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Q60846 (TNR8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 8
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen=CD30
Gene names
Name:Tnfrsf8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B By similarity.

Subunit structure

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Probable.

Tissue specificity

Detected in thymus and in activated splenocytes.

Induction

By concanavalin A and pokeweed mitogen in splenocytes.

Sequence similarities

Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 498480Tumor necrosis factor receptor superfamily member 8
PRO_0000034575

Regions

Topological domain19 – 258240Extracellular Potential
Transmembrane259 – 27921Helical; Potential
Topological domain280 – 498219Cytoplasmic Potential
Repeat28 – 6639TNFR-Cys 1
Repeat68 – 10639TNFR-Cys 2
Repeat107 – 15044TNFR-Cys 3

Amino acid modifications

Modified residue3531Phosphoserine By similarity
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation1831N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Disulfide bond29 ↔ 44 By similarity
Disulfide bond45 ↔ 58 By similarity
Disulfide bond48 ↔ 65 By similarity
Disulfide bond69 ↔ 81 By similarity
Disulfide bond84 ↔ 97 By similarity
Disulfide bond87 ↔ 105 By similarity
Disulfide bond107 ↔ 121 By similarity
Disulfide bond128 ↔ 146 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60846 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 98CA2A05B38AFA71

FASTA49853,216
        10         20         30         40         50         60 
MSALLTAAGL LFLGMLQAFP TDRPLKTTCA GDLSHYPGEA ARNCCYQCPS GLSPTQPCPR 

        70         80         90        100        110        120 
GPAHCRKQCA PDYYVNEDGK CTACVTCLPG LVEKAPCSGN SPRICECQPG MHCCTPAVNS 

       130        140        150        160        170        180 
CARCKLHCSG EEVVKSPGTA KKDTICELPS SGSGPNCSNP GDRKTLTSHA TPQAMPTLES 

       190        200        210        220        230        240 
PANDSARSLL PMRVTNLVQE DATELVKVPE SSSSKAREPS PDPGNAEKNM TLELPSPGTL 

       250        260        270        280        290        300 
PDISTSENSK EPASTASTLS LVVDAWTSSR MQPTSPLSTG TPFLDPGPVL FWVAMVVLLV 

       310        320        330        340        350        360 
GSGSFLLCYW KACRRRFQQK FHLDYLVQTF QPKMEQTDSC PTEKLTQPQR SGSVTDPSTG 

       370        380        390        400        410        420 
HKLSPVSPPP AVETCASVGA TYLENLPLLD DSPAGNPFSP REPPEPRVST EHTNNRIEKI 

       430        440        450        460        470        480 
YIMKADTVIV GSVKTEVPEG RAPAGSTESE LEAELEVDHA PHYPEQETEP PLGSCTEVMF 

       490 
SVEEGGKEDH GPTTVSEK 

« Hide

References

[1]"Structure and expression of murine CD30 and its role in cytokine production."
Bowen M.A., Lee R.K., Miragliotta G., Nam S.Y., Podack E.R.
J. Immunol. 156:442-449(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Splenocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25416 mRNA. Translation: AAA92887.1.
CCDSCCDS18915.1.
RefSeqNP_033427.1. NM_009401.2.
UniGeneMm.12810.

3D structure databases

ProteinModelPortalQ60846.
SMRQ60846. Positions 29-185.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ60846.

Proteomic databases

PRIDEQ60846.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602.
GeneID21941.
KEGGmmu:21941.
UCSCuc008vrv.1. mouse.

Organism-specific databases

CTD943.
MGIMGI:99908. Tnfrsf8.

Phylogenomic databases

eggNOGNOG45191.
GeneTreeENSGT00510000049215.
HOGENOMHOG000220871.
HOVERGENHBG005054.
InParanoidQ60846.
KOK05145.
OMAVEKTPCA.
OrthoDBEOG786H2Q.
PhylomeDBQ60846.
TreeFamTF331157.

Gene expression databases

ArrayExpressQ60846.
BgeeQ60846.
GenevestigatorQ60846.

Family and domain databases

InterProIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PfamPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSPR01923. TNFACTORR8.
SMARTSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301572.
PROQ60846.
SOURCESearch...

Entry information

Entry nameTNR8_MOUSE
AccessionPrimary (citable) accession number: Q60846
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot