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Reviewed, UniProtKB/Swiss-Prot Q60778 (IKBB_MOUSE)

Last modified January 19, 2010. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NF-kappa-B inhibitor beta
      Short name=NF-kappa-BIB
Alternative name(s):
    I-kappa-B-beta
      Short name=IkappaBbeta
      Short name=IkB-beta
      Short name=IkB-B
Gene names
Name: Nfkbib
Synonyms: Ikbb
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Subunit structure

Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2 By similarity. Interacts with the ligand-binding domain of THRB. Interacts with RELA and REL. Ref.3

Subcellular location

Cytoplasm. Nucleus.

Tissue specificity

Highly expressed in testis followed by spleen.

Post-translational modification

Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.

Sequence similarities

Belongs to the NF-kappa-B inhibitor family.

Contains 6 ANK repeats.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainANK repeat
Repeat
   PTMPhosphoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359NF-kappa-B inhibitor beta
PRO_0000067005

Regions

Repeat57 – 8630ANK 1
Repeat93 – 12230ANK 2
Repeat126 – 15530ANK 3
Repeat206 – 23530ANK 4
Repeat240 – 26930ANK 5
Repeat273 – 30230ANK 6

Amino acid modifications

Modified residue191Phosphoserine By similarity
Modified residue231Phosphoserine By similarity

Experimental info

Sequence conflict841H → T in BAB26774. Ref.2

Secondary structure

1 ................................... 359
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q60778-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BAE306CDDA7044E6

FASTA35938,001
        10         20         30         40         50         60 
MAGVACLGKT ADADEWCDSG LGSLGPDAAA PGGPGLGAEL GPELSWAPLV FGYVTEDGDT 

        70         80         90        100        110        120 
ALHLAVIHQH EPFLDFLLGF SAGHEYLDLQ NDLGQTALHL AAILGEASTV EKLYAAGAGV 

       130        140        150        160        170        180 
LVAERGGHTA LHLACRVRAH TCACVLLQPR PSHPRDASDT YLTQSQDCTP DTSHAPAAVD 

       190        200        210        220        230        240 
SQPNPENEEE PRDEDWRLQL EAENYDGHTP LHVAVIHKDA EMVRLLRDAG ADLNKPEPTC 

       250        260        270        280        290        300 
GRTPLHLAVE AQAASVLELL LKAGADPTAR MYGGRTPLGS ALLRPNPILA RLLRAHGAPE 

       310        320        330        340        350 
PEDEDDKLSP CSSSGSDSDS DNRDEGDEYD DIVVHSGRSQ NRQPPSPASK PLPDDPNPA

« Hide

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References

« Hide 'large scale' references
[1]"IkappaB-beta regulates the persistent response in a biphasic activation of NF-kappaB."
Thompson J.E., Phillips R.J., Erdjument-Bromage H., Tempst P., Ghosh S.
Cell 80:573-582(1995) [PubMed: 7867065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: B-cell.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Tongue.
[3]"Role of unphosphorylated, newly synthesized IkappaB beta in persistent activation of NF-kappaB."
Suyang H., Phillips R.J., Douglas I., Ghosh S.
Mol. Cell. Biol. 16:5444-5449(1996) [PubMed: 8816457] [Abstract]
Cited for: CHARACTERIZATION, INTERACTION WITH RELA AND REL.
[4]"A subclass of Ras proteins that regulate the degradation of IkappaB."
Fenwick C., Na S.-Y., Voll R.E., Zhong H., Im S.-Y., Lee J.W., Ghosh S.
Science 287:869-873(2000) [PubMed: 10657303] [Abstract]
Cited for: KAPPA B RAS-BINDING.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U19799 mRNA. Translation: AAC52166.1.
AK010218 mRNA. Translation: BAB26774.1.
IPIIPI00310330.
RefSeqNP_035038.2.
UniGeneMm.220333

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K3ZX-ray2.50D50-331[»]
1OY3X-ray2.05D50-331[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ60778. 1 interaction.
STRINGQ60778.

PTM databases

PhosphoSiteQ60778.

Proteomic databases

PRIDEQ60778.

Genome annotation databases

EnsemblENSMUST00000032815; ENSMUSP00000032815; ENSMUSG00000030595; Mus musculus. [Genome view]
ENSMUST00000085851; ENSMUSP00000083012; ENSMUSG00000030595; Mus musculus. [Genome view]
GeneID18036.
KEGGmmu:18036.

Organism-specific databases

CTD18036.
MGIMGI:104752. Nfkbib.

Phylogenomic databases

HOVERGENQ60778.
InParanoidQ60778.

Gene expression databases

ArrayExpressQ60778.
BgeeQ60778.
GenevestigatorQ60778.
GermOnlineENSMUSG00000030595. Mus musculus.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR015681. NF_kB_inhbitor.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PANTHERPTHR18958:SF236. NF_kB_inhbitor. 1 hit.
PfamPF00023. Ank. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
[Graphical view]
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameIKBB_MOUSE
AccessionPrimary (citable) accession number: Q60778
Secondary accession number(s): Q9D6L5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents