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Q60769

- TNAP3_MOUSE

UniProt

Q60769 - TNAP3_MOUSE

Protein

Tumor necrosis factor alpha-induced protein 3

Gene

Tnfaip3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.6 Publications

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei100 – 1001By similarity
    Active sitei103 – 1031NucleophileBy similarity
    Active sitei256 – 2561Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri381 – 41636A20-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 49936A20-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 53334A20-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri586 – 62136A20-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 67136A20-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri695 – 73036A20-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri741 – 77535A20-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. kinase binding Source: BHF-UCL
    3. ligase activity Source: UniProtKB-KW
    4. protein binding Source: IntAct
    5. ubiquitin-protein transferase activity Source: UniProtKB
    6. ubiquitin-specific protease activity Source: UniProtKB
    7. ubiquitin thiolesterase activity Source: UniProtKB
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. B-1 B cell homeostasis Source: BHF-UCL
    3. cellular response to hydrogen peroxide Source: UniProtKB
    4. cellular response to lipopolysaccharide Source: BHF-UCL
    5. inflammatory response Source: UniProtKB-KW
    6. marginal zone B cell differentiation Source: BHF-UCL
    7. negative regulation of autophagy Source: BHF-UCL
    8. negative regulation of B cell activation Source: BHF-UCL
    9. negative regulation of CD40 signaling pathway Source: BHF-UCL
    10. negative regulation of cell death Source: BHF-UCL
    11. negative regulation of chronic inflammatory response Source: BHF-UCL
    12. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    13. negative regulation of endothelial cell apoptotic process Source: Ensembl
    14. negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    15. negative regulation of granuloma formation Source: BHF-UCL
    16. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
    17. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    18. negative regulation of inflammatory response Source: UniProtKB
    19. negative regulation of innate immune response Source: UniProtKB
    20. negative regulation of interleukin-1 beta production Source: BHF-UCL
    21. negative regulation of interleukin-2 production Source: Ensembl
    22. negative regulation of interleukin-6 production Source: BHF-UCL
    23. negative regulation of NF-kappaB transcription factor activity Source: Ensembl
    24. negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway Source: BHF-UCL
    25. negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway Source: BHF-UCL
    26. negative regulation of protein ubiquitination Source: Ensembl
    27. negative regulation of smooth muscle cell proliferation Source: BHF-UCL
    28. negative regulation of toll-like receptor 3 signaling pathway Source: Ensembl
    29. negative regulation of toll-like receptor 5 signaling pathway Source: BHF-UCL
    30. negative regulation of tumor necrosis factor production Source: BHF-UCL
    31. positive regulation of hepatocyte proliferation Source: BHF-UCL
    32. positive regulation of protein catabolic process Source: BHF-UCL
    33. protein deubiquitination Source: BHF-UCL
    34. protein K11-linked deubiquitination Source: UniProtKB
    35. protein K48-linked deubiquitination Source: UniProtKB
    36. protein K48-linked ubiquitination Source: UniProtKB
    37. protein K63-linked deubiquitination Source: UniProtKB
    38. regulation of germinal center formation Source: BHF-UCL
    39. regulation of immunoglobulin production Source: BHF-UCL
    40. regulation of innate immune response Source: BHF-UCL
    41. response to molecule of bacterial origin Source: BHF-UCL
    42. response to muramyl dipeptide Source: BHF-UCL
    43. response to wounding Source: BHF-UCL
    44. tolerance induction to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Ligase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis, Inflammatory response, Ubl conjugation pathway

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198532. Negative regulators of RIG-I/MDA5 signaling.
    REACT_211125. NOD1/2 Signaling Pathway.

