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Reviewed, UniProtKB/Swiss-Prot Q60759 (GCDH_MOUSE)

Last modified January 19, 2010. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7
Gene names
Name: Gcdh
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.

Catalytic activity

Glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.

Cofactor

FAD.

Pathway

Amino-acid metabolism; lysine degradation.

Amino-acid metabolism; tryptophan metabolism.

Subunit structure

Homotetramer.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial inner membrane

Inferred from direct assay. Source: MGI

mitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

glutaryl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4444Mitochondrion Potential
Chain45 – 438394Glutaryl-CoA dehydrogenase, mitochondrial
PRO_0000000528

Regions

Nucleotide binding177 – 18610FAD By similarity
Nucleotide binding177 – 1804FAD By similarity
Nucleotide binding212 – 2143FAD By similarity
Nucleotide binding387 – 3915FAD By similarity
Nucleotide binding416 – 4183FAD By similarity
Region138 – 1392Substrate binding By similarity
Region287 – 2948Substrate binding By similarity

Sites

Active site4141Proton acceptor By similarity
Binding site1861FAD By similarity
Binding site1861Substrate; via carbonyl oxygen By similarity
Binding site2941Substrate By similarity
Binding site3191FAD By similarity
Binding site3301FAD By similarity
Binding site4151Substrate; via amide nitrogen By similarity
Binding site4161FAD By similarity
Binding site4341FAD; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q60759-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B91D78319067753E

FASTA43848,647
        10         20         30         40         50         60 
MSLRGVSAQL LSRRSGLRFP RFPRTWSSAA AHTEKTQIRP AKSSRPVFDW KDPLILEEQL 

        70         80         90        100        110        120 
TADEKLIRDT FRNYWQERLM SQILLANRNE VFHRDIVYEM GELGVLGPTI KGYGCAGVSS 

       130        140        150        160        170        180 
VAYGLLTREL ERVDSGYRSM MSVQSSLVMH PIYTYGSEEQ RQKYLPRLAK GELLGCFGLT 

       190        200        210        220        230        240 
EPNHGSDPGG METRARHNPS NQSYTLSGTK TWITNSPVAD LFIVWARCED NCIPGFILEK 

       250        260        270        280        290        300 
GMRGSSAPRI EGKFSLRASA TGMIIMDSVE VPEENVLPNV SSLAGPFGCL NTARYGITWG 

       310        320        330        340        350        360 
VLGAAEFCLH TARQYALDRI QFGVPLARNQ LVQKKLADML TEITLGLHAC LQLGRLKDQD 

       370        380        390        400        410        420 
KATPEMVSML KRNNCGKALD IARQARDILG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 

       430 
ALILGRAITG IQAFTVGK

« Hide

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References

[1]"Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene."
Koeller D.M., Digiulio K.A., Angeloni S.V., Dowler L.L., Frerman F.E., White R.A., Goodman S.I.
Genomics 28:508-512(1995) [PubMed: 7490088] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18992 mRNA. Translation: AAB04679.1.
IPIIPI00120233.
UniGeneMm.2475

3D structure databases

SMRQ60759. Positions 48-435.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ60759.

Proteomic databases

PRIDEQ60759.

Genome annotation databases

EnsemblENSMUST00000003907; ENSMUSP00000003907; ENSMUSG00000003809; Mus musculus. [Genome view]
ENSMUST00000109745; ENSMUSP00000105367; ENSMUSG00000003809; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:104541. Gcdh.

Phylogenomic databases

eggNOGroNOG13883.
HOGENOMHBG699365.
HOVERGENQ60759.
InParanoidQ60759.

Enzyme and pathway databases

BRENDA1.3.99.7. 244.

Gene expression databases

ArrayExpressQ60759.
BgeeQ60759.
CleanExMM_GCDH.
GenevestigatorQ60759.
GermOnlineENSMUSG00000003809. Mus musculus.

Family and domain databases

InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
PROSITEPS00072. ACYL_COA_DH_1. False negative.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameGCDH_MOUSE
AccessionPrimary (citable) accession number: Q60759
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents