyme and pathway databases

BRENDA4.4.1.20. 3474.

Gene expression databases

ArrayExpressQ60860.
BgeeQ60860.
CleanExMM_LTC4S.
GenevestigatorQ60860.

Family and domain databases

Gene3D1.20.120.550. 1 hit.
InterProIPR001446. 5_LipOase_AP.
IPR018295. FLAP/GST2/LTC4S_CS.
IPR023352. MAPEG-like_dom.
IPR001129. Membr-assoc_MAPEG.
[Graphical view]
PfamPF01124. MAPEG. 1 hit.
[Graphical view]
PRINTSPR00488. 5LPOXGNASEAP.
PROSITEPS01297. FLAP_GST2_LTC4S. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291112.
PROQ60860.
SOURCESearch...

Entry information

Entry nameLTC4S_MOUSE
AccessionPrimary (citable) accession number: Q60860
Secondary accession number(s): Q5SVR7, Q9QVS1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot