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Protein

Cyclin-dependent kinase 4 inhibitor D

Gene

Cdkn2d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK4 and CDK6 and inhibits them.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_289448. Cyclin D associated events in G1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_339940. Oncogene Induced Senescence.
REACT_350665. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor D
Alternative name(s):
p19-INK4d
Gene namesi
Name:Cdkn2d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:105387. Cdkn2d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Cyclin-dependent kinase 4 inhibitor DPRO_0000144189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ60773.
PRIDEiQ60773.

PTM databases

PhosphoSiteiQ60773.

Interactioni

Subunit structurei

Interacts with CDK6.By similarity

Protein-protein interaction databases

IntActiQ60773. 1 interaction.
MINTiMINT-1539403.
STRINGi10090.ENSMUSP00000083561.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1711Combined sources
Helixi21 – 299Combined sources
Helixi45 – 484Combined sources
Helixi54 – 629Combined sources
Turni72 – 743Combined sources
Helixi77 – 848Combined sources
Helixi87 – 959Combined sources
Helixi110 – 1178Combined sources
Helixi120 – 1267Combined sources
Helixi127 – 1293Combined sources
Helixi142 – 1487Combined sources
Helixi152 – 1609Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773.
SMRiQ60773. Positions 6-165.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60773.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6929ANK 1Add
BLAST
Repeati73 – 10230ANK 2Add
BLAST
Repeati106 – 13530ANK 3Add
BLAST
Repeati138 – 16528ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60773.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG7TTQ94.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60773-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM
60 70 80 90 100
FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV
110 120 130 140 150
NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG
160
AQNLMDILQG HMMIPM
Length:166
Mass (Da):17,809
Last modified:October 3, 2012 - v2
Checksum:i7B95D6C2294F9259
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161A → R in AAC52194 (PubMed:7739547).Curated
Sequence conflicti17 – 171A → P in AAA85437 (PubMed:7739548).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA. Translation: AAC52194.1.
U20497 mRNA. Translation: AAA85437.1.
AK132906 mRNA. Translation: BAE21414.1.
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1.
BC013898 mRNA. Translation: AAH13898.1.
CCDSiCCDS22901.1.
PIRiA57379.
B57378.
RefSeqiNP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGeneiMm.29020.

Genome annotation databases

EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
GeneIDi12581.
KEGGimmu:12581.
UCSCiuc009okw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19597 mRNA. Translation: AAC52194.1.
U20497 mRNA. Translation: AAA85437.1.
AK132906 mRNA. Translation: BAE21414.1.
AC122525 Genomic DNA. No translation available.
CH466522 Genomic DNA. Translation: EDL25176.1.
BC013898 mRNA. Translation: AAH13898.1.
CCDSiCCDS22901.1.
PIRiA57379.
B57378.
RefSeqiNP_034008.2. NM_009878.3.
XP_006510031.1. XM_006509968.1.
UniGeneiMm.29020.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AP7NMR-A1-166[»]
1BLXX-ray1.90B1-166[»]
ProteinModelPortaliQ60773.
SMRiQ60773. Positions 6-165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60773. 1 interaction.
MINTiMINT-1539403.
STRINGi10090.ENSMUSP00000083561.

PTM databases

PhosphoSiteiQ60773.

Proteomic databases

PaxDbiQ60773.
PRIDEiQ60773.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086374; ENSMUSP00000083561; ENSMUSG00000096472.
GeneIDi12581.
KEGGimmu:12581.
UCSCiuc009okw.1. mouse.

Organism-specific databases

CTDi1032.
MGIiMGI:105387. Cdkn2d.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60773.
KOiK06623.
OMAiPIHIAIR.
OrthoDBiEOG7TTQ94.
TreeFamiTF333311.

Enzyme and pathway databases

ReactomeiREACT_289448. Cyclin D associated events in G1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_339940. Oncogene Induced Senescence.
REACT_350665. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

EvolutionaryTraceiQ60773.
NextBioi281712.
PROiQ60773.
SOURCEiSearch...

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
    Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
    Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/Kaplan.
  2. "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4."
    Chan F.K.M., Zhang J., Cheng L., Shapiro D.N., Winoto A.
    Mol. Cell. Biol. 15:2682-2688(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  7. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiCDN2D_MOUSE
AccessioniPrimary (citable) accession number: Q60773
Secondary accession number(s): Q60794, Q91YV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.