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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

Tnfrsf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8By similarity
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen: CD30By similarity
Gene namesi
Name:Tnfrsf8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99908 Tnfrsf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 258ExtracellularSequence analysisAdd BLAST240
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 498CytoplasmicSequence analysisAdd BLAST219

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003457519 – 498Tumor necrosis factor receptor superfamily member 8Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation
Disulfide bondi69 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 121PROSITE-ProRule annotation
Disulfide bondi128 ↔ 146PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei339PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ60846
PaxDbiQ60846
PRIDEiQ60846

PTM databases

iPTMnetiQ60846
PhosphoSitePlusiQ60846

Expressioni

Tissue specificityi

Detected in thymus and in activated splenocytes.

Inductioni

By concanavalin A and pokeweed mitogen in splenocytes.

Gene expression databases

BgeeiENSMUSG00000028602
ExpressionAtlasiQ60846 baseline and differential
GenevisibleiQ60846 MM

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030339

Structurei

3D structure databases

ProteinModelPortaliQ60846
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 66TNFR-Cys 1Add BLAST39
Repeati68 – 106TNFR-Cys 2Add BLAST39
Repeati107 – 150TNFR-Cys 3Add BLAST44

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAX Eukaryota
ENOG410YM0N LUCA
GeneTreeiENSGT00510000049215
HOGENOMiHOG000220871
HOVERGENiHBG005054
InParanoidiQ60846
KOiK05145
OMAiMFCATSA
OrthoDBiEOG091G03XW
PhylomeDBiQ60846
TreeFamiTF331157

Family and domain databases

CDDicd13409 TNFRSF8, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020416 TNFR_8
IPR034002 TNFRSF8_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
PRINTSiPR01923 TNFACTORR8
SMARTiView protein in SMART
SM00208 TNFR, 3 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLTAAGL LFLGMLQAFP TDRPLKTTCA GDLSHYPGEA ARNCCYQCPS
60 70 80 90 100
GLSPTQPCPR GPAHCRKQCA PDYYVNEDGK CTACVTCLPG LVEKAPCSGN
110 120 130 140 150
SPRICECQPG MHCCTPAVNS CARCKLHCSG EEVVKSPGTA KKDTICELPS
160 170 180 190 200
SGSGPNCSNP GDRKTLTSHA TPQAMPTLES PANDSARSLL PMRVTNLVQE
210 220 230 240 250
DATELVKVPE SSSSKAREPS PDPGNAEKNM TLELPSPGTL PDISTSENSK
260 270 280 290 300
EPASTASTLS LVVDAWTSSR MQPTSPLSTG TPFLDPGPVL FWVAMVVLLV
310 320 330 340 350
GSGSFLLCYW KACRRRFQQK FHLDYLVQTF QPKMEQTDSC PTEKLTQPQR
360 370 380 390 400
SGSVTDPSTG HKLSPVSPPP AVETCASVGA TYLENLPLLD DSPAGNPFSP
410 420 430 440 450
REPPEPRVST EHTNNRIEKI YIMKADTVIV GSVKTEVPEG RAPAGSTESE
460 470 480 490
LEAELEVDHA PHYPEQETEP PLGSCTEVMF SVEEGGKEDH GPTTVSEK
Length:498
Mass (Da):53,216
Last modified:November 1, 1996 - v1
Checksum:i98CA2A05B38AFA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25416 mRNA Translation: AAA92887.1
CCDSiCCDS18915.1
RefSeqiNP_033427.1, NM_009401.2
UniGeneiMm.12810

Genome annotation databases

EnsembliENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602
GeneIDi21941
KEGGimmu:21941
UCSCiuc008vrv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTNR8_MOUSE
AccessioniPrimary (citable) accession number: Q60846
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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