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Q60772 (CDN2C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 4 inhibitor C
Alternative name(s):
Cyclin-dependent kinase 6 inhibitor
p18-INK4c
p18-INK6
Gene names
Name:Cdkn2c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Subunit structure

Heterodimer of p18 with CDK6 By similarity.

Sequence similarities

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Contains 5 ANK repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168Cyclin-dependent kinase 4 inhibitor C
PRO_0000144187

Regions

Repeat4 – 3330ANK 1
Repeat37 – 6529ANK 2
Repeat69 – 9830ANK 3
Repeat102 – 13231ANK 4
Repeat136 – 16530ANK 5

Sequences

Sequence LengthMass (Da)Tools
Q60772 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BC88D5489307E128

FASTA16818,066
        10         20         30         40         50         60 
MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG 

        70         80         90        100        110        120 
ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED NEGNLPLHLA AKEGHLPVVE 

       130        140        150        160 
FLMKHTACNV GHRNHKGDTA FDLARFYGRN EVISLMEANG VGGATSLQ 

« Hide

References

« Hide 'large scale' references
[1]"Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6."
Hirai H., Roussel M.F., Kato J.-Y., Ashmun R.A., Sherr C.J.
Mol. Cell. Biol. 15:2672-2681(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/Kaplan.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N-3.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19596 mRNA. Translation: AAC52193.1.
BC027026 mRNA. Translation: AAH27026.1.
PIRB57379.
RefSeqNP_031697.1. NM_007671.2.
XP_006502761.1. XM_006502698.1.
UniGeneMm.1912.

3D structure databases

ProteinModelPortalQ60772.
SMRQ60772. Positions 5-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60250N.

PTM databases

PhosphoSiteQ60772.

Proteomic databases

PaxDbQ60772.
PRIDEQ60772.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063531; ENSMUSP00000070313; ENSMUSG00000028551.
ENSMUST00000097921; ENSMUSP00000095534; ENSMUSG00000028551.
GeneID12580.
KEGGmmu:12580.
UCSCuc008ucr.1. mouse.

Organism-specific databases

CTD1031.
MGIMGI:105388. Cdkn2c.

Phylogenomic databases

eggNOGCOG0666.
GeneTreeENSGT00390000004527.
HOGENOMHOG000290191.
HOVERGENHBG050870.
InParanoidQ60772.
KOK06622.
OMALMKHTAC.
OrthoDBEOG7ZSHVC.
PhylomeDBQ60772.
TreeFamTF333311.

Gene expression databases

ArrayExpressQ60772.
BgeeQ60772.
GenevestigatorQ60772.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio281708.
PROQ60772.
SOURCESearch...

Entry information

Entry nameCDN2C_MOUSE
AccessionPrimary (citable) accession number: Q60772
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot