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Q60755

- CALCR_MOUSE

UniProt

Q60755 - CALCR_MOUSE

Protein

Calcitonin receptor

Gene

Calcr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

    GO - Molecular functioni

    1. calcitonin receptor activity Source: MGI

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    2. negative regulation of ossification Source: MGI
    3. osteoclast differentiation Source: MGI
    4. positive regulation of cytosolic calcium ion concentration Source: MGI
    5. regulation of mRNA stability Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin receptor
    Short name:
    CT-R
    Gene namesi
    Name:Calcr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:101950. Calcr.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: MGI
    2. cilium Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4141Sequence AnalysisAdd
    BLAST
    Chaini42 – 533492Calcitonin receptorPRO_0000012807Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi72 ↔ 98By similarity
    Disulfide bondi89 ↔ 129By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 151By similarity
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60755.

    PTM databases

    PhosphoSiteiQ60755.

    Expressioni

    Gene expression databases

    CleanExiMM_CALCR.
    GenevestigatoriQ60755.

    Interactioni

    Subunit structurei

    Interacts with GPRASP2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ60755.
    SMRiQ60755. Positions 60-152, 162-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini42 – 170129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini191 – 1977CytoplasmicSequence Analysis
    Topological domaini218 – 27457ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini335 – 35016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini375 – 39723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini416 – 42712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini450 – 53384CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei171 – 19020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33420Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei351 – 37424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41518Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei428 – 44922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255868.
    GeneTreeiENSGT00750000117654.
    HOVERGENiHBG102129.
    InParanoidiQ60755.
    KOiK04576.
    OMAiTHEAESY.
    PhylomeDBiQ60755.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q60755-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPRRSRVKR RNLRKPKMRF LLVNRFTLLL LLLVSPTPVL QAPTNLTDSG    50
    LDQEPFLYLV GRKKLLDAQY KCYDRIHQLP SYEGEGLYCN RTWDGWMCWD 100
    DTPAGATAYQ HCPDYFPDFD TAEKVSKYCD ENGEWFRHPD SNRTWSNYTL 150
    CNAFTSEKLQ NAYVLYYLAL VGHSLSIAAL VASMLIFWIF KNLSCQRVTL 200
    HKHMFLTYIL NSIIIIIHLV EVVPNGDLVR RDPMHIFHHN THMWTMQWEL 250
    SPPLPLSAHE GKMDPHASEV ISCKVLHFLH QYMMSCNYFW MLCEGIYLHT 300
    LIVMAVFTDE QRLRWYYLLG WGFPIVPTII HAITRALYYN DNCWLSAETH 350
    LLYIIHGPVM VALVVNFFFL LNIVRVLVTK MRQTHEAESY MYLKAVKATM 400
    VLVPLLGIQF VVFPWRPSNK VLGKIYDYLM HSLIHFQGFF VATIYCFCNH 450
    EVQVTLKRQW TQFKIQWSQR WGRRRRPTNR VVSAPRAVAF AEPDGLPIYI 500
    CHQEPRNPPI SNNEGEESTE MIPMNVIQQD ASA 533
    Length:533
    Mass (Da):62,469
    Last modified:October 16, 2013 - v2
    Checksum:i2598AF1EC7AA570B
    GO
    Isoform 2 (identifier: Q60755-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         234-270: Missing.

