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Q60754 (MARCO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Macrophage receptor MARCO
Alternative name(s):
Macrophage receptor with collagenous structure
Gene names
Name:Marco
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Subunit structure

Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands. Ref.3

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Tissue specificity

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes.

Sequence similarities

Contains 1 collagen-like domain.

Contains 1 SRCR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Macrophage receptor MARCO
PRO_0000181632

Regions

Topological domain1 – 4848Cytoplasmic Potential
Transmembrane49 – 6921Helical; Signal-anchor for type II membrane protein; Potential
Topological domain70 – 518449Extracellular Potential
Domain149 – 418270Collagen-like
Domain423 – 51896SRCR

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation1381N-linked (GlcNAc...) Potential
Disulfide bond446 ↔ 507 By similarity
Disulfide bond459 ↔ 517 By similarity
Disulfide bond487 ↔ 497 By similarity

Secondary structure

................ 518
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q60754 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B09E7601ECA23637

FASTA51852,730
        10         20         30         40         50         60 
MGSKELLKEE DFLGSTEDRA DFDQAMFPVM ETFEINDPVP KKRNGGTFCM AVMAIHLILL 

        70         80         90        100        110        120 
TAGTALLLIQ VLNLQEQLQM LEMCCGNGSL AIEDKPFFSL QWAPKTHLVP RAQGLQALQA 

       130        140        150        160        170        180 
QLSWVHTSQE QLRQQFNNLT QNPELFQIKG ERGSPGPKGA PGAPGIPGLP GPAAEKGEKG 

       190        200        210        220        230        240 
AAGRDGTPGV QGPQGPPGSK GEAGLQGLTG APGKQGATGA PGPRGEKGSK GDIGLTGPKG 

       250        260        270        280        290        300 
EHGTKGDKGD LGLPGNKGDM GMKGDTGPMG SPGAQGGKGD AGKPGLPGLA GSPGVKGDQG 

       310        320        330        340        350        360 
KPGVQGVPGP QGAPGLSGAK GEPGRTGLPG PAGPPGIAGN PGIAGVKGSK GDTGIQGQKG 

       370        380        390        400        410        420 
TKGESGVPGL VGRKGDTGSP GLAGPKGEPG RVGQKGDPGM KGSSGQQGQK GEKGQKGESF 

       430        440        450        460        470        480 
QRVRIMGGTN RGRAEVYYNN EWGTICDDDW DNNDATVFCR MLGYSRGRAL SSYGGGSGNI 

       490        500        510 
WLDNVNCRGT ENSLWDCSKN SWGNHNCVHN EDAGVECS 

« Hide

References

[1]"Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages."
Elomaa O., Kangas M., Sahlberg C., Tuukkanen J., Sormunen R., Liakka A., Thesleff I., Kraal G., Tryggvason K.
Cell 80:603-609(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor."
Kangas M., Brannstrom A., Elomaa O., Matsuda Y., Eddy R., Shows T.B., Tryggvason K.
Genomics 58:82-89(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Crystal structure of the cysteine-rich domain of scavenger receptor MARCO reveals the presence of a basic and an acidic cluster that both contribute to ligand recognition."
Ojala J.R., Pikkarainen T., Tuuttila A., Sandalova T., Tryggvason K.
J. Biol. Chem. 282:16654-16666(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 421-518, SUBUNIT, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18424 mRNA. Translation: AAA68638.1.
AF128423 expand/collapse EMBL AC list , AF127927, AF127928, AF128169, AF128170, AF128171, AF127601, AF127602, AF128419, AF128420, AF128421, AF128422 Genomic DNA. Translation: AAD51136.1.
PIRA55840.
RefSeqNP_034896.1. NM_010766.2.
UniGeneMm.1856.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2OY3X-ray1.78A421-518[»]
2OYAX-ray1.77A/B421-518[»]
ProteinModelPortalQ60754.
SMRQ60754. Positions 421-518.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997199.
STRING10090.ENSMUSP00000027639.

PTM databases

PhosphoSiteQ60754.

Proteomic databases

PaxDbQ60754.
PRIDEQ60754.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027639; ENSMUSP00000027639; ENSMUSG00000026390.
GeneID17167.
KEGGmmu:17167.
UCSCuc007cjl.1. mouse.

Organism-specific databases

CTD8685.
MGIMGI:1309998. Marco.

Phylogenomic databases

eggNOGNOG297041.
GeneTreeENSGT00640000091447.
HOGENOMHOG000085659.
HOVERGENHBG004933.
InParanoidQ60754.
KOK13884.
OMASHNCNHN.
OrthoDBEOG7HHWSF.
PhylomeDBQ60754.
TreeFamTF330855.

Enzyme and pathway databases

ReactomeREACT_196573. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

ArrayExpressQ60754.
BgeeQ60754.
CleanExMM_MARCO.
GenevestigatorQ60754.

Family and domain databases

Gene3D3.10.250.10. 1 hit.
InterProIPR008160. Collagen.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamPF01391. Collagen. 2 hits.
PF00530. SRCR. 1 hit.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
SMARTSM00202. SR. 1 hit.
[Graphical view]
SUPFAMSSF56487. SSF56487. 1 hit.
PROSITEPS00420. SRCR_1. 1 hit.
PS50287. SRCR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ60754.
NextBio291450.
PROQ60754.
SOURCESearch...

Entry information

Entry nameMARCO_MOUSE
AccessionPrimary (citable) accession number: Q60754
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot