Q60847 (COCA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XII) chain

Gene names

Name:

Col12a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix By similarity.
Subunit structure	Trimer of identical chains each containing 190 kDa of non-triple-helical sequences By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Highest expression in tendons, perichondrium, skin, cornea, sclera, blood vessels, and periosteum.
Developmental stage	The long NC3 XIIA isoforms are predominant at early stages (ED7 and 11); at later stages of development (ED15 and 17) the short NC3 XIIB forms become the major forms. As the short NC3 forms become the major product, the long splice variant continues to be expressed in several tissues, even after birth. The long NC1 isoforms, XIIA-1 and XIIB-1, peak in 15-day old embryos and decrease in 17-day old ones. The expression of the short NC1 form XIIB-2 remains constant throughout late stages of embryonic development (ED15 and ED17).
Post-translational modification	The triple-helical tail is stabilized by disulfide bonds at each end By similarity. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity. O-glycosylation of isoform 2; glycosaminoglycan of chondroitin-sulfate type By similarity.
Sequence similarities	Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. Contains 4 collagen-like domains. Contains 18 fibronectin type-III domains. Contains 1 laminin G-like domain. Contains 4 VWFA domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Domain	Collagen Repeat Signal
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	collagen Inferred from electronic annotation. Source: UniProtKB-KW extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: The final tissue form of collagen XII may contain homotrimers or any combination of the various isoforms.

Isoform 1 (identifier: Q60847-1)

Also known as: XIIA-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q60847-2)

Also known as: ER#K; XIIA-2;

The sequence of this isoform differs from the canonical sequence as follows:
     3063-3065: EPY → GSG
     3066-3120: Missing.

Isoform 3 (identifier: Q60847-3)

Also known as: XIIB-1;

The sequence of this isoform differs from the canonical sequence as follows:
     25-1186: Missing.

Isoform 4 (identifier: Q60847-4)

Also known as: XIIB-2;

The sequence of this isoform differs from the canonical sequence as follows:
     25-1186: Missing.
     3063-3065: EPY → GSG
     3066-3120: Missing.

Isoform 5 (identifier: Q60847-5)

The sequence of this isoform differs from the canonical sequence as follows:
     3063-3068: EPYVPE → GMLLPS
     3069-3120: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 3120	3097	Collagen alpha-1(XII) chain		PRO_0000005784
Regions
	Domain	24 – 112	89	Fibronectin type-III 1
	Domain	140 – 316	177	VWFA 1
	Domain	333 – 422	90	Fibronectin type-III 2
	Domain	440 – 616	177	VWFA 2
	Domain	631 – 719	89	Fibronectin type-III 3
	Domain	722 – 810	89	Fibronectin type-III 4
	Domain	813 – 901	89	Fibronectin type-III 5
	Domain	904 – 993	90	Fibronectin type-III 6
	Domain	995 – 1083	89	Fibronectin type-III 7
	Domain	1086 – 1175	90	Fibronectin type-III 8
	Domain	1199 – 1371	173	VWFA 3
	Domain	1384 – 1472	89	Fibronectin type-III 9
	Domain	1474 – 1563	90	Fibronectin type-III 10
	Domain	1565 – 1652	88	Fibronectin type-III 11
	Domain	1656 – 1743	88	Fibronectin type-III 12
	Domain	1754 – 1843	90	Fibronectin type-III 13
	Domain	1845 – 1933	89	Fibronectin type-III 14
	Domain	1935 – 2024	90	Fibronectin type-III 15
	Domain	2026 – 2115	90	Fibronectin type-III 16
	Domain	2117 – 2204	88	Fibronectin type-III 17
	Domain	2208 – 2294	87	Fibronectin type-III 18
	Domain	2325 – 2498	174	VWFA 4
	Domain	2522 – 2714	193	Laminin G-like
	Domain	2749 – 2800	52	Collagen-like 1
	Domain	2804 – 2854	51	Collagen-like 2
	Domain	2855 – 2899	45	Collagen-like 3
	Domain	2943 – 2992	50	Collagen-like 4
	Region	2453 – 2748	296	Nonhelical region (NC3)
	Region	2749 – 2900	152	Triple-helical region (COL2) with 1 imperfection
	Region	2901 – 2943	43	Nonhelical region (NC2)
	Region	2944 – 3046	103	Triple-helical region (COL1) with 2 imperfections
	Region	3047 – 3120	74	Nonhelical region (NC1)
	Motif	862 – 864	3	Cell attachment site Potential
	Motif	2781 – 2783	3	Cell attachment site Potential
	Motif	2897 – 2899	3	Cell attachment site Potential
	Compositional bias	865 – 868	4	Poly-Thr
Amino acid modifications
	Modified residue	2946	1	4-hydroxyproline By similarity
	Modified residue	2949	1	4-hydroxyproline By similarity
	Modified residue	2952	1	4-hydroxyproline By similarity
	Modified residue	2961	1	4-hydroxyproline By similarity
	Modified residue	2967	1	4-hydroxyproline By similarity
	Modified residue	2970	1	4-hydroxyproline By similarity
	Modified residue	2973	1	4-hydroxyproline By similarity
	Modified residue	2985	1	4-hydroxyproline By similarity
	Modified residue	3002	1	4-hydroxyproline By similarity
	Modified residue	3005	1	4-hydroxyproline By similarity
	Modified residue	3016	1	4-hydroxyproline By similarity
	Modified residue	3025	1	4-hydroxyproline By similarity
	Modified residue	3028	1	4-hydroxyproline By similarity
	Modified residue	3031	1	4-hydroxyproline By similarity
	Glycosylation	700	1	N-linked (GlcNAc...) Potential
	Glycosylation	798	1	O-linked (Xyl...) (chondroitin sulfate) Potential
	Glycosylation	889	1	O-linked (Xyl...) (chondroitin sulfate) Potential
	Glycosylation	981	1	O-linked (Xyl...) (chondroitin sulfate) Potential
	Glycosylation	1765	1	N-linked (GlcNAc...) Potential
	Glycosylation	2208	1	N-linked (GlcNAc...) Potential
	Glycosylation	2530	1	N-linked (GlcNAc...) Potential
	Glycosylation	2681	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	25 – 1186	1162	Missing in isoform 3 and isoform 4.		VSP_001150
	Alternative sequence	3063 – 3068	6	EPYVPE → GMLLPS in isoform 5.		VSP_023404
	Alternative sequence	3063 – 3065	3	EPY → GSG in isoform 2 and isoform 4.		VSP_001151
	Alternative sequence	3066 – 3120	55	Missing in isoform 2 and isoform 4.		VSP_001152
	Alternative sequence	3069 – 3120	52	Missing in isoform 5.		VSP_023405
Experimental info
	Sequence conflict	245	1	A → G in AAA99719. Ref.1
	Sequence conflict	421	1	K → KTQPK in AAA99719. Ref.1
	Sequence conflict	453	1	I → T in AAA99719. Ref.1
	Sequence conflict	552	1	K → E in AAA99719. Ref.1
	Sequence conflict	611	1	E → V in AAB07047. Ref.1
	Sequence conflict	611	1	E → V in AAA99719. Ref.1
	Sequence conflict	690	1	N → S in AAA99719. Ref.1
	Sequence conflict	797	1	S → P in AAA99719. Ref.1
	Sequence conflict	954	1	P → N in AAA99719. Ref.1
	Sequence conflict	1079	1	G → R in AAA99719. Ref.1
	Sequence conflict	1271	1	Y → N in AAA99719. Ref.1
	Sequence conflict	1472	1	T → A in AAA99719. Ref.1
	Sequence conflict	1524	1	G → E in AAA99719. Ref.1
	Sequence conflict	1773	1	V → I in AAA99719. Ref.1
	Sequence conflict	1831	1	D → G in AAA99719. Ref.1
	Sequence conflict	1939	1	A → S in AAA99719. Ref.1
	Sequence conflict	2005	1	N → Y in AAA99719. Ref.1
	Sequence conflict	2428 – 2429	2	PK → R in AAA99719. Ref.1
	Sequence conflict	2432	1	V → G in AAA99719. Ref.1
	Sequence conflict	2515	1	L → Q in AAA99719. Ref.1
	Sequence conflict	2551 – 2552	2	SY → DS in AAA99719. Ref.1
	Sequence conflict	2861 – 2864	4	Missing in AAA99719. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (XIIA-1) [UniParc]. Last modified March 6, 2007. Version 3. Checksum: C4D9264E3C5C8CB5	FASTA	3,120	340,214
	10 20 30 40 50 60 MQTRLPRALA ALGVALLLSS IEAEVDPPSD LNFKIIDENT VHMSWERPVD PIVGYRITVD 70 80 90 100 110 120 PTTDGPTKEF TLAASTTETL LSDLIPETQY VVTITSYNEV EESVPVIGQL TIQTGGPTKP 130 140 150 160 170 180 GEKKPGKTEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIVALVSAF DIGEEKTRVG 190 200 210 220 230 240 VVQYSSDTRT EFNLNQYYRR EDLLAAVKKI PYKGGNTMTG DAIDYLVKNT FTESAGSRAG 250 260 270 280 290 300 FPKVAIIITD GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 310 320 330 340 350 360 NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VVTELSSKYI RLSWDPSPSA 370 380 390 400 410 420 VTGYKILLTP MAAGSRHHAL SVGPQTTTLN VRDLTADTEY QISVFAMKGL TSSEPTSVME 430 440 450 460 470 480 KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLAKSF EISPNRVQIS 490 500 510 520 530 540 LVQYSRDPHT EFTLKEFNRV EDIIKAINTF PYRGGSTNTG KAMTYVREKI FVPNKGSRSN 550 560 570 580 590 600 VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 610 620 630 640 650 660 DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLRF TQVTANSFKA EWSPPGDNVF 670 680 690 700 710 720 SYHVTYKDAN GDDEVTVVEP ASSTSVVLNN LRPETLYLVN VTAEYEDGFS VPITGEETTA 730 740 750 760 770 780 EVKGVPRNLK VTDETTDSFK LTWSQAPGRV LRYRIRYRPV SGGESKEVST PANQRRKTLE 790 800 810 820 830 840 NLTPDTKYEI SVIAEYSSGP GSPLTGNAAT EEVRGNPRDL RVSDATTSTL KLSWSRAPGK 850 860 870 880 890 900 VKQYLVTYTP AAGGETQEVT VRGDTTTTML RKLKEGTQYD LSVTALYASG AGEALSGKGS 910 920 930 940 950 960 TLEERGSPQN LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIEAGE TTLPGDAIHT 970 980 990 1000 1010 1020 MIENLQPETK YKISVFATYS SGEGEPVTGD ATTELSQDSK ILRVDEETEH TMRVTWKAAP 1030 1040 1050 1060 1070 1080 GKVVNYRVVY RPQGGGRQMV AKVPPTVTST VLKRLQPQTT YDITVLPMYK TGEGKLRQGS 1090 1100 1110 1120 1130 1140 GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVLGPYDN 1150 1160 1170 1180 1190 1200 TVVLEELRAG TTYRVNVFGM FDGGESLPLV GQEMTTLSDT TVTPFLSSGM DCLTRAEADI 1210 1220 1230 1240 1250 1260 VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK 1270 1280 1290 1300 1310 1320 SLLQAVANLP YKGGNTLTGM ALNFIRQQSF KTQAGMRPRA RKIGVLITDG KSQDDVEAPS 1330 1340 1350 1360 1370 1380 KKLKDEGVEL FAIGIKNADE VELKMIATDP DDTHAYNVAD FESLSKIVDD LTINLCNSVK 1390 1400 1410 1420 1430 1440 GPGDLEAPTN LVISERTHRS FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLDTSTV 1450 1460 1470 1480 1490 1500 LKDLKPETDY VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1510 1520 1530 1540 1550 1560 TGYTVSYQPT RSPEGTKPKE MRVGPTVNDV QLTGLLPNTE YEVTVQAVLY DLTSEPAKAR 1570 1580 1590 1600 1610 1620 EVTLPLPRPQ DVKLRDVTHS TMNVVWEPVL GKVRKYIVRY KTPDEEFKEV EVDRSRASTI 1630 1640 1650 1660 1670 1680 LKDLSSQTQY TVSVSAVYDE GTSPPATAYD TTRRVPAPTN LQFTEVTPES FRGTWDHGAS 1690 1700 1710 1720 1730 1740 DVSLYRITWA PVGNPDKMET ILNGDENTLV FENLNPNTPY EVSITAIYPD ESESEDLSGT 1750 1760 1770 1780 1790 1800 ERTLRLIPLT TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT 1810 1820 1830 1840 1850 1860 ITVGGRQNSV LLQKLKPDTP YTITVYSQYP DGEGGRMTGR GKTKPLNTVR NLRVYDPSTS 1870 1880 1890 1900 1910 1920 SLSVRWDHAE GNPRQYKLFY APTSGGPEEL VPIPGNTNYA ILRNLQPDTP YTITVVPVYT 1930 1940 1950 1960 1970 1980 EGDGGRTSDT GRTLVRGLAR NIQVYNPTPN SLDVRWDPAP GPVQQYRIVY SPVAGTRPSE 1990 2000 2010 2020 2030 2040 SIVVPGNTRT VHLERLIPDT PYSVNIVALY SDGEGNPSPS QGRTLPRSGP RNIRVFGETT 2050 2060 2070 2080 2090 2100 NSLSVAWDHA DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVILQPLQPD TPYKITVIAI 2110 2120 2130 2140 2150 2160 YEDGDGGHLT GNGRTVGLLP PQNIHIFDEW YTRFRVSWDP SPSPVLGYKI VYKPVGSNEP 2170 2180 2190 2200 2210 2220 MEAFVGEVTS YTLHNLNPST TYDVSVYAQY DSGLSVPLTD QGTTLYLNVT DLKTYQVGWD 2230 2240 2250 2260 2270 2280 TFCVKWSPHR AATSYRLKLS PADGTRGQEI TVRGSETSHC FTGLSPEAEY GVTVFVQTPN 2290 2300 2310 2320 2330 2340 LEGPGVPIKE QTTVKPTEAP TEPPTPSPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN 2350 2360 2370 2380 2390 2400 FNKVVKFIFN TVGAFDEVNP AGIQVSFVQY SDEVKSEFKL NTYNDKALAL GALQNIRYRG 2410 2420 2430 2440 2450 2460 GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAAFVI QQSGFSVFVV 2470 2480 2490 2500 2510 2520 GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT FVCETATSSC PLIYLDGYTS 2530 2540 2550 2560 2570 2580 PGFKMLEAYN LTEKNFASVQ GVSLESGSFP SYSAYRLQKN AFINQPTAEL HPNGLPPSYT 2590 2600 2610 2620 2630 2640 IILLFRLLPE TPSDPFAIWQ ITDRDYRPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD 2650 2660 2670 2680 2690 2700 EVKTLFYGSF HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS 2710 2720 2730 2740 2750 2760 ATFQIQSFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP PGPPGPAGGP 2770 2780 2790 2800 2810 2820 GAKGPRGERG INGAVGPPGP RGDTGPPGPQ GPPGPQGPNG LSIPGEQGRQ GMKGDAGEPG 2830 2840 2850 2860 2870 2880 LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG 2890 2900 2910 2920 2930 2940 DHGRPGQSGL KGEKGDRGDI ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR 2950 2960 2970 2980 2990 3000 NQPGPPGPPG PPGSAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGTGSQGPRG 3010 3020 3030 3040 3050 3060 PPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ CASIPYNGQG 3070 3080 3090 3100 3110 3120 YPEPYVPEGG AYLPEREPFI VPVEPERTAE YEDDYGADEP DQQHPDHMRW RRALRPGPAE
	Isoform 2 (ER#K) (XIIA-2) [UniParc]. Checksum: 0FE5F351A4051FD7	FASTA	3,065	333,671
	10 20 30 40 50 60 MQTRLPRALA ALGVALLLSS IEAEVDPPSD LNFKIIDENT VHMSWERPVD PIVGYRITVD 70 80 90 100 110 120 PTTDGPTKEF TLAASTTETL LSDLIPETQY VVTITSYNEV EESVPVIGQL TIQTGGPTKP 130 140 150 160 170 180 GEKKPGKTEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIVALVSAF DIGEEKTRVG 190 200 210 220 230 240 VVQYSSDTRT EFNLNQYYRR EDLLAAVKKI PYKGGNTMTG DAIDYLVKNT FTESAGSRAG 250 260 270 280 290 300 FPKVAIIITD GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 310 320 330 340 350 360 NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VVTELSSKYI RLSWDPSPSA 370 380 390 400 410 420 VTGYKILLTP MAAGSRHHAL SVGPQTTTLN VRDLTADTEY QISVFAMKGL TSSEPTSVME 430 440 450 460 470 480 KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLAKSF EISPNRVQIS 490 500 510 520 530 540 LVQYSRDPHT EFTLKEFNRV EDIIKAINTF PYRGGSTNTG KAMTYVREKI FVPNKGSRSN 550 560 570 580 590 600 VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 610 620 630 640 650 660 DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLRF TQVTANSFKA EWSPPGDNVF 670 680 690 700 710 720 SYHVTYKDAN GDDEVTVVEP ASSTSVVLNN LRPETLYLVN VTAEYEDGFS VPITGEETTA 730 740 750 760 770 780 EVKGVPRNLK VTDETTDSFK LTWSQAPGRV LRYRIRYRPV SGGESKEVST PANQRRKTLE 790 800 810 820 830 840 NLTPDTKYEI SVIAEYSSGP GSPLTGNAAT EEVRGNPRDL RVSDATTSTL KLSWSRAPGK 850 860 870 880 890 900 VKQYLVTYTP AAGGETQEVT VRGDTTTTML RKLKEGTQYD LSVTALYASG AGEALSGKGS 910 920 930 940 950 960 TLEERGSPQN LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIEAGE TTLPGDAIHT 970 980 990 1000 1010 1020 MIENLQPETK YKISVFATYS SGEGEPVTGD ATTELSQDSK ILRVDEETEH TMRVTWKAAP 1030 1040 1050 1060 1070 1080 GKVVNYRVVY RPQGGGRQMV AKVPPTVTST VLKRLQPQTT YDITVLPMYK TGEGKLRQGS 1090 1100 1110 1120 1130 1140 GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVLGPYDN 1150 1160 1170 1180 1190 1200 TVVLEELRAG TTYRVNVFGM FDGGESLPLV GQEMTTLSDT TVTPFLSSGM DCLTRAEADI 1210 1220 1230 1240 1250 1260 VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK 1270 1280 1290 1300 1310 1320 SLLQAVANLP YKGGNTLTGM ALNFIRQQSF KTQAGMRPRA RKIGVLITDG KSQDDVEAPS 1330 1340 1350 1360 1370 1380 KKLKDEGVEL FAIGIKNADE VELKMIATDP DDTHAYNVAD FESLSKIVDD LTINLCNSVK 1390 1400 1410 1420 1430 1440 GPGDLEAPTN LVISERTHRS FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLDTSTV 1450 1460 1470 1480 1490 1500 LKDLKPETDY VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1510 1520 1530 1540 1550 1560 TGYTVSYQPT RSPEGTKPKE MRVGPTVNDV QLTGLLPNTE YEVTVQAVLY DLTSEPAKAR 1570 1580 1590 1600 1610 1620 EVTLPLPRPQ DVKLRDVTHS TMNVVWEPVL GKVRKYIVRY KTPDEEFKEV EVDRSRASTI 1630 1640 1650 1660 1670 1680 LKDLSSQTQY TVSVSAVYDE GTSPPATAYD TTRRVPAPTN LQFTEVTPES FRGTWDHGAS 1690 1700 1710 1720 1730 1740 DVSLYRITWA PVGNPDKMET ILNGDENTLV FENLNPNTPY EVSITAIYPD ESESEDLSGT 1750 1760 1770 1780 1790 1800 ERTLRLIPLT TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT 1810 1820 1830 1840 1850 1860 ITVGGRQNSV LLQKLKPDTP YTITVYSQYP DGEGGRMTGR GKTKPLNTVR NLRVYDPSTS 1870 1880 1890 1900 1910 1920 SLSVRWDHAE GNPRQYKLFY APTSGGPEEL VPIPGNTNYA ILRNLQPDTP YTITVVPVYT 1930 1940 1950 1960 1970 1980 EGDGGRTSDT GRTLVRGLAR NIQVYNPTPN SLDVRWDPAP GPVQQYRIVY SPVAGTRPSE 1990 2000 2010 2020 2030 2040 SIVVPGNTRT VHLERLIPDT PYSVNIVALY SDGEGNPSPS QGRTLPRSGP RNIRVFGETT 2050 2060 2070 2080 2090 2100 NSLSVAWDHA DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVILQPLQPD TPYKITVIAI 2110 2120 2130 2140 2150 2160 YEDGDGGHLT GNGRTVGLLP PQNIHIFDEW YTRFRVSWDP SPSPVLGYKI VYKPVGSNEP 2170 2180 2190 2200 2210 2220 MEAFVGEVTS YTLHNLNPST TYDVSVYAQY DSGLSVPLTD QGTTLYLNVT DLKTYQVGWD 2230 2240 2250 2260 2270 2280 TFCVKWSPHR AATSYRLKLS PADGTRGQEI TVRGSETSHC FTGLSPEAEY GVTVFVQTPN 2290 2300 2310 2320 2330 2340 LEGPGVPIKE QTTVKPTEAP TEPPTPSPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN 2350 2360 2370 2380 2390 2400 FNKVVKFIFN TVGAFDEVNP AGIQVSFVQY SDEVKSEFKL NTYNDKALAL GALQNIRYRG 2410 2420 2430 2440 2450 2460 GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAAFVI QQSGFSVFVV 2470 2480 2490 2500 2510 2520 GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT FVCETATSSC PLIYLDGYTS 2530 2540 2550 2560 2570 2580 PGFKMLEAYN LTEKNFASVQ GVSLESGSFP SYSAYRLQKN AFINQPTAEL HPNGLPPSYT 2590 2600 2610 2620 2630 2640 IILLFRLLPE TPSDPFAIWQ ITDRDYRPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD 2650 2660 2670 2680 2690 2700 EVKTLFYGSF HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS 2710 2720 2730 2740 2750 2760 ATFQIQSFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP PGPPGPAGGP 2770 2780 2790 2800 2810 2820 GAKGPRGERG INGAVGPPGP RGDTGPPGPQ GPPGPQGPNG LSIPGEQGRQ GMKGDAGEPG 2830 2840 2850 2860 2870 2880 LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG 2890 2900 2910 2920 2930 2940 DHGRPGQSGL KGEKGDRGDI ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR 2950 2960 2970 2980 2990 3000 NQPGPPGPPG PPGSAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGTGSQGPRG 3010 3020 3030 3040 3050 3060 PPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ CASIPYNGQG YPGSG
	Isoform 3 (XIIB-1) [UniParc]. Checksum: 9F869932749E4D20	FASTA	1,958	212,624
	10 20 30 40 50 60 MQTRLPRALA ALGVALLLSS IEAESSGMDC LTRAEADIVL LVDGSWSIGR ANFRTVRSFI 70 80 90 100 110 120 SRIVEVFEIG PKRVQIALAQ YSGDPRTEWQ LNAHRDKKSL LQAVANLPYK GGNTLTGMAL 130 140 150 160 170 180 NFIRQQSFKT QAGMRPRARK IGVLITDGKS QDDVEAPSKK LKDEGVELFA IGIKNADEVE 190 200 210 220 230 240 LKMIATDPDD THAYNVADFE SLSKIVDDLT INLCNSVKGP GDLEAPTNLV ISERTHRSFR 250 260 270 280 290 300 VSWTPPSDSV DRYKVEYYPV SGGKRQEFYV SRLDTSTVLK DLKPETDYVV NVYSVVEDEY 310 320 330 340 350 360 SEPLKGTEKT LPVPVVSLNI YDVGPTTMHV QWQPVGGATG YTVSYQPTRS PEGTKPKEMR 370 380 390 400 410 420 VGPTVNDVQL TGLLPNTEYE VTVQAVLYDL TSEPAKAREV TLPLPRPQDV KLRDVTHSTM 430 440 450 460 470 480 NVVWEPVLGK VRKYIVRYKT PDEEFKEVEV DRSRASTILK DLSSQTQYTV SVSAVYDEGT 490 500 510 520 530 540 SPPATAYDTT RRVPAPTNLQ FTEVTPESFR GTWDHGASDV SLYRITWAPV GNPDKMETIL 550 560 570 580 590 600 NGDENTLVFE NLNPNTPYEV SITAIYPDES ESEDLSGTER TLRLIPLTTQ APKSGPRNLQ 610 620 630 640 650 660 VYNATSNSLT VKWDPASGRV QKYRITYQPS TGEGNEQTIT VGGRQNSVLL QKLKPDTPYT 670 680 690 700 710 720 ITVYSQYPDG EGGRMTGRGK TKPLNTVRNL RVYDPSTSSL SVRWDHAEGN PRQYKLFYAP 730 740 750 760 770 780 TSGGPEELVP IPGNTNYAIL RNLQPDTPYT ITVVPVYTEG DGGRTSDTGR TLVRGLARNI 790 800 810 820 830 840 QVYNPTPNSL DVRWDPAPGP VQQYRIVYSP VAGTRPSESI VVPGNTRTVH LERLIPDTPY 850 860 870 880 890 900 SVNIVALYSD GEGNPSPSQG RTLPRSGPRN IRVFGETTNS LSVAWDHADG PVQQYRIIYS 910 920 930 940 950 960 PTVGDPIDEY TTVPGRRNNV ILQPLQPDTP YKITVIAIYE DGDGGHLTGN GRTVGLLPPQ 970 980 990 1000 1010 1020 NIHIFDEWYT RFRVSWDPSP SPVLGYKIVY KPVGSNEPME AFVGEVTSYT LHNLNPSTTY 1030 1040 1050 1060 1070 1080 DVSVYAQYDS GLSVPLTDQG TTLYLNVTDL KTYQVGWDTF CVKWSPHRAA TSYRLKLSPA 1090 1100 1110 1120 1130 1140 DGTRGQEITV RGSETSHCFT GLSPEAEYGV TVFVQTPNLE GPGVPIKEQT TVKPTEAPTE 1150 1160 1170 1180 1190 1200 PPTPSPPPTI PPARDVCKGA KADIVFLTDA SWSIGDDNFN KVVKFIFNTV GAFDEVNPAG 1210 1220 1230 1240 1250 1260 IQVSFVQYSD EVKSEFKLNT YNDKALALGA LQNIRYRGGN TRTGKALTFI KEKVLTWESG 1270 1280 1290 1300 1310 1320 MRKNVPKVLV VVTDGRSQDE VKKAAFVIQQ SGFSVFVVGV ADVDYNELAN IASKPSERHV 1330 1340 1350 1360 1370 1380 FIVDDFESFE KIEDNLITFV CETATSSCPL IYLDGYTSPG FKMLEAYNLT EKNFASVQGV 1390 1400 1410 1420 1430 1440 SLESGSFPSY SAYRLQKNAF INQPTAELHP NGLPPSYTII LLFRLLPETP SDPFAIWQIT 1450 1460 1470 1480 1490 1500 DRDYRPQVGV IADPSSKTLS FFNKDTRGEV QTVTFDTDEV KTLFYGSFHK VHIVVTSKSV 1510 1520 1530 1540 1550 1560 KIYIDCYEII EKDIKEAGNI TTDGYEILGK LLKGERKSAT FQIQSFDIVC SPVWTSRDRC 1570 1580 1590 1600 1610 1620 CDIPSRRDEA KCPALPNACT CTQDSVGPPG PPGPAGGPGA KGPRGERGIN GAVGPPGPRG 1630 1640 1650 1660 1670 1680 DTGPPGPQGP PGPQGPNGLS IPGEQGRQGM KGDAGEPGLP GRTGTPGLPG PPGPMGPPGD 1690 1700 1710 1720 1730 1740 RGFTGKDGAM GPRGPPGPPG SPGSPGVTGP SGKPGKPGDH GRPGQSGLKG EKGDRGDIAS 1750 1760 1770 1780 1790 1800 QNMMRAVARQ VCEQLISGQM SRFNQMLNQI PNDYHSSRNQ PGPPGPPGPP GSAGARGEPG 1810 1820 1830 1840 1850 1860 PGGRPGFPGT PGMQGPPGER GLPGEKGERG TGSQGPRGPP GPPGPQGESR TGPPGSTGSR 1870 1880 1890 1900 1910 1920 GPPGPPGRPG NSGIRGPPGP PGYCDSSQCA SIPYNGQGYP EPYVPEGGAY LPEREPFIVP 1930 1940 1950 VEPERTAEYE DDYGADEPDQ QHPDHMRWRR ALRPGPAE
	Isoform 4 (XIIB-2) [UniParc]. Checksum: B5A0AF0676EFC951	FASTA	1,903	206,081
	10 20 30 40 50 60 MQTRLPRALA ALGVALLLSS IEAESSGMDC LTRAEADIVL LVDGSWSIGR ANFRTVRSFI 70 80 90 100 110 120 SRIVEVFEIG PKRVQIALAQ YSGDPRTEWQ LNAHRDKKSL LQAVANLPYK GGNTLTGMAL 130 140 150 160 170 180 NFIRQQSFKT QAGMRPRARK IGVLITDGKS QDDVEAPSKK LKDEGVELFA IGIKNADEVE 190 200 210 220 230 240 LKMIATDPDD THAYNVADFE SLSKIVDDLT INLCNSVKGP GDLEAPTNLV ISERTHRSFR 250 260 270 280 290 300 VSWTPPSDSV DRYKVEYYPV SGGKRQEFYV SRLDTSTVLK DLKPETDYVV NVYSVVEDEY 310 320 330 340 350 360 SEPLKGTEKT LPVPVVSLNI YDVGPTTMHV QWQPVGGATG YTVSYQPTRS PEGTKPKEMR 370 380 390 400 410 420 VGPTVNDVQL TGLLPNTEYE VTVQAVLYDL TSEPAKAREV TLPLPRPQDV KLRDVTHSTM 430 440 450 460 470 480 NVVWEPVLGK VRKYIVRYKT PDEEFKEVEV DRSRASTILK DLSSQTQYTV SVSAVYDEGT 490 500 510 520 530 540 SPPATAYDTT RRVPAPTNLQ FTEVTPESFR GTWDHGASDV SLYRITWAPV GNPDKMETIL 550 560 570 580 590 600 NGDENTLVFE NLNPNTPYEV SITAIYPDES ESEDLSGTER TLRLIPLTTQ APKSGPRNLQ 610 620 630 640 650 660 VYNATSNSLT VKWDPASGRV QKYRITYQPS TGEGNEQTIT VGGRQNSVLL QKLKPDTPYT 670 680 690 700 710 720 ITVYSQYPDG EGGRMTGRGK TKPLNTVRNL RVYDPSTSSL SVRWDHAEGN PRQYKLFYAP 730 740 750 760 770 780 TSGGPEELVP IPGNTNYAIL RNLQPDTPYT ITVVPVYTEG DGGRTSDTGR TLVRGLARNI 790 800 810 820 830 840 QVYNPTPNSL DVRWDPAPGP VQQYRIVYSP VAGTRPSESI VVPGNTRTVH LERLIPDTPY 850 860 870 880 890 900 SVNIVALYSD GEGNPSPSQG RTLPRSGPRN IRVFGETTNS LSVAWDHADG PVQQYRIIYS 910 920 930 940 950 960 PTVGDPIDEY TTVPGRRNNV ILQPLQPDTP YKITVIAIYE DGDGGHLTGN GRTVGLLPPQ 970 980 990 1000 1010 1020 NIHIFDEWYT RFRVSWDPSP SPVLGYKIVY KPVGSNEPME AFVGEVTSYT LHNLNPSTTY 1030 1040 1050 1060 1070 1080 DVSVYAQYDS GLSVPLTDQG TTLYLNVTDL KTYQVGWDTF CVKWSPHRAA TSYRLKLSPA 1090 1100 1110 1120 1130 1140 DGTRGQEITV RGSETSHCFT GLSPEAEYGV TVFVQTPNLE GPGVPIKEQT TVKPTEAPTE 1150 1160 1170 1180 1190 1200 PPTPSPPPTI PPARDVCKGA KADIVFLTDA SWSIGDDNFN KVVKFIFNTV GAFDEVNPAG 1210 1220 1230 1240 1250 1260 IQVSFVQYSD EVKSEFKLNT YNDKALALGA LQNIRYRGGN TRTGKALTFI KEKVLTWESG 1270 1280 1290 1300 1310 1320 MRKNVPKVLV VVTDGRSQDE VKKAAFVIQQ SGFSVFVVGV ADVDYNELAN IASKPSERHV 1330 1340 1350 1360 1370 1380 FIVDDFESFE KIEDNLITFV CETATSSCPL IYLDGYTSPG FKMLEAYNLT EKNFASVQGV 1390 1400 1410 1420 1430 1440 SLESGSFPSY SAYRLQKNAF INQPTAELHP NGLPPSYTII LLFRLLPETP SDPFAIWQIT 1450 1460 1470 1480 1490 1500 DRDYRPQVGV IADPSSKTLS FFNKDTRGEV QTVTFDTDEV KTLFYGSFHK VHIVVTSKSV 1510 1520 1530 1540 1550 1560 KIYIDCYEII EKDIKEAGNI TTDGYEILGK LLKGERKSAT FQIQSFDIVC SPVWTSRDRC 1570 1580 1590 1600 1610 1620 CDIPSRRDEA KCPALPNACT CTQDSVGPPG PPGPAGGPGA KGPRGERGIN GAVGPPGPRG 1630 1640 1650 1660 1670 1680 DTGPPGPQGP PGPQGPNGLS IPGEQGRQGM KGDAGEPGLP GRTGTPGLPG PPGPMGPPGD 1690 1700 1710 1720 1730 1740 RGFTGKDGAM GPRGPPGPPG SPGSPGVTGP SGKPGKPGDH GRPGQSGLKG EKGDRGDIAS 1750 1760 1770 1780 1790 1800 QNMMRAVARQ VCEQLISGQM SRFNQMLNQI PNDYHSSRNQ PGPPGPPGPP GSAGARGEPG 1810 1820 1830 1840 1850 1860 PGGRPGFPGT PGMQGPPGER GLPGEKGERG TGSQGPRGPP GPPGPQGESR TGPPGSTGSR 1870 1880 1890 1900 GPPGPPGRPG NSGIRGPPGP PGYCDSSQCA SIPYNGQGYP GSG
	Isoform 5 [UniParc]. Checksum: 72C55C50A6D351A4	FASTA	3,068	334,069
	10 20 30 40 50 60 MQTRLPRALA ALGVALLLSS IEAEVDPPSD LNFKIIDENT VHMSWERPVD PIVGYRITVD 70 80 90 100 110 120 PTTDGPTKEF TLAASTTETL LSDLIPETQY VVTITSYNEV EESVPVIGQL TIQTGGPTKP 130 140 150 160 170 180 GEKKPGKTEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIVALVSAF DIGEEKTRVG 190 200 210 220 230 240 VVQYSSDTRT EFNLNQYYRR EDLLAAVKKI PYKGGNTMTG DAIDYLVKNT FTESAGSRAG 250 260 270 280 290 300 FPKVAIIITD GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA 310 320 330 340 350 360 NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VVTELSSKYI RLSWDPSPSA 370 380 390 400 410 420 VTGYKILLTP MAAGSRHHAL SVGPQTTTLN VRDLTADTEY QISVFAMKGL TSSEPTSVME 430 440 450 460 470 480 KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLAKSF EISPNRVQIS 490 500 510 520 530 540 LVQYSRDPHT EFTLKEFNRV EDIIKAINTF PYRGGSTNTG KAMTYVREKI FVPNKGSRSN 550 560 570 580 590 600 VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE 610 620 630 640 650 660 DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLRF TQVTANSFKA EWSPPGDNVF 670 680 690 700 710 720 SYHVTYKDAN GDDEVTVVEP ASSTSVVLNN LRPETLYLVN VTAEYEDGFS VPITGEETTA 730 740 750 760 770 780 EVKGVPRNLK VTDETTDSFK LTWSQAPGRV LRYRIRYRPV SGGESKEVST PANQRRKTLE 790 800 810 820 830 840 NLTPDTKYEI SVIAEYSSGP GSPLTGNAAT EEVRGNPRDL RVSDATTSTL KLSWSRAPGK 850 860 870 880 890 900 VKQYLVTYTP AAGGETQEVT VRGDTTTTML RKLKEGTQYD LSVTALYASG AGEALSGKGS 910 920 930 940 950 960 TLEERGSPQN LVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIEAGE TTLPGDAIHT 970 980 990 1000 1010 1020 MIENLQPETK YKISVFATYS SGEGEPVTGD ATTELSQDSK ILRVDEETEH TMRVTWKAAP 1030 1040 1050 1060 1070 1080 GKVVNYRVVY RPQGGGRQMV AKVPPTVTST VLKRLQPQTT YDITVLPMYK TGEGKLRQGS 1090 1100 1110 1120 1130 1140 GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVLGPYDN 1150 1160 1170 1180 1190 1200 TVVLEELRAG TTYRVNVFGM FDGGESLPLV GQEMTTLSDT TVTPFLSSGM DCLTRAEADI 1210 1220 1230 1240 1250 1260 VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK 1270 1280 1290 1300 1310 1320 SLLQAVANLP YKGGNTLTGM ALNFIRQQSF KTQAGMRPRA RKIGVLITDG KSQDDVEAPS 1330 1340 1350 1360 1370 1380 KKLKDEGVEL FAIGIKNADE VELKMIATDP DDTHAYNVAD FESLSKIVDD LTINLCNSVK 1390 1400 1410 1420 1430 1440 GPGDLEAPTN LVISERTHRS FRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLDTSTV 1450 1460 1470 1480 1490 1500 LKDLKPETDY VVNVYSVVED EYSEPLKGTE KTLPVPVVSL NIYDVGPTTM HVQWQPVGGA 1510 1520 1530 1540 1550 1560 TGYTVSYQPT RSPEGTKPKE MRVGPTVNDV QLTGLLPNTE YEVTVQAVLY DLTSEPAKAR 1570 1580 1590 1600 1610 1620 EVTLPLPRPQ DVKLRDVTHS TMNVVWEPVL GKVRKYIVRY KTPDEEFKEV EVDRSRASTI 1630 1640 1650 1660 1670 1680 LKDLSSQTQY TVSVSAVYDE GTSPPATAYD TTRRVPAPTN LQFTEVTPES FRGTWDHGAS 1690 1700 1710 1720 1730 1740 DVSLYRITWA PVGNPDKMET ILNGDENTLV FENLNPNTPY EVSITAIYPD ESESEDLSGT 1750 1760 1770 1780 1790 1800 ERTLRLIPLT TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT 1810 1820 1830 1840 1850 1860 ITVGGRQNSV LLQKLKPDTP YTITVYSQYP DGEGGRMTGR GKTKPLNTVR NLRVYDPSTS 1870 1880 1890 1900 1910 1920 SLSVRWDHAE GNPRQYKLFY APTSGGPEEL VPIPGNTNYA ILRNLQPDTP YTITVVPVYT 1930 1940 1950 1960 1970 1980 EGDGGRTSDT GRTLVRGLAR NIQVYNPTPN SLDVRWDPAP GPVQQYRIVY SPVAGTRPSE 1990 2000 2010 2020 2030 2040 SIVVPGNTRT VHLERLIPDT PYSVNIVALY SDGEGNPSPS QGRTLPRSGP RNIRVFGETT 2050 2060 2070 2080 2090 2100 NSLSVAWDHA DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVILQPLQPD TPYKITVIAI 2110 2120 2130 2140 2150 2160 YEDGDGGHLT GNGRTVGLLP PQNIHIFDEW YTRFRVSWDP SPSPVLGYKI VYKPVGSNEP 2170 2180 2190 2200 2210 2220 MEAFVGEVTS YTLHNLNPST TYDVSVYAQY DSGLSVPLTD QGTTLYLNVT DLKTYQVGWD 2230 2240 2250 2260 2270 2280 TFCVKWSPHR AATSYRLKLS PADGTRGQEI TVRGSETSHC FTGLSPEAEY GVTVFVQTPN 2290 2300 2310 2320 2330 2340 LEGPGVPIKE QTTVKPTEAP TEPPTPSPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN 2350 2360 2370 2380 2390 2400 FNKVVKFIFN TVGAFDEVNP AGIQVSFVQY SDEVKSEFKL NTYNDKALAL GALQNIRYRG 2410 2420 2430 2440 2450 2460 GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAAFVI QQSGFSVFVV 2470 2480 2490 2500 2510 2520 GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT FVCETATSSC PLIYLDGYTS 2530 2540 2550 2560 2570 2580 PGFKMLEAYN LTEKNFASVQ GVSLESGSFP SYSAYRLQKN AFINQPTAEL HPNGLPPSYT 2590 2600 2610 2620 2630 2640 IILLFRLLPE TPSDPFAIWQ ITDRDYRPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD 2650 2660 2670 2680 2690 2700 EVKTLFYGSF HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS 2710 2720 2730 2740 2750 2760 ATFQIQSFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP PGPPGPAGGP 2770 2780 2790 2800 2810 2820 GAKGPRGERG INGAVGPPGP RGDTGPPGPQ GPPGPQGPNG LSIPGEQGRQ GMKGDAGEPG 2830 2840 2850 2860 2870 2880 LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG 2890 2900 2910 2920 2930 2940 DHGRPGQSGL KGEKGDRGDI ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR 2950 2960 2970 2980 2990 3000 NQPGPPGPPG PPGSAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGTGSQGPRG 3010 3020 3030 3040 3050 3060 PPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ CASIPYNGQG YPGMLLPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development." Boehme K., Li Y., Oh P.S., Olsen B.R. Dev. Dyn. 204:432-445(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), ALTERNATIVE SPLICING (ISOFORMS 1 AND 3). Strain: C57BL/6J and Swiss Webster. Tissue: Skin.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing." Kania A.M., Reichenberger E., Baur S.T., Karimbux N.Y., Taylor R.W., Olsen B.R., Nishimura I. J. Biol. Chem. 274:22053-22059(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3047-3120, ALTERNATIVE SPLICING (ISOFORMS 2 AND 4). Strain: C57BL/6J. Tissue: Skin fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25652 mRNA. Translation: AAA99719.1. AC157477 Genomic DNA. No translation available. AC166055 Genomic DNA. No translation available. U57095 mRNA. Translation: AAB07047.1.
IPI	IPI00121430. IPI00230527. IPI00319976. IPI00776316. IPI00830892.
PIR	C44479. D44479.
UniGene	Mm.3819.
3D structure databases
ProteinModelPortal	Q60847.
SMR	Q60847. Positions 25-110, 140-308, 333-415, 440-616, 631-1179, 1197-1371, 1378-2312, 2325-2487, 2510-2726.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4091424.
PTM databases
PhosphoSite	Q60847.
Proteomic databases
PaxDb	Q60847.
PRIDE	Q60847.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000071750; ENSMUSP00000071662; ENSMUSG00000032332.
Organism-specific databases
MGI	MGI:88448. Col12a1.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00700000104243.
HOGENOM	HOG000111877.
HOVERGEN	HBG051060.
InParanoid	Q60847.
Gene expression databases
ArrayExpress	Q60847.
Bgee	Q60847.
CleanEx	MM_COL12A1.
Genevestigator	Q60847.
GermOnline	ENSMUSG00000032332. Mus musculus.
Family and domain databases
Gene3D	2.60.120.200. 1 hit. 2.60.40.10. 18 hits. 3.40.50.410. 4 hits.
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR001791. Laminin_G. IPR002035. VWF_A. [Graphical view]
Pfam	PF01391. Collagen. 4 hits. PF00041. fn3. 18 hits. PF00092. VWA. 4 hits. [Graphical view]
SMART	SM00060. FN3. 18 hits. SM00210. TSPN. 1 hit. SM00327. VWA. 4 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 18 hits.
PROSITE	PS50853. FN3. 18 hits. PS50025. LAM_G_DOMAIN. False negative. PS50234. VWFA. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

COCA1_MOUSE

Accession

Primary (citable) accession number: Q60847
Secondary accession number(s): P70322

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	March 6, 2007
Last modified:	May 29, 2013
This is version 121 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program