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Protein

Zinc transporter 1

Gene

Slc30a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

GO - Molecular functioni

GO - Biological processi

  • cadmium ion transmembrane transport Source: Ensembl
  • calcium ion import Source: Ensembl
  • cellular calcium ion homeostasis Source: BHF-UCL
  • cellular zinc ion homeostasis Source: BHF-UCL
  • detoxification of cadmium ion Source: Ensembl
  • in utero embryonic development Source: MGI
  • negative regulation of calcium ion import Source: BHF-UCL
  • negative regulation of neurotransmitter secretion Source: Ensembl
  • negative regulation of zinc ion transmembrane import Source: BHF-UCL
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc II ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:Slc30a1
Synonyms:Znt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1345281. Slc30a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 35ExtracellularSequence analysis4
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 78CytoplasmicSequence analysisAdd BLAST22
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 243CytoplasmicSequence analysisAdd BLAST109
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 303ExtracellularSequence analysisAdd BLAST39
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 503CytoplasmicSequence analysisAdd BLAST179

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060921 – 503Zinc transporter 1Add BLAST503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Modified residuei502PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ60738.
MaxQBiQ60738.
PaxDbiQ60738.
PRIDEiQ60738.

PTM databases

iPTMnetiQ60738.
PhosphoSitePlusiQ60738.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSMUSG00000037434.
ExpressionAtlasiQ60738. baseline and differential.
GenevisibleiQ60738. MM.

Interactioni

Subunit structurei

Multimer.Curated

Protein-protein interaction databases

IntActiQ60738. 1 interactor.
MINTiMINT-4140673.
STRINGi10090.ENSMUSP00000042410.

Structurei

3D structure databases

ProteinModelPortaliQ60738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 1566 X 2 AA approximate repeats of H-GAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ60738.
KOiK14688.
OMAiHHHSGFS.
OrthoDBiEOG091G08R5.
PhylomeDBiQ60738.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA
60 70 80 90 100
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA
110 120 130 140 150
VERFIEPHEM QQPLVVLSVG VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH
160 170 180 190 200
GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD QEETNTLVAN TSNSNGLKAD
210 220 230 240 250
QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM RGVFLHVLGD
260 270 280 290 300
ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM
310 320 330 340 350
RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH
360 370 380 390 400
LVKELRDVDG VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD
410 420 430 440 450
VFHNHGIHAT TIQPEFASVG SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS
460 470 480 490 500
GKDAEKAPTV SISCLELSEN LEKKARRTKA EGSLPAVVIE IKNVPNKQPE

SSL
Length:503
Mass (Da):54,716
Last modified:November 1, 1996 - v1
Checksum:i7C4FF93FC13CDA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1.
BC052166 mRNA. Translation: AAH52166.1.
CCDSiCCDS15625.1.
PIRiS54302.
RefSeqiNP_033605.1. NM_009579.3.
UniGeneiMm.9024.

Genome annotation databases

EnsembliENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneIDi22782.
KEGGimmu:22782.
UCSCiuc007edc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1.
BC052166 mRNA. Translation: AAH52166.1.
CCDSiCCDS15625.1.
PIRiS54302.
RefSeqiNP_033605.1. NM_009579.3.
UniGeneiMm.9024.

3D structure databases

ProteinModelPortaliQ60738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60738. 1 interactor.
MINTiMINT-4140673.
STRINGi10090.ENSMUSP00000042410.

PTM databases

iPTMnetiQ60738.
PhosphoSitePlusiQ60738.

Proteomic databases

EPDiQ60738.
MaxQBiQ60738.
PaxDbiQ60738.
PRIDEiQ60738.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneIDi22782.
KEGGimmu:22782.
UCSCiuc007edc.1. mouse.

Organism-specific databases

CTDi7779.
MGIiMGI:1345281. Slc30a1.

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ60738.
KOiK14688.
OMAiHHHSGFS.
OrthoDBiEOG091G08R5.
PhylomeDBiQ60738.
TreeFamiTF313924.

Enzyme and pathway databases

ReactomeiR-MMU-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ60738.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037434.
ExpressionAtlasiQ60738. baseline and differential.
GenevisibleiQ60738. MM.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT1_MOUSE
AccessioniPrimary (citable) accession number: Q60738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.