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Q60772

- CDN2C_MOUSE

UniProt

Q60772 - CDN2C_MOUSE

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Protein
Cyclin-dependent kinase 4 inhibitor C
Gene
Cdkn2c
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

GO - Biological processi

  1. G1/S transition of mitotic cell cycle Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. negative regulation of cell growth Source: Ensembl
  4. negative regulation of cell proliferation Source: MGI
  5. oligodendrocyte differentiation Source: Ensembl
  6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:Cdkn2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:105388. Cdkn2c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Cyclin-dependent kinase 4 inhibitor C
PRO_0000144187Add
BLAST

Proteomic databases

MaxQBiQ60772.
PaxDbiQ60772.
PRIDEiQ60772.

PTM databases

PhosphoSiteiQ60772.

Expressioni

Gene expression databases

ArrayExpressiQ60772.
BgeeiQ60772.
GenevestigatoriQ60772.

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6 By similarity.

Protein-protein interaction databases

DIPiDIP-60250N.

Structurei

3D structure databases

ProteinModelPortaliQ60772.
SMRiQ60772. Positions 5-160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3330ANK 1
Add
BLAST
Repeati37 – 6529ANK 2
Add
BLAST
Repeati69 – 9830ANK 3
Add
BLAST
Repeati102 – 13231ANK 4
Add
BLAST
Repeati136 – 16530ANK 5
Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60772.
KOiK06622.
OMAiKDQTGFA.
OrthoDBiEOG7ZSHVC.
PhylomeDBiQ60772.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60772-1 [UniParc]FASTAAdd to Basket

« Hide

MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP    50
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED 100
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN 150
EVISLMEANG VGGATSLQ 168
Length:168
Mass (Da):18,066
Last modified:November 1, 1996 - v1
Checksum:iBC88D5489307E128
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
CCDSiCCDS18467.1.
PIRiB57379.
RefSeqiNP_031697.1. NM_007671.2.
XP_006502761.1. XM_006502698.1.
UniGeneiMm.1912.

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneIDi12580.
KEGGimmu:12580.
UCSCiuc008ucr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19596 mRNA. Translation: AAC52193.1 .
BC027026 mRNA. Translation: AAH27026.1 .
CCDSi CCDS18467.1.
PIRi B57379.
RefSeqi NP_031697.1. NM_007671.2.
XP_006502761.1. XM_006502698.1.
UniGenei Mm.1912.

3D structure databases

ProteinModelPortali Q60772.
SMRi Q60772. Positions 5-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60250N.

PTM databases

PhosphoSitei Q60772.

Proteomic databases

MaxQBi Q60772.
PaxDbi Q60772.
PRIDEi Q60772.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000063531 ; ENSMUSP00000070313 ; ENSMUSG00000028551 .
ENSMUST00000097921 ; ENSMUSP00000095534 ; ENSMUSG00000028551 .
GeneIDi 12580.
KEGGi mmu:12580.
UCSCi uc008ucr.1. mouse.

Organism-specific databases

CTDi 1031.
MGIi MGI:105388. Cdkn2c.

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00390000004527.
HOGENOMi HOG000290191.
HOVERGENi HBG050870.
InParanoidi Q60772.
KOi K06622.
OMAi KDQTGFA.
OrthoDBi EOG7ZSHVC.
PhylomeDBi Q60772.
TreeFami TF333311.

Enzyme and pathway databases

Reactomei REACT_188970. Oxidative Stress Induced Senescence.
REACT_188971. Oncogene Induced Senescence.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

NextBioi 281708.
PROi Q60772.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60772.
Bgeei Q60772.
Genevestigatori Q60772.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
    Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
    Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/Kaplan.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCDN2C_MOUSE
AccessioniPrimary (citable) accession number: Q60772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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