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Q60773

- CDN2D_MOUSE

UniProt

Q60773 - CDN2D_MOUSE

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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

Cdkn2d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

GO - Biological processi

  1. autophagic cell death Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. DNA synthesis involved in DNA repair Source: Ensembl
  4. G1/S transition of mitotic cell cycle Source: Ensembl
  5. negative regulation of cell growth Source: Ensembl
  6. negative regulation of cell proliferation Source: Ensembl
  7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  8. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  9. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  10. response to retinoic acid Source: Ensembl
  11. response to UV Source: Ensembl
  12. response to vitamin D Source: Ensembl
  13. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:Cdkn2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:105387. Cdkn2d.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Cyclin-dependent kinase 4 inhibitor DPRO_0000144189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ60773.
PRIDEiQ60773.

PTM databases

PhosphoSiteiQ60773.

Expressioni

Gene expression databases

GenevestigatoriQ60773.

Interactioni

Subunit structurei

Interacts with CDK6.By similarity

Protein-protein interaction databases

IntActiQ60773. 1 interaction.
MINTiMINT-1539403.
STRINGi10090.ENSMUSP00000083561.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1711
Helixi21 – 299
Helixi45 – 484
Helixi54 – 629
Turni72 – 743
Helixi77 – 848
Helixi87 – 959
Helixi110 – 1178
Helixi120 – 1267
Helixi127 – 1293
Helixi142 – 1487
Helixi152 – 1609

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773.
SMRiQ60773. Positions 6-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60773.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6929ANK 1Add
BLAST
Repeati73 – 10230ANK 2Add
BLAST
Repeati106 – 13530ANK 3Add
BLAST
Repeati138 – 16528ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60773.
KOiK06623.
OMAiVMMFGSS.
OrthoDBiEOG7TTQ94.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60773-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG
160
AQNLMDILQG HMMIPM
Length:166
Mass (Da):17,809
Last modified:October 3, 2012 - v2
Checksum:i7B95D6C2294F9259
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161A → R in AAC52194. (PubMed:7739547)Curated
Sequence conflicti17 – 171A → P in AAA85437. (PubMed:7739548)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19597 mRNA. Translation: AAC52194.1.
U20497 mRNA. Translation: AAA85437.1.
AK132906 mRNA. Translation: BAE21414.1.
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1.
BC013898 mRNA. Translation: AAH13898.1.
CCDSiCCDS22901.1.
PIRiA57379.
B57378.
RefSeqiNP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGeneiMm.29020.

Genome annotation databases

EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
GeneIDi12581.
KEGGimmu:12581.
UCSCiuc009okw.1. mouse.
uc012gpd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19597 mRNA. Translation: AAC52194.1 .
U20497 mRNA. Translation: AAA85437.1 .
AK132906 mRNA. Translation: BAE21414.1 .
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1 .
BC013898 mRNA. Translation: AAH13898.1 .
CCDSi CCDS22901.1.
PIRi A57379.
B57378.
RefSeqi NP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGenei Mm.29020.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AP7 NMR - A 1-166 [» ]
1BLX X-ray 1.90 B 1-166 [» ]
ProteinModelPortali Q60773.
SMRi Q60773. Positions 6-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60773. 1 interaction.
MINTi MINT-1539403.
STRINGi 10090.ENSMUSP00000083561.

PTM databases

PhosphoSitei Q60773.

Proteomic databases

PaxDbi Q60773.
PRIDEi Q60773.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086374 ; ENSMUSP00000083561 ; ENSMUSG00000096472 .
GeneIDi 12581.
KEGGi mmu:12581.
UCSCi uc009okw.1. mouse.
uc012gpd.1. mouse.

Organism-specific databases

CTDi 1032.
MGIi MGI:105387. Cdkn2d.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00390000004527.
HOGENOMi HOG000290191.
HOVERGENi HBG050870.
InParanoidi Q60773.
KOi K06623.
OMAi VMMFGSS.
OrthoDBi EOG7TTQ94.
TreeFami TF333311.

Enzyme and pathway databases

Reactomei REACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

EvolutionaryTracei Q60773.
NextBioi 281712.
PROi Q60773.
SOURCEi Search...

Gene expression databases

Genevestigatori Q60773.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
    Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
    Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/Kaplan.
  2. "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4."
    Chan F.K.M., Zhang J., Cheng L., Shapiro D.N., Winoto A.
    Mol. Cell. Biol. 15:2682-2688(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCDN2D_MOUSE
AccessioniPrimary (citable) accession number: Q60773
Secondary accession number(s): Q60794, Q91YV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3