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Q60738 (ZNT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 1

Short name=ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene names
Name:Slc30a1
Synonyms:Znt1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

Subunit structure

Multimer Probable.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandZinc
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcadmium ion transmembrane transport

Inferred from electronic annotation. Source: Ensembl

calcium ion import

Inferred from electronic annotation. Source: Ensembl

cellular calcium ion homeostasis

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

cellular zinc ion homeostasis

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

detoxification of cadmium ion

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from mutant phenotype PubMed 15452870. Source: MGI

negative regulation of calcium ion import

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

negative regulation of neurotransmitter secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of zinc ion transmembrane import

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

zinc ion transport

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

   Cellular_componentT-tubule

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence orthology Ref.1. Source: MGI

   Molecular_functioncalcium channel inhibitor activity

Inferred from direct assay PubMed 15451416. Source: BHF-UCL

zinc ion transmembrane transporter activity

Inferred from sequence orthology Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Zinc transporter 1
PRO_0000206092

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 354Extracellular Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 7822Cytoplasmic Potential
Transmembrane79 – 9921Helical; Potential
Topological domain100 – 11314Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 243109Cytoplasmic Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 30339Extracellular Potential
Transmembrane304 – 32421Helical; Potential
Topological domain325 – 503179Cytoplasmic Potential
Region145 – 156126 X 2 AA approximate repeats of H-G

Amino acid modifications

Modified residue5021Phosphoserine Ref.3
Glycosylation2941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q60738 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7C4FF93FC13CDA22

FASTA50354,716
        10         20         30         40         50         60 
MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA LVVALVAERF 

        70         80         90        100        110        120 
ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA VERFIEPHEM QQPLVVLSVG 

       130        140        150        160        170        180 
VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD 

       190        200        210        220        230        240 
QEETNTLVAN TSNSNGLKAD QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM 

       250        260        270        280        290        300 
RGVFLHVLGD ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM 

       310        320        330        340        350        360 
RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH LVKELRDVDG 

       370        380        390        400        410        420 
VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD VFHNHGIHAT TIQPEFASVG 

       430        440        450        460        470        480 
SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS GKDAEKAPTV SISCLELSEN LEKKARRTKA 

       490        500 
EGSLPAVVIE IKNVPNKQPE SSL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc."
Palmiter R.D., Findley S.D.
EMBO J. 14:639-649(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17132 Genomic DNA. Translation: AAA79233.1.
BC052166 mRNA. Translation: AAH52166.1.
CCDSCCDS15625.1.
PIRS54302.
RefSeqNP_033605.1. NM_009579.3.
UniGeneMm.9024.

3D structure databases

ProteinModelPortalQ60738.
SMRQ60738. Positions 28-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ60738. 1 interaction.
MINTMINT-4140673.

PTM databases

PhosphoSiteQ60738.

Proteomic databases

PaxDbQ60738.
PRIDEQ60738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneID22782.
KEGGmmu:22782.
UCSCuc007edc.1. mouse.

Organism-specific databases

CTD7779.
MGIMGI:1345281. Slc30a1.

Phylogenomic databases

eggNOGCOG1230.
GeneTreeENSGT00550000074381.
HOGENOMHOG000166089.
HOVERGENHBG000588.
InParanoidQ60738.
KOK14688.
OMARACLLEC.
OrthoDBEOG7034GQ.
PhylomeDBQ60738.
TreeFamTF313924.

Gene expression databases

ArrayExpressQ60738.
BgeeQ60738.
GenevestigatorQ60738.

Family and domain databases

Gene3D1.20.1510.10. 3 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

NextBio303351.
PROQ60738.
SOURCESearch...

Entry information

Entry nameZNT1_MOUSE
AccessionPrimary (citable) accession number: Q60738
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot