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Q60854

- SPB6_MOUSE

UniProt

Q60854 - SPB6_MOUSE

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Protein

Serpin B6

Gene

Serpinb6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei343 – 3442Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: BHF-UCL

GO - Biological processi

  1. gonad development Source: BHF-UCL
  2. negative regulation of endopeptidase activity Source: BHF-UCL
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.030.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B6
Alternative name(s):
Placental thrombin inhibitor
Proteinase inhibitor 6
Short name:
PI-6
Gene namesi
Name:Serpinb6
Synonyms:Serpinb6a, Spi3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:103123. Serpinb6a.

Subcellular locationi

Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: InterPro
  3. intracellular Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Serpin B6PRO_0000094107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei197 – 1971N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ60854.
PaxDbiQ60854.
PRIDEiQ60854.

PTM databases

PhosphoSiteiQ60854.

Expressioni

Tissue specificityi

Expressed in the inner ear hair cells, keratinocytes of hair follicles and epidermis in abdominal skin.2 Publications

Developmental stagei

At E13.5, weakly detected in utricle sensory epithelium but not in hair cells. At E16.5, more prominently detected in crista hair cells. Hair cell expression is sustained in postnatal mice. In cochlea, detected in cochlear hair cells in embryo and in hair cells and the greater epithelial ridge (GER) region in early postnatal age.1 Publication

Gene expression databases

BgeeiQ60854.
ExpressionAtlasiQ60854. baseline and differential.
GenevestigatoriQ60854.

Interactioni

Subunit structurei

Forms a complex with the monomeric form of beta-tryptase.By similarity

Protein-protein interaction databases

IntActiQ60854. 2 interactions.
MINTiMINT-1855884.

Structurei

Secondary structure

1
378
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2120
Helixi31 – 4414
Helixi47 – 5711
Helixi59 – 613
Helixi65 – 7713
Beta strandi82 – 9716
Helixi101 – 11111
Beta strandi114 – 1185
Turni120 – 1223
Helixi124 – 13916
Beta strandi157 – 17216
Helixi176 – 1783
Beta strandi180 – 18910
Beta strandi191 – 20818
Turni209 – 2124
Beta strandi213 – 23422
Beta strandi236 – 2383
Helixi241 – 2444
Helixi247 – 2548
Helixi256 – 2583
Beta strandi260 – 26910
Beta strandi271 – 2733
Beta strandi276 – 2783
Helixi281 – 2844
Turni285 – 2873
Turni290 – 2923
Turni294 – 2963
Turni300 – 3023
Beta strandi312 – 3209
Beta strandi322 – 33615
Beta strandi350 – 3545
Turni355 – 3584
Beta strandi359 – 3635

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M37model-A1-378[»]
ProteinModelPortaliQ60854.
SMRiQ60854. Positions 1-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiQ60854.
KOiK13963.
OrthoDBiEOG7327PB.
PhylomeDBiQ60854.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60854-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPLQEANGT FALNLLKILG EDSSKNVFLS PMSISSALAM VFMGAKGTTA
60 70 80 90 100
SQMAQALALD KCSGNGGGDV HQGFQSLLTE VNKTGTQYLL RTANRLFGDK
110 120 130 140 150
TCDLLASFKD SCLKFYEAEL EELDFQGATE ESRQHINTWV AKKTEDKIKE
160 170 180 190 200
VLSPGTVNSD TSLVLVNAIY FKGNWEKQFN KEHTREMPFK VSKNEEKPVQ
210 220 230 240 250
MMFKKSTFKM TYIGEIFTKI LLLPYVSSEL NMIIMLPDEH VELSTVEKEV
260 270 280 290 300
TYEKFIEWTR LDKMDEEEVE VFLPKFKLEE NYNMNDALYK LGMTDAFGGR
310 320 330 340 350
ADFSGMSSKQ GLFLSKVVHK AFVEVNEEGT EAAAATAGMM TVRCMRFTPR
360 370
FCADHPFLFF IHHVKTNGIL FCGRFSSP
Length:378
Mass (Da):42,599
Last modified:November 1, 1996 - v1
Checksum:i4B0F5E1A030BBDF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25844 mRNA. Translation: AAA79684.1.
BC006766 mRNA. Translation: AAH06766.1.
BC057950 mRNA. Translation: AAH57950.1.
CCDSiCCDS26441.1.
PIRiA57488.
RefSeqiNP_001157590.1. NM_001164118.1.
NP_001230121.1. NM_001243192.1.
NP_033280.1. NM_009254.3.
XP_006516686.1. XM_006516623.1.
XP_006516687.1. XM_006516624.1.
UniGeneiMm.252210.
Mm.374799.
Mm.486427.

Genome annotation databases

EnsembliENSMUST00000043552; ENSMUSP00000041016; ENSMUSG00000060147.
ENSMUST00000076532; ENSMUSP00000075848; ENSMUSG00000060147.
ENSMUST00000167163; ENSMUSP00000131115; ENSMUSG00000060147.
GeneIDi20719.
KEGGimmu:20719.
UCSCiuc007qap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25844 mRNA. Translation: AAA79684.1 .
BC006766 mRNA. Translation: AAH06766.1 .
BC057950 mRNA. Translation: AAH57950.1 .
CCDSi CCDS26441.1.
PIRi A57488.
RefSeqi NP_001157590.1. NM_001164118.1.
NP_001230121.1. NM_001243192.1.
NP_033280.1. NM_009254.3.
XP_006516686.1. XM_006516623.1.
XP_006516687.1. XM_006516624.1.
UniGenei Mm.252210.
Mm.374799.
Mm.486427.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M37 model - A 1-378 [» ]
ProteinModelPortali Q60854.
SMRi Q60854. Positions 1-378.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60854. 2 interactions.
MINTi MINT-1855884.

Protein family/group databases

MEROPSi I04.030.

PTM databases

PhosphoSitei Q60854.

Proteomic databases

MaxQBi Q60854.
PaxDbi Q60854.
PRIDEi Q60854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043552 ; ENSMUSP00000041016 ; ENSMUSG00000060147 .
ENSMUST00000076532 ; ENSMUSP00000075848 ; ENSMUSG00000060147 .
ENSMUST00000167163 ; ENSMUSP00000131115 ; ENSMUSG00000060147 .
GeneIDi 20719.
KEGGi mmu:20719.
UCSCi uc007qap.2. mouse.

Organism-specific databases

CTDi 20719.
MGIi MGI:103123. Serpinb6a.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi Q60854.
KOi K13963.
OrthoDBi EOG7327PB.
PhylomeDBi Q60854.

Miscellaneous databases

NextBioi 299313.
PROi Q60854.
SOURCEi Search...

Gene expression databases

Bgeei Q60854.
ExpressionAtlasi Q60854. baseline and differential.
Genevestigatori Q60854.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins."
    Sun J., Rose J.B., Bird P.
    J. Biol. Chem. 270:16089-16096(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
    Scott F.L., Sun J., Whisstock J.C., Kato K., Bird P.I.
    J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSPB6_MOUSE
AccessioniPrimary (citable) accession number: Q60854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3