SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q60765

- ATF3_MOUSE

UniProt

Q60765 - ATF3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cyclic AMP-dependent transcription factor ATF-3
Gene
Atf3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter By similarity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. gluconeogenesis Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of cell proliferation Source: Ensembl
  4. skeletal muscle cell differentiation Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_90370. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene namesi
Name:Atf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:109384. Atf3.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Cyclic AMP-dependent transcription factor ATF-3
PRO_0000076582Add
BLAST

Proteomic databases

PRIDEiQ60765.

PTM databases

PhosphoSiteiQ60765.

Expressioni

Inductioni

By stress.1 Publication

Gene expression databases

ArrayExpressiQ60765.
BgeeiQ60765.
CleanExiMM_ATF3.
GenevestigatoriQ60765.

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.

Protein-protein interaction databases

BioGridi198234. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ60765.
SMRiQ60765. Positions 87-149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 14964bZIP
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni88 – 11023Basic motif By similarity
Add
BLAST
Regioni114 – 14229Leucine-zipper By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.

Phylogenomic databases

eggNOGiNOG242494.
GeneTreeiENSGT00730000110847.
HOGENOMiHOG000034126.
HOVERGENiHBG003381.
InParanoidiQ60765.
KOiK09032.
OMAiADISCSA.
OrthoDBiEOG70S777.
PhylomeDBiQ60765.
TreeFamiTF326301.

Family and domain databases

InterProiIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60765-1 [UniParc]FASTAAdd to Basket

« Hide

MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ    50
NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA 100
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR 150
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S 181
Length:181
Mass (Da):20,722
Last modified:November 1, 1996 - v1
Checksum:iD641C8C6D14A457D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19118 mRNA. Translation: AAB48941.1.
BC019946 mRNA. Translation: AAH19946.1.
BC064799 mRNA. Translation: AAH64799.1.
CCDSiCCDS15616.1.
RefSeqiNP_031524.2. NM_007498.3.
UniGeneiMm.2706.

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628.
GeneIDi11910.
KEGGimmu:11910.
UCSCiuc007ece.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19118 mRNA. Translation: AAB48941.1 .
BC019946 mRNA. Translation: AAH19946.1 .
BC064799 mRNA. Translation: AAH64799.1 .
CCDSi CCDS15616.1.
RefSeqi NP_031524.2. NM_007498.3.
UniGenei Mm.2706.

3D structure databases

ProteinModelPortali Q60765.
SMRi Q60765. Positions 87-149.
ModBasei Search...

Protein-protein interaction databases

BioGridi 198234. 5 interactions.

PTM databases

PhosphoSitei Q60765.

Proteomic databases

PRIDEi Q60765.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027941 ; ENSMUSP00000027941 ; ENSMUSG00000026628 .
GeneIDi 11910.
KEGGi mmu:11910.
UCSCi uc007ece.1. mouse.

Organism-specific databases

CTDi 467.
MGIi MGI:109384. Atf3.

Phylogenomic databases

eggNOGi NOG242494.
GeneTreei ENSGT00730000110847.
HOGENOMi HOG000034126.
HOVERGENi HBG003381.
InParanoidi Q60765.
KOi K09032.
OMAi ADISCSA.
OrthoDBi EOG70S777.
PhylomeDBi Q60765.
TreeFami TF326301.

Enzyme and pathway databases

Reactomei REACT_90370. ATF4 activates genes.

Miscellaneous databases

NextBioi 279977.
PROi Q60765.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60765.
Bgeei Q60765.
CleanExi MM_ATF3.
Genevestigatori Q60765.

Family and domain databases

InterProi IPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a lipopolysaccharide inducible transcription factor in murine macrophages."
    Drysdale B.E., Howard D.L., Johnson R.J.
    Mol. Immunol. 33:989-998(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Macrophage.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland and Osteoblast.
  3. "Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
    Alter J., Bengal E.
    PLoS ONE 6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiATF3_MOUSE
AccessioniPrimary (citable) accession number: Q60765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi