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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

Tnfrsf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8
Alternative name(s):
CD30L receptor
Lymphocyte activation antigen CD30
CD_antigen: CD30
Gene namesi
Name:Tnfrsf8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:99908. Tnfrsf8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 258ExtracellularSequence analysisAdd BLAST240
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 498CytoplasmicSequence analysisAdd BLAST219

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003457519 – 498Tumor necrosis factor receptor superfamily member 8Add BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation
Disulfide bondi69 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 121PROSITE-ProRule annotation
Disulfide bondi128 ↔ 146PROSITE-ProRule annotation
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Modified residuei339PhosphoserineBy similarity1
Modified residuei353PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ60846.
PaxDbiQ60846.
PRIDEiQ60846.

PTM databases

iPTMnetiQ60846.
PhosphoSitePlusiQ60846.

Expressioni

Tissue specificityi

Detected in thymus and in activated splenocytes.

Inductioni

By concanavalin A and pokeweed mitogen in splenocytes.

Gene expression databases

BgeeiENSMUSG00000028602.
ExpressionAtlasiQ60846. baseline and differential.
GenevisibleiQ60846. MM.

Interactioni

Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030339.

Structurei

3D structure databases

ProteinModelPortaliQ60846.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 66TNFR-Cys 1Add BLAST39
Repeati68 – 106TNFR-Cys 2Add BLAST39
Repeati107 – 150TNFR-Cys 3Add BLAST44

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZAX. Eukaryota.
ENOG410YM0N. LUCA.
GeneTreeiENSGT00510000049215.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiQ60846.
KOiK05145.
OMAiMFCATSA.
OrthoDBiEOG091G03XW.
PhylomeDBiQ60846.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60846-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALLTAAGL LFLGMLQAFP TDRPLKTTCA GDLSHYPGEA ARNCCYQCPS
60 70 80 90 100
GLSPTQPCPR GPAHCRKQCA PDYYVNEDGK CTACVTCLPG LVEKAPCSGN
110 120 130 140 150
SPRICECQPG MHCCTPAVNS CARCKLHCSG EEVVKSPGTA KKDTICELPS
160 170 180 190 200
SGSGPNCSNP GDRKTLTSHA TPQAMPTLES PANDSARSLL PMRVTNLVQE
210 220 230 240 250
DATELVKVPE SSSSKAREPS PDPGNAEKNM TLELPSPGTL PDISTSENSK
260 270 280 290 300
EPASTASTLS LVVDAWTSSR MQPTSPLSTG TPFLDPGPVL FWVAMVVLLV
310 320 330 340 350
GSGSFLLCYW KACRRRFQQK FHLDYLVQTF QPKMEQTDSC PTEKLTQPQR
360 370 380 390 400
SGSVTDPSTG HKLSPVSPPP AVETCASVGA TYLENLPLLD DSPAGNPFSP
410 420 430 440 450
REPPEPRVST EHTNNRIEKI YIMKADTVIV GSVKTEVPEG RAPAGSTESE
460 470 480 490
LEAELEVDHA PHYPEQETEP PLGSCTEVMF SVEEGGKEDH GPTTVSEK
Length:498
Mass (Da):53,216
Last modified:November 1, 1996 - v1
Checksum:i98CA2A05B38AFA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25416 mRNA. Translation: AAA92887.1.
CCDSiCCDS18915.1.
RefSeqiNP_033427.1. NM_009401.2.
UniGeneiMm.12810.

Genome annotation databases

EnsembliENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602.
GeneIDi21941.
KEGGimmu:21941.
UCSCiuc008vrv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25416 mRNA. Translation: AAA92887.1.
CCDSiCCDS18915.1.
RefSeqiNP_033427.1. NM_009401.2.
UniGeneiMm.12810.

3D structure databases

ProteinModelPortaliQ60846.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030339.

PTM databases

iPTMnetiQ60846.
PhosphoSitePlusiQ60846.

Proteomic databases

EPDiQ60846.
PaxDbiQ60846.
PRIDEiQ60846.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030339; ENSMUSP00000030339; ENSMUSG00000028602.
GeneIDi21941.
KEGGimmu:21941.
UCSCiuc008vrv.1. mouse.

Organism-specific databases

CTDi943.
MGIiMGI:99908. Tnfrsf8.

Phylogenomic databases

eggNOGiENOG410IZAX. Eukaryota.
ENOG410YM0N. LUCA.
GeneTreeiENSGT00510000049215.
HOGENOMiHOG000220871.
HOVERGENiHBG005054.
InParanoidiQ60846.
KOiK05145.
OMAiMFCATSA.
OrthoDBiEOG091G03XW.
PhylomeDBiQ60846.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-MMU-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiQ60846.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028602.
ExpressionAtlasiQ60846. baseline and differential.
GenevisibleiQ60846. MM.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020416. TNFR_8.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01923. TNFACTORR8.
SMARTiSM00208. TNFR. 3 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR8_MOUSE
AccessioniPrimary (citable) accession number: Q60846
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.