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Q60837 (I12R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-12 receptor subunit beta-1
Short name=IL-12 receptor subunit beta-1
Short name=IL-12R subunit beta-1
Short name=IL-12R-beta-1
Alternative name(s):
IL-12 receptor beta component
CD_antigen=CD212
Gene names
Name:Il12rb1
Synonyms:Il12rb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length738 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.

Subunit structure

Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor By similarity. Ref.3

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

The box 1 motif is required for JAK interaction and/or activation.

Sequence similarities

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Contains 5 fibronectin type-III domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Il12rb2P973782EBI-2481455,EBI-6253448

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 738719Interleukin-12 receptor subunit beta-1
PRO_0000010918

Regions

Topological domain20 – 565546Extracellular Potential
Transmembrane566 – 59126Helical; Potential
Topological domain592 – 738147Cytoplasmic Potential
Domain44 – 14299Fibronectin type-III 1
Domain152 – 258107Fibronectin type-III 2
Domain259 – 359101Fibronectin type-III 3
Domain360 – 465106Fibronectin type-III 4
Domain466 – 56297Fibronectin type-III 5
Motif244 – 2485WSXWS motif
Motif598 – 6069Box 1 motif
Compositional bias230 – 2345Poly-Arg

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation3741N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential
Glycosylation4771N-linked (GlcNAc...) Potential
Disulfide bond53 ↔ 63 By similarity

Experimental info

Sequence conflict71A → P in AAA87457. Ref.1
Sequence conflict1621R → G in AAA87457. Ref.1
Sequence conflict2091R → C in AAA87457. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q60837 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 595CF60E8B5C74F1

FASTA73881,788
        10         20         30         40         50         60 
MDMMGLAGTS KHITFLLLCQ LGASGPGDGC CVEKTSFPEG ASGSPLGPRN LSCYRVSKTD 

        70         80         90        100        110        120 
YECSWQYDGP EDNVSHVLWC CFVPPNHTHT GQERCRYFSS GPDRTVQFWE QDGIPVLSKV 

       130        140        150        160        170        180 
NFWVESRLGN RTMKSQKISQ YLYNWTKTTP PLGHIKVSQS HRQLRMDWNV SEEAGAEVQF 

       190        200        210        220        230        240 
RRRMPTTNWT LGDCGPQVNS GSGVLGDIRG SMSESCLCPS ENMAQEIQIR RRRRLSSGAP 

       250        260        270        280        290        300 
GGPWSDWSMP VCVPPEVLPQ AKIKFLVEPL NQGGRRRLTM QGQSPQLAVP EGCRGRPGAQ 

       310        320        330        340        350        360 
VKKHLVLVRM LSCRCQAQTS KTVPLGKKLN LSGATYDLNV LAKTRFGRST IQKWHLPAQE 

       370        380        390        400        410        420 
LTETRALNVS VGGNMTSMQW AAQAPGTTYC LEWQPWFQHR NHTHCTLIVP EEEDPAKMVT 

       430        440        450        460        470        480 
HSWSSKPTLE QEECYRITVF ASKNPKNPML WATVLSSYYF GGNASRAGTP RHVSVRNQTG 

       490        500        510        520        530        540 
DSVSVEWTAS QLSTCPGVLT QYVVRCEAED GAWESEWLVP PTKTQVTLDG LRSRVMYKVQ 

       550        560        570        580        590        600 
VRADTARLPG AWSHPQRFSF EVQISRLSII FASLGSFASV LLVGSLGYIG LNRAAWHLCP 

       610        620        630        640        650        660 
PLPTPCGSTA VEFPGSQGKQ AWQWCNPEDF PEVLYPRDAL VVEMPGDRGD GTESPQAAPE 

       670        680        690        700        710        720 
CALDTRRPLE TQRQRQVQAL SEARRLGLAR EDCPRGDLAH VTLPLLLGGV TQGASVLDDL 

       730 
WRTHKTAEPG PPTLGQEA

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a mouse IL-12 receptor-beta component."
Chua A.O., Wilkinson V.L., Presky D.H., Gubler U.
J. Immunol. 155:4286-4294(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone.
[3]"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U.
Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U23922 mRNA. Translation: AAA87457.1.
AK137577 mRNA. Translation: BAE23414.1.
IPIIPI00121384.
PIRI49295.
RefSeqNP_032379.2. NM_008353.2.
UniGeneMm.731.

3D structure databases

ProteinModelPortalQ60837.
SMRQ60837. Positions 117-151, 469-561.
ModBaseSearch...

Protein-protein interaction databases

IntActQ60837. 1 interaction.

PTM databases

PhosphoSiteQ60837.

Proteomic databases

PRIDEQ60837.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000808; ENSMUSP00000000808; ENSMUSG00000000791.
GeneID16161.
KEGGmmu:16161.

Organism-specific databases

CTD3594.
MGIMGI:104579. Il12rb1.

Phylogenomic databases

eggNOGNOG42645.
GeneTreeENSGT00390000012431.
HOGENOMHOG000082476.
HOVERGENHBG052058.
InParanoidQ3UV59.
KOK05063.
OMACPGVLKE.
OrthoDBEOG43TZV3.

Gene expression databases

BgeeQ60837.
CleanExMM_IL12RB1.
GenevestigatorQ60837.
GermOnlineENSMUSG00000000791. Mus musculus.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 1 hit.
PROSITEPS50853. FN3. 1 hit.
PS01353. HEMATOPO_REC_L_F2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio288983.
SOURCESearch...

Entry information

Entry nameI12R1_MOUSE
AccessionPrimary (citable) accession number: Q60837
Secondary accession number(s): Q3UV59
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents