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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

Cdkn2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:Cdkn2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:105387. Cdkn2d.

Subcellular locationi

GO - Cellular componenti

  • cyclin D2-CDK4 complex Source: MGI
  • cytoplasm Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441891 – 166Cyclin-dependent kinase 4 inhibitor DAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ60773.
PaxDbiQ60773.
PRIDEiQ60773.

PTM databases

PhosphoSitePlusiQ60773.

Expressioni

Gene expression databases

BgeeiENSMUSG00000096472.
GenevisibleiQ60773. MM.

Interactioni

Subunit structurei

Interacts with CDK6.By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI

Protein-protein interaction databases

IntActiQ60773. 1 interactor.
MINTiMINT-1539403.
STRINGi10090.ENSMUSP00000083561.

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 17Combined sources11
Helixi21 – 29Combined sources9
Helixi45 – 48Combined sources4
Helixi54 – 62Combined sources9
Turni72 – 74Combined sources3
Helixi77 – 84Combined sources8
Helixi87 – 95Combined sources9
Helixi110 – 117Combined sources8
Helixi120 – 126Combined sources7
Helixi127 – 129Combined sources3
Helixi142 – 148Combined sources7
Helixi152 – 160Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773.
SMRiQ60773.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60773.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 69ANK 1Add BLAST29
Repeati73 – 102ANK 2Add BLAST30
Repeati106 – 135ANK 3Add BLAST30
Repeati138 – 165ANK 4Add BLAST28

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60773.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG091G0PMC.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG
160
AQNLMDILQG HMMIPM
Length:166
Mass (Da):17,809
Last modified:October 3, 2012 - v2
Checksum:i7B95D6C2294F9259
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16A → R in AAC52194 (PubMed:7739547).Curated1
Sequence conflicti17A → P in AAA85437 (PubMed:7739548).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA. Translation: AAC52194.1.
U20497 mRNA. Translation: AAA85437.1.
AK132906 mRNA. Translation: BAE21414.1.
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1.
BC013898 mRNA. Translation: AAH13898.1.
CCDSiCCDS22901.1.
PIRiA57379.
B57378.
RefSeqiNP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGeneiMm.29020.

Genome annotation databases

EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
GeneIDi12581.
KEGGimmu:12581.
UCSCiuc009okw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA. Translation: AAC52194.1.
U20497 mRNA. Translation: AAA85437.1.
AK132906 mRNA. Translation: BAE21414.1.
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1.
BC013898 mRNA. Translation: AAH13898.1.
CCDSiCCDS22901.1.
PIRiA57379.
B57378.
RefSeqiNP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGeneiMm.29020.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773.
SMRiQ60773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60773. 1 interactor.
MINTiMINT-1539403.
STRINGi10090.ENSMUSP00000083561.

PTM databases

PhosphoSitePlusiQ60773.

Proteomic databases

EPDiQ60773.
PaxDbiQ60773.
PRIDEiQ60773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
GeneIDi12581.
KEGGimmu:12581.
UCSCiuc009okw.1. mouse.

Organism-specific databases

CTDi1032.
MGIiMGI:105387. Cdkn2d.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60773.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG091G0PMC.
TreeFamiTF333311.

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Miscellaneous databases

EvolutionaryTraceiQ60773.
PROiQ60773.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000096472.
GenevisibleiQ60773. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2D_MOUSE
AccessioniPrimary (citable) accession number: Q60773
Secondary accession number(s): Q60794, Q91YV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.