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Q60755 (CALCR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcitonin receptor
Short name=CT-R
Gene names
Name:Calcr
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Subunit structure

Interacts with GPRASP2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncalcitonin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 515491Calcitonin receptor
PRO_0000012807

Regions

Topological domain25 – 153129Extracellular Potential
Transmembrane154 – 17320Helical; Name=1; Potential
Topological domain174 – 1807Cytoplasmic Potential
Transmembrane181 – 20020Helical; Name=2; Potential
Topological domain201 – 25757Extracellular Potential
Transmembrane258 – 28023Helical; Name=3; Potential
Topological domain281 – 29717Cytoplasmic Potential
Transmembrane298 – 31720Helical; Name=4; Potential
Topological domain318 – 33316Extracellular Potential
Transmembrane334 – 35724Helical; Name=5; Potential
Topological domain358 – 38023Cytoplasmic Potential
Transmembrane381 – 39818Helical; Name=6; Potential
Topological domain399 – 41012Extracellular Potential
Transmembrane411 – 43222Helical; Name=7; Potential
Topological domain433 – 51583Cytoplasmic Potential

Amino acid modifications

Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Disulfide bond55 ↔ 81 By similarity
Disulfide bond72 ↔ 112 By similarity
Disulfide bond95 ↔ 134 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60755 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: ACB90D2DC3CF166F

FASTA51560,167
        10         20         30         40         50         60 
MRFLLVNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD AQYKCYDRIH 

        70         80         90        100        110        120 
QLPSYEGEGL YCNRTWDGWM CWDDTPAGAT AYQHCPDYFP DFDTAEKVSK YCDENGEWFR 

       130        140        150        160        170        180 
HPDSNRTWSN YTLCNAFTSE KLQNAYVLYY LALVGHSLSI AALVASMLIF WIFKNLSCQR 

       190        200        210        220        230        240 
VTLHKHMFLT YILNSIIIII HLVEVVPNGD LVRRDPMHIF HHNTHMWTMQ WELSPPLPLC 

       250        260        270        280        290        300 
AHEGKMDPHA SEVISCKVLH FLHQYMMSCN YFWMLCEGIY LHTLIVMAVF TDEQRLRWYY 

       310        320        330        340        350        360 
LLGWGFPIVP TIIHAITRAL YYNDNCWLSA ETHLLYIIHG PVMVALVVNF FFLLNIVRVL 

       370        380        390        400        410        420 
VTKMRQTHEA ESYMYLKAVK ATMVLVPLLG IQFVVFPWRP SNKVLGKIYD YLMHSLIHFQ 

       430        440        450        460        470        480 
GFFVATIYCF CNHEVQVTLK RQWTQFKIQW SQRWGRRRPT NRVVSAPRAV AFAEPDGLPI 

       490        500        510 
YICHQEPRNP PISNNEGEES TEMIPMNVIQ QDASA

« Hide

References

[1]"Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene."
Yamin M., Gorn A.H., Flannery M.R., Jenkins N.A., Gilbert D.J., Copeland N.G., Tapp D.R., Krane S.M., Goldring S.R.
Endocrinology 135:2635-2643(1994) [PubMed: 7988453] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18542 mRNA. Translation: AAA69521.1.
IPIIPI00310307.
PIRI49154.
UniGeneMm.4642.

3D structure databases

ProteinModelPortalQ60755.
SMRQ60755. Positions 43-135.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ60755.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ60755.

Proteomic databases

PRIDEQ60755.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:101950. Calcr.

Phylogenomic databases

eggNOGroNOG14395.
HOVERGENHBG102129.
InParanoidQ60755.

Gene expression databases

ArrayExpressQ60755.
BgeeQ60755.
CleanExMM_CALCR.
GenevestigatorQ60755.
GermOnlineENSMUSG00000023964. Mus musculus.

Family and domain databases

InterProIPR003287. GCPR_2_calcitonin_rcpt-like.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF67. Calctnin_rcpt. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameCALCR_MOUSE
AccessionPrimary (citable) accession number: Q60755
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 19, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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