    Protein family/group databases

    MEROPSiC64.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor alpha-induced protein 3 (EC:3.4.19.12, EC:6.3.2.-)
    Short name:
    TNF alpha-induced protein 3
    Alternative name(s):
    Putative DNA-binding protein A20
    Zinc finger protein A20
    Gene namesi
    Name:Tnfaip3
    Synonyms:Tnfip3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1196377. Tnfaip3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: MGI
    3. lysosome Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Lysosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi100 – 1001D → A: Loss of deubiquitinating activity. 1 Publication
    Mutagenesisi103 – 1031C → A: Loss of deubiquitinating activity, does not disassemble TRAF6:UBE2N ubiquitin ligase complex, abolioshes TAX1BP1 interaction with UBE2N. 2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 775774Tumor necrosis factor alpha-induced protein 3PRO_0000188793Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei451 – 4511PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ60769.

    PTM databases

    PhosphoSiteiQ60769.

    Expressioni

    Tissue specificityi

    Found in most tissues during development. Strikingly high levels are found in lymphoid organs, including the thymus, spleen, and gut-associated lymphoid tissue. Constitutively expressed in immature and mature thymocyte subpopulations as well as in resting peripheral T-cells; activation of these leads to down-regulation.

    Inductioni

    By cytokines. TNF-alpha may regulate expression in the thymus. Up-regulated in presence of reactive oxygen species (ROS), like H2O2, in LPS-tolerized macrophages.1 Publication

    Gene expression databases

    ArrayExpressiQ60769.
    BgeeiQ60769.
    CleanExiMM_TNFAIP3.
    GenevestigatoriQ60769.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with TNIP1, TAX1BP1 and TRAF2. Interacts with RNF11, ITCH and TAX1BP1 only after TNF stimulation; these interaction are transient and they are lost after 1 hour of stimulation with TNF By similarity. Interacts with YWHAZ and YWHAH. Interacts with IKBKG; the interaction is induced by TNF stimulation and by polyubiquitin. Interacts with RIPK1. Interacts with UBE2N; the interaction requires TAX1BP1. Interacts with TRAF6 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tnip1Q9WUU83EBI-646595,EBI-6126152
    Traf2P394293EBI-646595,EBI-520016

    Protein-protein interaction databases

    BioGridi204243. 15 interactions.
    DIPiDIP-41120N.
    IntActiQ60769. 6 interactions.
    MINTiMINT-97373.
    STRINGi10090.ENSMUSP00000101167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60769.
    SMRiQ60769. Positions 3-362, 382-419, 588-620, 743-775.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini92 – 263172OTUPROSITE-ProRule annotationAdd
    BLAST
    Repeati286 – 317321Add
    BLAST
    Repeati324 – 356332Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 300243TRAF-bindingBy similarityAdd
    BLAST
    Regioni157 – 1593Interaction with ubiquitinBy similarity
    Regioni190 – 1923Interaction with ubiquitinBy similarity
    Regioni224 – 2274Interaction with ubiquitinBy similarity
    Regioni286 – 356712 X approximate repeatsAdd
    BLAST
    Regioni369 – 775407Interaction with TNIP1Add
    BLAST
    Regioni386 – 44560Interaction with RIPK1By similarityAdd
    BLAST
    Regioni590 – 64051Required for proteosomal degradation of UBE2N and UBE2D3, TRAF6 deubiquitination, and TAX1BP1 interaction with UBE2NAdd
    BLAST
    Regioni591 – 775185Sufficient for inhibitory activity of TNF-induced NF-kappa-B activityAdd
    BLAST
    Regioni682 – 77594Required for lysosomal localization and for TRAF2 lysosomal degradationBy similarityAdd
    BLAST

    Domaini

    The A20-type zinc fingers mediate the ubiquitin ligase activity. The A20-type zinc finger 4 selectively recognizes 'Lys-63'-linked polyubiquitin. The A20-type zinc finger 4-7 are sufficient to bind polyubiquitin By similarity.By similarity
    The OTU domain mediates the deubiquitinase activity.By similarity

    Sequence similaritiesi

    Belongs to the peptidase C64 family.Curated
    Contains 7 A20-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri381 – 41636A20-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri464 – 49936A20-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri500 – 53334A20-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri586 – 62136A20-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri636 – 67136A20-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri695 – 73036A20-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri741 – 77535A20-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG248343.
    GeneTreeiENSGT00530000062989.
    HOGENOMiHOG000133004.
    HOVERGENiHBG059260.
    InParanoidiQ3U968.
    KOiK11859.
    OMAiCETPNCP.
    OrthoDBiEOG7JHM57.
    TreeFamiTF323312.

    Family and domain databases

    InterProiIPR003323. OTU.
    IPR002653. Znf_A20.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    PF01754. zf-A20. 6 hits.
    [Graphical view]
    SMARTiSM00259. ZnF_A20. 7 hits.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    PS51036. ZF_A20. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60769-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEQLLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIYHF KTMHRYTLEM    50
    FRTCQFCPQF REIIHKALID RSVQASLESQ KKLNWCREVR KLVALKTNGD 100
    GNCLMHAACQ YMWGVQDTDL VLRKALCSTL KETDTRNFKF RWQLESLKSQ 150
    EFVETGLCYD TRNWNDEWDN LVKMASADTP AARSGLQYNS LEEIHIFVLS 200
    NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA QECYRYPIVL 250
    GYDSQHFVPL VTLKDSGPEL RAVPLVNRDR GRFEDLKVHF LTDPENEMKE 300
    KLLKEYLIVM EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ 350
    HEYKKWQENS DQARRAAHAQ NPLEPSTPQL SLMDIKCETP NCPFFMSVNT 400
    QPLCHECSER RQKNQSKLPK LNSKLGPEGL PGVGLGSSNW SPEETAGGPH 450
    SAPPTAPSLF LFSETTAMKC RSPGCPFTLN VQHNGFCERC HARQINASHT 500
    ADPGKCQACL QDVTRTFNGI CSTCFKRTTA EPSSSLTSSI PASCHQRSKS 550
    DPSQLIQSLT PHSCHRTGNV SPSGCLSQAA RTPGDRAGTS KCRKAGCMYF 600
    GTPENKGFCT LCFIEYRENK QSVTASEKAG SPAPRFQNNV PCLGRECGTL 650
    GSTMFEGYCQ KCFIEAQNQR FHEARRTEEQ LRSSQHRDMP RTTQVASRLK 700
    CARASCKNIL ACRSEELCME CQHLSQRVGS VAHRGEPTPE EPPKQRCRAP 750
    ACDHFGNAKC NGYCNECYQF KQMYG 775
    Length:775
    Mass (Da):87,654
    Last modified:July 27, 2011 - v2
    Checksum:i32349928908B3185
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti627 – 6271E → A in AAC52153. (PubMed:7836754)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19463 mRNA. Translation: AAC52153.1.
    AK151921 mRNA. Translation: BAE30799.1.
    CCDSiCCDS23715.1.
    PIRiI49237.
    RefSeqiNP_033423.3. NM_009397.3.
    XP_006512765.1. XM_006512702.1.
    UniGeneiMm.116683.

    Genome annotation databases

    EnsembliENSMUST00000019997; ENSMUSP00000019997; ENSMUSG00000019850.
    ENSMUST00000105527; ENSMUSP00000101167; ENSMUSG00000019850.
    GeneIDi21929.
    KEGGimmu:21929.
    UCSCiuc007ena.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19463 mRNA. Translation: AAC52153.1 .
    AK151921 mRNA. Translation: BAE30799.1 .
    CCDSi CCDS23715.1.
    PIRi I49237.
    RefSeqi NP_033423.3. NM_009397.3.
    XP_006512765.1. XM_006512702.1.
    UniGenei Mm.116683.

    3D structure databases

    ProteinModelPortali Q60769.
    SMRi Q60769. Positions 3-362, 382-419, 588-620, 743-775.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204243. 15 interactions.
    DIPi DIP-41120N.
    IntActi Q60769. 6 interactions.
    MINTi MINT-97373.
    STRINGi 10090.ENSMUSP00000101167.

    Protein family/group databases

    MEROPSi C64.003.

    PTM databases

    PhosphoSitei Q60769.

    Proteomic databases

    PRIDEi Q60769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019997 ; ENSMUSP00000019997 ; ENSMUSG00000019850 .
    ENSMUST00000105527 ; ENSMUSP00000101167 ; ENSMUSG00000019850 .
    GeneIDi 21929.
    KEGGi mmu:21929.
    UCSCi uc007ena.3. mouse.

    Organism-specific databases

    CTDi 7128.
    MGIi MGI:1196377. Tnfaip3.

    Phylogenomic databases

    eggNOGi NOG248343.
    GeneTreei ENSGT00530000062989.
    HOGENOMi HOG000133004.
    HOVERGENi HBG059260.
    InParanoidi Q3U968.
    KOi K11859.
    OMAi CETPNCP.
    OrthoDBi EOG7JHM57.
    TreeFami TF323312.

    Enzyme and pathway databases

    Reactomei REACT_198532. Negative regulators of RIG-I/MDA5 signaling.
    REACT_211125. NOD1/2 Signaling Pathway.

    Miscellaneous databases

    NextBioi 301520.
    PROi Q60769.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60769.
    Bgeei Q60769.
    CleanExi MM_TNFAIP3.
    Genevestigatori Q60769.

    Family and domain databases

    InterProi IPR003323. OTU.
    IPR002653. Znf_A20.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    PF01754. zf-A20. 6 hits.
    [Graphical view ]
    SMARTi SM00259. ZnF_A20. 7 hits.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    PS51036. ZF_A20. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Lymphoid expression and regulation of A20, an inhibitor of programmed cell death."
      Tewari M., Wolf F.W., Seldin M.F., O'Shea K.S., Dixit V.M., Turka L.A.
      J. Immunol. 154:1699-1706(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The zinc finger protein A20 inhibits TNF-induced NF-B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-B-inhibiting protein ABIN."
      Heyninck K., De Valck D., Vanden Berghe W., Van Criekinge W., Contreras R., Fiers W., Haegeman G., Beyaert R.
      J. Cell Biol. 145:1471-1482(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    4. "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
      Klinkenberg M., Van Huffel S., Heyninck K., Beyaert R.
      FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TNIP2; TAX1BP1; IKBKG AND TNIP1.
    5. "The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses."
      Boone D.L., Turer E.E., Lee E.G., Ahmad R.C., Wheeler M.T., Tsui C., Hurley P., Chien M., Chai S., Hitotsumatsu O., McNally E., Pickart C., Ma A.
      Nat. Immunol. 5:1052-1060(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF ASP-100 AND CYS-103.
    6. "The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals."
      Hitotsumatsu O., Ahmad R.C., Tavares R., Wang M., Philpott D., Turer E.E., Lee B.L., Shiffin N., Advincula R., Malynn B.A., Werts C., Ma A.
      Immunity 28:381-390(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling."
      Shembade N., Parvatiyar K., Harhaj N.S., Harhaj E.W.
      EMBO J. 28:513-522(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TAX1BP1; RNF11 AND RIPK1.
    8. "Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes."
      Shembade N., Ma A., Harhaj E.W.
      Science 327:1135-1139(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH UBE2N, MUTAGENESIS OF CYS-103.
    9. "Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through ROS."
      Li Y., Zhang P., Wang C., Han C., Meng J., Liu X., Xu S., Li N., Wang Q., Shi X., Cao X.
      J. Biol. Chem. 288:16225-16234(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiTNAP3_MOUSE
    AccessioniPrimary (citable) accession number: Q60769
    Secondary accession number(s): Q3U968
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3