Q60772 (CDN2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 4 inhibitor C

Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6

Gene names

Name:

Cdkn2c

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Subunit structure	Heterodimer of p18 with CDK6 By similarity.
Sequence similarities	Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Contains 5 ANK repeats.

Ontologies

Keywords
Biological process	Cell cycle
Domain	ANK repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from genetic interaction PubMed 17409423. Source: MGI oligodendrocyte differentiation Inferred from electronic annotation. Source: Compara regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	cyclin-dependent protein serine/threonine kinase inhibitor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Cyclin-dependent kinase 4 inhibitor C		PRO_0000144187
Regions
	Repeat	4 – 33	30	ANK 1
	Repeat	37 – 65	29	ANK 2
	Repeat	69 – 98	30	ANK 3
	Repeat	102 – 132	31	ANK 4
	Repeat	136 – 165	30	ANK 5

Sequences

	Sequence		Length	Mass (Da)
	Q60772 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: BC88D5489307E128	FASTA	168	18,066
	10 20 30 40 50 60 MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG 70 80 90 100 110 120 ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED NEGNLPLHLA AKEGHLPVVE 130 140 150 160 FLMKHTACNV GHRNHKGDTA FDLARFYGRN EVISLMEANG VGGATSLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6." Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J. Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/Kaplan.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19596 mRNA. Translation: AAC52193.1. BC027026 mRNA. Translation: AAH27026.1.
IPI	IPI00120297.
PIR	B57379.
RefSeq	NP_031697.1. NM_007671.2.
UniGene	Mm.1912.
3D structure databases
ProteinModelPortal	Q60772.
SMR	Q60772. Positions 5-160.
ModBase	Search...
PTM databases
PhosphoSite	Q60772.
Proteomic databases
PaxDb	Q60772.
PRIDE	Q60772.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551. ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneID	12580.
KEGG	mmu:12580.
UCSC	uc008ucr.1. mouse.
Organism-specific databases
CTD	1031.
MGI	MGI:105388. Cdkn2c.
Phylogenomic databases
eggNOG	COG0666.
GeneTree	ENSGT00390000004527.
HOGENOM	HOG000290191.
HOVERGEN	HBG050870.
InParanoid	Q60772.
KO	K06622.
OMA	KDQTGFA.
OrthoDB	EOG4S4PHS.
Gene expression databases
ArrayExpress	Q60772.
Bgee	Q60772.
Genevestigator	Q60772.
GermOnline	ENSMUSG00000028551. Mus musculus.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	281708.
SOURCE	Search...

Entry information

Entry name

CDN2C_MOUSE

Accession

Primary (citable) accession number: Q60772

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program