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Q60765 (ATF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclic AMP-dependent transcription factor ATF-3

Short name=cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene names
Name:Atf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter By similarity.

Subunit structure

Binds DNA as a homodimer or a heterodimer.

Subcellular location

Nucleus.

Induction

By stress. Ref.3

Sequence similarities

Belongs to the bZIP family. ATF subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Cyclic AMP-dependent transcription factor ATF-3
PRO_0000076582

Regions

Domain86 – 14964bZIP
Region88 – 11023Basic motif By similarity
Region114 – 14229Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60765 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D641C8C6D14A457D

FASTA18120,722
        10         20         30         40         50         60 
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ NKHLCHRMSS 

        70         80         90        100        110        120 
ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA AKCRNKKKEK TECLQKESEK 

       130        140        150        160        170        180 
LESVNAELKA QIEELKNEKQ HLIYMLNLHR PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ 


S 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a lipopolysaccharide inducible transcription factor in murine macrophages."
Drysdale B.E., Howard D.L., Johnson R.J.
Mol. Immunol. 33:989-998(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Macrophage.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland and Osteoblast.
[3]"Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
Alter J., Bengal E.
PLoS ONE 6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSCCDS15616.1.
RefSeqNP_031524.2. NM_007498.3.
UniGeneMm.2706.

3D structure databases

ProteinModelPortalQ60765.
SMRQ60765. Positions 87-149.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198234. 5 interactions.

PTM databases

PhosphoSiteQ60765.

Proteomic databases

PRIDEQ60765.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
GeneID11910.
KEGGmmu:11910.
UCSCuc007ece.1. mouse.

Organism-specific databases

CTD467.
MGIMGI:109384. Atf3.

Phylogenomic databases

eggNOGNOG242494.
GeneTreeENSGT00730000110847.
HOGENOMHOG000034126.
HOVERGENHBG003381.
InParanoidQ60765.
KOK09032.
OMAADISCSA.
OrthoDBEOG70S777.
PhylomeDBQ60765.
TreeFamTF326301.

Gene expression databases

ArrayExpressQ60765.
BgeeQ60765.
CleanExMM_ATF3.
GenevestigatorQ60765.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279977.
PROQ60765.
SOURCESearch...

Entry information

Entry nameATF3_MOUSE
AccessionPrimary (citable) accession number: Q60765
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot