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Protein

Interleukin-15 receptor subunit alpha

Gene

Il15ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction involves SYK (By similarity).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15 receptor subunit alpha
Short name:
IL-15 receptor subunit alpha
Short name:
IL-15R-alpha
Short name:
IL-15RA
Alternative name(s):
CD_antigen: CD215
Cleaved into the following chain:
Soluble interleukin-15 receptor subunit alpha
Short name:
sIL-15 receptor subunit alpha
Short name:
sIL-15R-alpha
Short name:
sIL-15RA
Gene namesi
Name:Il15ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104644. Il15ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 205173ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621HelicalSequence analysisAdd
BLAST
Topological domaini227 – 26337CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 263231Interleukin-15 receptor subunit alphaPRO_0000011045Add
BLAST
Chaini33 – ?Soluble interleukin-15 receptor subunit alphaPRO_0000333856

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 78PROSITE-ProRule annotation1 Publication
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Disulfide bondi62 ↔ 96PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylated by activated SYK.By similarity
N-glycosylated and O-glycosylated.By similarity
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE. It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ60819.
PRIDEiQ60819.

Miscellaneous databases

PMAP-CutDBQ60819.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiQ60819.
CleanExiMM_IL15RA.
ExpressionAtlasiQ60819. baseline and differential.
GenevisibleiQ60819. MM.

Interactioni

Subunit structurei

The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates. Interacts with SYK (By similarity).By similarity

Protein-protein interaction databases

IntActiQ60819. 1 interaction.
STRINGi10090.ENSMUSP00000077878.

Structurei

Secondary structure

1
263
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi57 – 593Combined sources
Beta strandi66 – 683Combined sources
Beta strandi75 – 806Combined sources
Turni82 – 843Combined sources
Beta strandi87 – 893Combined sources
Beta strandi96 – 983Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19C/F33-103[»]
ProteinModelPortaliQ60819.
SMRiQ60819. Positions 35-103.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60819.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9865SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWP4. Eukaryota.
ENOG410Z8MM. LUCA.
GeneTreeiENSGT00390000000121.
HOVERGENiHBG052061.
InParanoidiQ60819.
KOiK05074.
OMAiLLACYIK.
OrthoDBiEOG7V767N.
PhylomeDBiQ60819.
TreeFamiTF338443.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPQLRGYG VQAIPVLLLL LLLLLLPLRV TPGTTCPPPV SIEHADIRVK
60 70 80 90 100
NYSVNSRERY VCNSGFKRKA GTSTLIECVI NKNTNVAHWT TPSLKCIRDP
110 120 130 140 150
SLAHYSPVPT VVTPKVTSQP ESPSPSAKEP EAFSPKSDTA MTTETAIMPG
160 170 180 190 200
SRLTPSQTTS AGTTGTGSHK SSRAPSLAAT MTLEPTASTS LRITEISPHS
210 220 230 240 250
SKMTKVAIST SVLLVGAGVV MAFLAWYIKS RQPSQPCRVE VETMETVPMT
260
VRASSKEDED TGA
Length:263
Mass (Da):28,061
Last modified:November 1, 1996 - v1
Checksum:iBFCC2CE4BA58B504
GO
Isoform 2 (identifier: Q60819-2) [UniParc]FASTAAdd to basket

Also known as: 1A

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.

Show »
Length:230
Mass (Da):24,638
Checksum:i23CF1CE4DA3F70F1
GO
Isoform 3 (identifier: Q60819-3) [UniParc]FASTAAdd to basket

Also known as: 1B, IL-15R-alphadelta4

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.

Show »
Length:197
Mass (Da):21,366
Checksum:i1D16A75C518B986B
GO
Isoform 4 (identifier: Q60819-4) [UniParc]FASTAAdd to basket

Also known as: 1C, IL-15R-alphadelta34

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-195: E → K

Show »
Length:166
Mass (Da):18,122
Checksum:i94DC3A60B7CD883B
GO
Isoform 5 (identifier: Q60819-5) [UniParc]FASTAAdd to basket

Also known as: 2, 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-128: Missing.
     129-140: Missing.

Show »
Length:123
Mass (Da):12,905
Checksum:iB43C11755D9823DC
GO
Isoform 6 (identifier: Q60819-6) [UniParc]FASTAAdd to basket

Also known as: IL-15R-alphadelta345

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-206: EISPHSSKMTKV → M

Show »
Length:155
Mass (Da):16,929
Checksum:iB74A423264627E66
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 5. 2 PublicationsVSP_012627Add
BLAST
Alternative sequencei98 – 12831Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_012628Add
BLAST
Alternative sequencei129 – 14012Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_012629Add
BLAST
Alternative sequencei141 – 16121Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_012630Add
BLAST
Alternative sequencei162 – 19433Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationVSP_012631Add
BLAST
Alternative sequencei195 – 20612EISPH…KMTKV → M in isoform 6. CuratedVSP_012633Add
BLAST
Alternative sequencei195 – 1951E → K in isoform 4. 1 PublicationVSP_012632

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22339 Genomic DNA. Translation: AAC52240.1.
AY219715 mRNA. Translation: AAO62310.1.
AY219716 mRNA. Translation: AAO62311.1.
AY219717 mRNA. Translation: AAO62312.1.
AY221616 mRNA. Translation: AAO74882.1.
AL831794 Genomic DNA. Translation: CAM13743.1.
AL831794 Genomic DNA. Translation: CAM13744.1.
AL831794 Genomic DNA. Translation: CAM13745.1.
BC022705 mRNA. Translation: AAH22705.1.
CCDSiCCDS15686.1. [Q60819-1]
CCDS15687.1. [Q60819-5]
CCDS70977.1. [Q60819-2]
CCDS70978.1. [Q60819-3]
CCDS70979.1. [Q60819-4]
PIRiS57346.
RefSeqiNP_001258426.1. NM_001271497.1. [Q60819-5]
NP_001258428.1. NM_001271499.1. [Q60819-2]
NP_001258429.1. NM_001271500.1. [Q60819-3]
NP_001258430.1. NM_001271501.1. [Q60819-4]
NP_032384.1. NM_008358.2. [Q60819-1]
NP_598597.1. NM_133836.2. [Q60819-5]
XP_006497427.1. XM_006497364.1. [Q60819-5]
UniGeneiMm.200196.

