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Protein

Protein phosphatase 1 regulatory subunit 1B

Gene

Ppp1r1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1.

GO - Molecular functioni

GO - Biological processi

  • behavioral response to cocaine Source: MGI
  • histone H3-S10 phosphorylation Source: MGI
  • intracellular signal transduction Source: GO_Central
  • locomotory behavior Source: MGI
  • negative regulation of female receptivity Source: MGI
  • negative regulation of phosphoprotein phosphatase activity Source: MGI
  • negative regulation of protein kinase activity Source: GO_Central
  • response to amphetamine Source: MGI
  • response to morphine Source: MGI
  • transcription, DNA-templated Source: MGI
  • visual learning Source: MGI

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-180024. DARPP-32 events.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1B
Alternative name(s):
DARPP-32
Dopamine- and cAMP-regulated neuronal phosphoprotein
Gene namesi
Name:Ppp1r1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:94860. Ppp1r1b.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714741 – 194Protein phosphatase 1 regulatory subunit 1BAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei34Phosphothreonine; by PKABy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei75PhosphothreonineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei130PhosphoserineBy similarity1
Modified residuei192PhosphoserineCombined sources1

Post-translational modificationi

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.By similarity
Phosphorylation of Thr-34 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ60829.
PeptideAtlasiQ60829.
PRIDEiQ60829.

PTM databases

iPTMnetiQ60829.
PhosphoSitePlusiQ60829.

Expressioni

Gene expression databases

BgeeiENSMUSG00000061718.
GenevisibleiQ60829. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ60829. 1 interactor.
MINTiMINT-4098740.
STRINGi10090.ENSMUSP00000077760.

Structurei

3D structure databases

ProteinModelPortaliQ60829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J1BH. Eukaryota.
ENOG4111TN1. LUCA.
GeneTreeiENSGT00730000111283.
HOGENOMiHOG000290193.
HOVERGENiHBG099182.
InParanoidiQ60829.
KOiK15494.
OMAiANPCAYT.
OrthoDBiEOG091G0NO6.
PhylomeDBiQ60829.
TreeFamiTF332576.

Family and domain databases

InterProiView protein in InterPro
IPR015670. DARPP-32.
IPR008466. PPP1R1A/B/C.
PANTHERiPTHR15417. PTHR15417. 1 hit.
PTHR15417:SF2. PTHR15417:SF2. 1 hit.
PfamiView protein in Pfam
PF05395. DARPP-32. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60829-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR VSEHSSPEEE
60 70 80 90 100
ASPHQRTSGE GHHPKSKRPN PCAYTPPSLK AVQHLQTISN LSENQASEEE
110 120 130 140 150
DELGELRELG YPQEDDEEDE DEEEDEEEDS QAEVLKGSRG TVGQKPTCGR
160 170 180 190
GLEGPWERPP PLDEPQRDGN SEDQVEGRAT LSEPGEEPQH PSPP
Length:194
Mass (Da):21,781
Last modified:October 10, 2002 - v2
Checksum:iE0509291E6615EA3
GO
Isoform 2 (identifier: Q60829-2) [UniParc]FASTAAdd to basket
Also known as: DARPP-30

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:158
Mass (Da):17,556
Checksum:i33141573EA030243
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0250581 – 36Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY640620 mRNA. Translation: AAT66920.1.
AY640621 mRNA. Translation: AAT66921.1.
AL591390 Genomic DNA. Translation: CAM22017.1.
BC011122 mRNA. Translation: AAH11122.1.
BC026568 mRNA. Translation: AAH26568.1.
BC031129 mRNA. Translation: AAH31129.1.
U23160 Genomic DNA. Translation: AAA93223.1.
AK141563 mRNA. Translation: BAE24736.1.
CCDSiCCDS25344.1. [Q60829-1]
CCDS83889.1. [Q60829-2]
RefSeqiNP_001300899.1. NM_001313970.1. [Q60829-2]
NP_659077.1. NM_144828.2. [Q60829-1]
UniGeneiMm.45372.

Genome annotation databases

EnsembliENSMUST00000078694; ENSMUSP00000077760; ENSMUSG00000061718. [Q60829-1]
ENSMUST00000137634; ENSMUSP00000123528; ENSMUSG00000061718. [Q60829-2]
ENSMUST00000150762; ENSMUSP00000121147; ENSMUSG00000061718. [Q60829-2]
GeneIDi19049.
KEGGimmu:19049.
UCSCiuc007lfz.1. mouse. [Q60829-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPR1B_MOUSE
AccessioniPrimary (citable) accession number: Q60829
Secondary accession number(s): A2A564
, Q3URF2, Q6DV86, Q91XB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: October 25, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families