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Protein

Interleukin-12 receptor subunit beta-1

Gene

Il12rb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-447115. Interleukin-12 signaling.
R-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-12 receptor subunit beta-1
Short name:
IL-12 receptor subunit beta-1
Short name:
IL-12R subunit beta-1
Short name:
IL-12R-beta-1
Alternative name(s):
IL-12 receptor beta component
CD_antigen: CD212
Gene namesi
Name:Il12rb1
Synonyms:Il12rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104579. Il12rb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 565ExtracellularSequence analysisAdd BLAST546
Transmembranei566 – 591HelicalSequence analysisAdd BLAST26
Topological domaini592 – 738CytoplasmicSequence analysisAdd BLAST147

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • interleukin-12 receptor complex Source: MGI
  • interleukin-23 receptor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001091820 – 738Interleukin-12 receptor subunit beta-1Add BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi53 ↔ 63By similarity
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1
Glycosylationi463N-linked (GlcNAc...)Sequence analysis1
Glycosylationi477N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ60837.
PaxDbiQ60837.
PRIDEiQ60837.

PTM databases

PhosphoSitePlusiQ60837.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000791.
CleanExiMM_IL12RB1.
GenevisibleiQ60837. MM.

Interactioni

Subunit structurei

Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Il12rb2P973782EBI-2481455,EBI-6253448

Protein-protein interaction databases

BioGridi200611. 1 interactor.
IntActiQ60837. 1 interactor.
STRINGi10090.ENSMUSP00000000808.

Structurei

3D structure databases

ProteinModelPortaliQ60837.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 152Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST106
Domaini152 – 258Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST107
Domaini259 – 359Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST101
Domaini360 – 465Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST106
Domaini469 – 565Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi244 – 248WSXWS motif5
Motifi598 – 606Box 1 motif9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 234Poly-Arg5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJY4. Eukaryota.
ENOG410YV8S. LUCA.
GeneTreeiENSGT00390000012431.
HOGENOMiHOG000082476.
HOVERGENiHBG052058.
InParanoidiQ60837.
KOiK05063.
OMAiKEYVVRC.
OrthoDBiEOG091G052Z.
TreeFamiTF338613.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60837-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMMGLAGTS KHITFLLLCQ LGASGPGDGC CVEKTSFPEG ASGSPLGPRN
60 70 80 90 100
LSCYRVSKTD YECSWQYDGP EDNVSHVLWC CFVPPNHTHT GQERCRYFSS
110 120 130 140 150
GPDRTVQFWE QDGIPVLSKV NFWVESRLGN RTMKSQKISQ YLYNWTKTTP
160 170 180 190 200
PLGHIKVSQS HRQLRMDWNV SEEAGAEVQF RRRMPTTNWT LGDCGPQVNS
210 220 230 240 250
GSGVLGDIRG SMSESCLCPS ENMAQEIQIR RRRRLSSGAP GGPWSDWSMP
260 270 280 290 300
VCVPPEVLPQ AKIKFLVEPL NQGGRRRLTM QGQSPQLAVP EGCRGRPGAQ
310 320 330 340 350
VKKHLVLVRM LSCRCQAQTS KTVPLGKKLN LSGATYDLNV LAKTRFGRST
360 370 380 390 400
IQKWHLPAQE LTETRALNVS VGGNMTSMQW AAQAPGTTYC LEWQPWFQHR
410 420 430 440 450
NHTHCTLIVP EEEDPAKMVT HSWSSKPTLE QEECYRITVF ASKNPKNPML
460 470 480 490 500
WATVLSSYYF GGNASRAGTP RHVSVRNQTG DSVSVEWTAS QLSTCPGVLT
510 520 530 540 550
QYVVRCEAED GAWESEWLVP PTKTQVTLDG LRSRVMYKVQ VRADTARLPG
560 570 580 590 600
AWSHPQRFSF EVQISRLSII FASLGSFASV LLVGSLGYIG LNRAAWHLCP
610 620 630 640 650
PLPTPCGSTA VEFPGSQGKQ AWQWCNPEDF PEVLYPRDAL VVEMPGDRGD
660 670 680 690 700
GTESPQAAPE CALDTRRPLE TQRQRQVQAL SEARRLGLAR EDCPRGDLAH
710 720 730
VTLPLLLGGV TQGASVLDDL WRTHKTAEPG PPTLGQEA
Length:738
Mass (Da):81,788
Last modified:July 27, 2011 - v2
Checksum:i595CF60E8B5C74F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → P in AAA87457 (PubMed:7594587).Curated1
Sequence conflicti162R → G in AAA87457 (PubMed:7594587).Curated1
Sequence conflicti209R → C in AAA87457 (PubMed:7594587).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23922 mRNA. Translation: AAA87457.1.
AK137577 mRNA. Translation: BAE23414.1.
CCDSiCCDS22382.1.
PIRiI49295.
RefSeqiNP_032379.2. NM_008353.2.
UniGeneiMm.731.

Genome annotation databases

EnsembliENSMUST00000000808; ENSMUSP00000000808; ENSMUSG00000000791.
GeneIDi16161.
KEGGimmu:16161.
UCSCiuc009mbr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23922 mRNA. Translation: AAA87457.1.
AK137577 mRNA. Translation: BAE23414.1.
CCDSiCCDS22382.1.
PIRiI49295.
RefSeqiNP_032379.2. NM_008353.2.
UniGeneiMm.731.

3D structure databases

ProteinModelPortaliQ60837.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200611. 1 interactor.
IntActiQ60837. 1 interactor.
STRINGi10090.ENSMUSP00000000808.

PTM databases

PhosphoSitePlusiQ60837.

Proteomic databases

EPDiQ60837.
PaxDbiQ60837.
PRIDEiQ60837.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000808; ENSMUSP00000000808; ENSMUSG00000000791.
GeneIDi16161.
KEGGimmu:16161.
UCSCiuc009mbr.2. mouse.

Organism-specific databases

CTDi3594.
MGIiMGI:104579. Il12rb1.

Phylogenomic databases

eggNOGiENOG410IJY4. Eukaryota.
ENOG410YV8S. LUCA.
GeneTreeiENSGT00390000012431.
HOGENOMiHOG000082476.
HOVERGENiHBG052058.
InParanoidiQ60837.
KOiK05063.
OMAiKEYVVRC.
OrthoDBiEOG091G052Z.
TreeFamiTF338613.

Enzyme and pathway databases

ReactomeiR-MMU-447115. Interleukin-12 signaling.
R-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ60837.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000791.
CleanExiMM_IL12RB1.
GenevisibleiQ60837. MM.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI12R1_MOUSE
AccessioniPrimary (citable) accession number: Q60837
Secondary accession number(s): Q3UV59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.