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Protein

Macrophage receptor MARCO

Gene

Marco

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: MGI
  • endocytosis Source: MGI
  • innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_346699. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Gene namesi
Name:Marco
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1309998. Marco.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini70 – 518449ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Macrophage receptor MARCOPRO_0000181632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi446 ↔ 507PROSITE-ProRule annotation
Disulfide bondi459 ↔ 517PROSITE-ProRule annotation
Disulfide bondi487 ↔ 497PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60754.
PRIDEiQ60754.

PTM databases

PhosphoSiteiQ60754.

Expressioni

Tissue specificityi

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes.

Gene expression databases

BgeeiQ60754.
CleanExiMM_MARCO.
ExpressionAtlasiQ60754. baseline and differential.
GenevisibleiQ60754. MM.

Interactioni

Subunit structurei

Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.1 Publication

Protein-protein interaction databases

MINTiMINT-4997199.
STRINGi10090.ENSMUSP00000027639.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi422 – 43817Combined sources
Beta strandi441 – 4466Combined sources
Helixi452 – 46110Combined sources
Beta strandi465 – 4706Combined sources
Beta strandi480 – 4823Combined sources
Helixi494 – 4963Combined sources
Helixi509 – 5113Combined sources
Beta strandi514 – 5185Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OY3X-ray1.78A421-518[»]
2OYAX-ray1.77A/B421-518[»]
ProteinModelPortaliQ60754.
SMRiQ60754. Positions 421-518.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60754.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 418270Collagen-likeAdd
BLAST
Domaini423 – 51896SRCRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 collagen-like domain.Curated
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297041.
GeneTreeiENSGT00790000122993.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ60754.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG7HHWSF.
PhylomeDBiQ60754.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKELLKEE DFLGSTEDRA DFDQAMFPVM ETFEINDPVP KKRNGGTFCM
60 70 80 90 100
AVMAIHLILL TAGTALLLIQ VLNLQEQLQM LEMCCGNGSL AIEDKPFFSL
110 120 130 140 150
QWAPKTHLVP RAQGLQALQA QLSWVHTSQE QLRQQFNNLT QNPELFQIKG
160 170 180 190 200
ERGSPGPKGA PGAPGIPGLP GPAAEKGEKG AAGRDGTPGV QGPQGPPGSK
210 220 230 240 250
GEAGLQGLTG APGKQGATGA PGPRGEKGSK GDIGLTGPKG EHGTKGDKGD
260 270 280 290 300
LGLPGNKGDM GMKGDTGPMG SPGAQGGKGD AGKPGLPGLA GSPGVKGDQG
310 320 330 340 350
KPGVQGVPGP QGAPGLSGAK GEPGRTGLPG PAGPPGIAGN PGIAGVKGSK
360 370 380 390 400
GDTGIQGQKG TKGESGVPGL VGRKGDTGSP GLAGPKGEPG RVGQKGDPGM
410 420 430 440 450
KGSSGQQGQK GEKGQKGESF QRVRIMGGTN RGRAEVYYNN EWGTICDDDW
460 470 480 490 500
DNNDATVFCR MLGYSRGRAL SSYGGGSGNI WLDNVNCRGT ENSLWDCSKN
510
SWGNHNCVHN EDAGVECS
Length:518
Mass (Da):52,730
Last modified:November 1, 1996 - v1
Checksum:iB09E7601ECA23637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18424 mRNA. Translation: AAA68638.1.
AF128423
, AF127927, AF127928, AF128169, AF128170, AF128171, AF127601, AF127602, AF128419, AF128420, AF128421, AF128422 Genomic DNA. Translation: AAD51136.1.
CCDSiCCDS15234.1.
PIRiA55840.
RefSeqiNP_034896.1. NM_010766.2.
UniGeneiMm.1856.

Genome annotation databases

EnsembliENSMUST00000027639; ENSMUSP00000027639; ENSMUSG00000026390.
GeneIDi17167.
KEGGimmu:17167.
UCSCiuc007cjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18424 mRNA. Translation: AAA68638.1.
AF128423
, AF127927, AF127928, AF128169, AF128170, AF128171, AF127601, AF127602, AF128419, AF128420, AF128421, AF128422 Genomic DNA. Translation: AAD51136.1.
CCDSiCCDS15234.1.
PIRiA55840.
RefSeqiNP_034896.1. NM_010766.2.
UniGeneiMm.1856.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OY3X-ray1.78A421-518[»]
2OYAX-ray1.77A/B421-518[»]
ProteinModelPortaliQ60754.
SMRiQ60754. Positions 421-518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997199.
STRINGi10090.ENSMUSP00000027639.

PTM databases

PhosphoSiteiQ60754.

Proteomic databases

PaxDbiQ60754.
PRIDEiQ60754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027639; ENSMUSP00000027639; ENSMUSG00000026390.
GeneIDi17167.
KEGGimmu:17167.
UCSCiuc007cjl.1. mouse.

Organism-specific databases

CTDi8685.
MGIiMGI:1309998. Marco.

Phylogenomic databases

eggNOGiNOG297041.
GeneTreeiENSGT00790000122993.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ60754.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG7HHWSF.
PhylomeDBiQ60754.
TreeFamiTF330855.

Enzyme and pathway databases

ReactomeiREACT_346699. Scavenging by Class A Receptors.

Miscellaneous databases

EvolutionaryTraceiQ60754.
NextBioi291450.
PROiQ60754.
SOURCEiSearch...

Gene expression databases

BgeeiQ60754.
CleanExiMM_MARCO.
ExpressionAtlasiQ60754. baseline and differential.
GenevisibleiQ60754. MM.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages."
    Elomaa O., Kangas M., Sahlberg C., Tuukkanen J., Sormunen R., Liakka A., Thesleff I., Kraal G., Tryggvason K.
    Cell 80:603-609(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor."
    Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K.
    Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition."
    Ojala J.R., Pikkarainen T., Tuuttila A., Sandalova T., Tryggvason K.
    J. Biol. Chem. 282:16654-16666(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 421-518, SUBUNIT, DISULFIDE BONDS.

Entry informationi

Entry nameiMARCO_MOUSE
AccessioniPrimary (citable) accession number: Q60754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.