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Q60821

- ZBT17_MOUSE

UniProt

Q60821 - ZBT17_MOUSE

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Protein

Zinc finger and BTB domain-containing protein 17

Gene

Zbtb17

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri297 – 31923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54325C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62824C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri708 – 73023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. ectoderm development Source: MGI
  2. gastrulation with mouth forming second Source: MGI
  3. positive regulation of transcription, DNA-templated Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 17
Alternative name(s):
LP-1
Polyomavirus late initiator promoter-binding protein
Zinc finger protein 100
Short name:
Zfp-100
Zinc finger protein 151
Zinc finger protein Z13
Gene namesi
Name:Zbtb17
Synonyms:Zfp100, Znf151
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:107410. Zbtb17.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice produce inviable embryos which are severely retarded in early development and do not undergo normal gastrulation due to massive apoptosis of ectodermal cells around day 7.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 794794Zinc finger and BTB domain-containing protein 17PRO_0000047731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki388 – 388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki472 – 472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Undergoes 'Lys-48'-linked polyubiquitination at Lys-388 and Lys-472 and subsequent proteasomal degradation in a TRAF2-dependent manner and upon TNFA stimulation.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ60821.
PaxDbiQ60821.
PRIDEiQ60821.

PTM databases

PhosphoSiteiQ60821.

Expressioni

Tissue specificityi

Found in all the embryonic and adult tissues examined.

Developmental stagei

Expressed ubiquitously from early embryogenesis (6.5 dpc) to organogenesis, predominantly in neural and epithelial tissues.1 Publication

Gene expression databases

BgeeiQ60821.
CleanExiMM_ZBTB17.
GenevestigatoriQ60821.

Interactioni

Subunit structurei

Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts (via the C-terminal zinc fingers) with GFI1; the interaction results in the recruitment of MYC to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest.2 Publications

Protein-protein interaction databases

BioGridi204631. 2 interactions.
DIPiDIP-48690N.

Structurei

3D structure databases

ProteinModelPortaliQ60821.
SMRiQ60821. Positions 1-115, 297-626, 698-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 104104BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni260 – 29940Interaction with MYCBy similarityAdd
BLAST
Regioni628 – 794167Interaction with HCFC1By similarityAdd
BLAST
Regioni628 – 70982Interaction with MYCBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri297 – 31923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri325 – 34723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri353 – 37523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri381 – 40323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri409 – 43123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri437 – 45923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri465 – 48723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri493 – 51523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54325C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62824C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri708 – 73023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000231298.
HOVERGENiHBG054919.
InParanoidiQ60821.
KOiK10500.
OMAiCDSCGDK.
OrthoDBiEOG7KSX7Q.
TreeFamiTF332047.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60821-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDFPQHSQRV LEQLNQQRQL GLLCDCTFVV DGVDFKAHKA VLAACSEYFK
60 70 80 90 100
MLFVDQKDVV HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVASFLQ
110 120 130 140 150
MQDIVTACHT LKSLAEPSST TGESADASAV EGGDKRAKDE KAAATMLSRL
160 170 180 190 200
DQARGSSSTG PGRELKEERG GQAESASSGA EQTEKADAPR EPPPVELKPD
210 220 230 240 250
PTSSMAAAEA EALSESSEQE MEVEPASKGE DGQEEEGAGP ATVKEEGMHL
260 270 280 290 300
DNGEPPEENE ESAGTDSGQE LGMEGQNLRS GTYGDRTESK AYGSIIHKCE
310 320 330 340 350
DCGKEFTHTG NFKRHIRIHT GEKPFSCREC SKAFSDPAAC KAHEKTHSPL
360 370 380 390 400
KPYGCEECGK SYRLISLLNL HKKRHSGEAR YRCGDCGKLF TTSGNLKRHQ
410 420 430 440 450
LVHSGQKPYQ CDYCGRSFSD PTSKMRHLET HDTDKEHKCP HCDKKFNQVG
460 470 480 490 500
NLKAHLKIHI ADGPLKCREC GKQFTTSGNL KRHLRIHSGE KPYVCTHCQR
510 520 530 540 550
QFADPGALQR HVRIHTGEKP CQCVICGKAF TQASSLIAHV RQHTGEKPYV
560 570 580 590 600
CERCGKRFVQ SSQLANHIRH HDNIRPHKCS VCSKAFVNVG DLSKHIIIHT
610 620 630 640 650
GEKPYLCDKC GRGFNRVDNL RSHVKTVHQG KAGIKILEPE EGGEVSVVTV
660 670 680 690 700
DDMVTLATEA LAATAVTQLT VVPVGAAVTA DETEVLKAEI SKAVKQVQEE
710 720 730 740 750
DPNTHILYAC DSCGDKFLDA NSLAQHVRIH TAQALVMFQT DADFYQQYGP
760 770 780 790
GSTWPAGQML QAGELVFRPR DGTEGQPTLA ESPPTAPDCL PPAE
Length:794
Mass (Da):86,758
Last modified:July 27, 2011 - v2
Checksum:i54CF6CF0D2C60303
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511D → G in AAA64848. 1 PublicationCurated
Sequence conflicti151 – 1511D → G in AAA85493. (PubMed:7575457)Curated
Sequence conflicti507 – 5071A → G in AAA64848. 1 PublicationCurated
Sequence conflicti573 – 5731N → K in AAA85493. (PubMed:7575457)Curated
Sequence conflicti577 – 5771H → D in AAA64848. 1 PublicationCurated
Sequence conflicti577 – 5771H → D in AAA85493. (PubMed:7575457)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22396 mRNA. Translation: AAA64848.1.
U14556 mRNA. Translation: AAA85493.1.
AL670285 Genomic DNA. Translation: CAM20401.1.
CH466615 Genomic DNA. Translation: EDL13378.1.
CCDSiCCDS18875.1.
PIRiS59069.
RefSeqiNP_033567.2. NM_009541.2.
UniGeneiMm.389590.

Genome annotation databases

EnsembliENSMUST00000006377; ENSMUSP00000006377; ENSMUSG00000006215.
GeneIDi22642.
KEGGimmu:22642.
UCSCiuc008vol.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U22396 mRNA. Translation: AAA64848.1 .
U14556 mRNA. Translation: AAA85493.1 .
AL670285 Genomic DNA. Translation: CAM20401.1 .
CH466615 Genomic DNA. Translation: EDL13378.1 .
CCDSi CCDS18875.1.
PIRi S59069.
RefSeqi NP_033567.2. NM_009541.2.
UniGenei Mm.389590.

3D structure databases

ProteinModelPortali Q60821.
SMRi Q60821. Positions 1-115, 297-626, 698-740.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204631. 2 interactions.
DIPi DIP-48690N.

PTM databases

PhosphoSitei Q60821.

Proteomic databases

MaxQBi Q60821.
PaxDbi Q60821.
PRIDEi Q60821.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006377 ; ENSMUSP00000006377 ; ENSMUSG00000006215 .
GeneIDi 22642.
KEGGi mmu:22642.
UCSCi uc008vol.2. mouse.

Organism-specific databases

CTDi 7709.
MGIi MGI:107410. Zbtb17.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118922.
HOGENOMi HOG000231298.
HOVERGENi HBG054919.
InParanoidi Q60821.
KOi K10500.
OMAi CDSCGDK.
OrthoDBi EOG7KSX7Q.
TreeFami TF332047.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 303035.
PROi Q60821.
SOURCEi Search...

Gene expression databases

Bgeei Q60821.
CleanExi MM_ZBTB17.
Genevestigatori Q60821.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA for polyomavirus late initiator promoter binding protein, LP-1."
    Rapp L., Carmichael G.G.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13."
    Schulz T.C., Hopwood B., Rathjen P.D., Wells J.R.E.
    Biochem. J. 311:219-224(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Miz1 is required for early embryonic development during gastrulation."
    Adhikary S., Peukert K., Karsunky H., Beuger V., Lutz W., Elsaesser H.-P., Moeroey T., Eilers M.
    Mol. Cell. Biol. 23:7648-7657(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  6. "A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A."
    Liu Q., Basu S., Qiu Y., Tang F., Dong F.
    Oncogene 29:2843-2852(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GFI1, FUNCTION.
  7. "IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1."
    Saba I., Kosan C., Vassen L., Moroy T.
    Blood 117:3370-3381(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN LYMPHOCYTE DEVELOPMENT.
  8. "Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-alpha-induced JNK activation and inflammation."
    Liu J., Yan J., Jiang S., Wen J., Chen L., Zhao Y., Lin A.
    Proc. Natl. Acad. Sci. U.S.A. 109:191-196(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION AT LYS-388 AND LYS-472, INTERACTION WITH TRAF2.

Entry informationi

Entry nameiZBT17_MOUSE
AccessioniPrimary (citable) accession number: Q60821
Secondary accession number(s): A2ADB9, Q60699
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3