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Q60773

- CDN2D_MOUSE

UniProt

Q60773 - CDN2D_MOUSE

Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

Cdkn2d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. autophagic cell death Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. DNA synthesis involved in DNA repair Source: Ensembl
    4. G1/S transition of mitotic cell cycle Source: Ensembl
    5. negative regulation of cell growth Source: Ensembl
    6. negative regulation of cell proliferation Source: Ensembl
    7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    8. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    9. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    10. response to retinoic acid Source: Ensembl
    11. response to UV Source: Ensembl
    12. response to vitamin D Source: Ensembl
    13. sensory perception of sound Source: MGI

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor D
    Alternative name(s):
    p19-INK4d
    Gene namesi
    Name:Cdkn2d
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:105387. Cdkn2d.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Cyclin-dependent kinase 4 inhibitor DPRO_0000144189Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ60773.
    PRIDEiQ60773.

    PTM databases

    PhosphoSiteiQ60773.

    Expressioni

    Gene expression databases

    GenevestigatoriQ60773.

    Interactioni

    Subunit structurei

    Interacts with CDK6.By similarity

    Protein-protein interaction databases

    IntActiQ60773. 1 interaction.
    MINTiMINT-1539403.
    STRINGi10090.ENSMUSP00000083561.

    Structurei

    Secondary structure

    1
    166
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1711
    Helixi21 – 299
    Helixi45 – 484
    Helixi54 – 629
    Turni72 – 743
    Helixi77 – 848
    Helixi87 – 959
    Helixi110 – 1178
    Helixi120 – 1267
    Helixi127 – 1293
    Helixi142 – 1487
    Helixi152 – 1609

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AP7NMR-A1-166[»]
    1BLXX-ray1.90B1-166[»]
    ProteinModelPortaliQ60773.
    SMRiQ60773. Positions 6-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ60773.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 6929ANK 1Add
    BLAST
    Repeati73 – 10230ANK 2Add
    BLAST
    Repeati106 – 13530ANK 3Add
    BLAST
    Repeati138 – 16528ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00390000004527.
    HOGENOMiHOG000290191.
    HOVERGENiHBG050870.
    InParanoidiQ60773.
    KOiK06623.
    OMAiVMMFGSS.
    OrthoDBiEOG7TTQ94.
    TreeFamiTF333311.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60773-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM    50
    FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV 100
    NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG 150
    AQNLMDILQG HMMIPM 166
    Length:166
    Mass (Da):17,809
    Last modified:October 3, 2012 - v2
    Checksum:i7B95D6C2294F9259
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161A → R in AAC52194. (PubMed:7739547)Curated
    Sequence conflicti17 – 171A → P in AAA85437. (PubMed:7739548)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19597 mRNA. Translation: AAC52194.1.
    U20497 mRNA. Translation: AAA85437.1.
    AK132906 mRNA. Translation: BAE21414.1.
    AC122525 Genomic DNA. No translation available.
    CH466522 Genomic DNA. Translation: EDL25176.1.
    BC013898 mRNA. Translation: AAH13898.1.
    CCDSiCCDS22901.1.
    PIRiA57379.
    B57378.
    RefSeqiNP_034008.2. NM_009878.3.
    XP_006510031.1. XM_006509968.1.
    UniGeneiMm.29020.

    Genome annotation databases

    EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
    GeneIDi12581.
    KEGGimmu:12581.
    UCSCiuc009okw.1. mouse.
    uc012gpd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19597 mRNA. Translation: AAC52194.1 .
    U20497 mRNA. Translation: AAA85437.1 .
    AK132906 mRNA. Translation: BAE21414.1 .
    AC122525 Genomic DNA. No translation available.
    CH466522 Genomic DNA. Translation: EDL25176.1 .
    BC013898 mRNA. Translation: AAH13898.1 .
    CCDSi CCDS22901.1.
    PIRi A57379.
    B57378.
    RefSeqi NP_034008.2. NM_009878.3.
    XP_006510031.1. XM_006509968.1.
    UniGenei Mm.29020.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AP7 NMR - A 1-166 [» ]
    1BLX X-ray 1.90 B 1-166 [» ]
    ProteinModelPortali Q60773.
    SMRi Q60773. Positions 6-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60773. 1 interaction.
    MINTi MINT-1539403.
    STRINGi 10090.ENSMUSP00000083561.

    PTM databases

    PhosphoSitei Q60773.

    Proteomic databases

    PaxDbi Q60773.
    PRIDEi Q60773.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086374 ; ENSMUSP00000083561 ; ENSMUSG00000096472 .
    GeneIDi 12581.
    KEGGi mmu:12581.
    UCSCi uc009okw.1. mouse.
    uc012gpd.1. mouse.

    Organism-specific databases

    CTDi 1032.
    MGIi MGI:105387. Cdkn2d.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00390000004527.
    HOGENOMi HOG000290191.
    HOVERGENi HBG050870.
    InParanoidi Q60773.
    KOi K06623.
    OMAi VMMFGSS.
    OrthoDBi EOG7TTQ94.
    TreeFami TF333311.

    Enzyme and pathway databases

    Reactomei REACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Miscellaneous databases

    EvolutionaryTracei Q60773.
    NextBioi 281712.
    PROi Q60773.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q60773.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
      Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
      Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C57BL/Kaplan.
    2. "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4."
      Chan F.K.M., Zhang J., Cheng L., Shapiro D.N., Winoto A.
      Mol. Cell. Biol. 15:2682-2688(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    7. Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiCDN2D_MOUSE
    AccessioniPrimary (citable) accession number: Q60773
    Secondary accession number(s): Q60794, Q91YV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3