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Q60765

- ATF3_MOUSE

UniProt

Q60765 - ATF3_MOUSE

Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. gluconeogenesis Source: MGI
    2. negative regulation of transcription, DNA-templated Source: MGI
    3. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. positive regulation of cell proliferation Source: Ensembl
    5. skeletal muscle cell differentiation Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_90370. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclic AMP-dependent transcription factor ATF-3
    Short name:
    cAMP-dependent transcription factor ATF-3
    Alternative name(s):
    Activating transcription factor 3
    Transcription factor LRG-21
    Gene namesi
    Name:Atf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109384. Atf3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Cyclic AMP-dependent transcription factor ATF-3PRO_0000076582Add
    BLAST

    Proteomic databases

    PRIDEiQ60765.

    PTM databases

    PhosphoSiteiQ60765.

    Expressioni

    Inductioni

    By stress.1 Publication

    Gene expression databases

    ArrayExpressiQ60765.
    BgeeiQ60765.
    CleanExiMM_ATF3.
    GenevestigatoriQ60765.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer or a heterodimer.

    Protein-protein interaction databases

    BioGridi198234. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60765.
    SMRiQ60765. Positions 87-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 14964bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni88 – 11023Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni114 – 14229Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. ATF subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242494.
    GeneTreeiENSGT00730000110847.
    HOGENOMiHOG000034126.
    HOVERGENiHBG003381.
    InParanoidiQ60765.
    KOiK09032.
    OMAiADISCSA.
    OrthoDBiEOG70S777.
    PhylomeDBiQ60765.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60765-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ    50
    NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA 100
    AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR 150
    PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S 181
    Length:181
    Mass (Da):20,722
    Last modified:November 1, 1996 - v1
    Checksum:iD641C8C6D14A457D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19118 mRNA. Translation: AAB48941.1.
    BC019946 mRNA. Translation: AAH19946.1.
    BC064799 mRNA. Translation: AAH64799.1.
    CCDSiCCDS15616.1.
    RefSeqiNP_031524.2. NM_007498.3.
    UniGeneiMm.2706.

    Genome annotation databases

    EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
    GeneIDi11910.
    KEGGimmu:11910.
    UCSCiuc007ece.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19118 mRNA. Translation: AAB48941.1 .
    BC019946 mRNA. Translation: AAH19946.1 .
    BC064799 mRNA. Translation: AAH64799.1 .
    CCDSi CCDS15616.1.
    RefSeqi NP_031524.2. NM_007498.3.
    UniGenei Mm.2706.

    3D structure databases

    ProteinModelPortali Q60765.
    SMRi Q60765. Positions 87-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198234. 5 interactions.

    PTM databases

    PhosphoSitei Q60765.

    Proteomic databases

    PRIDEi Q60765.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027941 ; ENSMUSP00000027941 ; ENSMUSG00000026628 .
    GeneIDi 11910.
    KEGGi mmu:11910.
    UCSCi uc007ece.1. mouse.

    Organism-specific databases

    CTDi 467.
    MGIi MGI:109384. Atf3.

    Phylogenomic databases

    eggNOGi NOG242494.
    GeneTreei ENSGT00730000110847.
    HOGENOMi HOG000034126.
    HOVERGENi HBG003381.
    InParanoidi Q60765.
    KOi K09032.
    OMAi ADISCSA.
    OrthoDBi EOG70S777.
    PhylomeDBi Q60765.
    TreeFami TF326301.

    Enzyme and pathway databases

    Reactomei REACT_90370. ATF4 activates genes.

    Miscellaneous databases

    NextBioi 279977.
    PROi Q60765.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60765.
    Bgeei Q60765.
    CleanExi MM_ATF3.
    Genevestigatori Q60765.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a lipopolysaccharide inducible transcription factor in murine macrophages."
      Drysdale B.E., Howard D.L., Johnson R.J.
      Mol. Immunol. 33:989-998(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Macrophage.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland and Osteoblast.
    3. "Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
      Alter J., Bengal E.
      PLoS ONE 6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiATF3_MOUSE
    AccessioniPrimary (citable) accession number: Q60765
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3