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Q60847

- COCA1_MOUSE

UniProt

Q60847 - COCA1_MOUSE

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Protein
Collagen alpha-1(XII) chain
Gene
Col12a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XII) chain
Gene namesi
Name:Col12a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:88448. Col12a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 31203097Collagen alpha-1(XII) chain
PRO_0000005784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi700 – 7001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi798 – 7981O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi889 – 8891O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi981 – 9811O-linked (Xyl...) (chondroitin sulfate) Reviewed prediction
Glycosylationi1765 – 17651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2208 – 22081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2530 – 25301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2681 – 26811N-linked (GlcNAc...) Reviewed prediction
Modified residuei2946 – 294614-hydroxyproline By similarity
Modified residuei2949 – 294914-hydroxyproline By similarity
Modified residuei2952 – 295214-hydroxyproline By similarity
Modified residuei2961 – 296114-hydroxyproline By similarity
Modified residuei2967 – 296714-hydroxyproline By similarity
Modified residuei2970 – 297014-hydroxyproline By similarity
Modified residuei2973 – 297314-hydroxyproline By similarity
Modified residuei2985 – 298514-hydroxyproline By similarity
Modified residuei3002 – 300214-hydroxyproline By similarity
Modified residuei3005 – 300514-hydroxyproline By similarity
Modified residuei3016 – 301614-hydroxyproline By similarity
Modified residuei3025 – 302514-hydroxyproline By similarity
Modified residuei3028 – 302814-hydroxyproline By similarity
Modified residuei3031 – 303114-hydroxyproline By similarity

Post-translational modificationi

The triple-helical tail is stabilized by disulfide bonds at each end By similarity.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
O-glycosylation of isoform 2; glycosaminoglycan of chondroitin-sulfate type By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ60847.
PaxDbiQ60847.
PRIDEiQ60847.

PTM databases

PhosphoSiteiQ60847.

Expressioni

Tissue specificityi

Highest expression in tendons, perichondrium, skin, cornea, sclera, blood vessels, and periosteum.

Developmental stagei

The long NC3 XIIA isoforms are predominant at early stages (ED7 and 11); at later stages of development (ED15 and 17) the short NC3 XIIB forms become the major forms. As the short NC3 forms become the major product, the long splice variant continues to be expressed in several tissues, even after birth. The long NC1 isoforms, XIIA-1 and XIIB-1, peak in 15-day old embryos and decrease in 17-day old ones. The expression of the short NC1 form XIIB-2 remains constant throughout late stages of embryonic development (ED15 and ED17).

Gene expression databases

ArrayExpressiQ60847.
BgeeiQ60847.
CleanExiMM_COL12A1.
GenevestigatoriQ60847.

Interactioni

Subunit structurei

Trimer of identical chains each containing 190 kDa of non-triple-helical sequences By similarity.

Protein-protein interaction databases

IntActiQ60847. 1 interaction.
MINTiMINT-4091424.

Structurei

3D structure databases

ProteinModelPortaliQ60847.
SMRiQ60847. Positions 25-1179, 1196-1367, 1378-2312, 2319-2726.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11791Fibronectin type-III 1
Add
BLAST
Domaini140 – 316177VWFA 1
Add
BLAST
Domaini336 – 42691Fibronectin type-III 2
Add
BLAST
Domaini440 – 616177VWFA 2
Add
BLAST
Domaini634 – 72390Fibronectin type-III 3
Add
BLAST
Domaini725 – 81692Fibronectin type-III 4
Add
BLAST
Domaini817 – 90589Fibronectin type-III 5
Add
BLAST
Domaini907 – 99892Fibronectin type-III 6
Add
BLAST
Domaini1000 – 108788Fibronectin type-III 7
Add
BLAST
Domaini1089 – 117991Fibronectin type-III 8
Add
BLAST
Domaini1199 – 1371173VWFA 3
Add
BLAST
Domaini1387 – 147589Fibronectin type-III 9
Add
BLAST
Domaini1476 – 156792Fibronectin type-III 10
Add
BLAST
Domaini1568 – 165891Fibronectin type-III 11
Add
BLAST
Domaini1659 – 175496Fibronectin type-III 12
Add
BLAST
Domaini1757 – 185195Fibronectin type-III 13
Add
BLAST
Domaini1852 – 193786Fibronectin type-III 14
Add
BLAST
Domaini1938 – 202891Fibronectin type-III 15
Add
BLAST
Domaini2029 – 211991Fibronectin type-III 16
Add
BLAST
Domaini2120 – 220889Fibronectin type-III 17
Add
BLAST
Domaini2209 – 229688Fibronectin type-III 18
Add
BLAST
Domaini2325 – 2498174VWFA 4
Add
BLAST
Domaini2522 – 2714193Laminin G-like
Add
BLAST
Domaini2749 – 280052Collagen-like 1
Add
BLAST
Domaini2804 – 285451Collagen-like 2
Add
BLAST
Domaini2855 – 289945Collagen-like 3
Add
BLAST
Domaini2943 – 299250Collagen-like 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2453 – 2748296Nonhelical region (NC3)
Add
BLAST
Regioni2749 – 2900152Triple-helical region (COL2) with 1 imperfection
Add
BLAST
Regioni2901 – 294343Nonhelical region (NC2)
Add
BLAST
Regioni2944 – 3046103Triple-helical region (COL1) with 2 imperfections
Add
BLAST
Regioni3047 – 312074Nonhelical region (NC1)
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi862 – 8643Cell attachment site Reviewed prediction
Motifi2781 – 27833Cell attachment site Reviewed prediction
Motifi2897 – 28993Cell attachment site Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi865 – 8684Poly-Thr

Sequence similaritiesi

Contains 4 VWFA domains.

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00740000115118.
HOGENOMiHOG000111877.
HOVERGENiHBG051060.
InParanoidiQ60847.
KOiK08132.
OrthoDBiEOG71P290.
PhylomeDBiQ60847.
TreeFamiTF329914.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.10. 18 hits.
3.40.50.410. 4 hits.
InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 4 hits.
PF00041. fn3. 18 hits.
PF00092. VWA. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 18 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 11 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 4 hits.
PROSITEiPS50853. FN3. 18 hits.
PS50234. VWFA. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: The final tissue form of collagen XII may contain homotrimers or any combination of the various isoforms.

Isoform 1 (identifier: Q60847-1) [UniParc]FASTAAdd to Basket

Also known as: XIIA-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTRLPRALA ALGVALLLSS IEAEVDPPSD LNFKIIDENT VHMSWERPVD     50
PIVGYRITVD PTTDGPTKEF TLAASTTETL LSDLIPETQY VVTITSYNEV 100
EESVPVIGQL TIQTGGPTKP GEKKPGKTEI QKCSVSAWTD LVFLVDGSWS 150
VGRNNFKYIL DFIVALVSAF DIGEEKTRVG VVQYSSDTRT EFNLNQYYRR 200
EDLLAAVKKI PYKGGNTMTG DAIDYLVKNT FTESAGSRAG FPKVAIIITD 250
GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 300
NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VVTELSSKYI 350
RLSWDPSPSA VTGYKILLTP MAAGSRHHAL SVGPQTTTLN VRDLTADTEY 400
QISVFAMKGL TSSEPTSVME KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS 450
IGIANFVKVR AFLEVLAKSF EISPNRVQIS LVQYSRDPHT EFTLKEFNRV 500
EDIIKAINTF PYRGGSTNTG KAMTYVREKI FVPNKGSRSN VPKVMILITD 550
GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 600
DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLRF TQVTANSFKA 650
EWSPPGDNVF SYHVTYKDAN GDDEVTVVEP ASSTSVVLNN LRPETLYLVN 700
VTAEYEDGFS VPITGEETTA EVKGVPRNLK VTDETTDSFK LTWSQAPGRV 750
LRYRIRYRPV SGGESKEVST PANQRRKTLE NLTPDTKYEI SVIAEYSSGP 800
GSPLTGNAAT EEVRGNPRDL RVSDATTSTL KLSWSRAPGK VKQYLVTYTP 850
AAGGETQEVT VRGDTTTTML RKLKEGTQYD LSVTALYASG AGEALSGKGS 900
TLEERGSPQN LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIEAGE 950
TTLPGDAIHT MIENLQPETK YKISVFATYS SGEGEPVTGD ATTELSQDSK 1000
ILRVDEETEH TMRVTWKAAP GKVVNYRVVY RPQGGGRQMV AKVPPTVTST 1050
VLKRLQPQTT YDITVLPMYK TGEGKLRQGS GTTASRFKSP RNLKTSDPTM 1100
SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVLGPYDN TVVLEELRAG 1150
TTYRVNVFGM FDGGESLPLV GQEMTTLSDT TVTPFLSSGM DCLTRAEADI 1200
VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE 1250
WQLNAHRDKK SLLQAVANLP YKGGNTLTGM ALNFIRQQSF KTQAGMRPRA 1300
RKIGVLITDG KSQDDVEAPS KKLKDEGVEL FAIGIKNADE VELKMIATDP 1350
DDTHAYNVAD FESLSKIVDD LTINLCNSVK GPGDLEAPTN LVISERTHRS 1400
FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLDTSTV LKDLKPETDY 1450
VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1500
TGYTVSYQPT RSPEGTKPKE MRVGPTVNDV QLTGLLPNTE YEVTVQAVLY 1550
DLTSEPAKAR EVTLPLPRPQ DVKLRDVTHS TMNVVWEPVL GKVRKYIVRY 1600
KTPDEEFKEV EVDRSRASTI LKDLSSQTQY TVSVSAVYDE GTSPPATAYD 1650
TTRRVPAPTN LQFTEVTPES FRGTWDHGAS DVSLYRITWA PVGNPDKMET 1700
ILNGDENTLV FENLNPNTPY EVSITAIYPD ESESEDLSGT ERTLRLIPLT 1750
TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT 1800
ITVGGRQNSV LLQKLKPDTP YTITVYSQYP DGEGGRMTGR GKTKPLNTVR 1850
NLRVYDPSTS SLSVRWDHAE GNPRQYKLFY APTSGGPEEL VPIPGNTNYA 1900
ILRNLQPDTP YTITVVPVYT EGDGGRTSDT GRTLVRGLAR NIQVYNPTPN 1950
SLDVRWDPAP GPVQQYRIVY SPVAGTRPSE SIVVPGNTRT VHLERLIPDT 2000
PYSVNIVALY SDGEGNPSPS QGRTLPRSGP RNIRVFGETT NSLSVAWDHA 2050
DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVILQPLQPD TPYKITVIAI 2100
YEDGDGGHLT GNGRTVGLLP PQNIHIFDEW YTRFRVSWDP SPSPVLGYKI 2150
VYKPVGSNEP MEAFVGEVTS YTLHNLNPST TYDVSVYAQY DSGLSVPLTD 2200
QGTTLYLNVT DLKTYQVGWD TFCVKWSPHR AATSYRLKLS PADGTRGQEI 2250
TVRGSETSHC FTGLSPEAEY GVTVFVQTPN LEGPGVPIKE QTTVKPTEAP 2300
TEPPTPSPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN FNKVVKFIFN 2350
TVGAFDEVNP AGIQVSFVQY SDEVKSEFKL NTYNDKALAL GALQNIRYRG 2400
GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAAFVI 2450
QQSGFSVFVV GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT 2500
FVCETATSSC PLIYLDGYTS PGFKMLEAYN LTEKNFASVQ GVSLESGSFP 2550
SYSAYRLQKN AFINQPTAEL HPNGLPPSYT IILLFRLLPE TPSDPFAIWQ 2600
ITDRDYRPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD EVKTLFYGSF 2650
HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS 2700
ATFQIQSFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP 2750
PGPPGPAGGP GAKGPRGERG INGAVGPPGP RGDTGPPGPQ GPPGPQGPNG 2800
LSIPGEQGRQ GMKGDAGEPG LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG 2850
AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG DHGRPGQSGL KGEKGDRGDI 2900
ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR NQPGPPGPPG 2950
PPGSAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGTGSQGPRG 3000
PPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ 3050
CASIPYNGQG YPEPYVPEGG AYLPEREPFI VPVEPERTAE YEDDYGADEP 3100
DQQHPDHMRW RRALRPGPAE 3120
Length:3,120
Mass (Da):340,214
Last modified:March 6, 2007 - v3
Checksum:iC4D9264E3C5C8CB5
GO
Isoform 2 (identifier: Q60847-2) [UniParc]FASTAAdd to Basket

Also known as: ER#K, XIIA-2

The sequence of this isoform differs from the canonical sequence as follows:
     3063-3065: EPY → GSG
     3066-3120: Missing.

Show »
Length:3,065
Mass (Da):333,671
Checksum:i0FE5F351A4051FD7
GO
Isoform 3 (identifier: Q60847-3) [UniParc]FASTAAdd to Basket

Also known as: XIIB-1

The sequence of this isoform differs from the canonical sequence as follows:
     25-1186: Missing.

Show »
Length:1,958
Mass (Da):212,624
Checksum:i9F869932749E4D20
GO
Isoform 4 (identifier: Q60847-4) [UniParc]FASTAAdd to Basket

Also known as: XIIB-2

The sequence of this isoform differs from the canonical sequence as follows:
     25-1186: Missing.
     3063-3065: EPY → GSG
     3066-3120: Missing.

Show »
Length:1,903
Mass (Da):206,081
Checksum:iB5A0AF0676EFC951
GO
Isoform 5 (identifier: Q60847-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     3063-3068: EPYVPE → GMLLPS
     3069-3120: Missing.

Show »
Length:3,068
Mass (Da):334,069
Checksum:i72C55C50A6D351A4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 11861162Missing in isoform 3 and isoform 4.
VSP_001150Add
BLAST
Alternative sequencei3063 – 30686EPYVPE → GMLLPS in isoform 5.
VSP_023404
Alternative sequencei3063 – 30653EPY → GSG in isoform 2 and isoform 4.
VSP_001151
Alternative sequencei3066 – 312055Missing in isoform 2 and isoform 4.
VSP_001152Add
BLAST
Alternative sequencei3069 – 312052Missing in isoform 5.
VSP_023405Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451A → G in AAA99719. 1 Publication
Sequence conflicti421 – 4211K → KTQPK in AAA99719. 1 Publication
Sequence conflicti453 – 4531I → T in AAA99719. 1 Publication
Sequence conflicti552 – 5521K → E in AAA99719. 1 Publication
Sequence conflicti611 – 6111E → V in AAB07047. 1 Publication
Sequence conflicti611 – 6111E → V in AAA99719. 1 Publication
Sequence conflicti690 – 6901N → S in AAA99719. 1 Publication
Sequence conflicti797 – 7971S → P in AAA99719. 1 Publication
Sequence conflicti954 – 9541P → N in AAA99719. 1 Publication
Sequence conflicti1079 – 10791G → R in AAA99719. 1 Publication
Sequence conflicti1271 – 12711Y → N in AAA99719. 1 Publication
Sequence conflicti1472 – 14721T → A in AAA99719. 1 Publication
Sequence conflicti1524 – 15241G → E in AAA99719. 1 Publication
Sequence conflicti1773 – 17731V → I in AAA99719. 1 Publication
Sequence conflicti1831 – 18311D → G in AAA99719. 1 Publication
Sequence conflicti1939 – 19391A → S in AAA99719. 1 Publication
Sequence conflicti2005 – 20051N → Y in AAA99719. 1 Publication
Sequence conflicti2428 – 24292PK → R in AAA99719. 1 Publication
Sequence conflicti2432 – 24321V → G in AAA99719. 1 Publication
Sequence conflicti2515 – 25151L → Q in AAA99719. 1 Publication
Sequence conflicti2551 – 25522SY → DS in AAA99719. 1 Publication
Sequence conflicti2861 – 28644Missing in AAA99719. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25652 mRNA. Translation: AAA99719.1.
AC157477 Genomic DNA. No translation available.
AC166055 Genomic DNA. No translation available.
U57095 mRNA. Translation: AAB07047.1.
CCDSiCCDS72284.1. [Q60847-2]
PIRiC44479.
D44479.
RefSeqiNP_001277237.1. NM_001290308.1. [Q60847-2]
XP_006510861.1. XM_006510798.1. [Q60847-5]
UniGeneiMm.3819.

Genome annotation databases

EnsembliENSMUST00000071750; ENSMUSP00000071662; ENSMUSG00000032332. [Q60847-2]
GeneIDi12816.
KEGGimmu:12816.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25652 mRNA. Translation: AAA99719.1 .
AC157477 Genomic DNA. No translation available.
AC166055 Genomic DNA. No translation available.
U57095 mRNA. Translation: AAB07047.1 .
CCDSi CCDS72284.1. [Q60847-2 ]
PIRi C44479.
D44479.
RefSeqi NP_001277237.1. NM_001290308.1. [Q60847-2 ]
XP_006510861.1. XM_006510798.1. [Q60847-5 ]
UniGenei Mm.3819.

3D structure databases

ProteinModelPortali Q60847.
SMRi Q60847. Positions 25-1179, 1196-1367, 1378-2312, 2319-2726.
ModBasei Search...

Protein-protein interaction databases

IntActi Q60847. 1 interaction.
MINTi MINT-4091424.

PTM databases

PhosphoSitei Q60847.

Proteomic databases

MaxQBi Q60847.
PaxDbi Q60847.
PRIDEi Q60847.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000071750 ; ENSMUSP00000071662 ; ENSMUSG00000032332 . [Q60847-2 ]
GeneIDi 12816.
KEGGi mmu:12816.

Organism-specific databases

CTDi 1303.
MGIi MGI:88448. Col12a1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00740000115118.
HOGENOMi HOG000111877.
HOVERGENi HBG051060.
InParanoidi Q60847.
KOi K08132.
OrthoDBi EOG71P290.
PhylomeDBi Q60847.
TreeFami TF329914.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

PROi Q60847.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60847.
Bgeei Q60847.
CleanExi MM_COL12A1.
Genevestigatori Q60847.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
2.60.40.10. 18 hits.
3.40.50.410. 4 hits.
InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001791. Laminin_G.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01391. Collagen. 4 hits.
PF00041. fn3. 18 hits.
PF00092. VWA. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 18 hits.
SM00210. TSPN. 1 hit.
SM00327. VWA. 4 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 11 hits.
SSF49899. SSF49899. 1 hit.
SSF53300. SSF53300. 4 hits.
PROSITEi PS50853. FN3. 18 hits.
PS50234. VWFA. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development."
    Boehme K., Li Y., Oh P.S., Olsen B.R.
    Dev. Dyn. 204:432-445(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING (ISOFORMS 1 AND 3).
    Strain: C57BL/6J and Swiss Webster.
    Tissue: Skin.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing."
    Kania A.M., Reichenberger E., Baur S.T., Karimbux N.Y., Taylor R.W., Olsen B.R., Nishimura I.
    J. Biol. Chem. 274:22053-22059(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3047-3120, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4).
    Strain: C57BL/6J.
    Tissue: Skin fibroblast.

Entry informationi

Entry nameiCOCA1_MOUSE
AccessioniPrimary (citable) accession number: Q60847
Secondary accession number(s): P70322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 6, 2007
Last modified: September 3, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi