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Q60847

- COCA1_MOUSE

UniProt

Q60847 - COCA1_MOUSE

Protein

Collagen alpha-1(XII) chain

Gene

Col12a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 3 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix.By similarity

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XII) chain
    Gene namesi
    Name:Col12a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:88448. Col12a1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: Ensembl
    3. extracellular vesicular exosome Source: Ensembl
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 31203097Collagen alpha-1(XII) chainPRO_0000005784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi700 – 7001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi798 – 7981O-linked (Xyl...) (chondroitin sulfate)Sequence Analysis
    Glycosylationi889 – 8891O-linked (Xyl...) (chondroitin sulfate)Sequence Analysis
    Glycosylationi981 – 9811O-linked (Xyl...) (chondroitin sulfate)Sequence Analysis
    Glycosylationi1765 – 17651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2208 – 22081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2530 – 25301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2681 – 26811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei2946 – 294614-hydroxyprolineBy similarity
    Modified residuei2949 – 294914-hydroxyprolineBy similarity
    Modified residuei2952 – 295214-hydroxyprolineBy similarity
    Modified residuei2961 – 296114-hydroxyprolineBy similarity
    Modified residuei2967 – 296714-hydroxyprolineBy similarity
    Modified residuei2970 – 297014-hydroxyprolineBy similarity
    Modified residuei2973 – 297314-hydroxyprolineBy similarity
    Modified residuei2985 – 298514-hydroxyprolineBy similarity
    Modified residuei3002 – 300214-hydroxyprolineBy similarity
    Modified residuei3005 – 300514-hydroxyprolineBy similarity
    Modified residuei3016 – 301614-hydroxyprolineBy similarity
    Modified residuei3025 – 302514-hydroxyprolineBy similarity
    Modified residuei3028 – 302814-hydroxyprolineBy similarity
    Modified residuei3031 – 303114-hydroxyprolineBy similarity

    Post-translational modificationi

    The triple-helical tail is stabilized by disulfide bonds at each end.By similarity
    Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
    O-glycosylation of isoform 2; glycosaminoglycan of chondroitin-sulfate type.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiQ60847.
    PaxDbiQ60847.
    PRIDEiQ60847.

    PTM databases

    PhosphoSiteiQ60847.

    Expressioni

    Tissue specificityi

    Highest expression in tendons, perichondrium, skin, cornea, sclera, blood vessels, and periosteum.

    Developmental stagei

    The long NC3 XIIA isoforms are predominant at early stages (ED7 and 11); at later stages of development (ED15 and 17) the short NC3 XIIB forms become the major forms. As the short NC3 forms become the major product, the long splice variant continues to be expressed in several tissues, even after birth. The long NC1 isoforms, XIIA-1 and XIIB-1, peak in 15-day old embryos and decrease in 17-day old ones. The expression of the short NC1 form XIIB-2 remains constant throughout late stages of embryonic development (ED15 and ED17).

    Gene expression databases

    ArrayExpressiQ60847.
    BgeeiQ60847.
    CleanExiMM_COL12A1.
    GenevestigatoriQ60847.

    Interactioni

    Subunit structurei

    Trimer of identical chains each containing 190 kDa of non-triple-helical sequences.By similarity

    Protein-protein interaction databases

    IntActiQ60847. 1 interaction.
    MINTiMINT-4091424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60847.
    SMRiQ60847. Positions 25-1179, 1196-1367, 1378-2312, 2319-2726.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11791Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini140 – 316177VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini336 – 42691Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini440 – 616177VWFA 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini634 – 72390Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini725 – 81692Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini817 – 90589Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini907 – 99892Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini1000 – 108788Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1089 – 117991Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1199 – 1371173VWFA 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1387 – 147589Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini1476 – 156792Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1568 – 165891Fibronectin type-III 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini1659 – 175496Fibronectin type-III 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1757 – 185195Fibronectin type-III 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1852 – 193786Fibronectin type-III 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini1938 – 202891Fibronectin type-III 15PROSITE-ProRule annotationAdd
    BLAST
    Domaini2029 – 211991Fibronectin type-III 16PROSITE-ProRule annotationAdd
    BLAST
    Domaini2120 – 220889Fibronectin type-III 17PROSITE-ProRule annotationAdd
    BLAST
    Domaini2209 – 229688Fibronectin type-III 18PROSITE-ProRule annotationAdd
    BLAST
    Domaini2325 – 2498174VWFA 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2522 – 2714193Laminin G-likeAdd
    BLAST
    Domaini2749 – 280052Collagen-like 1Add
    BLAST
    Domaini2804 – 285451Collagen-like 2Add
    BLAST
    Domaini2855 – 289945Collagen-like 3Add
    BLAST
    Domaini2943 – 299250Collagen-like 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2453 – 2748296Nonhelical region (NC3)Add
    BLAST
    Regioni2749 – 2900152Triple-helical region (COL2) with 1 imperfectionAdd
    BLAST
    Regioni2901 – 294343Nonhelical region (NC2)Add
    BLAST
    Regioni2944 – 3046103Triple-helical region (COL1) with 2 imperfectionsAdd
    BLAST
    Regioni3047 – 312074Nonhelical region (NC1)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi862 – 8643Cell attachment siteSequence Analysis
    Motifi2781 – 27833Cell attachment siteSequence Analysis
    Motifi2897 – 28993Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi865 – 8684Poly-Thr

    Sequence similaritiesi

    Contains 4 collagen-like domains.Curated
    Contains 18 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 4 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00740000115118.
    HOGENOMiHOG000111877.
    HOVERGENiHBG051060.
    InParanoidiQ60847.
    KOiK08132.
    OrthoDBiEOG71P290.
    PhylomeDBiQ60847.
    TreeFamiTF329914.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    2.60.40.10. 18 hits.
    3.40.50.410. 4 hits.
    InterProiIPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001791. Laminin_G.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01391. Collagen. 4 hits.
    PF00041. fn3. 18 hits.
    PF00092. VWA. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 18 hits.
    SM00210. TSPN. 1 hit.
    SM00327. VWA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 11 hits.
    SSF49899. SSF49899. 1 hit.
    SSF53300. SSF53300. 4 hits.
    PROSITEiPS50853. FN3. 18 hits.
    PS50234. VWFA. 4 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: The final tissue form of collagen XII may contain homotrimers or any combination of the various isoforms.

    Isoform 1 (identifier: Q60847-1) [UniParc]FASTAAdd to Basket

    Also known as: XIIA-1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTRLPRALA ALGVALLLSS IEAEVDPPSD LNFKIIDENT VHMSWERPVD     50
    PIVGYRITVD PTTDGPTKEF TLAASTTETL LSDLIPETQY VVTITSYNEV 100
    EESVPVIGQL TIQTGGPTKP GEKKPGKTEI QKCSVSAWTD LVFLVDGSWS 150
    VGRNNFKYIL DFIVALVSAF DIGEEKTRVG VVQYSSDTRT EFNLNQYYRR 200
    EDLLAAVKKI PYKGGNTMTG DAIDYLVKNT FTESAGSRAG FPKVAIIITD 250
    GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 300
    NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VVTELSSKYI 350
    RLSWDPSPSA VTGYKILLTP MAAGSRHHAL SVGPQTTTLN VRDLTADTEY 400
    QISVFAMKGL TSSEPTSVME KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS 450
    IGIANFVKVR AFLEVLAKSF EISPNRVQIS LVQYSRDPHT EFTLKEFNRV 500
    EDIIKAINTF PYRGGSTNTG KAMTYVREKI FVPNKGSRSN VPKVMILITD 550
    GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 600
    DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLRF TQVTANSFKA 650
    EWSPPGDNVF SYHVTYKDAN GDDEVTVVEP ASSTSVVLNN LRPETLYLVN 700
    VTAEYEDGFS VPITGEETTA EVKGVPRNLK VTDETTDSFK LTWSQAPGRV 750
    LRYRIRYRPV SGGESKEVST PANQRRKTLE NLTPDTKYEI SVIAEYSSGP 800
    GSPLTGNAAT EEVRGNPRDL RVSDATTSTL KLSWSRAPGK VKQYLVTYTP 850
    AAGGETQEVT VRGDTTTTML RKLKEGTQYD LSVTALYASG AGEALSGKGS 900
    TLEERGSPQN LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIEAGE 950
    TTLPGDAIHT MIENLQPETK YKISVFATYS SGEGEPVTGD ATTELSQDSK 1000
    ILRVDEETEH TMRVTWKAAP GKVVNYRVVY RPQGGGRQMV AKVPPTVTST 1050
    VLKRLQPQTT YDITVLPMYK TGEGKLRQGS GTTASRFKSP RNLKTSDPTM 1100
    SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVLGPYDN TVVLEELRAG 1150
    TTYRVNVFGM FDGGESLPLV GQEMTTLSDT TVTPFLSSGM DCLTRAEADI 1200
    VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE 1250
    WQLNAHRDKK SLLQAVANLP YKGGNTLTGM ALNFIRQQSF KTQAGMRPRA 1300
    RKIGVLITDG KSQDDVEAPS KKLKDEGVEL FAIGIKNADE VELKMIATDP 1350
    DDTHAYNVAD FESLSKIVDD LTINLCNSVK GPGDLEAPTN LVISERTHRS 1400
    FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLDTSTV LKDLKPETDY 1450
    VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1500
    TGYTVSYQPT RSPEGTKPKE MRVGPTVNDV QLTGLLPNTE YEVTVQAVLY 1550
    DLTSEPAKAR EVTLPLPRPQ DVKLRDVTHS TMNVVWEPVL GKVRKYIVRY 1600
