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Q60765

- ATF3_MOUSE

UniProt

Q60765 - ATF3_MOUSE

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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. gluconeogenesis Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. positive regulation of cell proliferation Source: Ensembl
  5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_90370. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene namesi
Name:Atf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109384. Atf3.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Cyclic AMP-dependent transcription factor ATF-3PRO_0000076582Add
BLAST

Proteomic databases

PRIDEiQ60765.

PTM databases

PhosphoSiteiQ60765.

Expressioni

Inductioni

By stress.1 Publication

Gene expression databases

BgeeiQ60765.
CleanExiMM_ATF3.
ExpressionAtlasiQ60765. baseline and differential.
GenevestigatoriQ60765.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.

Protein-protein interaction databases

BioGridi198234. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ60765.
SMRiQ60765. Positions 87-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 14964bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11023Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni114 – 14229Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG242494.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ60765.
KOiK09032.
OMAiADISCSA.
OrthoDBiEOG70S777.
PhylomeDBiQ60765.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60765-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,722
Last modified:November 1, 1996 - v1
Checksum:iD641C8C6D14A457D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSiCCDS15616.1.
RefSeqiNP_031524.2. NM_007498.3.
UniGeneiMm.2706.

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
GeneIDi11910.
KEGGimmu:11910.
UCSCiuc007ece.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19118 mRNA. Translation: AAB48941.1 .
BC019946 mRNA. Translation: AAH19946.1 .
BC064799 mRNA. Translation: AAH64799.1 .
CCDSi CCDS15616.1.
RefSeqi NP_031524.2. NM_007498.3.
UniGenei Mm.2706.

3D structure databases

ProteinModelPortali Q60765.
SMRi Q60765. Positions 87-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198234. 5 interactions.

PTM databases

PhosphoSitei Q60765.

Proteomic databases

PRIDEi Q60765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027941 ; ENSMUSP00000027941 ; ENSMUSG00000026628 .
GeneIDi 11910.
KEGGi mmu:11910.
UCSCi uc007ece.1. mouse.

Organism-specific databases

CTDi 467.
MGIi MGI:109384. Atf3.

Phylogenomic databases

eggNOGi NOG242494.
GeneTreei ENSGT00730000110847.
HOGENOMi HOG000034126.
HOVERGENi HBG003381.
InParanoidi Q60765.
KOi K09032.
OMAi ADISCSA.
OrthoDBi EOG70S777.
PhylomeDBi Q60765.
TreeFami TF326301.

Enzyme and pathway databases

Reactomei REACT_90370. ATF4 activates genes.

Miscellaneous databases

NextBioi 279977.
PROi Q60765.
SOURCEi Search...

Gene expression databases

Bgeei Q60765.
CleanExi MM_ATF3.
ExpressionAtlasi Q60765. baseline and differential.
Genevestigatori Q60765.

Family and domain databases

InterProi IPR000837. AP-1.
IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a lipopolysaccharide inducible transcription factor in murine macrophages."
    Drysdale B.E., Howard D.L., Johnson R.J.
    Mol. Immunol. 33:989-998(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland and Osteoblast.
  3. "Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
    Alter J., Bengal E.
    PLoS ONE 6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiATF3_MOUSE
AccessioniPrimary (citable) accession number: Q60765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3