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Protein

Calcitonin receptor

Gene

Calcr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Gene namesi
Name:Calcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:101950. Calcr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini42 – 170129ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 19020Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini191 – 1977CytoplasmicSequence Analysis
Transmembranei198 – 21720Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini218 – 27457ExtracellularSequence AnalysisAdd
BLAST
Transmembranei275 – 29723Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini298 – 31417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei315 – 33420Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini335 – 35016ExtracellularSequence AnalysisAdd
BLAST
Transmembranei351 – 37424Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini375 – 39723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei398 – 41518Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini416 – 42712ExtracellularSequence AnalysisAdd
BLAST
Transmembranei428 – 44922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini450 – 53384CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • acrosomal vesicle Source: MGI
  • axon Source: Ensembl
  • cilium Source: MGI
  • cytosol Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4141Sequence AnalysisAdd
BLAST
Chaini42 – 533492Calcitonin receptorPRO_0000012807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi72 ↔ 98By similarity
Disulfide bondi89 ↔ 129By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 151By similarity
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60755.

PTM databases

PhosphoSiteiQ60755.

Expressioni

Gene expression databases

CleanExiMM_CALCR.
ExpressionAtlasiQ60755. baseline and differential.

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075070.

Structurei

3D structure databases

ProteinModelPortaliQ60755.
SMRiQ60755. Positions 60-152, 162-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ60755.
KOiK04576.
OMAiYTLCNAF.
PhylomeDBiQ60755.
TreeFamiTF315710.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q60755-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPRRSRVKR RNLRKPKMRF LLVNRFTLLL LLLVSPTPVL QAPTNLTDSG
60 70 80 90 100
LDQEPFLYLV GRKKLLDAQY KCYDRIHQLP SYEGEGLYCN RTWDGWMCWD
110 120 130 140 150
DTPAGATAYQ HCPDYFPDFD TAEKVSKYCD ENGEWFRHPD SNRTWSNYTL
160 170 180 190 200
CNAFTSEKLQ NAYVLYYLAL VGHSLSIAAL VASMLIFWIF KNLSCQRVTL
210 220 230 240 250
HKHMFLTYIL NSIIIIIHLV EVVPNGDLVR RDPMHIFHHN THMWTMQWEL
260 270 280 290 300
SPPLPLSAHE GKMDPHASEV ISCKVLHFLH QYMMSCNYFW MLCEGIYLHT
310 320 330 340 350
LIVMAVFTDE QRLRWYYLLG WGFPIVPTII HAITRALYYN DNCWLSAETH
360 370 380 390 400
LLYIIHGPVM VALVVNFFFL LNIVRVLVTK MRQTHEAESY MYLKAVKATM
410 420 430 440 450
VLVPLLGIQF VVFPWRPSNK VLGKIYDYLM HSLIHFQGFF VATIYCFCNH
460 470 480 490 500
EVQVTLKRQW TQFKIQWSQR WGRRRRPTNR VVSAPRAVAF AEPDGLPIYI
510 520 530
CHQEPRNPPI SNNEGEESTE MIPMNVIQQD ASA
Length:533
Mass (Da):62,469
Last modified:October 16, 2013 - v2
Checksum:i2598AF1EC7AA570B
GO
Isoform 2 (identifier: Q60755-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-270: Missing.

Show »
Length:496
Mass (Da):58,126
Checksum:i33CC7381BC9C4A15
GO

Sequence cautioni

The sequence AAA69521.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti257 – 2571S → C in AAA69521 (PubMed:7988453).Curated
Sequence conflicti473 – 4731Missing in AAA69521 (PubMed:7988453).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei234 – 27037Missing in isoform 2. 1 PublicationVSP_053294Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18542 mRNA. Translation: AAA69521.1. Different initiation.
AK039161 mRNA. Translation: BAC30261.1.
AK162391 mRNA. Translation: BAE36888.1.
AK133983 mRNA. Translation: BAE21967.1.
AK138275 mRNA. Translation: BAE23606.1.
AC066688 Genomic DNA. No translation available.
AC161368 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13991.1.
CH466533 Genomic DNA. Translation: EDL13992.1.
BC119232 mRNA. Translation: AAI19233.1.
BC119272 mRNA. Translation: AAI19273.1.
CCDSiCCDS39416.1. [Q60755-2]
CCDS39417.1. [Q60755-1]
PIRiI49154.
RefSeqiNP_001036190.1. NM_001042725.1. [Q60755-2]
NP_031614.2. NM_007588.2. [Q60755-1]
XP_006505035.1. XM_006504972.1. [Q60755-1]
XP_006505036.1. XM_006504973.2. [Q60755-2]
UniGeneiMm.4642.

Genome annotation databases

EnsembliENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
GeneIDi12311.
KEGGimmu:12311.
UCSCiuc009ave.1. mouse. [Q60755-2]
uc009avf.1. mouse. [Q60755-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18542 mRNA. Translation: AAA69521.1. Different initiation.
AK039161 mRNA. Translation: BAC30261.1.
AK162391 mRNA. Translation: BAE36888.1.
AK133983 mRNA. Translation: BAE21967.1.
AK138275 mRNA. Translation: BAE23606.1.
AC066688 Genomic DNA. No translation available.
AC161368 Genomic DNA. No translation available.
CH466533 Genomic DNA. Translation: EDL13991.1.
CH466533 Genomic DNA. Translation: EDL13992.1.
BC119232 mRNA. Translation: AAI19233.1.
BC119272 mRNA. Translation: AAI19273.1.
CCDSiCCDS39416.1. [Q60755-2]
CCDS39417.1. [Q60755-1]
PIRiI49154.
RefSeqiNP_001036190.1. NM_001042725.1. [Q60755-2]
NP_031614.2. NM_007588.2. [Q60755-1]
XP_006505035.1. XM_006504972.1. [Q60755-1]
XP_006505036.1. XM_006504973.2. [Q60755-2]
UniGeneiMm.4642.

3D structure databases

ProteinModelPortaliQ60755.
SMRiQ60755. Positions 60-152, 162-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075070.

Chemistry

GuidetoPHARMACOLOGYi43.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ60755.

Proteomic databases

PRIDEiQ60755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
GeneIDi12311.
KEGGimmu:12311.
UCSCiuc009ave.1. mouse. [Q60755-2]
uc009avf.1. mouse. [Q60755-1]

Organism-specific databases

CTDi799.
MGIiMGI:101950. Calcr.

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiQ60755.
KOiK04576.
OMAiYTLCNAF.
PhylomeDBiQ60755.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiREACT_301868. Calcitonin-like ligand receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi280862.
PROiQ60755.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CALCR.
ExpressionAtlasiQ60755. baseline and differential.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene."
    Yamin M., Gorn A.H., Flannery M.R., Jenkins N.A., Gilbert D.J., Copeland N.G., Tapp D.R., Krane S.M., Goldring S.R.
    Endocrinology 135:2635-2643(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Diencephalon and Hypothalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCALCR_MOUSE
AccessioniPrimary (citable) accession number: Q60755
Secondary accession number(s): F6X7J4, Q3UUL9, Q8CAB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: July 22, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.