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Protein

Disintegrin and metalloproteinase domain-containing protein 1a

Gene

Adam1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in sperm-egg fusion.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi370Zinc; catalyticBy similarity1
Active sitei371PROSITE-ProRule annotation1
Metal bindingi374Zinc; catalyticBy similarity1
Metal bindingi380Zinc; catalyticBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: InterPro
  • metallopeptidase activity Source: UniProtKB

GO - Biological processi

  • binding of sperm to zona pellucida Source: MGI
  • fusion of sperm to egg plasma membrane Source: UniProtKB
  • proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.4.24.B8. 3474.

Protein family/group databases

MEROPSiM12.202.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 1a (EC:3.4.24.-)
Short name:
ADAM 1a
Alternative name(s):
Fertilin subunit alpha-a
Gene namesi
Name:Adam1a
Synonyms:Adam1, Ftna
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2429504. Adam1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini? – 740ExtracellularSequence analysis
Transmembranei741 – 761HelicalSequence analysisAdd BLAST21
Topological domaini762 – 791CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000029033? – 791Disintegrin and metalloproteinase domain-containing protein 1a
Signal peptidei1 – 65Sequence analysisAdd BLAST65
PropeptideiPRO_000002903266 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi345 ↔ 424By similarity
Disulfide bondi385 ↔ 408By similarity
Disulfide bondi387 ↔ 393By similarity
Glycosylationi407N-linked (GlcNAc...)Sequence analysis1
Glycosylationi484N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi494 ↔ 514By similarity
Glycosylationi630N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi667 ↔ 679Sequence analysis
Disulfide bondi673 ↔ 685Sequence analysis
Disulfide bondi687 ↔ 696Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60813.
PRIDEiQ60813.

PTM databases

iPTMnetiQ60813.
PhosphoSitePlusiQ60813.

Expressioni

Tissue specificityi

Testis.1 Publication

Developmental stagei

Expression is low at 20, 22 and 24 days after birth but has increased by day 60.1 Publication

Gene expression databases

BgeeiENSMUSG00000072647.
CleanExiMM_ADAM1A.
ExpressionAtlasiQ60813. baseline and differential.
GenevisibleiQ60813. MM.

Interactioni

Subunit structurei

Heterodimer with ADAM2/fertilin subunit beta.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098320.

Structurei

3D structure databases

ProteinModelPortaliQ60813.
SMRiQ60813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini235 – 429Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini438 – 522DisintegrinPROSITE-ProRule annotationAdd BLAST85
Domaini663 – 697EGF-likePROSITE-ProRule annotationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi523 – 657Cys-richAdd BLAST135

