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Q60772

- CDN2C_MOUSE

UniProt

Q60772 - CDN2C_MOUSE

Protein

Cyclin-dependent kinase 4 inhibitor C

Gene

Cdkn2c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. G1/S transition of mitotic cell cycle Source: Ensembl
    3. negative regulation of cell growth Source: Ensembl
    4. negative regulation of cell proliferation Source: MGI
    5. oligodendrocyte differentiation Source: Ensembl
    6. regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Enzyme and pathway databases

    ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 4 inhibitor C
    Alternative name(s):
    Cyclin-dependent kinase 6 inhibitor
    p18-INK4c
    p18-INK6
    Gene namesi
    Name:Cdkn2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:105388. Cdkn2c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168Cyclin-dependent kinase 4 inhibitor CPRO_0000144187Add
    BLAST

    Proteomic databases

    MaxQBiQ60772.
    PaxDbiQ60772.
    PRIDEiQ60772.

    PTM databases

    PhosphoSiteiQ60772.

    Expressioni

    Gene expression databases

    ArrayExpressiQ60772.
    BgeeiQ60772.
    GenevestigatoriQ60772.

    Interactioni

    Subunit structurei

    Heterodimer of p18 with CDK6.By similarity

    Protein-protein interaction databases

    DIPiDIP-60250N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60772.
    SMRiQ60772. Positions 5-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati4 – 3330ANK 1Add
    BLAST
    Repeati37 – 6529ANK 2Add
    BLAST
    Repeati69 – 9830ANK 3Add
    BLAST
    Repeati102 – 13231ANK 4Add
    BLAST
    Repeati136 – 16530ANK 5Add
    BLAST

    Sequence similaritiesi

    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    GeneTreeiENSGT00390000004527.
    HOGENOMiHOG000290191.
    HOVERGENiHBG050870.
    InParanoidiQ60772.
    KOiK06622.
    OMAiKDQTGFA.
    OrthoDBiEOG7ZSHVC.
    PhylomeDBiQ60772.
    TreeFamiTF333311.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60772-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP    50
    EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED 100
    NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN 150
    EVISLMEANG VGGATSLQ 168
    Length:168
    Mass (Da):18,066
    Last modified:November 1, 1996 - v1
    Checksum:iBC88D5489307E128
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19596 mRNA. Translation: AAC52193.1.
    BC027026 mRNA. Translation: AAH27026.1.
    CCDSiCCDS18467.1.
    PIRiB57379.
    RefSeqiNP_031697.1. NM_007671.2.
    XP_006502761.1. XM_006502698.1.
    UniGeneiMm.1912.

    Genome annotation databases

    EnsembliENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
    ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
    GeneIDi12580.
    KEGGimmu:12580.
    UCSCiuc008ucr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19596 mRNA. Translation: AAC52193.1 .
    BC027026 mRNA. Translation: AAH27026.1 .
    CCDSi CCDS18467.1.
    PIRi B57379.
    RefSeqi NP_031697.1. NM_007671.2.
    XP_006502761.1. XM_006502698.1.
    UniGenei Mm.1912.

    3D structure databases

    ProteinModelPortali Q60772.
    SMRi Q60772. Positions 5-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60250N.

    PTM databases

    PhosphoSitei Q60772.

    Proteomic databases

    MaxQBi Q60772.
    PaxDbi Q60772.
    PRIDEi Q60772.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063531 ; ENSMUSP00000070313 ; ENSMUSG00000028551 .
    ENSMUST00000097921 ; ENSMUSP00000095534 ; ENSMUSG00000028551 .
    GeneIDi 12580.
    KEGGi mmu:12580.
    UCSCi uc008ucr.1. mouse.

    Organism-specific databases

    CTDi 1031.
    MGIi MGI:105388. Cdkn2c.

    Phylogenomic databases

    eggNOGi COG0666.
    GeneTreei ENSGT00390000004527.
    HOGENOMi HOG000290191.
    HOVERGENi HBG050870.
    InParanoidi Q60772.
    KOi K06622.
    OMAi KDQTGFA.
    OrthoDBi EOG7ZSHVC.
    PhylomeDBi Q60772.
    TreeFami TF333311.

    Enzyme and pathway databases

    Reactomei REACT_188970. Oxidative Stress Induced Senescence.
    REACT_188971. Oncogene Induced Senescence.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).

    Miscellaneous databases

    NextBioi 281708.
    PROi Q60772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60772.
    Bgeei Q60772.
    Genevestigatori Q60772.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
      Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
      Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/Kaplan.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCDN2C_MOUSE
    AccessioniPrimary (citable) accession number: Q60772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3