    KTPDEEFKEV EVDRSRASTI LKDLSSQTQY TVSVSAVYDE GTSPPATAYD 1650
    TTRRVPAPTN LQFTEVTPES FRGTWDHGAS DVSLYRITWA PVGNPDKMET 1700
    ILNGDENTLV FENLNPNTPY EVSITAIYPD ESESEDLSGT ERTLRLIPLT 1750
    TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT 1800
    ITVGGRQNSV LLQKLKPDTP YTITVYSQYP DGEGGRMTGR GKTKPLNTVR 1850
    NLRVYDPSTS SLSVRWDHAE GNPRQYKLFY APTSGGPEEL VPIPGNTNYA 1900
    ILRNLQPDTP YTITVVPVYT EGDGGRTSDT GRTLVRGLAR NIQVYNPTPN 1950
    SLDVRWDPAP GPVQQYRIVY SPVAGTRPSE SIVVPGNTRT VHLERLIPDT 2000
    PYSVNIVALY SDGEGNPSPS QGRTLPRSGP RNIRVFGETT NSLSVAWDHA 2050
    DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVILQPLQPD TPYKITVIAI 2100
    YEDGDGGHLT GNGRTVGLLP PQNIHIFDEW YTRFRVSWDP SPSPVLGYKI 2150
    VYKPVGSNEP MEAFVGEVTS YTLHNLNPST TYDVSVYAQY DSGLSVPLTD 2200
    QGTTLYLNVT DLKTYQVGWD TFCVKWSPHR AATSYRLKLS PADGTRGQEI 2250
    TVRGSETSHC FTGLSPEAEY GVTVFVQTPN LEGPGVPIKE QTTVKPTEAP 2300
    TEPPTPSPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN FNKVVKFIFN 2350
    TVGAFDEVNP AGIQVSFVQY SDEVKSEFKL NTYNDKALAL GALQNIRYRG 2400
    GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAAFVI 2450
    QQSGFSVFVV GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT 2500
    FVCETATSSC PLIYLDGYTS PGFKMLEAYN LTEKNFASVQ GVSLESGSFP 2550
    SYSAYRLQKN AFINQPTAEL HPNGLPPSYT IILLFRLLPE TPSDPFAIWQ 2600
    ITDRDYRPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD EVKTLFYGSF 2650
    HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS 2700
    ATFQIQSFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP 2750
    PGPPGPAGGP GAKGPRGERG INGAVGPPGP RGDTGPPGPQ GPPGPQGPNG 2800
    LSIPGEQGRQ GMKGDAGEPG LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG 2850
    AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG DHGRPGQSGL KGEKGDRGDI 2900
    ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR NQPGPPGPPG 2950
    PPGSAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGTGSQGPRG 3000
    PPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ 3050
    CASIPYNGQG YPEPYVPEGG AYLPEREPFI VPVEPERTAE YEDDYGADEP 3100
    DQQHPDHMRW RRALRPGPAE 3120
    Length:3,120
    Mass (Da):340,214
    Last modified:March 6, 2007 - v3
    Checksum:iC4D9264E3C5C8CB5
    GO
    Isoform 2 (identifier: Q60847-2) [UniParc]FASTAAdd to Basket

    Also known as: ER#K, XIIA-2

    The sequence of this isoform differs from the canonical sequence as follows:
         3063-3065: EPY → GSG
         3066-3120: Missing.

    Show »
    Length:3,065
    Mass (Da):333,671
    Checksum:i0FE5F351A4051FD7
    GO
    Isoform 3 (identifier: Q60847-3) [UniParc]FASTAAdd to Basket

    Also known as: XIIB-1

    The sequence of this isoform differs from the canonical sequence as follows:
         25-1186: Missing.

    Show »
    Length:1,958
    Mass (Da):212,624
    Checksum:i9F869932749E4D20
    GO
    Isoform 4 (identifier: Q60847-4) [UniParc]FASTAAdd to Basket

    Also known as: XIIB-2

    The sequence of this isoform differs from the canonical sequence as follows:
         25-1186: Missing.
         3063-3065: EPY → GSG
         3066-3120: Missing.

    Show »
    Length:1,903
    Mass (Da):206,081
    Checksum:iB5A0AF0676EFC951
    GO
    Isoform 5 (identifier: Q60847-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         3063-3068: EPYVPE → GMLLPS
         3069-3120: Missing.