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000033819.
HOVERGENiHBG006978.
InParanoidiQ60813.
KOiK08607.
OMAiEDERKSH.
OrthoDBiEOG091G02N2.
PhylomeDBiQ60813.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAAAGRGF ASSLSSPQIR RIALKEAKLT PHIWAALHWN LGLRLVPSVR
60 70 80 90 100
VGILVLLIFL PSTFCDIGSV YNSSYETVIP ERLPGKGGKD PGGKVSYMLL
110 120 130 140 150
MQGQKQLLHL EVKGHYPENN FPVYSYHNGI LRQEMPLLSQ DCHYEGYMEG
160 170 180 190 200
VPGSFVSVNI CSGLRGVLIK EETSYGIEPM LSSKNFEHVL YTMEHQPVVS
210 220 230 240 250
CSVTPKDSPG DTSHPPRSRK PDDLLVLTDW WSHTKYVEMF VVVNHQRFQM
260 270 280 290 300
WGSNINETVQ AVMDIIALAN SFTRGINTEV VLVGLEIWTE GDPIEVPVDL
310 320 330 340 350
QTTLRNFNFW RQEKLVGRVR HDVAHLIVGH RPGENEGQAF LRGACSGEFA
360 370 380 390 400
AAVEAFHHED VLLFAALMAH ELGHNLGIQH DHPTCTCGPK HFCLMGEKIG
410 420 430 440 450
KDSGFSNCSS DHFLRFLHDH RGACLLDEPG RQSRMRRAAN CGNGVVEDLE
460 470 480 490 500
ECDCGSDCDS HPCCSPTCTL KEGAQCSEGL CCYNCTFKKK GSLCRPAEDV
510 520 530 540 550
CDLPEYCDGS TQECPANSYM QDGTQCDRIY YCLGGWCKNP DKQCSRIYGY
560 570 580 590 600
PARSAPEECY ISVNTKANRF GNCGHPTSAN FRYETCSDED VFCGKLVCTD
610 620 630 640 650
VRYLPKVKPL HSLLQVPYGE DWCWSMDAYN ITDVPDDGDV QSGTFCAPNK
660 670 680 690 700
VCMEYICTGR GVLQYNCEPQ EMCHGNGVCN NFKHCHCDAG FAPPDCSSPG
710 720 730 740 750
NGGSVDSGPV GKPADRHLSL SFLAEESPDD KMEDEEVNLK VMVLVVPIFL
760 770 780 790
VVLLCCLMLI AYLWSEVQEV VSPPSSSESS SSSSWSDSDS Q
Length:791
Mass (Da):87,490
Last modified:September 26, 2003 - v3
Checksum:i0D36DD0D914A39AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117P → S in BAB86768 (PubMed:12095680).Curated1
Sequence conflicti192T → A in AAA74920 (PubMed:7750654).Curated1
Sequence conflicti395M → R in BAB86768 (PubMed:12095680).Curated1
Sequence conflicti519Y → I in AAA74920 (PubMed:7750654).Curated1
Sequence conflicti644T → S in AAA74920 (PubMed:7750654).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048844 Genomic DNA. Translation: BAB86768.1.
BC052093 mRNA. Translation: AAH52093.1.
U22056 mRNA. Translation: AAA74920.1.
U06144 mRNA. Translation: AAA18423.1.
CCDSiCCDS19637.1.
PIRiI48942.
RefSeqiNP_742124.2. NM_172126.2.
UniGeneiMm.1453.

Genome annotation databases

EnsembliENSMUST00000100757; ENSMUSP00000098320; ENSMUSG00000072647.
GeneIDi280668.
KEGGimmu:280668.
UCSCiuc008zjo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048844 Genomic DNA. Translation: BAB86768.1.
BC052093 mRNA. Translation: AAH52093.1.
U22056 mRNA. Translation: AAA74920.1.
U06144 mRNA. Translation: AAA18423.1.
CCDSiCCDS19637.1.
PIRiI48942.
RefSeqiNP_742124.2. NM_172126.2.
UniGeneiMm.1453.

3D structure databases

ProteinModelPortaliQ60813.
SMRiQ60813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000098320.

Protein family/group databases

MEROPSiM12.202.

PTM databases

iPTMnetiQ60813.
PhosphoSitePlusiQ60813.

Proteomic databases

PaxDbiQ60813.
PRIDEiQ60813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100757; ENSMUSP00000098320; ENSMUSG00000072647.
GeneIDi280668.
KEGGimmu:280668.
UCSCiuc008zjo.1. mouse.

Organism-specific databases

CTDi8759.
MGIiMGI:2429504. Adam1a.

Phylogenomic databases

eggNOGiKOG3607. Eukaryota.
ENOG410XX2M. LUCA.
GeneTreeiENSGT00760000118888.
HOGENOMiHOG000033819.
HOVERGENiHBG006978.
InParanoidiQ60813.
KOiK08607.
OMAiEDERKSH.
OrthoDBiEOG091G02N2.
PhylomeDBiQ60813.
TreeFamiTF314733.

Enzyme and pathway databases

BRENDAi3.4.24.B8. 3474.

Miscellaneous databases

PROiQ60813.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072647.
CleanExiMM_ADAM1A.
ExpressionAtlasiQ60813. baseline and differential.
GenevisibleiQ60813. MM.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADM1A_MOUSE
AccessioniPrimary (citable) accession number: Q60813
Secondary accession number(s): Q60617, Q80WR7, Q8R533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.