Q60753 (CTF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cardiotrophin-1
Short name=CT-1

Gene names

Name:

Ctf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Subcellular location	Secreted.
Tissue specificity	Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.
Sequence similarities	Belongs to the IL-6 superfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	leukemia inhibitory factor signaling pathway Inferred from electronic annotation. Source: Compara neuron development Inferred from genetic interaction PubMed 15716414. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Cardiotrophin-1		PRO_0000058763

Sequences

	Sequence		Length	Mass (Da)
	Q60753 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 8B3D414A0B3B232F	FASTA	203	21,509
	10 20 30 40 50 60 MSQREGSLED HQTDSSISFL PHLEAKIRQT HNLARLLTKY AEQLLEEYVQ QQGEPFGLPG 70 80 90 100 110 120 FSPPRLPLAG LSGPAPSHAG LPVSERLRQD AAALSVLPAL LDAVRRRQAE LNPRAPRLLR 130 140 150 160 170 180 SLEDAARQVR ALGAAVETVL AALGAAARGP GPEPVTVATL FTANSTAGIF SAKVLGFHVC 190 200 GLYGEWVSRT EGDLGQLVPG GVA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy." Pennica D., King K.L., Shaw K.J., Luis E., Rullamas J., Luoh S.-M., Darbonne W.C., Knutzon D.S., Yen R., Chien K.R., Baker J.B., Wood W.I. Proc. Natl. Acad. Sci. U.S.A. 92:1142-1146(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18366 mRNA. Translation: AAC52173.1. BC024381 mRNA. Translation: AAH24381.1.
IPI	IPI00120226.
PIR	I49153.
RefSeq	NP_031821.1. NM_007795.1.
UniGene	Mm.389954.
3D structure databases
ProteinModelPortal	Q60753.
SMR	Q60753. Positions 27-194.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5773N.
Proteomic databases
PaxDb	Q60753.
PRIDE	Q60753.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000047393; ENSMUSP00000049161; ENSMUSG00000042340.
GeneID	13019.
KEGG	mmu:13019.
Organism-specific databases
CTD	1489.
MGI	MGI:105115. Ctf1.
Phylogenomic databases
eggNOG	NOG44809.
GeneTree	ENSGT00510000049046.
HOGENOM	HOG000112040.
HOVERGEN	HBG000455.
InParanoid	Q60753.
KO	K05422.
OMA	REWVSRT.
OrthoDB	EOG4QC16M.
Gene expression databases
ArrayExpress	Q60753.
Bgee	Q60753.
CleanEx	MM_CTF1.
Genevestigator	Q60753.
GermOnline	ENSMUSG00000042340. Mus musculus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR010681. PRF. [Graphical view]
PANTHER	PTHR21353. PTHR21353. 1 hit.
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	282884.
SOURCE	Search...

Entry information

Entry name

CTF1_MOUSE

Accession

Primary (citable) accession number: Q60753

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program