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Q60793

- KLF4_MOUSE

UniProt

Q60793 - KLF4_MOUSE

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Protein

Krueppel-like factor 4

Gene

Klf4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri400 – 42425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. DNA binding Source: MGI
  3. double-stranded DNA binding Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. phosphatidylinositol 3-kinase regulator activity Source: Ensembl
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. RNA polymerase II transcription factor binding Source: BHF-UCL
  8. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  9. sequence-specific DNA binding Source: MGI
  10. sequence-specific DNA binding transcription factor activity Source: MGI
  11. sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: BHF-UCL
  12. transcription factor binding Source: UniProtKB
  13. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cellular response to cycloheximide Source: Ensembl
  3. cellular response to growth factor stimulus Source: Ensembl
  4. cellular response to hydrogen peroxide Source: Ensembl
  5. cellular response to laminar fluid shear stress Source: Ensembl
  6. cellular response to peptide Source: Ensembl
  7. epidermal cell differentiation Source: MGI
  8. epidermis morphogenesis Source: MGI
  9. fat cell differentiation Source: BHF-UCL
  10. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  11. negative regulation of cell proliferation Source: MGI
  12. negative regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
  13. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  14. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. negative regulation of heterotypic cell-cell adhesion Source: Ensembl
  16. negative regulation of interleukin-8 biosynthetic process Source: Ensembl
  17. negative regulation of muscle hyperplasia Source: Ensembl
  18. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
  19. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  20. negative regulation of protein kinase B signaling Source: Ensembl
  21. negative regulation of response to cytokine stimulus Source: Ensembl
  22. negative regulation of smooth muscle cell proliferation Source: Ensembl
  23. negative regulation of transcription, DNA-templated Source: UniProtKB
  24. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. positive regulation of cellular protein metabolic process Source: Ensembl
  26. positive regulation of hemoglobin biosynthetic process Source: Ensembl
  27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  28. positive regulation of transcription, DNA-templated Source: UniProtKB
  29. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  30. post-embryonic camera-type eye development Source: MGI
  31. post-embryonic hemopoiesis Source: Ensembl
  32. regulation of cell differentiation Source: UniProtKB
  33. regulation of cell proliferation Source: MGI
  34. regulation of transcription from RNA polymerase II promoter Source: MGI
  35. response to organic substance Source: MGI
  36. response to retinoic acid Source: MGI
  37. stem cell maintenance Source: UniProtKB
  38. transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_233293. Synthesis, secretion, and deacylation of Ghrelin.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 4
Alternative name(s):
Epithelial zinc finger protein EZF
Gut-enriched krueppel-like factor
Gene namesi
Name:Klf4
Synonyms:Ezf, Gklf, Zie
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1342287. Klf4.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Biotechnological usei

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.2 Publications

Disruption phenotypei

Death shortly after birth due to loss of epidermal barrier function resulting from perturbation of late-stage epidermal differentiation structures including the cornified envelope. When selectively deleted in the surface ectoderm-derived structures of the eye, embryos develop normally and adults are viable and fertile but mutants display down-regulation of Krt12 and Aqp5 and multiple ocular defects including corneal epithelial fragility, stromal edema, defective lens and loss of conjunctival goblet cells.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Krueppel-like factor 4PRO_0000047168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki32 – 32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei251 – 2511PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ60793.

PTM databases

PhosphoSiteiQ60793.

Expressioni

Tissue specificityi

Highest expression in the colon. Lower levels in testis, lung and small intestine.

Inductioni

By interferon-gamma in Stat1-dependent manner.1 Publication

Gene expression databases

BgeeiQ60793.
CleanExiMM_KLF4.
ExpressionAtlasiQ60793. baseline and differential.
GenevestigatoriQ60793.

Interactioni

Subunit structurei

Interacts with MUC1 (via the C-terminal domain) (By similarity). Interacts with POU5F1/OCT4 and SOX2. Interacts with MEIS2 isoform MeisD and PBX1 isoform PBX1a.By similarity2 Publications

Protein-protein interaction databases

BioGridi200966. 5 interactions.
DIPiDIP-59920N.
IntActiQ60793. 1 interaction.