Genome annotation databases

EnsembliENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206. [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206. [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206. [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206. [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206. [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206. [Q60819-5]
GeneIDi16169.
KEGGimmu:16169.
UCSCiuc008iiw.2. mouse. [Q60819-6]
uc008iix.2. mouse. [Q60819-1]
uc008iiy.2. mouse. [Q60819-2]
uc008iiz.2. mouse. [Q60819-3]
uc008ija.2. mouse. [Q60819-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22339 Genomic DNA. Translation: AAC52240.1.
AY219715 mRNA. Translation: AAO62310.1.
AY219716 mRNA. Translation: AAO62311.1.
AY219717 mRNA. Translation: AAO62312.1.
AY221616 mRNA. Translation: AAO74882.1.
AL831794 Genomic DNA. Translation: CAM13743.1.
AL831794 Genomic DNA. Translation: CAM13744.1.
AL831794 Genomic DNA. Translation: CAM13745.1.
BC022705 mRNA. Translation: AAH22705.1.
CCDSiCCDS15686.1. [Q60819-1]
CCDS15687.1. [Q60819-5]
CCDS70977.1. [Q60819-2]
CCDS70978.1. [Q60819-3]
CCDS70979.1. [Q60819-4]
PIRiS57346.
RefSeqiNP_001258426.1. NM_001271497.1. [Q60819-5]
NP_001258428.1. NM_001271499.1. [Q60819-2]
NP_001258429.1. NM_001271500.1. [Q60819-3]
NP_001258430.1. NM_001271501.1. [Q60819-4]
NP_032384.1. NM_008358.2. [Q60819-1]
NP_598597.1. NM_133836.2. [Q60819-5]
XP_006497427.1. XM_006497364.1. [Q60819-5]
UniGeneiMm.200196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19C/F33-103[»]
ProteinModelPortaliQ60819.
SMRiQ60819. Positions 35-103.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60819. 1 interaction.
STRINGi10090.ENSMUSP00000077878.

Proteomic databases

PaxDbiQ60819.
PRIDEiQ60819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206. [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206. [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206. [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206. [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206. [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206. [Q60819-5]
GeneIDi16169.
KEGGimmu:16169.
UCSCiuc008iiw.2. mouse. [Q60819-6]
uc008iix.2. mouse. [Q60819-1]
uc008iiy.2. mouse. [Q60819-2]
uc008iiz.2. mouse. [Q60819-3]
uc008ija.2. mouse. [Q60819-4]

Organism-specific databases

CTDi3601.
MGIiMGI:104644. Il15ra.

Phylogenomic databases

eggNOGiENOG410IWP4. Eukaryota.
ENOG410Z8MM. LUCA.
GeneTreeiENSGT00390000000121.
HOVERGENiHBG052061.
InParanoidiQ60819.
KOiK05074.
OMAiLLACYIK.
OrthoDBiEOG7V767N.
PhylomeDBiQ60819.
TreeFamiTF338443.

Miscellaneous databases

ChiTaRSiIl15ra. mouse.
EvolutionaryTraceiQ60819.
NextBioi289007.
PMAP-CutDBQ60819.
PROiQ60819.
SOURCEiSearch...

Gene expression databases

BgeeiQ60819.
CleanExiMM_IL15RA.
ExpressionAtlasiQ60819. baseline and differential.
GenevisibleiQ60819. MM.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor."
    Giri J.G., Kumaki S., Ahdieh M., Friend D.J., Loomis A., Shanebeck K., DuBose R., Cosman D., Park L.S., Anderson D.M.
    EMBO J. 14:3654-3663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), LIGAND-BINDING, SUBUNIT, TISSUE SPECIFICITY.
  2. "Cytokine requirements for the growth and development of mouse NK cells in vitro."
    Toomey J.A., Gays F., Foster D., Brooks C.G.
    J. Leukoc. Biol. 74:233-242(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  5. "Mast cells express novel functional IL-15 receptor alpha isoforms."
    Bulanova E., Budagian V., Orinska Z., Krause H., Paus R., Bulfone-Paus S.
    J. Immunol. 170:5045-5055(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 3; 4 AND 6), FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH SYK.
  6. Cited for: RETRACTION.
  7. "Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17)."
    Budagian V., Bulanova E., Orinska Z., Ludwig A., Rose-John S., Saftig P., Borden E.C., Bulfone-Paus S.
    J. Biol. Chem. 279:40368-40375(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING BY ADAM17.
  8. "Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation."
    Olsen S.K., Ota N., Kishishita S., Kukimoto-Niino M., Murayama K., Uchiyama H., Toyama M., Terada T., Shirouzu M., Kanagawa O., Yokoyama S.
    J. Biol. Chem. 282:37191-37204(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 33-103 IN COMPLEX WITH IL15, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiI15RA_MOUSE
AccessioniPrimary (citable) accession number: Q60819
Secondary accession number(s): A2AP35
, A2AP36, A2AP37, Q80Z90, Q80Z91, Q80Z92, Q8R5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.