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Q60755 (CALCR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcitonin receptor

Short name=CT-R
Gene names
Name:Calcr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Subunit structure

Interacts with GPRASP2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence caution

The sequence AAA69521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q60755-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q60755-2)

The sequence of this isoform differs from the canonical sequence as follows:
     234-270: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4141 Potential
Chain42 – 533492Calcitonin receptor
PRO_0000012807

Regions

Topological domain42 – 170129Extracellular Potential
Transmembrane171 – 19020Helical; Name=1; Potential
Topological domain191 – 1977Cytoplasmic Potential
Transmembrane198 – 21720Helical; Name=2; Potential
Topological domain218 – 27457Extracellular Potential
Transmembrane275 – 29723Helical; Name=3; Potential
Topological domain298 – 31417Cytoplasmic Potential
Transmembrane315 – 33420Helical; Name=4; Potential
Topological domain335 – 35016Extracellular Potential
Transmembrane351 – 37424Helical; Name=5; Potential
Topological domain375 – 39723Cytoplasmic Potential
Transmembrane398 – 41518Helical; Name=6; Potential
Topological domain416 – 42712Extracellular Potential
Transmembrane428 – 44922Helical; Name=7; Potential
Topological domain450 – 53384Cytoplasmic Potential

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Disulfide bond72 ↔ 98 By similarity
Disulfide bond89 ↔ 129 By similarity
Disulfide bond112 ↔ 151 By similarity

Natural variations

Alternative sequence234 – 27037Missing in isoform 2.
VSP_053294

Experimental info

Sequence conflict2571S → C in AAA69521. Ref.1
Sequence conflict4731Missing in AAA69521. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: 2598AF1EC7AA570B

FASTA53362,469
        10         20         30         40         50         60 
MTPRRSRVKR RNLRKPKMRF LLVNRFTLLL LLLVSPTPVL QAPTNLTDSG LDQEPFLYLV 

        70         80         90        100        110        120 
GRKKLLDAQY KCYDRIHQLP SYEGEGLYCN RTWDGWMCWD DTPAGATAYQ HCPDYFPDFD 

       130        140        150        160        170        180 
TAEKVSKYCD ENGEWFRHPD SNRTWSNYTL CNAFTSEKLQ NAYVLYYLAL VGHSLSIAAL 

       190        200        210        220        230        240 
VASMLIFWIF KNLSCQRVTL HKHMFLTYIL NSIIIIIHLV EVVPNGDLVR RDPMHIFHHN 

       250        260        270        280        290        300 
THMWTMQWEL SPPLPLSAHE GKMDPHASEV ISCKVLHFLH QYMMSCNYFW MLCEGIYLHT 

       310        320        330        340        350        360 
LIVMAVFTDE QRLRWYYLLG WGFPIVPTII HAITRALYYN DNCWLSAETH LLYIIHGPVM 

       370        380        390        400        410        420 
VALVVNFFFL LNIVRVLVTK MRQTHEAESY MYLKAVKATM VLVPLLGIQF VVFPWRPSNK 

       430        440        450        460        470        480 
VLGKIYDYLM HSLIHFQGFF VATIYCFCNH EVQVTLKRQW TQFKIQWSQR WGRRRRPTNR 

       490        500        510        520        530 
VVSAPRAVAF AEPDGLPIYI CHQEPRNPPI SNNEGEESTE MIPMNVIQQD ASA 

« Hide

Isoform 2 [UniParc].

Checksum: 33CC7381BC9C4A15
Show »

FASTA49658,126

References

« Hide 'large scale' references
[1]"Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene."
Yamin M., Gorn A.H., Flannery M.R., Jenkins N.A., Gilbert D.J., Copeland N.G., Tapp D.R., Krane S.M., Goldring S.R.
Endocrinology 135:2635-2643(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: BALB/c.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Diencephalon and Hypothalamus.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18542 mRNA. Translation: AAA69521.1. Different initiation.
AK039161 mRNA. Translation: BAC30261.1.
AK162391 mRNA. Translation: BAE36888.1.
AK133983 mRNA. Translation: BAE21967.1.
AK138275 mRNA. Translation: BAE23606.1.
AC066688 Genomic DNA. No translation available.
AC161368 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13991.1.
CH466533 Genomic DNA. Translation: EDL13992.1.
BC119232 mRNA. Translation: AAI19233.1.
BC119272 mRNA. Translation: AAI19273.1.
CCDSCCDS39416.1. [Q60755-2]
CCDS39417.1. [Q60755-1]
PIRI49154.
RefSeqNP_001036190.1. NM_001042725.1. [Q60755-2]
NP_031614.2. NM_007588.2. [Q60755-1]
XP_006505035.1. XM_006504972.1. [Q60755-1]
XP_006505036.1. XM_006504973.1. [Q60755-2]
UniGeneMm.4642.

3D structure databases

ProteinModelPortalQ60755.
SMRQ60755. Positions 60-152, 162-453.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY43.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ60755.

Proteomic databases

PRIDEQ60755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
GeneID12311.
KEGGmmu:12311.
UCSCuc009ave.1. mouse.
uc009avf.1. mouse.

Organism-specific databases

CTD799.
MGIMGI:101950. Calcr.

Phylogenomic databases

eggNOGNOG255868.
GeneTreeENSGT00750000117654.
HOVERGENHBG102129.
InParanoidQ60755.
KOK04576.
OMATHEAESY.
PhylomeDBQ60755.
TreeFamTF315710.

Gene expression databases

CleanExMM_CALCR.
GenevestigatorQ60755.

Family and domain databases

InterProIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280862.
PROQ60755.
SOURCESearch...

Entry information

Entry nameCALCR_MOUSE
AccessionPrimary (citable) accession number: Q60755
Secondary accession number(s): F6X7J4, Q3UUL9, Q8CAB0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries