Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-15 receptor subunit alpha

Gene

Il15ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction involves SYK (By similarity).By similarity2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-15 receptor subunit alpha
Short name:
IL-15 receptor subunit alpha
Short name:
IL-15R-alpha
Short name:
IL-15RA
Alternative name(s):
CD_antigen: CD215
Cleaved into the following chain:
Soluble interleukin-15 receptor subunit alpha
Short name:
sIL-15 receptor subunit alpha
Short name:
sIL-15R-alpha
Short name:
sIL-15RA
Gene namesi
Name:Il15ra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104644. Il15ra.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 205ExtracellularSequence analysisAdd BLAST173
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 263CytoplasmicSequence analysisAdd BLAST37

GO - Cellular componenti

  • cytoplasmic vesicle Source: MGI
  • extracellular space Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000001104533 – 263Interleukin-15 receptor subunit alphaAdd BLAST231
ChainiPRO_000033385633 – ?Soluble interleukin-15 receptor subunit alpha

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 78PROSITE-ProRule annotation1 Publication
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi62 ↔ 96PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylated by activated SYK.By similarity
N-glycosylated and O-glycosylated.By similarity
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE. It also binds IL15 and thus interferes with IL15 binding to the membrane receptor (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ60819.
PRIDEiQ60819.

Miscellaneous databases

PMAP-CutDBQ60819.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000023206.
CleanExiMM_IL15RA.
ExpressionAtlasiQ60819. baseline and differential.
GenevisibleiQ60819. MM.

Interactioni

Subunit structurei

The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates. Interacts with SYK (By similarity).By similarity

Protein-protein interaction databases

IntActiQ60819. 1 interactor.
STRINGi10090.ENSMUSP00000077878.

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi57 – 59Combined sources3
Beta strandi66 – 68Combined sources3
Beta strandi75 – 80Combined sources6
Turni82 – 84Combined sources3
Beta strandi87 – 89Combined sources3
Beta strandi96 – 98Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19C/F33-103[»]
ProteinModelPortaliQ60819.
SMRiQ60819.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60819.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 98SushiPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWP4. Eukaryota.
ENOG410Z8MM. LUCA.
GeneTreeiENSGT00390000000121.
HOVERGENiHBG052061.
InParanoidiQ60819.
KOiK05074.
OMAiLLACYIK.
OrthoDBiEOG091G0OD7.
PhylomeDBiQ60819.
TreeFamiTF338443.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60819-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPQLRGYG VQAIPVLLLL LLLLLLPLRV TPGTTCPPPV SIEHADIRVK
60 70 80 90 100
NYSVNSRERY VCNSGFKRKA GTSTLIECVI NKNTNVAHWT TPSLKCIRDP
110 120 130 140 150
SLAHYSPVPT VVTPKVTSQP ESPSPSAKEP EAFSPKSDTA MTTETAIMPG
160 170 180 190 200
SRLTPSQTTS AGTTGTGSHK SSRAPSLAAT MTLEPTASTS LRITEISPHS
210 220 230 240 250
SKMTKVAIST SVLLVGAGVV MAFLAWYIKS RQPSQPCRVE VETMETVPMT
260
VRASSKEDED TGA
Length:263
Mass (Da):28,061
Last modified:November 1, 1996 - v1
Checksum:iBFCC2CE4BA58B504
GO
Isoform 2 (identifier: Q60819-2) [UniParc]FASTAAdd to basket
Also known as: 1A

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.

Show »
Length:230
Mass (Da):24,638
Checksum:i23CF1CE4DA3F70F1
GO
Isoform 3 (identifier: Q60819-3) [UniParc]FASTAAdd to basket
Also known as: 1B, IL-15R-alphadelta4

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.

Show »
Length:197
Mass (Da):21,366
Checksum:i1D16A75C518B986B
GO
Isoform 4 (identifier: Q60819-4) [UniParc]FASTAAdd to basket
Also known as: 1C, IL-15R-alphadelta34

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-195: E → K

Show »
Length:166
Mass (Da):18,122
Checksum:i94DC3A60B7CD883B
GO
Isoform 5 (identifier: Q60819-5) [UniParc]FASTAAdd to basket
Also known as: 2, 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-128: Missing.
     129-140: Missing.

Show »
Length:123
Mass (Da):12,905
Checksum:iB43C11755D9823DC
GO
Isoform 6 (identifier: Q60819-6) [UniParc]FASTAAdd to basket
Also known as: IL-15R-alphadelta345

The sequence of this isoform differs from the canonical sequence as follows:
     98-128: Missing.
     129-140: Missing.
     141-161: Missing.
     162-194: Missing.
     195-206: EISPHSSKMTKV → M

Show »
Length:155
Mass (Da):16,929
Checksum:iB74A423264627E66
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126271 – 97Missing in isoform 5. 2 PublicationsAdd BLAST97
Alternative sequenceiVSP_01262898 – 128Missing in isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_012629129 – 140Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_012630141 – 161Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_012631162 – 194Missing in isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_012633195 – 206EISPH…KMTKV → M in isoform 6. CuratedAdd BLAST12
Alternative sequenceiVSP_012632195E → K in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22339 Genomic DNA. Translation: AAC52240.1.
AY219715 mRNA. Translation: AAO62310.1.
AY219716 mRNA. Translation: AAO62311.1.
AY219717 mRNA. Translation: AAO62312.1.
AY221616 mRNA. Translation: AAO74882.1.
AL831794 Genomic DNA. Translation: CAM13743.1.
AL831794 Genomic DNA. Translation: CAM13744.1.
AL831794 Genomic DNA. Translation: CAM13745.1.
BC022705 mRNA. Translation: AAH22705.1.
CCDSiCCDS15686.1. [Q60819-1]
CCDS15687.1. [Q60819-5]
CCDS70977.1. [Q60819-2]
CCDS70978.1. [Q60819-3]
CCDS70979.1. [Q60819-4]
PIRiS57346.
RefSeqiNP_001258426.1. NM_001271497.1. [Q60819-5]
NP_001258428.1. NM_001271499.1. [Q60819-2]
NP_001258429.1. NM_001271500.1. [Q60819-3]
NP_001258430.1. NM_001271501.1. [Q60819-4]
NP_032384.1. NM_008358.2. [Q60819-1]
NP_598597.1. NM_133836.2. [Q60819-5]
XP_006497427.1. XM_006497364.1. [Q60819-5]
XP_017171184.1. XM_017315695.1. [Q60819-6]
UniGeneiMm.200196.

Genome annotation databases

EnsembliENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206. [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206. [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206. [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206. [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206. [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206. [Q60819-5]
GeneIDi16169.
KEGGimmu:16169.
UCSCiuc008iiw.2. mouse. [Q60819-6]
uc008iix.2. mouse. [Q60819-1]
uc008iiy.2. mouse. [Q60819-2]
uc008iiz.2. mouse. [Q60819-3]
uc008ija.2. mouse. [Q60819-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22339 Genomic DNA. Translation: AAC52240.1.
AY219715 mRNA. Translation: AAO62310.1.
AY219716 mRNA. Translation: AAO62311.1.
AY219717 mRNA. Translation: AAO62312.1.
AY221616 mRNA. Translation: AAO74882.1.
AL831794 Genomic DNA. Translation: CAM13743.1.
AL831794 Genomic DNA. Translation: CAM13744.1.
AL831794 Genomic DNA. Translation: CAM13745.1.
BC022705 mRNA. Translation: AAH22705.1.
CCDSiCCDS15686.1. [Q60819-1]
CCDS15687.1. [Q60819-5]
CCDS70977.1. [Q60819-2]
CCDS70978.1. [Q60819-3]
CCDS70979.1. [Q60819-4]
PIRiS57346.
RefSeqiNP_001258426.1. NM_001271497.1. [Q60819-5]
NP_001258428.1. NM_001271499.1. [Q60819-2]
NP_001258429.1. NM_001271500.1. [Q60819-3]
NP_001258430.1. NM_001271501.1. [Q60819-4]
NP_032384.1. NM_008358.2. [Q60819-1]
NP_598597.1. NM_133836.2. [Q60819-5]
XP_006497427.1. XM_006497364.1. [Q60819-5]
XP_017171184.1. XM_017315695.1. [Q60819-6]
UniGeneiMm.200196.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSMX-ray2.19C/F33-103[»]
ProteinModelPortaliQ60819.
SMRiQ60819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60819. 1 interactor.
STRINGi10090.ENSMUSP00000077878.

Proteomic databases

PaxDbiQ60819.
PRIDEiQ60819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078834; ENSMUSP00000077878; ENSMUSG00000023206. [Q60819-1]
ENSMUST00000114831; ENSMUSP00000110480; ENSMUSG00000023206. [Q60819-2]
ENSMUST00000114832; ENSMUSP00000110481; ENSMUSG00000023206. [Q60819-6]
ENSMUST00000114833; ENSMUSP00000110482; ENSMUSG00000023206. [Q60819-4]
ENSMUST00000114834; ENSMUSP00000110483; ENSMUSG00000023206. [Q60819-3]
ENSMUST00000128156; ENSMUSP00000126364; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000135341; ENSMUSP00000132731; ENSMUSG00000023206. [Q60819-5]
ENSMUST00000138349; ENSMUSP00000131473; ENSMUSG00000023206. [Q60819-5]
GeneIDi16169.
KEGGimmu:16169.
UCSCiuc008iiw.2. mouse. [Q60819-6]
uc008iix.2. mouse. [Q60819-1]
uc008iiy.2. mouse. [Q60819-2]
uc008iiz.2. mouse. [Q60819-3]
uc008ija.2. mouse. [Q60819-4]

Organism-specific databases

CTDi3601.
MGIiMGI:104644. Il15ra.

Phylogenomic databases

eggNOGiENOG410IWP4. Eukaryota.
ENOG410Z8MM. LUCA.
GeneTreeiENSGT00390000000121.
HOVERGENiHBG052061.
InParanoidiQ60819.
KOiK05074.
OMAiLLACYIK.
OrthoDBiEOG091G0OD7.
PhylomeDBiQ60819.
TreeFamiTF338443.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiIl15ra. mouse.
EvolutionaryTraceiQ60819.
PMAP-CutDBQ60819.
PROiQ60819.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023206.
CleanExiMM_IL15RA.
ExpressionAtlasiQ60819. baseline and differential.
GenevisibleiQ60819. MM.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 1 hit.
[Graphical view]
SMARTiSM00032. CCP. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
PROSITEiPS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI15RA_MOUSE
AccessioniPrimary (citable) accession number: Q60819
Secondary accession number(s): A2AP35
, A2AP36, A2AP37, Q80Z90, Q80Z91, Q80Z92, Q8R5E4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.