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Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

Cdkn2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  2. protein kinase binding Source: MGI

GO - Biological processi

  1. cell cycle arrest Source: MGI
  2. G1/S transition of mitotic cell cycle Source: MGI
  3. negative regulation of cell growth Source: MGI
  4. negative regulation of cell proliferation Source: MGI
  5. negative regulation of phosphorylation Source: MGI
  6. negative regulation of protein serine/threonine kinase activity Source: MGI
  7. oligodendrocyte differentiation Source: Ensembl
  8. regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Enzyme and pathway databases

ReactomeiREACT_289448. Cyclin D associated events in G1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_339940. Oncogene Induced Senescence.
REACT_350665. Senescence-Associated Secretory Phenotype (SASP).

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:Cdkn2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105388. Cdkn2c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168Cyclin-dependent kinase 4 inhibitor CPRO_0000144187Add
BLAST

Proteomic databases

MaxQBiQ60772.
PaxDbiQ60772.
PRIDEiQ60772.

PTM databases

PhosphoSiteiQ60772.

Expressioni

Gene expression databases

BgeeiQ60772.
ExpressionAtlasiQ60772. baseline and differential.
GenevestigatoriQ60772.

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6.By similarity

Protein-protein interaction databases

DIPiDIP-60250N.

Structurei

3D structure databases

SMRiQ60772. Positions 5-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 3330ANK 1Add
BLAST
Repeati37 – 6529ANK 2Add
BLAST
Repeati69 – 9830ANK 3Add
BLAST
Repeati102 – 13231ANK 4Add
BLAST
Repeati136 – 16530ANK 5Add
BLAST

Sequence similaritiesi

Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60772.
KOiK06622.
OMAiLMKHTAC.
OrthoDBiEOG7ZSHVC.
PhylomeDBiQ60772.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN
160
EVISLMEANG VGGATSLQ
Length:168
Mass (Da):18,066
Last modified:November 1, 1996 - v1
Checksum:iBC88D5489307E128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
CCDSiCCDS18467.1.
PIRiB57379.
RefSeqiNP_001288297.1. NM_001301368.1.
NP_031697.1. NM_007671.3.
UniGeneiMm.1912.

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneIDi12580.
KEGGimmu:12580.
UCSCiuc008ucr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
CCDSiCCDS18467.1.
PIRiB57379.
RefSeqiNP_001288297.1. NM_001301368.1.
NP_031697.1. NM_007671.3.
UniGeneiMm.1912.

3D structure databases

SMRiQ60772. Positions 5-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60250N.

PTM databases

PhosphoSiteiQ60772.

Proteomic databases

MaxQBiQ60772.
PaxDbiQ60772.
PRIDEiQ60772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneIDi12580.
KEGGimmu:12580.
UCSCiuc008ucr.1. mouse.

Organism-specific databases

CTDi1031.
MGIiMGI:105388. Cdkn2c.

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60772.
KOiK06622.
OMAiLMKHTAC.
OrthoDBiEOG7ZSHVC.
PhylomeDBiQ60772.
TreeFamiTF333311.

Enzyme and pathway databases

ReactomeiREACT_289448. Cyclin D associated events in G1.
REACT_305463. Oxidative Stress Induced Senescence.
REACT_339940. Oncogene Induced Senescence.
REACT_350665. Senescence-Associated Secretory Phenotype (SASP).

Miscellaneous databases

NextBioi281708.
PROiQ60772.
SOURCEiSearch...

Gene expression databases

BgeeiQ60772.
ExpressionAtlasiQ60772. baseline and differential.
GenevestigatoriQ60772.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
    Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
    Mol. Cell. Biol. 15:2672-2681(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/Kaplan.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCDN2C_MOUSE
AccessioniPrimary (citable) accession number: Q60772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.