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Protein

Interleukin-12 receptor subunit beta-1

Gene

Il12rb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-447115. Interleukin-12 signaling.
R-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 receptor subunit beta-1
Short name:
IL-12 receptor subunit beta-1
Short name:
IL-12R subunit beta-1
Short name:
IL-12R-beta-1
Alternative name(s):
IL-12 receptor beta component
CD_antigen: CD212
Gene namesi
Name:Il12rb1
Synonyms:Il12rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104579. Il12rb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 565546ExtracellularSequence analysisAdd
BLAST
Transmembranei566 – 59126HelicalSequence analysisAdd
BLAST
Topological domaini592 – 738147CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • interleukin-12 receptor complex Source: MGI
  • interleukin-23 receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 738719Interleukin-12 receptor subunit beta-1PRO_0000010918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi53 ↔ 63By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ60837.
PaxDbiQ60837.
PRIDEiQ60837.

PTM databases

PhosphoSiteiQ60837.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000791.
CleanExiMM_IL12RB1.
GenevisibleiQ60837. MM.

Interactioni

Subunit structurei

Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Il12rb2P973782EBI-2481455,EBI-6253448

Protein-protein interaction databases

BioGridi200611. 1 interaction.
IntActiQ60837. 1 interaction.
STRINGi10090.ENSMUSP00000000808.

Structurei

3D structure databases

ProteinModelPortaliQ60837.
SMRiQ60837. Positions 468-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 152106Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini152 – 258107Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini259 – 359101Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini360 – 465106Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini469 – 56597Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi244 – 2485WSXWS motif
Motifi598 – 6069Box 1 motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi230 – 2345Poly-Arg

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJY4. Eukaryota.
ENOG410YV8S. LUCA.
GeneTreeiENSGT00390000012431.
HOGENOMiHOG000082476.
HOVERGENiHBG052058.
InParanoidiQ60837.
KOiK05063.
OMAiKEYVVRC.
OrthoDBiEOG091G052Z.
TreeFamiTF338613.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMMGLAGTS KHITFLLLCQ LGASGPGDGC CVEKTSFPEG ASGSPLGPRN
60 70 80 90 100
LSCYRVSKTD YECSWQYDGP EDNVSHVLWC CFVPPNHTHT GQERCRYFSS
110 120 130 140 150
GPDRTVQFWE QDGIPVLSKV NFWVESRLGN RTMKSQKISQ YLYNWTKTTP
160 170 180 190 200
PLGHIKVSQS HRQLRMDWNV SEEAGAEVQF RRRMPTTNWT LGDCGPQVNS
210 220 230 240 250
GSGVLGDIRG SMSESCLCPS ENMAQEIQIR RRRRLSSGAP GGPWSDWSMP
260 270 280 290 300
VCVPPEVLPQ AKIKFLVEPL NQGGRRRLTM QGQSPQLAVP EGCRGRPGAQ
310 320 330 340 350
VKKHLVLVRM LSCRCQAQTS KTVPLGKKLN LSGATYDLNV LAKTRFGRST
360 370 380 390 400
IQKWHLPAQE LTETRALNVS VGGNMTSMQW AAQAPGTTYC LEWQPWFQHR
410 420 430 440 450
NHTHCTLIVP EEEDPAKMVT HSWSSKPTLE QEECYRITVF ASKNPKNPML
460 470 480 490 500
WATVLSSYYF GGNASRAGTP RHVSVRNQTG DSVSVEWTAS QLSTCPGVLT
510 520 530 540 550
QYVVRCEAED GAWESEWLVP PTKTQVTLDG LRSRVMYKVQ VRADTARLPG
560 570 580 590 600
AWSHPQRFSF EVQISRLSII FASLGSFASV LLVGSLGYIG LNRAAWHLCP
610 620 630 640 650
PLPTPCGSTA VEFPGSQGKQ AWQWCNPEDF PEVLYPRDAL VVEMPGDRGD
660 670 680 690 700
GTESPQAAPE CALDTRRPLE TQRQRQVQAL SEARRLGLAR EDCPRGDLAH
710 720 730
VTLPLLLGGV TQGASVLDDL WRTHKTAEPG PPTLGQEA
Length:738
Mass (Da):81,788
Last modified:July 27, 2011 - v2
Checksum:i595CF60E8B5C74F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → P in AAA87457 (PubMed:7594587).Curated
Sequence conflicti162 – 1621R → G in AAA87457 (PubMed:7594587).Curated
Sequence conflicti209 – 2091R → C in AAA87457 (PubMed:7594587).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23922 mRNA. Translation: AAA87457.1.
AK137577 mRNA. Translation: BAE23414.1.
CCDSiCCDS22382.1.
PIRiI49295.
RefSeqiNP_032379.2. NM_008353.2.
UniGeneiMm.731.

Genome annotation databases

EnsembliENSMUST00000000808; ENSMUSP00000000808; ENSMUSG00000000791.
GeneIDi16161.
KEGGimmu:16161.
UCSCiuc009mbr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23922 mRNA. Translation: AAA87457.1.
AK137577 mRNA. Translation: BAE23414.1.
CCDSiCCDS22382.1.
PIRiI49295.
RefSeqiNP_032379.2. NM_008353.2.
UniGeneiMm.731.

3D structure databases

ProteinModelPortaliQ60837.
SMRiQ60837. Positions 468-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200611. 1 interaction.
IntActiQ60837. 1 interaction.
STRINGi10090.ENSMUSP00000000808.

PTM databases

PhosphoSiteiQ60837.

Proteomic databases

EPDiQ60837.
PaxDbiQ60837.
PRIDEiQ60837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000808; ENSMUSP00000000808; ENSMUSG00000000791.
GeneIDi16161.
KEGGimmu:16161.
UCSCiuc009mbr.2. mouse.

Organism-specific databases

CTDi3594.
MGIiMGI:104579. Il12rb1.

Phylogenomic databases

eggNOGiENOG410IJY4. Eukaryota.
ENOG410YV8S. LUCA.
GeneTreeiENSGT00390000012431.
HOGENOMiHOG000082476.
HOVERGENiHBG052058.
InParanoidiQ60837.
KOiK05063.
OMAiKEYVVRC.
OrthoDBiEOG091G052Z.
TreeFamiTF338613.

Enzyme and pathway databases

ReactomeiR-MMU-447115. Interleukin-12 signaling.
R-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ60837.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000791.
CleanExiMM_IL12RB1.
GenevisibleiQ60837. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI12R1_MOUSE
AccessioniPrimary (citable) accession number: Q60837
Secondary accession number(s): Q3UV59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.