    Show »
    Length:3,068
    Mass (Da):334,069
    Checksum:i72C55C50A6D351A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti245 – 2451A → G in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti421 – 4211K → KTQPK in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti453 – 4531I → T in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti552 – 5521K → E in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti611 – 6111E → V in AAB07047. (PubMed:8601036)Curated
    Sequence conflicti611 – 6111E → V in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti690 – 6901N → S in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti797 – 7971S → P in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti954 – 9541P → N in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1079 – 10791G → R in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1271 – 12711Y → N in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1472 – 14721T → A in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1524 – 15241G → E in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1773 – 17731V → I in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1831 – 18311D → G in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti1939 – 19391A → S in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2005 – 20051N → Y in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2428 – 24292PK → R in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2432 – 24321V → G in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2515 – 25151L → Q in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2551 – 25522SY → DS in AAA99719. (PubMed:8601036)Curated
    Sequence conflicti2861 – 28644Missing in AAA99719. (PubMed:8601036)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 11861162Missing in isoform 3 and isoform 4. CuratedVSP_001150Add
    BLAST
    Alternative sequencei3063 – 30686EPYVPE → GMLLPS in isoform 5. 1 PublicationVSP_023404
    Alternative sequencei3063 – 30653EPY → GSG in isoform 2 and isoform 4. CuratedVSP_001151
    Alternative sequencei3066 – 312055Missing in isoform 2 and isoform 4. CuratedVSP_001152Add
    BLAST
    Alternative sequencei3069 – 312052Missing in isoform 5. 1 PublicationVSP_023405Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25652 mRNA. Translation: AAA99719.1.
    AC157477 Genomic DNA. No translation available.
    AC166055 Genomic DNA. No translation available.
    U57095 mRNA. Translation: AAB07047.1.
    CCDSiCCDS72284.1. [Q60847-2]
    PIRiC44479.
    D44479.
    RefSeqiNP_001277237.1. NM_001290308.1. [Q60847-2]
    XP_006510861.1. XM_006510798.1. [Q60847-5]
    UniGeneiMm.3819.

    Genome annotation databases

    EnsembliENSMUST00000071750; ENSMUSP00000071662; ENSMUSG00000032332. [Q60847-2]
    GeneIDi12816.
    KEGGimmu:12816.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25652 mRNA. Translation: AAA99719.1 .
    AC157477 Genomic DNA. No translation available.
    AC166055 Genomic DNA. No translation available.
    U57095 mRNA. Translation: AAB07047.1 .
    CCDSi CCDS72284.1. [Q60847-2 ]
    PIRi C44479.
    D44479.
    RefSeqi NP_001277237.1. NM_001290308.1. [Q60847-2 ]
    XP_006510861.1. XM_006510798.1. [Q60847-5 ]
    UniGenei Mm.3819.

    3D structure databases

    ProteinModelPortali Q60847.
    SMRi Q60847. Positions 25-1179, 1196-1367, 1378-2312, 2319-2726.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60847. 1 interaction.
    MINTi MINT-4091424.

    PTM databases

    PhosphoSitei Q60847.

    Proteomic databases

    MaxQBi Q60847.
    PaxDbi Q60847.
    PRIDEi Q60847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000071750 ; ENSMUSP00000071662 ; ENSMUSG00000032332 . [Q60847-2 ]
    GeneIDi 12816.
    KEGGi mmu:12816.

    Organism-specific databases

    CTDi 1303.
    MGIi MGI:88448. Col12a1.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00740000115118.
    HOGENOMi HOG000111877.
    HOVERGENi HBG051060.
    InParanoidi Q60847.
    KOi K08132.
    OrthoDBi EOG71P290.
    PhylomeDBi Q60847.
    TreeFami TF329914.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    PROi Q60847.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60847.
    Bgeei Q60847.
    CleanExi MM_COL12A1.
    Genevestigatori Q60847.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    2.60.40.10. 18 hits.
    3.40.50.410. 4 hits.
    InterProi IPR008160. Collagen.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001791. Laminin_G.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01391. Collagen. 4 hits.
    PF00041. fn3. 18 hits.
    PF00092. VWA. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 18 hits.
    SM00210. TSPN. 1 hit.
    SM00327. VWA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 11 hits.
    SSF49899. SSF49899. 1 hit.
    SSF53300. SSF53300. 4 hits.
    PROSITEi PS50853. FN3. 18 hits.
    PS50234. VWFA. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development."
      Boehme K., Li Y., Oh P.S., Olsen B.R.
      Dev. Dyn. 204:432-445(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING (ISOFORMS 1 AND 3).
      Strain: C57BL/6J and Swiss Webster.
      Tissue: Skin.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing."
      Kania A.M., Reichenberger E., Baur S.T., Karimbux N.Y., Taylor R.W., Olsen B.R., Nishimura I.
      J. Biol. Chem. 274:22053-22059(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3047-3120, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4).
      Strain: C57BL/6J.
      Tissue: Skin fibroblast.

    Entry informationi

    Entry nameiCOCA1_MOUSE
    AccessioniPrimary (citable) accession number: Q60847
    Secondary accession number(s): P70322
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 136 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3