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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to amino acid starvation Source: ParkinsonsUK-UCL
  • endoplasmic reticulum unfolded protein response Source: ParkinsonsUK-UCL
  • gluconeogenesis Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: CACAO
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of TRAIL-activated apoptotic signaling pathway Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene namesi
Name:Atf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109384. Atf3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765821 – 181Cyclic AMP-dependent transcription factor ATF-3Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei162PhosphothreonineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ60765.
PaxDbiQ60765.
PRIDEiQ60765.

PTM databases

iPTMnetiQ60765.
PhosphoSitePlusiQ60765.

Expressioni

Inductioni

By stress.1 Publication

Gene expression databases

BgeeiENSMUSG00000026628.
CleanExiMM_ATF3.
ExpressionAtlasiQ60765. baseline and differential.
GenevisibleiQ60765. MM.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198234. 5 interactors.
STRINGi10090.ENSMUSP00000027941.

Structurei

3D structure databases

ProteinModelPortaliQ60765.
SMRiQ60765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 149bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 110Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni114 – 142Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ60765.
KOiK09032.
OMAiLVYMLNL.
OrthoDBiEOG091G0M4N.
PhylomeDBiQ60765.
TreeFamiTF326301.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR000837. AP-1.
IPR029812. ATF3.
IPR004827. bZIP.
IPR008917. TF_DNA-bd_sf.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF23. PTHR23351:SF23. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,722
Last modified:November 1, 1996 - v1
Checksum:iD641C8C6D14A457D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSiCCDS15616.1.
RefSeqiNP_031524.2. NM_007498.3.
UniGeneiMm.2706.

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
ENSMUST00000195117; ENSMUSP00000141492; ENSMUSG00000026628.
GeneIDi11910.
KEGGimmu:11910.
UCSCiuc007ece.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiATF3_MOUSE
AccessioniPrimary (citable) accession number: Q60765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families