Q607P2 (TYPH_METCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

MCA1717

Organism

Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]

Taxonomic identifier

243233 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Methylococcales › Methylococcaceae › Methylococcus › Methylococcus capsulatus

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleoside metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314703

Sequences

	Sequence		Length	Mass (Da)
	Q607P2 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: E5EFD62B1A7A1210	FASTA	516	56,438
	10 20 30 40 50 60 MSDEESIKTR LKLRPVAIDT YRENVAYLHR ECSVYRAEGF QALAKIRVGC NGKQIEAVLN 70 80 90 100 110 120 VVDDVCIVAP DELGLSEQAF QRFGEPAGQL VNVAQAEPPL SMDGVRRKIG GERLDYGDYQ 130 140 150 160 170 180 AITSDIAKGR YSKMEMAAFL VATGQNGLDR DEVLSLTRAM LETGVRLSWN EPLVADKHCI 190 200 210 220 230 240 GGIPGNRTSL LIVPIVAAHG MLIPKTSSRA ITSPAGTADT MEVLARTDLA PESLDRLVRM 250 260 270 280 290 300 ERGCLAWGGT TRLAPVDDML ISVERPLGID SQGQMVASIL SKKLAAGATH LLLDIPVGPT 310 320 330 340 350 360 AKVRQMRDAM SLRKLFEYVG DRVGLHLEAV ITDGAQPVGR GIGPVLEVRD VMQVLENDPE 370 380 390 400 410 420 APVDLREKSL RLAGRILEFD PDVRGGFGYS IARDILESGR ALAKMHRIID AQGRQERRLE 430 440 450 460 470 480 PGRLVFEVRA ERAGVVVGID NFFLAQTARL AGAPMSRGAG VDLLNKLGDT VEEGQPLYRV 490 500 510 YAEFPANFEF AREFTRTRSG YNIGDAAFLT KTHMEF

References

[1]

"Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath)." Ward N.L., Larsen O., Sakwa J., Bruseth L., Khouri H.M., Durkin A.S., Dimitrov G., Jiang L., Scanlan D., Kang K.H., Lewis M.R., Nelson K.E., Methe B.A., Wu M., Heidelberg J.F., Paulsen I.T., Fouts D.E., Ravel J. , Tettelin H., Ren Q., Read T.D., DeBoy R.T., Seshadri R., Salzberg S.L., Jensen H.B., Birkeland N.K., Nelson W.C., Dodson R.J., Grindhaug S.H., Holt I.E., Eidhammer I., Jonasen I., Vanaken S., Utterback T.R., Feldblyum T.V., Fraser C.M., Lillehaug J.R., Eisen J.A. PLoS Biol. 2:1616-1628(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33009 / NCIMB 11132 / Bath.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017282 Genomic DNA. Translation: AAU92022.1.
RefSeq	YP_114156.1. NC_002977.6.
3D structure databases
ProteinModelPortal	Q607P2.
ModBase	Search...
Protein-protein interaction databases
STRING	243233.MCA1717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAU92022; AAU92022; MCA1717.
GeneID	3102436.
KEGG	mca:MCA1717.
PATRIC	22607276. VBIMetCap22254_1746.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METCA

Accession

Primary (citable) accession number: Q607P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program