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Protein

Calcitonin receptor

Gene

Calcr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  • calcitonin receptor activity Source: MGI
  • protein transporter activity Source: MGI
  • receptor activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:Calcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101950. Calcr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 170ExtracellularSequence analysisAdd BLAST129
Transmembranei171 – 190Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini191 – 197CytoplasmicSequence analysis7
Transmembranei198 – 217Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini218 – 274ExtracellularSequence analysisAdd BLAST57
Transmembranei275 – 297Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini298 – 314CytoplasmicSequence analysisAdd BLAST17
Transmembranei315 – 334Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini335 – 350ExtracellularSequence analysisAdd BLAST16
Transmembranei351 – 374Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini375 – 397CytoplasmicSequence analysisAdd BLAST23
Transmembranei398 – 415Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini416 – 427ExtracellularSequence analysisAdd BLAST12
Transmembranei428 – 449Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini450 – 533CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
  • cilium Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 41Sequence analysisAdd BLAST41
ChainiPRO_000001280742 – 533Calcitonin receptorAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi72 ↔ 98By similarity
Disulfide bondi89 ↔ 129By similarity
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 151By similarity
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi147N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60755.
PRIDEiQ60755.

PTM databases

iPTMnetiQ60755.
PhosphoSitePlusiQ60755.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023964.
CleanExiMM_CALCR.
GenevisibleiQ60755. MM.

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075070.

Structurei

3D structure databases

ProteinModelPortaliQ60755.
SMRiQ60755.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ60755.
KOiK04576.
OMAiIYCFCNN.
OrthoDBiEOG091G027C.
PhylomeDBiQ60755.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60755-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPRRSRVKR RNLRKPKMRF LLVNRFTLLL LLLVSPTPVL QAPTNLTDSG
60 70 80 90 100
LDQEPFLYLV GRKKLLDAQY KCYDRIHQLP SYEGEGLYCN RTWDGWMCWD
110 120 130 140 150
DTPAGATAYQ HCPDYFPDFD TAEKVSKYCD ENGEWFRHPD SNRTWSNYTL
160 170 180 190 200
CNAFTSEKLQ NAYVLYYLAL VGHSLSIAAL VASMLIFWIF KNLSCQRVTL
210 220 230 240 250
HKHMFLTYIL NSIIIIIHLV EVVPNGDLVR RDPMHIFHHN THMWTMQWEL
260 270 280 290 300
SPPLPLSAHE GKMDPHASEV ISCKVLHFLH QYMMSCNYFW MLCEGIYLHT
310 320 330 340 350
LIVMAVFTDE QRLRWYYLLG WGFPIVPTII HAITRALYYN DNCWLSAETH
360 370 380 390 400
LLYIIHGPVM VALVVNFFFL LNIVRVLVTK MRQTHEAESY MYLKAVKATM
410 420 430 440 450
VLVPLLGIQF VVFPWRPSNK VLGKIYDYLM HSLIHFQGFF VATIYCFCNH
460 470 480 490 500
EVQVTLKRQW TQFKIQWSQR WGRRRRPTNR VVSAPRAVAF AEPDGLPIYI
510 520 530
CHQEPRNPPI SNNEGEESTE MIPMNVIQQD ASA
Length:533
Mass (Da):62,469
Last modified:October 16, 2013 - v2
Checksum:i2598AF1EC7AA570B
GO
Isoform 2 (identifier: Q60755-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-270: Missing.

Show »
Length:496
Mass (Da):58,126
Checksum:i33CC7381BC9C4A15
GO

Sequence cautioni

The sequence AAA69521 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257S → C in AAA69521 (PubMed:7988453).Curated1
Sequence conflicti473Missing in AAA69521 (PubMed:7988453).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053294234 – 270Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18542 mRNA. Translation: AAA69521.1. Different initiation.
AK039161 mRNA. Translation: BAC30261.1.
AK162391 mRNA. Translation: BAE36888.1.
AK133983 mRNA. Translation: BAE21967.1.
AK138275 mRNA. Translation: BAE23606.1.
AC066688 Genomic DNA. No translation available.
AC161368 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13991.1.
CH466533 Genomic DNA. Translation: EDL13992.1.
BC119232 mRNA. Translation: AAI19233.1.
BC119272 mRNA. Translation: AAI19273.1.
CCDSiCCDS39416.1. [Q60755-2]
CCDS39417.1. [Q60755-1]
PIRiI49154.
RefSeqiNP_001036190.1. NM_001042725.1. [Q60755-2]
NP_031614.2. NM_007588.2. [Q60755-1]
XP_006505035.1. XM_006504972.1. [Q60755-1]
XP_006505036.1. XM_006504973.2. [Q60755-2]
UniGeneiMm.4642.

Genome annotation databases

EnsembliENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
GeneIDi12311.
KEGGimmu:12311.
UCSCiuc009ave.1. mouse. [Q60755-2]
uc009avf.1. mouse. [Q60755-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18542 mRNA. Translation: AAA69521.1. Different initiation.
AK039161 mRNA. Translation: BAC30261.1.
AK162391 mRNA. Translation: BAE36888.1.
AK133983 mRNA. Translation: BAE21967.1.
AK138275 mRNA. Translation: BAE23606.1.
AC066688 Genomic DNA. No translation available.
AC161368 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13991.1.
CH466533 Genomic DNA. Translation: EDL13992.1.
BC119232 mRNA. Translation: AAI19233.1.
BC119272 mRNA. Translation: AAI19273.1.
CCDSiCCDS39416.1. [Q60755-2]
CCDS39417.1. [Q60755-1]
PIRiI49154.
RefSeqiNP_001036190.1. NM_001042725.1. [Q60755-2]
NP_031614.2. NM_007588.2. [Q60755-1]
XP_006505035.1. XM_006504972.1. [Q60755-1]
XP_006505036.1. XM_006504973.2. [Q60755-2]
UniGeneiMm.4642.

3D structure databases

ProteinModelPortaliQ60755.
SMRiQ60755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075070.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ60755.
PhosphoSitePlusiQ60755.

Proteomic databases

PaxDbiQ60755.
PRIDEiQ60755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
GeneIDi12311.
KEGGimmu:12311.
UCSCiuc009ave.1. mouse. [Q60755-2]
uc009avf.1. mouse. [Q60755-1]

Organism-specific databases

CTDi799.
MGIiMGI:101950. Calcr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ60755.
KOiK04576.
OMAiIYCFCNN.
OrthoDBiEOG091G027C.
PhylomeDBiQ60755.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiQ60755.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023964.
CleanExiMM_CALCR.
GenevisibleiQ60755. MM.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALCR_MOUSE
AccessioniPrimary (citable) accession number: Q60755
Secondary accession number(s): F6X7J4, Q3UUL9, Q8CAB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.