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Protein

Growth arrest-specific protein 8

Gene

Gas8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation (PubMed:17366626). May play a role in the spermatozoa motility (PubMed:11751847). May play a role in cilia motility (By similarity).By similarity2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • Rab GTPase binding Source: MGI

GO - Biological processi

  • axoneme assembly Source: MGI
  • brain development Source: MGI
  • cellular protein localization Source: MGI
  • cilium movement Source: MGI
  • cilium movement involved in cell motility Source: MGI
  • determination of left/right symmetry Source: MGI
  • flagellated sperm motility Source: UniProtKB
  • regulation of microtubule binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-5635838. Activation of SMO.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest-specific protein 8
Short name:
GAS-8
Alternative name(s):
Growth arrest-specific protein 11
Short name:
GAS-11
Gene namesi
Name:Gas8
Synonyms:Gas11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1202386. Gas8.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • cilium Source: MGI
  • Golgi apparatus Source: MGI
  • microtubule Source: UniProtKB
  • microtubule cytoskeleton Source: UniProtKB
  • motile cilium Source: MGI
  • sperm flagellum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203781 – 478Growth arrest-specific protein 8Add BLAST478

Proteomic databases

MaxQBiQ60779.
PaxDbiQ60779.
PRIDEiQ60779.

PTM databases

iPTMnetiQ60779.
PhosphoSitePlusiQ60779.

Expressioni

Tissue specificityi

Highly expressed in adult testes. Weakly or not expressed in other tested tissues.1 Publication

Developmental stagei

Weakly or not expressed in neonates and young adolescents. Then, it is strongly expressed postmeiotically. Accumulates in gametocytes as they approach the lumen of seminiferous tubules and thereafter.1 Publication

Inductioni

Expressed during serum starvation or contact inhibition of cells grown in murine fibroblasts.

Gene expression databases

BgeeiENSMUSG00000040220.
CleanExiMM_GAS8.
ExpressionAtlasiQ60779. baseline and differential.
GenevisibleiQ60779. MM.

Interactioni

Subunit structurei

Interacts with microtubules.1 Publication

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • Rab GTPase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090730.

Structurei

3D structure databases

ProteinModelPortaliQ60779.
SMRiQ60779.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 114Regulates microtubule-binding1 PublicationAdd BLAST114
Regioni115 – 258Microtubule-binding1 PublicationAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 207Sequence analysisAdd BLAST184
Coiled coili242 – 426Sequence analysisAdd BLAST185

Sequence similaritiesi

Belongs to the GAS8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE2T. Eukaryota.
ENOG410XPBD. LUCA.
GeneTreeiENSGT00390000009477.
HOGENOMiHOG000038763.
HOVERGENiHBG039458.
InParanoidiQ60779.
KOiK19942.
OMAiEHRTQEG.
OrthoDBiEOG091G0851.
PhylomeDBiQ60779.
TreeFamiTF323819.

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKKGKKG KAKGTAIVDG VAPEDMTKEQ VEEHVARIRE ELDREREERN
60 70 80 90 100
YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ
110 120 130 140 150
KVKHLLYEHQ NNLAEVKAEG TVVMKLAQKE HRTQEGALRK DMRVLKVELK
160 170 180 190 200
EQELANEVVI KNLCLKQAEE ITKMRNDFER QVREIEAKYD KKMKMLRDEL
210 220 230 240 250
DLRRKTEIHE VEERKNGQIS TLMQRHEEAF TDIKNYYNDI TLNNLALINS
260 270 280 290 300
LKEQMEDMRK KEEHMEREMA EVTLQNRRLA DPLQKAKDEM NEMQKRLGNH
310 320 330 340 350
ERDKQILVCT KARLKVAERE LKDLKWEHEV LEQRFIKVQQ EREELYRKFA
360 370 380 390 400
DAIQEVQQKT GFKNLLLERK LQALNAAVEK REVQFNEVLA ASNLDPTALT
410 420 430 440 450
LVSRKLEDVL ESKNTTIKDL QYELARVCKA HNDLLRTYEA KLLAFGIPLD
460 470
NVGFKPLETA VIGQTLGQGP AGLVGAPT
Length:478
Mass (Da):56,264
Last modified:July 19, 2003 - v2
Checksum:iA11AD16EFA2DE5E9
GO

Sequence cautioni

The sequence AAA85258 differs from that shown. Reason: Frameshift at positions 3 and 471.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti283L → Q in AAA85258 (PubMed:11751847).Curated1
Sequence conflicti339Q → L in AAA85258 (PubMed:11751847).Curated1
Sequence conflicti451N → D in AAA85258 (PubMed:11751847).Curated1
Sequence conflicti459T → I in AAA85258 (PubMed:11751847).Curated1
Sequence conflicti476A → S in AAA85258 (PubMed:11751847).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19859 mRNA. Translation: AAA85258.1. Frameshift.
BC003779 mRNA. Translation: AAH03779.2.
CCDSiCCDS40512.1.
RefSeqiNP_061343.2. NM_018855.2.
UniGeneiMm.117265.

Genome annotation databases

EnsembliENSMUST00000093043; ENSMUSP00000090730; ENSMUSG00000040220.
GeneIDi104346.
KEGGimmu:104346.
UCSCiuc009nwk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19859 mRNA. Translation: AAA85258.1. Frameshift.
BC003779 mRNA. Translation: AAH03779.2.
CCDSiCCDS40512.1.
RefSeqiNP_061343.2. NM_018855.2.
UniGeneiMm.117265.

3D structure databases

ProteinModelPortaliQ60779.
SMRiQ60779.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090730.

PTM databases

iPTMnetiQ60779.
PhosphoSitePlusiQ60779.

Proteomic databases

MaxQBiQ60779.
PaxDbiQ60779.
PRIDEiQ60779.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093043; ENSMUSP00000090730; ENSMUSG00000040220.
GeneIDi104346.
KEGGimmu:104346.
UCSCiuc009nwk.1. mouse.

Organism-specific databases

CTDi2622.
MGIiMGI:1202386. Gas8.

Phylogenomic databases

eggNOGiENOG410IE2T. Eukaryota.
ENOG410XPBD. LUCA.
GeneTreeiENSGT00390000009477.
HOGENOMiHOG000038763.
HOVERGENiHBG039458.
InParanoidiQ60779.
KOiK19942.
OMAiEHRTQEG.
OrthoDBiEOG091G0851.
PhylomeDBiQ60779.
TreeFamiTF323819.

Enzyme and pathway databases

ReactomeiR-MMU-5635838. Activation of SMO.

Miscellaneous databases

PROiQ60779.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040220.
CleanExiMM_GAS8.
ExpressionAtlasiQ60779. baseline and differential.
GenevisibleiQ60779. MM.

Family and domain databases

InterProiIPR025593. GAS8.
[Graphical view]
PfamiPF13851. GAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAS8_MOUSE
AccessioniPrimary (citable) accession number: Q60779
Secondary accession number(s): Q99L71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.