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Protein

Growth arrest-specific protein 7

Gene

Gas7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in promoting maturation and morphological differentiation of cerebellar neurons.

GO - Molecular functioni

  • actin filament binding Source: MGI

GO - Biological processi

  • actin filament bundle assembly Source: MGI
  • actin filament polymerization Source: MGI
  • neuron differentiation Source: MGI
  • neuron projection morphogenesis Source: MGI
  • regulation of cell shape Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 7
Short name:
GAS-7
Gene namesi
Name:Gas7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1202388. Gas7.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • ruffle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Growth arrest-specific protein 7PRO_0000076058Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621PhosphoserineBy similarity
Modified residuei108 – 1081PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60780.
PaxDbiQ60780.
PeptideAtlasiQ60780.
PRIDEiQ60780.

PTM databases

iPTMnetiQ60780.
PhosphoSiteiQ60780.

Expressioni

Tissue specificityi

Expressed abundantly in brain with lower levels in heart and testis. In the brain, expressed prominently in the Purkinje layer of the cerebellum, moderately in hippocampus, and less extensively in cerebral cortex and caudate putamen.1 Publication

Gene expression databases

CleanExiMM_GAS7.

Interactioni

GO - Molecular functioni

  • actin filament binding Source: MGI

Protein-protein interaction databases

IntActiQ60780. 2 interactions.
MINTiMINT-4095641.
STRINGi10090.ENSMUSP00000104322.

Structurei

3D structure databases

ProteinModelPortaliQ60780.
SMRiQ60780. Positions 24-56, 143-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5534WWPROSITE-ProRule annotationAdd
BLAST
Domaini141 – 401261F-BARPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili254 – 32875Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiQ60780.
PhylomeDBiQ60780.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60780-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALQKPGM VPPPPGEESQ TVILPPGWHS YLSPQGRRYY VNTTTNETTW
60 70 80 90 100
ERPSSSPGIS ASPAPHRSSL PTTVNGYHAS GTPAHPPETA HMSLRKSTGD
110 120 130 140 150
SQNLGSSSPG RKQSKENTIT INCVTFPHPD TMPEQQLLKP TEWSYCDYFW
160 170 180 190 200
ADKKDPQGNG TVAGFELLLQ KQLKGKQMQK EMSEFIRERI KIEEEYAKNL
210 220 230 240 250
AKLSQNSLAA QEEGSLGEAW AQVKKSLADE AEVHLKFSAK LHSEVEKPLM
260 270 280 290 300
NFRENFKKDM KKCDHHIADL RKQLASRYAS VEKARKALTE RQKDLEMKTQ
310 320 330 340 350
QLEIKLSNKT EEDIKKARRK STQAGDDLMR CVDLYNQAQS KWFEEMVTTT
360 370 380 390 400
LELERLEVER VEMIRQHLCQ YTQLRHETDM FNQSTVEPVD QLLRKVDPAK
410 420
DRELWVREHK TGNIRPVDME I
Length:421
Mass (Da):48,174
Last modified:November 1, 1996 - v1
Checksum:i8659C5AE3BF36766
GO
Isoform 2 (identifier: Q60780-2) [UniParc]FASTAAdd to basket
Also known as: GAS7-CB

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.
     82-101: TPAHPPETAHMSLRKSTGDS → MGKKMSNMENSFDDGSHLSP

Show »
Length:340
Mass (Da):39,610
Checksum:iE2A4839235B900A0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. CuratedVSP_006804Add
BLAST
Alternative sequencei82 – 10120TPAHP…STGDS → MGKKMSNMENSFDDGSHLSP in isoform 2. CuratedVSP_006805Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19860 mRNA. Translation: AAA85259.1.
AF133184 mRNA. Translation: AAF15397.1.
AF135442 Genomic DNA. Translation: AAF15398.1.
AF135442 Genomic DNA. Translation: AAF15399.1.
UniGeneiMm.152121.
Mm.40338.

Genome annotation databases

UCSCiuc007jmx.2. mouse. [Q60780-2]
uc033fwm.1. mouse. [Q60780-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19860 mRNA. Translation: AAA85259.1.
AF133184 mRNA. Translation: AAF15397.1.
AF135442 Genomic DNA. Translation: AAF15398.1.
AF135442 Genomic DNA. Translation: AAF15399.1.
UniGeneiMm.152121.
Mm.40338.

3D structure databases

ProteinModelPortaliQ60780.
SMRiQ60780. Positions 24-56, 143-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60780. 2 interactions.
MINTiMINT-4095641.
STRINGi10090.ENSMUSP00000104322.

PTM databases

iPTMnetiQ60780.
PhosphoSiteiQ60780.

Proteomic databases

MaxQBiQ60780.
PaxDbiQ60780.
PeptideAtlasiQ60780.
PRIDEiQ60780.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007jmx.2. mouse. [Q60780-2]
uc033fwm.1. mouse. [Q60780-1]

Organism-specific databases

MGIiMGI:1202388. Gas7.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
KOG2398. Eukaryota.
ENOG410Z5NV. LUCA.
HOGENOMiHOG000294146.
HOVERGENiHBG001320.
InParanoidiQ60780.
PhylomeDBiQ60780.

Miscellaneous databases

ChiTaRSiGas7. mouse.
PROiQ60780.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GAS7.

Family and domain databases

InterProiIPR031160. F_BAR.
IPR001060. FCH_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00055. FCH. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS51741. F_BAR. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS7_MOUSE
AccessioniPrimary (citable) accession number: Q60780
Secondary accession number(s): Q9QY25, Q9QY26, Q9QY34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.