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Q60738

- ZNT1_MOUSE

UniProt

Q60738 - ZNT1_MOUSE

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Protein

Zinc transporter 1

Gene

Slc30a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

GO - Molecular functioni

  1. calcium channel inhibitor activity Source: BHF-UCL
  2. zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. cadmium ion transmembrane transport Source: Ensembl
  2. calcium ion import Source: Ensembl
  3. cellular calcium ion homeostasis Source: BHF-UCL
  4. cellular zinc ion homeostasis Source: BHF-UCL
  5. detoxification of cadmium ion Source: Ensembl
  6. in utero embryonic development Source: MGI
  7. negative regulation of calcium ion import Source: BHF-UCL
  8. negative regulation of neurotransmitter secretion Source: Ensembl
  9. negative regulation of zinc ion transmembrane import Source: BHF-UCL
  10. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:Slc30a1
Synonyms:Znt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1345281. Slc30a1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. Golgi apparatus Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. nuclear membrane Source: Ensembl
  5. plasma membrane Source: MGI
  6. T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Zinc transporter 1PRO_0000206092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Modified residuei502 – 5021Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ60738.
PaxDbiQ60738.
PRIDEiQ60738.

PTM databases

PhosphoSiteiQ60738.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ60738.
ExpressionAtlasiQ60738. baseline and differential.
GenevestigatoriQ60738.

Interactioni

Subunit structurei

Multimer.Curated

Protein-protein interaction databases

IntActiQ60738. 1 interaction.
MINTiMINT-4140673.

Structurei

3D structure databases

ProteinModelPortaliQ60738.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 354ExtracellularSequence Analysis
Topological domaini57 – 7822CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
BLAST
Topological domaini135 – 243109CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini265 – 30339ExtracellularSequence AnalysisAdd
BLAST
Topological domaini325 – 503179CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 156126 X 2 AA approximate repeats of H-GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ60738.
KOiK14688.
OMAiRACLLEC.
OrthoDBiEOG7034GQ.
PhylomeDBiQ60738.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA
60 70 80 90 100
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA
110 120 130 140 150
VERFIEPHEM QQPLVVLSVG VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH
160 170 180 190 200
GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD QEETNTLVAN TSNSNGLKAD
210 220 230 240 250
QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM RGVFLHVLGD
260 270 280 290 300
ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM
310 320 330 340 350
RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH
360 370 380 390 400
LVKELRDVDG VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD
410 420 430 440 450
VFHNHGIHAT TIQPEFASVG SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS
460 470 480 490 500
GKDAEKAPTV SISCLELSEN LEKKARRTKA EGSLPAVVIE IKNVPNKQPE

SSL
Length:503
Mass (Da):54,716
Last modified:November 1, 1996 - v1
Checksum:i7C4FF93FC13CDA22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1.
BC052166 mRNA. Translation: AAH52166.1.
CCDSiCCDS15625.1.
PIRiS54302.
RefSeqiNP_033605.1. NM_009579.3.
UniGeneiMm.9024.

Genome annotation databases

EnsembliENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneIDi22782.
KEGGimmu:22782.
UCSCiuc007edc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1 .
BC052166 mRNA. Translation: AAH52166.1 .
CCDSi CCDS15625.1.
PIRi S54302.
RefSeqi NP_033605.1. NM_009579.3.
UniGenei Mm.9024.

3D structure databases

ProteinModelPortali Q60738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60738. 1 interaction.
MINTi MINT-4140673.

PTM databases

PhosphoSitei Q60738.

Proteomic databases

MaxQBi Q60738.
PaxDbi Q60738.
PRIDEi Q60738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044954 ; ENSMUSP00000042410 ; ENSMUSG00000037434 .
GeneIDi 22782.
KEGGi mmu:22782.
UCSCi uc007edc.1. mouse.

Organism-specific databases

CTDi 7779.
MGIi MGI:1345281. Slc30a1.

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000166089.
HOVERGENi HBG000588.
InParanoidi Q60738.
KOi K14688.
OMAi RACLLEC.
OrthoDBi EOG7034GQ.
PhylomeDBi Q60738.
TreeFami TF313924.

Miscellaneous databases

NextBioi 303351.
PROi Q60738.
SOURCEi Search...

Gene expression databases

Bgeei Q60738.
ExpressionAtlasi Q60738. baseline and differential.
Genevestigatori Q60738.

Family and domain databases

Gene3Di 1.20.1510.10. 3 hits.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc."
    Palmiter R.D., Findley S.D.
    EMBO J. 14:639-649(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNT1_MOUSE
AccessioniPrimary (citable) accession number: Q60738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3