Structurei

Secondary structure

1
483
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni405 – 4073Combined sources
Beta strandi410 – 4134Combined sources
Helixi414 – 4218Combined sources
Turni435 – 4373Combined sources
Beta strandi440 – 4434Combined sources
Helixi444 – 45512Combined sources
Beta strandi463 – 4664Combined sources
Beta strandi468 – 4714Combined sources
Helixi472 – 4787Combined sources
Helixi479 – 4824Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WBSX-ray1.70A395-483[»]
2WBUX-ray2.50A396-483[»]
4M9EX-ray1.85A396-483[»]
ProteinModelPortaliQ60793.
SMRiQ60793. Positions 397-483.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60793.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni443 – 47432Interaction with target DNAAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi176 – 385210Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri400 – 42425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000060173.
HOVERGENiHBG006220.
InParanoidiQ60793.
KOiK17846.
OMAiCTVGRPL.
OrthoDBiEOG747PJ4.
PhylomeDBiQ60793.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60793-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRPAGAP TNRWREELSH
60 70 80 90 100
MKRLPPLPGR PYDLAATVAT DLESGGAGAA CSSNNPALLA RRETEEFNDL
110 120 130 140 150
LDLDFILSNS LTHQESVAAT VTTSASASSS SSPASSGPAS APSTCSFSYP
160 170 180 190 200
IRAGGDPGVA ASNTGGGLLY SRESAPPPTA PFNLADINDV SPSGGFVAEL
210 220 230 240 250
LRPELDPVYI PPQQPQPPGG GLMGKFVLKA SLTTPGSEYS SPSVISVSKG
260 270 280 290 300
SPDGSHPVVV APYSGGPPRM CPKIKQEAVP SCTVSRSLEA HLSAGPQLSN
310 320 330 340 350
GHRPNTHDFP LGRQLPTRTT PTLSPEELLN SRDCHPGLPL PPGFHPHPGP
360 370 380 390 400
NYPPFLPDQM QSQVPSLHYQ ELMPPGSCLP EEPKPKRGRR SWPRKRTATH
410 420 430 440 450
TCDYAGCGKT YTKSSHLKAH LRTHTGEKPY HCDWDGCGWK FARSDELTRH
460 470 480
YRKHTGHRPF QCQKCDRAFS RSDHLALHMK RHF
Length:483
Mass (Da):51,880
Last modified:February 10, 2009 - v3
Checksum:i5D1B0BF7948C49B3
GO

Sequence cautioni

The sequence AAC52939.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH10301.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621S → R in AAC52939. (PubMed:8940147)Curated
Sequence conflicti185 – 1851A → G in AAC52939. (PubMed:8940147)Curated
Sequence conflicti302 – 3021H → Q in BAE33205. (PubMed:16141072)Curated
Sequence conflicti350 – 3501P → A in AAC52939. (PubMed:8940147)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20344 mRNA. Translation: AAC04892.1.
U70662 mRNA. Translation: AAC52939.1. Different initiation.
AF117109 Genomic DNA. Translation: AAD17223.1.
AY071827 Genomic DNA. Translation: AAL60058.1.
AK141244 mRNA. Translation: BAE24612.1.
AK144942 mRNA. Translation: BAE26147.1.
AK155343 mRNA. Translation: BAE33205.1.
AL732494 Genomic DNA. Translation: CAM20848.1.
CH466565 Genomic DNA. Translation: EDL02262.1.
BC010301 mRNA. Translation: AAH10301.2. Different initiation.
CCDSiCCDS18195.2.
RefSeqiNP_034767.2. NM_010637.3.
UniGeneiMm.4325.

Genome annotation databases

EnsembliENSMUST00000107619; ENSMUSP00000103245; ENSMUSG00000003032.
GeneIDi16600.
KEGGimmu:16600.
UCSCiuc008sxk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20344 mRNA. Translation: AAC04892.1 .
U70662 mRNA. Translation: AAC52939.1 . Different initiation.
AF117109 Genomic DNA. Translation: AAD17223.1 .
AY071827 Genomic DNA. Translation: AAL60058.1 .
AK141244 mRNA. Translation: BAE24612.1 .
AK144942 mRNA. Translation: BAE26147.1 .
AK155343 mRNA. Translation: BAE33205.1 .
AL732494 Genomic DNA. Translation: CAM20848.1 .
CH466565 Genomic DNA. Translation: EDL02262.1 .
BC010301 mRNA. Translation: AAH10301.2 . Different initiation.
CCDSi CCDS18195.2.
RefSeqi NP_034767.2. NM_010637.3.
UniGenei Mm.4325.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WBS X-ray 1.70 A 395-483 [» ]
2WBU X-ray 2.50 A 396-483 [» ]
4M9E X-ray 1.85 A 396-483 [» ]
ProteinModelPortali Q60793.
SMRi Q60793. Positions 397-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200966. 5 interactions.
DIPi DIP-59920N.
IntActi Q60793. 1 interaction.

PTM databases

PhosphoSitei Q60793.

Proteomic databases

PRIDEi Q60793.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107619 ; ENSMUSP00000103245 ; ENSMUSG00000003032 .
GeneIDi 16600.
KEGGi mmu:16600.
UCSCi uc008sxk.2. mouse.

Organism-specific databases

CTDi 9314.
MGIi MGI:1342287. Klf4.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118998.
HOGENOMi HOG000060173.
HOVERGENi HBG006220.
InParanoidi Q60793.
KOi K17846.
OMAi CTVGRPL.
OrthoDBi EOG747PJ4.
PhylomeDBi Q60793.
TreeFami TF350556.

Enzyme and pathway databases

Reactomei REACT_216222. Transcriptional regulation of pluripotent stem cells.
REACT_233293. Synthesis, secretion, and deacylation of Ghrelin.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

EvolutionaryTracei Q60793.
NextBioi 290177.
PROi Q60793.
SOURCEi Search...

Gene expression databases

Bgeei Q60793.
CleanExi MM_KLF4.
ExpressionAtlasi Q60793. baseline and differential.
Genevestigatori Q60793.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest."
    Shields J.M., Christy R.J., Yang V.W.
    J. Biol. Chem. 271:20009-20017(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells."
    Garrett-Sinha L.A., Eberspaecher H., Seldin M.F., de Crombrugghe B.
    J. Biol. Chem. 271:31384-31390(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X DBA/2.
    Tissue: Embryonic fibroblast.
  3. "Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)."
    Mahatan C.S., Kaestner K.H., Geiman D.E., Yang V.W.
    Nucleic Acids Res. 27:4562-4569(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: 129/SvJ.
  4. "STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression."
    Chen Z.-Y., Shie J.-L., Tseng C.-C.
    Exp. Cell Res. 281:19-27(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
    Strain: C57BL/6.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell, Embryonic stem cell and Mammary gland.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  9. "Klf4 is a transcription factor required for establishing the barrier function of the skin."
    Segre J.A., Bauer C., Fuchs E.
    Nat. Genet. 22:356-360(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  10. "Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4."
    Li Y., McClintick J., Zhong L., Edenberg H.J., Yoder M.C., Chan R.J.
    Blood 105:635-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors."
    Takahashi K., Yamanaka S.
    Cell 126:663-676(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.
  12. "Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells."
    Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., Niwa H.
    Mol. Cell. Biol. 26:7772-7782(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
    Swamynathan S.K., Katz J.P., Kaestner K.H., Ashery-Padan R., Crawford M.A., Piatigorsky J.
    Mol. Cell. Biol. 27:182-194(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  14. "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
    Wei Z., Yang Y., Zhang P., Andrianakos R., Hasegawa K., Lyu J., Chen X., Bai G., Liu C., Pera M., Lu W.
    Stem Cells 27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH POU5F1/OCT4 AND SOX2, BIOTECHNOLOGY.
  15. "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."
    Zhang P., Andrianakos R., Yang Y., Liu C., Lu W.
    J. Biol. Chem. 285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Crystal structure in complex with DNA."
    Schuetz A., Zocher G., Carstanjen D., Heinemann U.
    Submitted (APR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 395-483 IN COMPLEX WITH ZINC IONS AND DNA.

Entry informationi

Entry nameiKLF4_MOUSE
AccessioniPrimary (citable) accession number: Q60793
Secondary accession number(s): P70421
, Q3U2D6, Q3URS6, Q78K30, Q9R255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3