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Q60793 (KLF4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 4
Alternative name(s):
Epithelial zinc finger protein EZF
Gut-enriched krueppel-like factor
Gene names
Name:Klf4
Synonyms:Ezf, Gklf, Zie
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription By similarity. Ref.3 Ref.9 Ref.10 Ref.12 Ref.13 Ref.14 Ref.15

Subunit structure

Interacts with MUC1 (via the C-terminal domain) By similarity. Interacts with POU5F1/OCT4 and SOX2. Interacts with MEIS2 isoform MeisDand PBX1 isoform PBX1a Ref.14

Subcellular location

Nucleus Ref.9.

Tissue specificity

Highest expression in the colon. Lower levels in testis, lung and small intestine.

Induction

By interferon-gamma in Stat1-dependent manner. Ref.4

Disruption phenotype

Death shortly after birth due to loss of epidermal barrier function resulting from perturbation of late-stage epidermal differentiation structures including the cornified envelope. When selectively deleted in the surface ectoderm-derived structures of the eye, embryos develop normally and adults are viable and fertile but mutants display down-regulation of Krt12 and Aqp5 and multiple ocular defects including corneal epithelial fragility, stromal edema, defective lens and loss of conjunctival goblet cells. Ref.9 Ref.13

Biotechnological use

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.11 Ref.14

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence caution

The sequence AAC52939.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH10301.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMIsopeptide bond
Phosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from mutant phenotype Ref.13. Source: MGI

cellular response to cycloheximide

Inferred from electronic annotation. Source: Ensembl

cellular response to growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to peptide

Inferred from electronic annotation. Source: Ensembl

epidermal cell differentiation

Inferred from mutant phenotype Ref.9. Source: MGI

epidermis morphogenesis

Inferred from mutant phenotype Ref.9. Source: MGI

fat cell differentiation

Inferred from mutant phenotype PubMed 18396140. Source: BHF-UCL

negative regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

negative regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from direct assay Ref.1. Source: MGI

negative regulation of chemokine (C-X-C motif) ligand 2 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-8 biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of muscle hyperplasia

Inferred from electronic annotation. Source: Ensembl

negative regulation of phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

negative regulation of response to cytokine stimulus

Inferred from electronic annotation. Source: Ensembl

negative regulation of smooth muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity PubMed 9422764. Source: UniProtKB

positive regulation of hemoglobin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 18396140. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.12Ref.14. Source: UniProtKB

post-embryonic camera-type eye development

Inferred from mutant phenotype Ref.13. Source: MGI

post-embryonic hemopoiesis

Inferred from electronic annotation. Source: Ensembl

regulation of cell differentiation

Inferred from direct assay Ref.14. Source: UniProtKB

regulation of cell proliferation

Inferred from genetic interaction PubMed 17671182. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 19796622. Source: MGI

response to organic substance

Inferred from direct assay PubMed 18400104. Source: MGI

response to retinoic acid

Inferred from direct assay PubMed 18400104. Source: MGI

stem cell maintenance

Inferred from direct assay Ref.14. Source: UniProtKB

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 18396140. Source: BHF-UCL

   Cellular_componentnuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Non-traceable author statement PubMed 9422764. Source: UniProtKB

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from sequence or structural similarity PubMed 15820306. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription factor binding

Inferred from physical interaction PubMed 18396140. Source: BHF-UCL

RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

double-stranded DNA binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylinositol 3-kinase regulator activity

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from direct assay PubMed 22306741Ref.2. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 17130451. Source: MGI

sequence-specific DNA binding transcription factor recruiting transcription factor activity

Inferred from direct assay PubMed 18396140. Source: BHF-UCL

transcription factor binding

Inferred from physical interaction Ref.14. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from direct assay Ref.12. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Krueppel-like factor 4
PRO_0000047168

Regions

Zinc finger400 – 42425C2H2-type 1
Zinc finger430 – 45425C2H2-type 2
Zinc finger460 – 48223C2H2-type 3
Region443 – 47432Interaction with target DNA
Compositional bias176 – 385210Pro-rich

Amino acid modifications

Modified residue2511Phosphoserine By similarity
Cross-link32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Experimental info

Sequence conflict1621S → R in AAC52939. Ref.2
Sequence conflict1851A → G in AAC52939. Ref.2
Sequence conflict3021H → Q in BAE33205. Ref.5
Sequence conflict3501P → A in AAC52939. Ref.2

Secondary structure

................. 483
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q60793 [UniParc].

Last modified February 10, 2009. Version 3.
Checksum: 5D1B0BF7948C49B3

FASTA48351,880
        10         20         30         40         50         60 
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRPAGAP TNRWREELSH MKRLPPLPGR 

        70         80         90        100        110        120 
PYDLAATVAT DLESGGAGAA CSSNNPALLA RRETEEFNDL LDLDFILSNS LTHQESVAAT 

       130        140        150        160        170        180 
VTTSASASSS SSPASSGPAS APSTCSFSYP IRAGGDPGVA ASNTGGGLLY SRESAPPPTA 

       190        200        210        220        230        240 
PFNLADINDV SPSGGFVAEL LRPELDPVYI PPQQPQPPGG GLMGKFVLKA SLTTPGSEYS 

       250        260        270        280        290        300 
SPSVISVSKG SPDGSHPVVV APYSGGPPRM CPKIKQEAVP SCTVSRSLEA HLSAGPQLSN 

       310        320        330        340        350        360 
GHRPNTHDFP LGRQLPTRTT PTLSPEELLN SRDCHPGLPL PPGFHPHPGP NYPPFLPDQM 

       370        380        390        400        410        420 
QSQVPSLHYQ ELMPPGSCLP EEPKPKRGRR SWPRKRTATH TCDYAGCGKT YTKSSHLKAH 

       430        440        450        460        470        480 
LRTHTGEKPY HCDWDGCGWK FARSDELTRH YRKHTGHRPF QCQKCDRAFS RSDHLALHMK 


RHF 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest."
Shields J.M., Christy R.J., Yang V.W.
J. Biol. Chem. 271:20009-20017(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells."
Garrett-Sinha L.A., Eberspaecher H., Seldin M.F., de Crombrugghe B.
J. Biol. Chem. 271:31384-31390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X DBA/2.
Tissue: Embryonic fibroblast.
[3]"Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)."
Mahatan C.S., Kaestner K.H., Geiman D.E., Yang V.W.
Nucleic Acids Res. 27:4562-4569(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
Strain: 129/SvJ.
[4]"STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression."
Chen Z.-Y., Shie J.-L., Tseng C.-C.
Exp. Cell Res. 281:19-27(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
Strain: C57BL/6.
[5]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Dendritic cell, Embryonic stem cell and Mammary gland.
[6]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[7]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[9]"Klf4 is a transcription factor required for establishing the barrier function of the skin."
Segre J.A., Bauer C., Fuchs E.
Nat. Genet. 22:356-360(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[10]"Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4."
Li Y., McClintick J., Zhong L., Edenberg H.J., Yoder M.C., Chan R.J.
Blood 105:635-637(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors."
Takahashi K., Yamanaka S.
Cell 126:663-676(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: BIOTECHNOLOGY.
[12]"Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells."
Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., Niwa H.
Mol. Cell. Biol. 26:7772-7782(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
Swamynathan S.K., Katz J.P., Kaestner K.H., Ashery-Padan R., Crawford M.A., Piatigorsky J.
Mol. Cell. Biol. 27:182-194(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[14]"Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
Wei Z., Yang Y., Zhang P., Andrianakos R., Hasegawa K., Lyu J., Chen X., Bai G., Liu C., Pera M., Lu W.
Stem Cells 27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH POU5F1/OCT4 AND SOX2, BIOTECHNOLOGY.
[15]"Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."
Zhang P., Andrianakos R., Yang Y., Liu C., Lu W.
J. Biol. Chem. 285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[16]"Crystal structure in complex with DNA."
Schuetz A., Zocher G., Carstanjen D., Heinemann U.
Submitted (APR-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 395-483 IN COMPLEX WITH ZINC IONS AND DNA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U20344 mRNA. Translation: AAC04892.1.
U70662 mRNA. Translation: AAC52939.1. Different initiation.
AF117109 Genomic DNA. Translation: AAD17223.1.
AY071827 Genomic DNA. Translation: AAL60058.1.
AK141244 mRNA. Translation: BAE24612.1.
AK144942 mRNA. Translation: BAE26147.1.
AK155343 mRNA. Translation: BAE33205.1.
AL732494 Genomic DNA. Translation: CAM20848.1.
CH466565 Genomic DNA. Translation: EDL02262.1.
BC010301 mRNA. Translation: AAH10301.2. Different initiation.
CCDSCCDS18195.2.
RefSeqNP_034767.2. NM_010637.3.
UniGeneMm.4325.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WBSX-ray1.70A395-483[»]
2WBUX-ray2.50A396-483[»]
4M9EX-ray1.85A396-483[»]
ProteinModelPortalQ60793.
SMRQ60793. Positions 397-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200966. 5 interactions.
DIPDIP-59920N.
IntActQ60793. 1 interaction.

PTM databases

PhosphoSiteQ60793.

Proteomic databases

PRIDEQ60793.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107619; ENSMUSP00000103245; ENSMUSG00000003032.
GeneID16600.
KEGGmmu:16600.
UCSCuc008sxk.2. mouse.

Organism-specific databases

CTD9314.
MGIMGI:1342287. Klf4.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117252.
HOGENOMHOG000060173.
HOVERGENHBG006220.
InParanoidQ78K30.
KOK17846.
OMACTVGRPL.
OrthoDBEOG747PJ4.
PhylomeDBQ60793.
TreeFamTF350556.

Gene expression databases

ArrayExpressQ60793.
BgeeQ60793.
CleanExMM_KLF4.
GenevestigatorQ60793.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ60793.
NextBio290177.
PROQ60793.
SOURCESearch...

Entry information

Entry nameKLF4_MOUSE
AccessionPrimary (citable) accession number: Q60793
Secondary accession number(s): P70421 expand/collapse secondary AC list , Q3U2D6, Q3URS6, Q78K30, Q9R255
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot