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Protein

Macrophage receptor MARCO

Gene

Marco

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

GO - Molecular functioni

GO - Biological processi

  • apoptotic cell clearance Source: MGI
  • endocytosis Source: MGI
  • innate immune response Source: UniProtKB-KW
  • receptor-mediated endocytosis Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-3000480. Scavenging by Class A Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Gene namesi
Name:Marco
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1309998. Marco.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
Transmembranei49 – 69Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini70 – 518ExtracellularSequence analysisAdd BLAST449

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001816321 – 518Macrophage receptor MARCOAdd BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Glycosylationi138N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi446 ↔ 507PROSITE-ProRule annotation
Disulfide bondi459 ↔ 517PROSITE-ProRule annotation
Disulfide bondi487 ↔ 497PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60754.
PRIDEiQ60754.

PTM databases

PhosphoSitePlusiQ60754.

Expressioni

Tissue specificityi

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes.

Gene expression databases

BgeeiENSMUSG00000026390.
CleanExiMM_MARCO.
ExpressionAtlasiQ60754. baseline and differential.
GenevisibleiQ60754. MM.

Interactioni

Subunit structurei

Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.1 Publication

Protein-protein interaction databases

MINTiMINT-4997199.
STRINGi10090.ENSMUSP00000027639.

Structurei

Secondary structure

1518
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi422 – 438Combined sources17
Beta strandi441 – 446Combined sources6
Helixi452 – 461Combined sources10
Beta strandi465 – 470Combined sources6
Beta strandi480 – 482Combined sources3
Helixi494 – 496Combined sources3
Helixi509 – 511Combined sources3
Beta strandi514 – 518Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OY3X-ray1.78A421-518[»]
2OYAX-ray1.77A/B421-518[»]
ProteinModelPortaliQ60754.
SMRiQ60754.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60754.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 418Collagen-likeAdd BLAST270
Domaini423 – 518SRCRPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 1 collagen-like domain.Curated
Contains 1 SRCR domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHK7. Eukaryota.
ENOG410YHJF. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ60754.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG091G02XD.
PhylomeDBiQ60754.
TreeFamiTF330855.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60754-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKELLKEE DFLGSTEDRA DFDQAMFPVM ETFEINDPVP KKRNGGTFCM
60 70 80 90 100
AVMAIHLILL TAGTALLLIQ VLNLQEQLQM LEMCCGNGSL AIEDKPFFSL
110 120 130 140 150
QWAPKTHLVP RAQGLQALQA QLSWVHTSQE QLRQQFNNLT QNPELFQIKG
160 170 180 190 200
ERGSPGPKGA PGAPGIPGLP GPAAEKGEKG AAGRDGTPGV QGPQGPPGSK
210 220 230 240 250
GEAGLQGLTG APGKQGATGA PGPRGEKGSK GDIGLTGPKG EHGTKGDKGD
260 270 280 290 300
LGLPGNKGDM GMKGDTGPMG SPGAQGGKGD AGKPGLPGLA GSPGVKGDQG
310 320 330 340 350
KPGVQGVPGP QGAPGLSGAK GEPGRTGLPG PAGPPGIAGN PGIAGVKGSK
360 370 380 390 400
GDTGIQGQKG TKGESGVPGL VGRKGDTGSP GLAGPKGEPG RVGQKGDPGM
410 420 430 440 450
KGSSGQQGQK GEKGQKGESF QRVRIMGGTN RGRAEVYYNN EWGTICDDDW
460 470 480 490 500
DNNDATVFCR MLGYSRGRAL SSYGGGSGNI WLDNVNCRGT ENSLWDCSKN
510
SWGNHNCVHN EDAGVECS
Length:518
Mass (Da):52,730
Last modified:November 1, 1996 - v1
Checksum:iB09E7601ECA23637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18424 mRNA. Translation: AAA68638.1.
AF128423
, AF127927, AF127928, AF128169, AF128170, AF128171, AF127601, AF127602, AF128419, AF128420, AF128421, AF128422 Genomic DNA. Translation: AAD51136.1.
CCDSiCCDS15234.1.
PIRiA55840.
RefSeqiNP_034896.1. NM_010766.2.
UniGeneiMm.1856.

Genome annotation databases

EnsembliENSMUST00000027639; ENSMUSP00000027639; ENSMUSG00000026390.
GeneIDi17167.
KEGGimmu:17167.
UCSCiuc007cjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18424 mRNA. Translation: AAA68638.1.
AF128423
, AF127927, AF127928, AF128169, AF128170, AF128171, AF127601, AF127602, AF128419, AF128420, AF128421, AF128422 Genomic DNA. Translation: AAD51136.1.
CCDSiCCDS15234.1.
PIRiA55840.
RefSeqiNP_034896.1. NM_010766.2.
UniGeneiMm.1856.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OY3X-ray1.78A421-518[»]
2OYAX-ray1.77A/B421-518[»]
ProteinModelPortaliQ60754.
SMRiQ60754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997199.
STRINGi10090.ENSMUSP00000027639.

PTM databases

PhosphoSitePlusiQ60754.

Proteomic databases

PaxDbiQ60754.
PRIDEiQ60754.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027639; ENSMUSP00000027639; ENSMUSG00000026390.
GeneIDi17167.
KEGGimmu:17167.
UCSCiuc007cjl.1. mouse.

Organism-specific databases

CTDi8685.
MGIiMGI:1309998. Marco.

Phylogenomic databases

eggNOGiENOG410IHK7. Eukaryota.
ENOG410YHJF. LUCA.
GeneTreeiENSGT00850000132310.
HOGENOMiHOG000085659.
HOVERGENiHBG004933.
InParanoidiQ60754.
KOiK13884.
OMAiSHNCNHN.
OrthoDBiEOG091G02XD.
PhylomeDBiQ60754.
TreeFamiTF330855.

Enzyme and pathway databases

ReactomeiR-MMU-3000480. Scavenging by Class A Receptors.

Miscellaneous databases

EvolutionaryTraceiQ60754.
PROiQ60754.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026390.
CleanExiMM_MARCO.
ExpressionAtlasiQ60754. baseline and differential.
GenevisibleiQ60754. MM.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 1 hit.
PROSITEiPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMARCO_MOUSE
AccessioniPrimary (citable) accession number: Q60754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.