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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to amino acid starvation Source: ParkinsonsUK-UCL
  • endoplasmic reticulum unfolded protein response Source: ParkinsonsUK-UCL
  • gluconeogenesis Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: CACAO
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of TRAIL-activated apoptotic signaling pathway Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene namesi
Name:Atf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109384. Atf3.

Subcellular locationi

GO - Cellular componenti

  • CHOP-ATF3 complex Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Cyclic AMP-dependent transcription factor ATF-3PRO_0000076582Add
BLAST

Proteomic databases

PRIDEiQ60765.

PTM databases

PhosphoSiteiQ60765.

Expressioni

Inductioni

By stress.1 Publication

Gene expression databases

BgeeiQ60765.
CleanExiMM_ATF3.
ExpressionAtlasiQ60765. baseline and differential.
GenevisibleiQ60765. MM.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.

Protein-protein interaction databases

BioGridi198234. 5 interactions.
STRINGi10090.ENSMUSP00000027941.

Structurei

3D structure databases

ProteinModelPortaliQ60765.
SMRiQ60765. Positions 87-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 14964bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11023Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni114 – 14229Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242494.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ60765.
KOiK09032.
OMAiMKAEVAP.
OrthoDBiEOG70S777.
PhylomeDBiQ60765.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,722
Last modified:November 1, 1996 - v1
Checksum:iD641C8C6D14A457D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSiCCDS15616.1.
RefSeqiNP_031524.2. NM_007498.3.
UniGeneiMm.2706.

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
ENSMUST00000195117; ENSMUSP00000141492; ENSMUSG00000026628.
GeneIDi11910.
KEGGimmu:11910.
UCSCiuc007ece.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSiCCDS15616.1.
RefSeqiNP_031524.2. NM_007498.3.
UniGeneiMm.2706.

3D structure databases

ProteinModelPortaliQ60765.
SMRiQ60765. Positions 87-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198234. 5 interactions.
STRINGi10090.ENSMUSP00000027941.

PTM databases

PhosphoSiteiQ60765.

Proteomic databases

PRIDEiQ60765.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
ENSMUST00000195117; ENSMUSP00000141492; ENSMUSG00000026628.
GeneIDi11910.
KEGGimmu:11910.
UCSCiuc007ece.1. mouse.

Organism-specific databases

CTDi467.
MGIiMGI:109384. Atf3.

Phylogenomic databases

eggNOGiNOG242494.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ60765.
KOiK09032.
OMAiMKAEVAP.
OrthoDBiEOG70S777.
PhylomeDBiQ60765.
TreeFamiTF326301.

Miscellaneous databases

NextBioi279977.
PROiQ60765.
SOURCEiSearch...

Gene expression databases

BgeeiQ60765.
CleanExiMM_ATF3.
ExpressionAtlasiQ60765. baseline and differential.
GenevisibleiQ60765. MM.

Family and domain databases

InterProiIPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a lipopolysaccharide inducible transcription factor in murine macrophages."
    Drysdale B.E., Howard D.L., Johnson R.J.
    Mol. Immunol. 33:989-998(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland and Osteoblast.
  3. "Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
    Alter J., Bengal E.
    PLoS ONE 6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiATF3_MOUSE
AccessioniPrimary (citable) accession number: Q60765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 22, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.