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Protein

Cardiotrophin-1

Gene

Ctf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-1
Short name:
CT-1
Gene namesi
Name:Ctf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105115. Ctf1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Cardiotrophin-1PRO_0000058763Add
BLAST

Proteomic databases

MaxQBiQ60753.
PaxDbiQ60753.
PRIDEiQ60753.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Gene expression databases

BgeeiQ60753.
CleanExiMM_CTF1.
ExpressionAtlasiQ60753. baseline and differential.
GenevisibleiQ60753. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-5773N.
STRINGi10090.ENSMUSP00000049161.

Structurei

3D structure databases

ProteinModelPortaliQ60753.
SMRiQ60753. Positions 21-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IWMK. Eukaryota.
ENOG41119TK. LUCA.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ60753.
OMAiGLYREWV.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ60753.
TreeFamiTF333266.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ
60 70 80 90 100
QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL
110 120 130 140 150
LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP
160 170 180 190 200
GPEPVTVATL FTANSTAGIF SAKVLGFHVC GLYGEWVSRT EGDLGQLVPG

GVA
Length:203
Mass (Da):21,509
Last modified:November 1, 1996 - v1
Checksum:i8B3D414A0B3B232F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18366 mRNA. Translation: AAC52173.1.
BC024381 mRNA. Translation: AAH24381.1.
CCDSiCCDS21875.1.
PIRiI49153.
RefSeqiNP_031821.1. NM_007795.1.
UniGeneiMm.389954.

Genome annotation databases

EnsembliENSMUST00000047393; ENSMUSP00000049161; ENSMUSG00000042340.
GeneIDi13019.
UCSCiuc009jwm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18366 mRNA. Translation: AAC52173.1.
BC024381 mRNA. Translation: AAH24381.1.
CCDSiCCDS21875.1.
PIRiI49153.
RefSeqiNP_031821.1. NM_007795.1.
UniGeneiMm.389954.

3D structure databases

ProteinModelPortaliQ60753.
SMRiQ60753. Positions 21-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5773N.
STRINGi10090.ENSMUSP00000049161.

Proteomic databases

MaxQBiQ60753.
PaxDbiQ60753.
PRIDEiQ60753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047393; ENSMUSP00000049161; ENSMUSG00000042340.
GeneIDi13019.
UCSCiuc009jwm.2. mouse.

Organism-specific databases

CTDi1489.
MGIiMGI:105115. Ctf1.

Phylogenomic databases

eggNOGiENOG410IWMK. Eukaryota.
ENOG41119TK. LUCA.
GeneTreeiENSGT00510000049046.
HOGENOMiHOG000112040.
HOVERGENiHBG000455.
InParanoidiQ60753.
OMAiGLYREWV.
OrthoDBiEOG7VHSZW.
PhylomeDBiQ60753.
TreeFamiTF333266.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

PROiQ60753.
SOURCEiSearch...

Gene expression databases

BgeeiQ60753.
CleanExiMM_CTF1.
ExpressionAtlasiQ60753. baseline and differential.
GenevisibleiQ60753. MM.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010681. PRF.
[Graphical view]
PANTHERiPTHR21353. PTHR21353. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiCTF1_MOUSE
AccessioniPrimary (citable) accession number: Q60753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.