    Show »
    Length:496
    Mass (Da):58,126
    Checksum:i33CC7381BC9C4A15
    GO

    Sequence cautioni

    The sequence AAA69521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571S → C in AAA69521. (PubMed:7988453)Curated
    Sequence conflicti473 – 4731Missing in AAA69521. (PubMed:7988453)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei234 – 27037Missing in isoform 2. 1 PublicationVSP_053294Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18542 mRNA. Translation: AAA69521.1. Different initiation.
    AK039161 mRNA. Translation: BAC30261.1.
    AK162391 mRNA. Translation: BAE36888.1.
    AK133983 mRNA. Translation: BAE21967.1.
    AK138275 mRNA. Translation: BAE23606.1.
    AC066688 Genomic DNA. No translation available.
    AC161368 Genomic DNA. No translation available.
    CH466533 Genomic DNA. Translation: EDL13991.1.
    CH466533 Genomic DNA. Translation: EDL13992.1.
    BC119232 mRNA. Translation: AAI19233.1.
    BC119272 mRNA. Translation: AAI19273.1.
    CCDSiCCDS39416.1. [Q60755-2]
    CCDS39417.1. [Q60755-1]
    PIRiI49154.
    RefSeqiNP_001036190.1. NM_001042725.1. [Q60755-2]
    NP_031614.2. NM_007588.2. [Q60755-1]
    XP_006505035.1. XM_006504972.1. [Q60755-1]
    XP_006505036.1. XM_006504973.1. [Q60755-2]
    UniGeneiMm.4642.

    Genome annotation databases

    EnsembliENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
    ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
    ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
    ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
    ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
    GeneIDi12311.
    KEGGimmu:12311.
    UCSCiuc009ave.1. mouse.
    uc009avf.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U18542 mRNA. Translation: AAA69521.1 . Different initiation.
    AK039161 mRNA. Translation: BAC30261.1 .
    AK162391 mRNA. Translation: BAE36888.1 .
    AK133983 mRNA. Translation: BAE21967.1 .
    AK138275 mRNA. Translation: BAE23606.1 .
    AC066688 Genomic DNA. No translation available.
    AC161368 Genomic DNA. No translation available.
    CH466533 Genomic DNA. Translation: EDL13991.1 .
    CH466533 Genomic DNA. Translation: EDL13992.1 .
    BC119232 mRNA. Translation: AAI19233.1 .
    BC119272 mRNA. Translation: AAI19273.1 .
    CCDSi CCDS39416.1. [Q60755-2 ]
    CCDS39417.1. [Q60755-1 ]
    PIRi I49154.
    RefSeqi NP_001036190.1. NM_001042725.1. [Q60755-2 ]
    NP_031614.2. NM_007588.2. [Q60755-1 ]
    XP_006505035.1. XM_006504972.1. [Q60755-1 ]
    XP_006505036.1. XM_006504973.1. [Q60755-2 ]
    UniGenei Mm.4642.

    3D structure databases

    ProteinModelPortali Q60755.
    SMRi Q60755. Positions 60-152, 162-453.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 43.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q60755.

    Proteomic databases

    PRIDEi Q60755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075644 ; ENSMUSP00000075070 ; ENSMUSG00000023964 . [Q60755-1 ]
    ENSMUST00000115622 ; ENSMUSP00000111285 ; ENSMUSG00000023964 . [Q60755-2 ]
    ENSMUST00000168592 ; ENSMUSP00000130243 ; ENSMUSG00000023964 . [Q60755-2 ]
    ENSMUST00000170266 ; ENSMUSP00000132124 ; ENSMUSG00000023964 . [Q60755-1 ]
    ENSMUST00000171613 ; ENSMUSP00000130083 ; ENSMUSG00000023964 . [Q60755-2 ]
    GeneIDi 12311.
    KEGGi mmu:12311.
    UCSCi uc009ave.1. mouse.
    uc009avf.1. mouse.

    Organism-specific databases

    CTDi 799.
    MGIi MGI:101950. Calcr.

    Phylogenomic databases

    eggNOGi NOG255868.
    GeneTreei ENSGT00750000117654.
    HOVERGENi HBG102129.
    InParanoidi Q60755.
    KOi K04576.
    OMAi THEAESY.
    PhylomeDBi Q60755.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 280862.
    PROi Q60755.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CALCR.
    Genevestigatori Q60755.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene."
      Yamin M., Gorn A.H., Flannery M.R., Jenkins N.A., Gilbert D.J., Copeland N.G., Tapp D.R., Krane S.M., Goldring S.R.
      Endocrinology 135:2635-2643(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Diencephalon and Hypothalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCALCR_MOUSE
    AccessioniPrimary (citable) accession number: Q60755
    Secondary accession number(s): F6X7J4, Q3UUL9, Q8CAB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3