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Protein

ETS-related transcription factor Elf-1

Gene

Elf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that activates the LYN and BLK promoters.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi208 – 29083ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-1
Alternative name(s):
E74-like factor 1
Gene namesi
Name:Elf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:107180. Elf1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 612612ETS-related transcription factor Elf-1PRO_0000204086Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101PhosphoserineBy similarity
Modified residuei163 – 1631PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei168 – 1681PhosphoserineBy similarity
Modified residuei187 – 1871PhosphoserineBy similarity
Modified residuei190 – 1901PhosphothreonineBy similarity
Modified residuei431 – 4311PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ60775.
MaxQBiQ60775.
PaxDbiQ60775.
PRIDEiQ60775.

PTM databases

PhosphoSiteiQ60775.

Expressioni

Tissue specificityi

Predominantly found in hematopoietic cells. Detected in other cell types such as fibroblasts.

Gene expression databases

BgeeiQ60775.
CleanExiMM_ELF1.
ExpressionAtlasiQ60775. baseline and differential.
GenevisibleiQ60775. MM.

Interactioni

Subunit structurei

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1. Interacts with SP1; the interaction is inhibited by glycosylation of SP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199426. 3 interactions.
IntActiQ60775. 2 interactions.
MINTiMINT-1739410.
STRINGi10090.ENSMUSP00000046515.

Structurei

3D structure databases

ProteinModelPortaliQ60775.
SMRiQ60775. Positions 208-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi75 – 806Poly-Asp

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiQ60775.
KOiK09428.
OMAiNVMEDEQ.
OrthoDBiEOG73RBD1.
PhylomeDBiQ60775.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVVQQNDL VFEFASNGME DEQQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH NGDETIETIE
110 120 130 140 150
AAEALLNIDS PSPPVLDEKQ INNNIFSSSE DDIVAPITHV SVTLDGIPEV
160 170 180 190 200
METQQVQETN ADSPGASSPE QRKRKKGRKT KPPRPDSPTT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYID
310 320 330 340 350
DEDPSSSIES SDQSLSSTTA SSRNQANRSR VSSSPGIKGG AATILKPGNS
360 370 380 390 400
KAANPKDPVE VGQPSEVLRT VQPSQAPYPT QLFRTVHVVQ PVQAVPEEAT
410 420 430 440 450
IASTMQEEAA NSSVPSIRTI QASTQVPVVV SPGNQQLHTV TVPLTTVIAS
460 470 480 490 500
IDPSSGAGSQ KFILQTIPSS QPMTVLKENV MLQSQKPGSP SIVLSPTQVQ
510 520 530 540 550
QVLTSNVQSI CNGAGSVASA PSFSATTPVV TFSRSSQLVA HPPGTVITSV
560 570 580 590 600
IKAQETKTLK QEVEKKAEDD LNEDAEKSAQ QPQPYVMVLS SSNGFSSQVA
610
VKQNELLEPN SF
Length:612
Mass (Da):66,221
Last modified:November 1, 1996 - v1
Checksum:i442F4C85142B31F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19617 mRNA. Translation: AAB17097.1.
BC057134 mRNA. Translation: AAH57134.1.
CCDSiCCDS27301.1.
RefSeqiNP_001273340.1. NM_001286411.1.
NP_031946.1. NM_007920.4.
XP_011243248.1. XM_011244946.1.
XP_011243249.1. XM_011244947.1.
UniGeneiMm.20938.

Genome annotation databases

EnsembliENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461.
ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461.
GeneIDi13709.
KEGGimmu:13709.
UCSCiuc007utb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19617 mRNA. Translation: AAB17097.1.
BC057134 mRNA. Translation: AAH57134.1.
CCDSiCCDS27301.1.
RefSeqiNP_001273340.1. NM_001286411.1.
NP_031946.1. NM_007920.4.
XP_011243248.1. XM_011244946.1.
XP_011243249.1. XM_011244947.1.
UniGeneiMm.20938.

3D structure databases

ProteinModelPortaliQ60775.
SMRiQ60775. Positions 208-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199426. 3 interactions.
IntActiQ60775. 2 interactions.
MINTiMINT-1739410.
STRINGi10090.ENSMUSP00000046515.

PTM databases

PhosphoSiteiQ60775.

Proteomic databases

EPDiQ60775.
MaxQBiQ60775.
PaxDbiQ60775.
PRIDEiQ60775.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040131; ENSMUSP00000046515; ENSMUSG00000036461.
ENSMUST00000110835; ENSMUSP00000106459; ENSMUSG00000036461.
GeneIDi13709.
KEGGimmu:13709.
UCSCiuc007utb.2. mouse.

Organism-specific databases

CTDi1997.
MGIiMGI:107180. Elf1.

Phylogenomic databases

eggNOGiKOG3804. Eukaryota.
ENOG4111K4J. LUCA.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000049253.
HOVERGENiHBG007183.
InParanoidiQ60775.
KOiK09428.
OMAiNVMEDEQ.
OrthoDBiEOG73RBD1.
PhylomeDBiQ60775.
TreeFamiTF318679.

Miscellaneous databases

ChiTaRSiElf1. mouse.
NextBioi284470.
PROiQ60775.
SOURCEiSearch...

Gene expression databases

BgeeiQ60775.
CleanExiMM_ELF1.
ExpressionAtlasiQ60775. baseline and differential.
GenevisibleiQ60775. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR022084. TF_Elf_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF12310. Elf-1_N. 1 hit.
PF00178. Ets. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of the murine Elf-1 cDNA."
    Davis J.N., Roussel M.F.
    Gene 171:265-269(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiELF1_MOUSE
AccessioniPrimary (citable) accession number: Q60775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.