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Protein

Lymphocyte cytosolic protein 2

Gene

Lcp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in T-cell antigen receptor mediated signaling.1 Publication

GO - Biological processi

  • cytokine secretion Source: MGI
  • immune response Source: GO_Central
  • intracellular signal transduction Source: GO_Central
  • mast cell activation Source: MGI
  • positive regulation of protein kinase activity Source: Ensembl
  • T cell receptor signaling pathway Source: MGI
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-114604 GPVI-mediated activation cascade
R-MMU-202433 Generation of second messenger molecules
R-MMU-2424491 DAP12 signaling
R-MMU-2871796 FCERI mediated MAPK activation
R-MMU-2871809 FCERI mediated Ca+2 mobilization

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte cytosolic protein 2
Alternative name(s):
SH2 domain-containing leukocyte protein of 76 kDa
SLP-76 tyrosine phosphoprotein
Short name:
SLP76
Gene namesi
Name:Lcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1321402 Lcp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843691 – 533Lymphocyte cytosolic protein 2Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphotyrosineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei210PhosphoserineCombined sources1
Modified residuei410PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ60787
MaxQBiQ60787
PaxDbiQ60787
PRIDEiQ60787

PTM databases

iPTMnetiQ60787
PhosphoSitePlusiQ60787

Expressioni

Tissue specificityi

Highly expressed in spleen, thymus, and peripheral blood leukocytes.

Gene expression databases

BgeeiENSMUSG00000002699
CleanExiMM_LCP2
ExpressionAtlasiQ60787 baseline and differential
GenevisibleiQ60787 MM

Interactioni

Subunit structurei

Interacts with SHB. Interacts with PRAM1 (By similarity). Interacts with SLA (PubMed:10662792). Interacts with GRB2 (PubMed:7706237). Interacts with CBLB (PubMed:10646608). Interacts (via SH2 domain) with CD6 (via tyrosine phosphorylated C-terminus) (PubMed:16914752, PubMed:24584089). Interacts with FYB1 and the phosphorylated form of FYB2 (By similarity).By similarity5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi2011242 interactors.
ELMiQ60787
IntActiQ60787 27 interactors.
MINTiQ60787
STRINGi10090.ENSMUSP00000126796

Structurei

Secondary structure

1533
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi237 – 239Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OEBX-ray1.76C/D231-243[»]
2ETZNMR-B143-148[»]
2EU0NMR-B143-148[»]
ProteinModelPortaliQ60787
SMRiQ60787
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60787

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 78SAMAdd BLAST67
Domaini422 – 530SH2PROSITE-ProRule annotationAdd BLAST109

Domaini

The SH2 domain mediates interaction with SHB.By similarity

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IFFN Eukaryota
ENOG4111KZ2 LUCA
GeneTreeiENSGT00530000063094
HOVERGENiHBG006247
InParanoidiQ60787
KOiK07361
OMAiMSSNTFP

Family and domain databases

Gene3Di3.30.505.101 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKNVPFRS EVLAWNSDNL ADYFRKLNYR DCEKAVKKYH IDGARFLNLT
60 70 80 90 100
ENDIQKFPKL RMPLLSKLSQ DINKNEERRS IFTRKPQIPR FLEETESHEE
110 120 130 140 150
DDGGWSSFED DYESPNDDDP DGEDDGDYES PNEEEQALVD DAADYEPPPS
160 170 180 190 200
NNEEALQSSI LPPNSFHNTN SMYIDRPPTG KVSQQPPVPP LRPKPALPPL
210 220 230 240 250
PTGRNHSPLS PPHPNHEEPS RSGNNKTAKL PAPSIDRSTK PPLDRSLAPL
260 270 280 290 300
DREPFILGKK PPFSDKPSAP LGREHLPKIQ KPPLPPAMDR HERNERLGPV
310 320 330 340 350
TTRKPPVPRH GRGPDRREND EDDVHQRPLP QPSLPSMSSN TFPSRSVQPS
360 370 380 390 400
SKNTFPLAHM PGAFSESNIG FQQSASLPPY FSQGPGNRPP LRSEGRNLPL
410 420 430 440 450
PVPNRPQPPS PGEEETPLDE EWYVSYITRP EAEAALRKIN QDGTFLVRDS
460 470 480 490 500
SKKTANNPYV LMVLYKDKVY NIQIRYQEES QVYLLGTGLR GKEDFLSVSD
510 520 530
IIDYFRKMPL LLIDGKNRGS RYQCTLTHAA GCL
Length:533
Mass (Da):60,238
Last modified:July 27, 2011 - v2
Checksum:i50AEA025EF0DAD01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti306P → S in AAC52189 (PubMed:7706237).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20159 mRNA Translation: AAC52189.1
AK036727 mRNA Translation: BAC29553.1
AK170491 mRNA Translation: BAE41833.1
CH466604 Genomic DNA Translation: EDL23730.1
BC006948 mRNA Translation: AAH06948.1
CCDSiCCDS48768.1
PIRiB56110
RefSeqiNP_034826.2, NM_010696.3
UniGeneiMm.265350

Genome annotation databases

EnsembliENSMUST00000052413; ENSMUSP00000056621; ENSMUSG00000002699
GeneIDi16822
KEGGimmu:16822
UCSCiuc007ikv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLCP2_MOUSE
AccessioniPrimary (citable) accession number: Q60787
Secondary accession number(s): Q922M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome