Transcription factor 15 - Mus musculus (Mouse)

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Reviewed, UniProtKB/Swiss-Prot Q60756 (TCF15_MOUSE)

Last modified June 16, 2009. Version 67. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Transcription factor 15
Alternative name(s):
    bHLH-EC2 protein
    Paraxis
    Meso1

Gene names

Name:	Tcf15
Synonyms:	Bhlhec2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in heart and skeletal muscle.
Developmental stage	At 7.5 dpc, low expression is detected in a subdomain of the primitive mesoderm. At 8.5 dpc, expressed at high levels throughout the uncompartmentalized epithelial somites and in the rostral paraxial mesoderm. By 9.5 dpc, expression is confined to the somite and is most prominent in the myotome and dermatome. At 10 dpc, expression in somite declines in the myotome but persists at high level in the dermatome. At 10.5 dpc, expression is seen only in the somites in the caudal portion of the embryo.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

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Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	death Inferred from mutant phenotype. Source: MGI ear development Inferred from mutant phenotype. Source: MGI eating behavior Inferred from mutant phenotype. Source: MGI muscle organ morphogenesis Inferred from mutant phenotype. Source: MGI neuromuscular process controlling posture Inferred from mutant phenotype. Source: MGI paraxial mesoderm development Inferred from mutant phenotype. Source: MGI regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW respiratory system process Inferred from mutant phenotype. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype. Source: MGI skin development Inferred from mutant phenotype. Source: MGI somitogenesis Inferred from mutant phenotype. Source: MGI tail morphogenesis Inferred from mutant phenotype. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW transcription regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 195

195

Transcription factor 15

PRO_0000127462

Regions

Domain

83 – 123

Helix-loop-helix motif

DNA binding

70 – 82

Basic motif

Compositional bias

50 – 64

Gly-rich

Experimental info

Sequence conflict

130 – 131

DA → ELT in AAA86825. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q60756-1 [UniParc].

Last modified November 25, 2002. Version 2.
Checksum: F659B94C5F125E56
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FASTA

195

20,721

        10         20         30         40         50         60 
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGLEAARRG PGPGSGRRAS 

        70         80         90        100        110        120 
NGAGPVVVVR QRQAANARER DRTQSVNTAF TALRTLIPTE PVDRKLSKIE TLRLASSYIA 

       130        140        150        160        170        180 
HLANVLLLGD AADDGQPCFR AAGGGKSAVP AADGRQPRSI CTFCLSNQRK GGSRRDLGGS 

       190 
CLKVRGVAPL RGPRR

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites." Burgess R., Cserjesi P., Ligon K.L., Olson E.N. Dev. Biol. 168:296-306(1995) [PubMed: 7729571] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NIH Swiss. Tissue: Embryo.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2." Hidai H., Quertermous E.E., Espinosa R., Le Beau M.M., Quertermous T. Genomics 30:598-601(1995) [PubMed: 8825648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35. Strain: 129/SvJ.
[4]	"Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development." Blanar M.A., Crossley P.H., Peters K.G., Steingrimsson E., Copeland N.G., Jenkins N.A., Martin G.R., Rutter W.J. Proc. Natl. Acad. Sci. U.S.A. 92:5870-5874(1995) [PubMed: 7597044] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites." Quertermous E.E., Hidai H., Blanar M.A., Quertermous T. Proc. Natl. Acad. Sci. U.S.A. 91:7066-7070(1994) [PubMed: 8041747] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U18658 mRNA. Translation: AAA86825.1. BC027533 mRNA. Translation: AAH27533.1. U20164 Genomic DNA. Translation: AAB48215.1.
IPI	IPI00222980.
RefSeq	NP_033354.2.
UniGene	Mm.3881
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000068079. Mus musculus. [Contig view]
GeneID	21407.
KEGG	mmu:21407.
Organism-specific databases
MGI	MGI:104664. Tcf15.
Phylogenomic databases
HOGENOM	Q60756.
HOVERGEN	Q60756.
OMA	Q60756. DGRQPRS.
Gene expression databases
ArrayExpress	Q60756.
Bgee	Q60756.
CleanEx	MM_TCF15.
GermOnline	ENSMUSG00000068079. Mus musculus.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	300680.
SOURCE	Search...

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Entry information

Entry name

TCF15_MOUSE

Accession

Primary (citable) accession number: Q60756
Secondary accession number(s): Q60788

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents