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Protein

Claudin-11

Gene

Cldn11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

GO - Biological processi

  • axon ensheathment Source: MGI
  • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  • cell adhesion Source: MGI
  • spermatogenesis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-11
Alternative name(s):
Oligodendrocyte transmembrane protein
Oligodendrocyte-specific protein
Gene namesi
Name:Cldn11
Synonyms:Osp, Otm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106925. Cldn11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1CytoplasmicSequence analysis1
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 82ExtracellularSequence analysisAdd BLAST60
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 122CytoplasmicSequence analysisAdd BLAST19
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Topological domaini144 – 157ExtracellularSequence analysisAdd BLAST14
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 207CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001447621 – 207Claudin-11Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1
Modified residuei194PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60771.
PaxDbiQ60771.
PeptideAtlasiQ60771.
PRIDEiQ60771.

PTM databases

iPTMnetiQ60771.
PhosphoSitePlusiQ60771.
SwissPalmiQ60771.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037625.
CleanExiMM_CLDN11.
GenevisibleiQ60771. MM.

Interactioni

Subunit structurei

Interacts with tetraspanin-3/TSPAN3 (PubMed:11309411). Interacts with OCLN (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Csf1P071412EBI-309095,EBI-777188

GO - Molecular functioni

Protein-protein interaction databases

CORUMiQ60771.
IntActiQ60771. 2 interactors.
MINTiMINT-217520.
STRINGi10090.ENSMUSP00000042181.

Structurei

3D structure databases

ProteinModelPortaliQ60771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXU. Eukaryota.
ENOG41101XN. LUCA.
GeneTreeiENSGT00890000139496.
HOGENOMiHOG000220937.
HOVERGENiHBG102313.
InParanoidiQ60771.
KOiK06087.
OMAiYSLYTGW.
OrthoDBiEOG091G0MX2.
PhylomeDBiQ60771.
TreeFamiTF331936.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003555. Claudin11.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF6. PTHR12002:SF6. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01384. CLAUDIN11.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATCLQVVG FVTSFVGWIG IIVTTSTNDW VVTCSYTIPT CRKMDELGSK
60 70 80 90 100
GLWADCVMAT GLYHCKPLVD ILILPGYVQA CRALMIAASV LGLPAILLLL
110 120 130 140 150
TVLPCIRMGH EPGVAKYRRA QLAGVLLILL ALCAIVATIW FPVCAHREIT
160 170 180 190 200
IVSFGYSLYA GWIGAVMCLV GGCVIVCCSG DAQSFGENRF YYSSGSSSPT

HAKSAHV
Length:207
Mass (Da):22,114
Last modified:November 1, 1996 - v1
Checksum:iA3F936F15958F27B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196S → C in BAB23860 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19582 mRNA. Translation: AAB50270.1.
AF124426 mRNA. Translation: AAD17321.1.
AK005088 mRNA. Translation: BAB23810.1.
AK005171 mRNA. Translation: BAB23860.1.
AK161698 mRNA. Translation: BAE36538.1.
BC021659 mRNA. Translation: AAH21659.1.
CCDSiCCDS17290.1.
RefSeqiNP_032796.1. NM_008770.3.
UniGeneiMm.4425.

Genome annotation databases

EnsembliENSMUST00000046174; ENSMUSP00000042181; ENSMUSG00000037625.
GeneIDi18417.
KEGGimmu:18417.
UCSCiuc008ovw.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCLD11_MOUSE
AccessioniPrimary (citable) accession number: Q60771
Secondary accession number(s): Q545N5, Q9DB65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families