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Protein

Cardiotrophin-1

Gene

Ctf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotrophin-1
Short name:
CT-1
Gene namesi
Name:Ctf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105115 Ctf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000587631 – 203Cardiotrophin-1Add BLAST203

Proteomic databases

MaxQBiQ60753
PaxDbiQ60753
PRIDEiQ60753

PTM databases

PhosphoSitePlusiQ60753

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Gene expression databases

BgeeiENSMUSG00000042340
CleanExiMM_CTF1
ExpressionAtlasiQ60753 baseline and differential
GenevisibleiQ60753 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5773N
STRINGi10090.ENSMUSP00000049161

Structurei

3D structure databases

ProteinModelPortaliQ60753
SMRiQ60753
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Phylogenomic databases

eggNOGiENOG410IWMK Eukaryota
ENOG41119TK LUCA
GeneTreeiENSGT00510000049046
HOGENOMiHOG000112040
HOVERGENiHBG000455
InParanoidiQ60753
OMAiGLYREWV
OrthoDBiEOG091G0WXG
PhylomeDBiQ60753
TreeFamiTF333266

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010681 PRF/CT
PANTHERiPTHR21353 PTHR21353, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Q60753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ
60 70 80 90 100
QQGEPFGLPG FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL
110 120 130 140 150
LDAVRRRQAE LNPRAPRLLR SLEDAARQVR ALGAAVETVL AALGAAARGP
160 170 180 190 200
GPEPVTVATL FTANSTAGIF SAKVLGFHVC GLYGEWVSRT EGDLGQLVPG

GVA
Length:203
Mass (Da):21,509
Last modified:November 1, 1996 - v1
Checksum:i8B3D414A0B3B232F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18366 mRNA Translation: AAC52173.1
BC024381 mRNA Translation: AAH24381.1
CCDSiCCDS21875.1
PIRiI49153
RefSeqiNP_031821.1, NM_007795.1
UniGeneiMm.389954

Genome annotation databases

EnsembliENSMUST00000047393; ENSMUSP00000049161; ENSMUSG00000042340
GeneIDi13019
UCSCiuc009jwm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCTF1_MOUSE
AccessioniPrimary (citable) accession number: Q60753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health