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Q60738

- ZNT1_MOUSE

UniProt

Q60738 - ZNT1_MOUSE

Protein

Zinc transporter 1

Gene

Slc30a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

    GO - Molecular functioni

    1. calcium channel inhibitor activity Source: BHF-UCL
    2. zinc ion transmembrane transporter activity Source: MGI

    GO - Biological processi

    1. cadmium ion transmembrane transport Source: Ensembl
    2. calcium ion import Source: Ensembl
    3. cellular calcium ion homeostasis Source: BHF-UCL
    4. cellular zinc ion homeostasis Source: BHF-UCL
    5. detoxification of cadmium ion Source: Ensembl
    6. in utero embryonic development Source: MGI
    7. negative regulation of calcium ion import Source: BHF-UCL
    8. negative regulation of neurotransmitter secretion Source: Ensembl
    9. negative regulation of zinc ion transmembrane import Source: BHF-UCL
    10. zinc ion transport Source: BHF-UCL

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 1
    Short name:
    ZnT-1
    Alternative name(s):
    Solute carrier family 30 member 1
    Gene namesi
    Name:Slc30a1
    Synonyms:Znt1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1345281. Slc30a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI
    3. T-tubule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Zinc transporter 1PRO_0000206092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Modified residuei502 – 5021Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ60738.
    PRIDEiQ60738.

    PTM databases

    PhosphoSiteiQ60738.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ60738.
    BgeeiQ60738.
    GenevestigatoriQ60738.

    Interactioni

    Subunit structurei

    Multimer.Curated

    Protein-protein interaction databases

    IntActiQ60738. 1 interaction.
    MINTiMINT-4140673.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60738.
    SMRiQ60738. Positions 28-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 354ExtracellularSequence Analysis
    Topological domaini57 – 7822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 243109CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 30339ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini325 – 503179CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 156126 X 2 AA approximate repeats of H-GAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    GeneTreeiENSGT00550000074381.
    HOGENOMiHOG000166089.
    HOVERGENiHBG000588.
    InParanoidiQ60738.
    KOiK14688.
    OMAiRACLLEC.
    OrthoDBiEOG7034GQ.
    PhylomeDBiQ60738.
    TreeFamiTF313924.

    Family and domain databases

    Gene3Di1.20.1510.10. 3 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q60738-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA    50
    LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA 100
    VERFIEPHEM QQPLVVLSVG VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH 150
    GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD QEETNTLVAN TSNSNGLKAD 200
    QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM RGVFLHVLGD 250
    ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM 300
    RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH 350
    LVKELRDVDG VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD 400
    VFHNHGIHAT TIQPEFASVG SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS 450
    GKDAEKAPTV SISCLELSEN LEKKARRTKA EGSLPAVVIE IKNVPNKQPE 500
    SSL 503
    Length:503
    Mass (Da):54,716
    Last modified:November 1, 1996 - v1
    Checksum:i7C4FF93FC13CDA22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17132 Genomic DNA. Translation: AAA79233.1.
    BC052166 mRNA. Translation: AAH52166.1.
    CCDSiCCDS15625.1.
    PIRiS54302.
    RefSeqiNP_033605.1. NM_009579.3.
    UniGeneiMm.9024.

    Genome annotation databases

    EnsembliENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
    GeneIDi22782.
    KEGGimmu:22782.
    UCSCiuc007edc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17132 Genomic DNA. Translation: AAA79233.1 .
    BC052166 mRNA. Translation: AAH52166.1 .
    CCDSi CCDS15625.1.
    PIRi S54302.
    RefSeqi NP_033605.1. NM_009579.3.
    UniGenei Mm.9024.

    3D structure databases

    ProteinModelPortali Q60738.
    SMRi Q60738. Positions 28-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q60738. 1 interaction.
    MINTi MINT-4140673.

    PTM databases

    PhosphoSitei Q60738.

    Proteomic databases

    PaxDbi Q60738.
    PRIDEi Q60738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044954 ; ENSMUSP00000042410 ; ENSMUSG00000037434 .
    GeneIDi 22782.
    KEGGi mmu:22782.
    UCSCi uc007edc.1. mouse.

    Organism-specific databases

    CTDi 7779.
    MGIi MGI:1345281. Slc30a1.

    Phylogenomic databases

    eggNOGi COG1230.
    GeneTreei ENSGT00550000074381.
    HOGENOMi HOG000166089.
    HOVERGENi HBG000588.
    InParanoidi Q60738.
    KOi K14688.
    OMAi RACLLEC.
    OrthoDBi EOG7034GQ.
    PhylomeDBi Q60738.
    TreeFami TF313924.

    Miscellaneous databases

    NextBioi 303351.
    PROi Q60738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60738.
    Bgeei Q60738.
    Genevestigatori Q60738.

    Family and domain databases

    Gene3Di 1.20.1510.10. 3 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc."
      Palmiter R.D., Findley S.D.
      EMBO J. 14:639-649(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZNT1_MOUSE
    AccessioniPrimary (citable) accession number: Q60738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3