Reviewed, UniProtKB/Swiss-Prot Q60759 (GCDH_MOUSE)

Names and origin

Protein names

Recommended name:
    Glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7

Gene names

Name:

Gcdh

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.
Catalytic activity	Glutaryl-CoA + acceptor = crotonoyl-CoA + CO(2) + reduced acceptor.
Cofactor	FAD.
Pathway	Amino-acid metabolism; lysine degradation. Amino-acid metabolism; tryptophan metabolism.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial inner membrane Inferred from direct assay. Source: MGI mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro glutaryl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 44	44	Mitochondrion Potential
	Chain	45 – 438	394	Glutaryl-CoA dehydrogenase, mitochondrial		PRO_0000000528
Sites
	Active site	414	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q60759-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B91D78319067753E	FASTA	438	48,647
	10 20 30 40 50 60 MSLRGVSAQL LSRRSGLRFP RFPRTWSSAA AHTEKTQIRP AKSSRPVFDW KDPLILEEQL 70 80 90 100 110 120 TADEKLIRDT FRNYWQERLM SQILLANRNE VFHRDIVYEM GELGVLGPTI KGYGCAGVSS 130 140 150 160 170 180 VAYGLLTREL ERVDSGYRSM MSVQSSLVMH PIYTYGSEEQ RQKYLPRLAK GELLGCFGLT 190 200 210 220 230 240 EPNHGSDPGG METRARHNPS NQSYTLSGTK TWITNSPVAD LFIVWARCED NCIPGFILEK 250 260 270 280 290 300 GMRGSSAPRI EGKFSLRASA TGMIIMDSVE VPEENVLPNV SSLAGPFGCL NTARYGITWG 310 320 330 340 350 360 VLGAAEFCLH TARQYALDRI QFGVPLARNQ LVQKKLADML TEITLGLHAC LQLGRLKDQD 370 380 390 400 410 420 KATPEMVSML KRNNCGKALD IARQARDILG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 430 ALILGRAITG IQAFTVGK

References

[1]	"Cloning, structure, and chromosome localization of the mouse glutaryl-CoA dehydrogenase gene." Koeller D.M., Digiulio K.A., Angeloni S.V., Dowler L.L., Frerman F.E., White R.A., Goodman S.I. Genomics 28:508-512(1995) [PubMed: 7490088] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18992 mRNA. Translation: AAB04679.1.
UniGene	Mm.2475
3D structure databases
HSSP	HSSP built from PDB template 1BUC based on UniProtKB Q06319.
SMR	Q60759. Positions 48-435.
ModBase	Search...
PTM databases
PhosphoSite	Q60759.
Genome annotation databases
Ensembl	ENSMUSG00000003809. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:104541. Gcdh.
Phylogenomic databases
HOGENOM	Q60759.
HOVERGEN	Q60759.
Gene expression databases
ArrayExpress	Q60759.
CleanEx	MM_GCDH.
GermOnline	ENSMUSG00000003809. Mus musculus.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_DHase/Oxase_M. IPR006089. Acyl-CoA_DHase_CS. IPR006092. Acyl-CoA_DHase_N. IPR006090. Acyl-CoA_Oxase/DHase_1. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. False negative. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

GCDH_MOUSE

Accession

Primary (citable) accession number: Q60759

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)