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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

Tnfrsf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. cellular response to mechanical stimulus Source: Ensembl
  2. positive regulation of apoptotic process Source: MGI
  3. positive regulation of TRAIL biosynthetic process Source: MGI
  4. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen: CD30
Gene namesi
Name:Tnfrsf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:99908. Tnfrsf8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 258240ExtracellularSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Topological domaini280 – 498219CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 498480Tumor necrosis factor receptor superfamily member 8PRO_0000034575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation
Disulfide bondi69 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 121PROSITE-ProRule annotation
Disulfide bondi128 ↔ 146PROSITE-ProRule annotation
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Modified residuei353 – 3531PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ60846.

PTM databases

PhosphoSiteiQ60846.

Expressioni

Tissue specificityi

Detected in thymus and in activated splenocytes.

Inductioni

By concanavalin A and pokeweed mitogen in splenocytes.

Gene expression databases

BgeeiQ60846.
ExpressionAtlasiQ60846. baseline and differential.
GenevestigatoriQ60846.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ60846.
SMRiQ60846. Positions 29-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 6639TNFR-Cys 1Add
BLAST
Repeati68 – 10639TNFR-Cys 2Add
BLAST
Repeati107 – 15044TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45191.
GeneTreeiENSGT00510000049215.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiQ60846.
KOiK05145.
OMAiRACRKWI.
OrthoDBiEOG786H2Q.
PhylomeDBiQ60846.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60846-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSALLTAAGL LFLGMLQAFP TDRPLKTTCA GDLSHYPGEA ARNCCYQCPS
60 70 80 90 100
GLSPTQPCPR GPAHCRKQCA PDYYVNEDGK CTACVTCLPG LVEKAPCSGN
110 120 130 140 150
SPRICECQPG MHCCTPAVNS CARCKLHCSG EEVVKSPGTA KKDTICELPS
160 170 180 190 200
SGSGPNCSNP GDRKTLTSHA TPQAMPTLES PANDSARSLL PMRVTNLVQE
210 220 230 240 250
DATELVKVPE SSSSKAREPS PDPGNAEKNM TLELPSPGTL PDISTSENSK
260 270 280 290 300
EPASTASTLS LVVDAWTSSR MQPTSPLSTG TPFLDPGPVL FWVAMVVLLV
310 320 330 340 350
GSGSFLLCYW KACRRRFQQK FHLDYLVQTF QPKMEQTDSC PTEKLTQPQR
360 370 380 390 400
SGSVTDPSTG HKLSPVSPPP AVETCASVGA TYLENLPLLD DSPAGNPFSP
410 420 430 440 450
REPPEPRVST EHTNNRIEKI YIMKADTVIV GSVKTEVPEG RAPAGSTESE
460 470 480 490
LEAELEVDHA PHYPEQETEP PLGSCTEVMF SVEEGGKEDH GPTTVSEK
Length:498
Mass (Da):53,216
Last modified:November 1, 1996 - v1
Checksum:i98CA2A05B38AFA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25416 mRNA. Translation: AAA92887.1.
CCDSiCCDS18915.1.
RefSeqiNP_033427.1. NM_009401.2.
UniGeneiMm.12810.

Genome annotation databases

EnsembliENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602.
GeneIDi21941.
KEGGimmu:21941.
UCSCiuc008vrv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25416 mRNA. Translation: AAA92887.1.
CCDSiCCDS18915.1.
RefSeqiNP_033427.1. NM_009401.2.
UniGeneiMm.12810.

3D structure databases

ProteinModelPortaliQ60846.
SMRiQ60846. Positions 29-185.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ60846.

Proteomic databases

PRIDEiQ60846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602.
GeneIDi21941.
KEGGimmu:21941.
UCSCiuc008vrv.1. mouse.

Organism-specific databases

CTDi943.
MGIiMGI:99908. Tnfrsf8.

Phylogenomic databases

eggNOGiNOG45191.
GeneTreeiENSGT00510000049215.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiQ60846.
KOiK05145.
OMAiRACRKWI.
OrthoDBiEOG786H2Q.
PhylomeDBiQ60846.
TreeFamiTF331157.

Miscellaneous databases

NextBioi301572.
PROiQ60846.
SOURCEiSearch...

Gene expression databases

BgeeiQ60846.
ExpressionAtlasiQ60846. baseline and differential.
GenevestigatoriQ60846.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of murine CD30 and its role in cytokine production."
    Bowen M.A., Lee R.K., Miragliotta G., Nam S.Y., Podack E.R.
    J. Immunol. 156:442-449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Splenocyte.

Entry informationi

Entry nameiTNR8_MOUSE
AccessioniPrimary (citable) accession number: Q60846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.