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Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

Cdkn2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene namesi
Name:Cdkn2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:105388. Cdkn2c.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441871 – 168Cyclin-dependent kinase 4 inhibitor CAdd BLAST168

Proteomic databases

EPDiQ60772.
MaxQBiQ60772.
PaxDbiQ60772.
PeptideAtlasiQ60772.
PRIDEiQ60772.

PTM databases

iPTMnetiQ60772.
PhosphoSitePlusiQ60772.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028551.
GenevisibleiQ60772. MM.

Interactioni

Subunit structurei

Heterodimer of p18 with CDK6.By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI

Protein-protein interaction databases

DIPiDIP-60250N.
STRINGi10090.ENSMUSP00000070313.

Structurei

3D structure databases

ProteinModelPortaliQ60772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 33ANK 1Add BLAST30
Repeati37 – 65ANK 2Add BLAST29
Repeati69 – 98ANK 3Add BLAST30
Repeati102 – 132ANK 4Add BLAST31
Repeati136 – 165ANK 5Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60772.
KOiK06622.
OMAiNGGGPEN.
OrthoDBiEOG091G0PMC.
PhylomeDBiQ60772.
TreeFamiTF333311.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.

Sequencei

Sequence statusi: Complete.

Q60772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP
60 70 80 90 100
EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED
110 120 130 140 150
NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN
160
EVISLMEANG VGGATSLQ
Length:168
Mass (Da):18,066
Last modified:November 1, 1996 - v1
Checksum:iBC88D5489307E128
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
CCDSiCCDS18467.1.
PIRiB57379.
RefSeqiNP_001288297.1. NM_001301368.1.
NP_031697.1. NM_007671.3.
UniGeneiMm.1912.

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneIDi12580.
KEGGimmu:12580.
UCSCiuc008ucr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
CCDSiCCDS18467.1.
PIRiB57379.
RefSeqiNP_001288297.1. NM_001301368.1.
NP_031697.1. NM_007671.3.
UniGeneiMm.1912.

3D structure databases

ProteinModelPortaliQ60772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60250N.
STRINGi10090.ENSMUSP00000070313.

PTM databases

iPTMnetiQ60772.
PhosphoSitePlusiQ60772.

Proteomic databases

EPDiQ60772.
MaxQBiQ60772.
PaxDbiQ60772.
PeptideAtlasiQ60772.
PRIDEiQ60772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneIDi12580.
KEGGimmu:12580.
UCSCiuc008ucr.1. mouse.

Organism-specific databases

CTDi1031.
MGIiMGI:105388. Cdkn2c.

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000004527.
HOGENOMiHOG000290191.
HOVERGENiHBG050870.
InParanoidiQ60772.
KOiK06622.
OMAiNGGGPEN.
OrthoDBiEOG091G0PMC.
PhylomeDBiQ60772.
TreeFamiTF333311.

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.
R-MMU-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-MMU-2559585. Oncogene Induced Senescence.
R-MMU-69231. Cyclin D associated events in G1.

Miscellaneous databases

PROiPR:Q60772.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028551.
GenevisibleiQ60772. MM.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
SMARTiView protein in SMART
SM00248. ANK. 4 hits.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCDN2C_MOUSE
AccessioniPrimary (citable) accession number: Q60772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 12, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.