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Q60738

- ZNT1_MOUSE

UniProt

Q60738 - ZNT1_MOUSE

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Protein

Zinc transporter 1

Gene
Slc30a1, Znt1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.

GO - Molecular functioni

  1. calcium channel inhibitor activity Source: BHF-UCL
  2. zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  1. cadmium ion transmembrane transport Source: Ensembl
  2. calcium ion import Source: Ensembl
  3. cellular calcium ion homeostasis Source: BHF-UCL
  4. cellular zinc ion homeostasis Source: BHF-UCL
  5. detoxification of cadmium ion Source: Ensembl
  6. in utero embryonic development Source: MGI
  7. negative regulation of calcium ion import Source: BHF-UCL
  8. negative regulation of neurotransmitter secretion Source: Ensembl
  9. negative regulation of zinc ion transmembrane import Source: BHF-UCL
  10. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:Slc30a1
Synonyms:Znt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1345281. Slc30a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed predictionAdd
BLAST
Topological domaini32 – 354Extracellular Reviewed prediction
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST
Topological domaini57 – 7822Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei79 – 9921Helical; Reviewed predictionAdd
BLAST
Topological domaini100 – 11314Extracellular Reviewed predictionAdd
BLAST
Transmembranei114 – 13421Helical; Reviewed predictionAdd
BLAST
Topological domaini135 – 243109Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei244 – 26421Helical; Reviewed predictionAdd
BLAST
Topological domaini265 – 30339Extracellular Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Topological domaini325 – 503179Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
  3. T-tubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Zinc transporter 1PRO_0000206092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi294 – 2941N-linked (GlcNAc...) Reviewed prediction
Modified residuei502 – 5021Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ60738.
PRIDEiQ60738.

PTM databases

PhosphoSiteiQ60738.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

ArrayExpressiQ60738.
BgeeiQ60738.
GenevestigatoriQ60738.

Interactioni

Subunit structurei

Multimer Inferred.

Protein-protein interaction databases

IntActiQ60738. 1 interaction.
MINTiMINT-4140673.

Structurei

3D structure databases

ProteinModelPortaliQ60738.
SMRiQ60738. Positions 28-106.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 156126 X 2 AA approximate repeats of H-GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ60738.
KOiK14688.
OMAiRACLLEC.
OrthoDBiEOG7034GQ.
PhylomeDBiQ60738.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60738-1 [UniParc]FASTAAdd to Basket

« Hide

MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA    50
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA 100
VERFIEPHEM QQPLVVLSVG VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH 150
GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD QEETNTLVAN TSNSNGLKAD 200
QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM RGVFLHVLGD 250
ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM 300
RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH 350
LVKELRDVDG VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD 400
VFHNHGIHAT TIQPEFASVG SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS 450
GKDAEKAPTV SISCLELSEN LEKKARRTKA EGSLPAVVIE IKNVPNKQPE 500
SSL 503
Length:503
Mass (Da):54,716
Last modified:November 1, 1996 - v1
Checksum:i7C4FF93FC13CDA22
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1.
BC052166 mRNA. Translation: AAH52166.1.
CCDSiCCDS15625.1.
PIRiS54302.
RefSeqiNP_033605.1. NM_009579.3.
UniGeneiMm.9024.

Genome annotation databases

EnsembliENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneIDi22782.
KEGGimmu:22782.
UCSCiuc007edc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17132 Genomic DNA. Translation: AAA79233.1 .
BC052166 mRNA. Translation: AAH52166.1 .
CCDSi CCDS15625.1.
PIRi S54302.
RefSeqi NP_033605.1. NM_009579.3.
UniGenei Mm.9024.

3D structure databases

ProteinModelPortali Q60738.
SMRi Q60738. Positions 28-106.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q60738. 1 interaction.
MINTi MINT-4140673.

PTM databases

PhosphoSitei Q60738.

Proteomic databases

PaxDbi Q60738.
PRIDEi Q60738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044954 ; ENSMUSP00000042410 ; ENSMUSG00000037434 .
GeneIDi 22782.
KEGGi mmu:22782.
UCSCi uc007edc.1. mouse.

Organism-specific databases

CTDi 7779.
MGIi MGI:1345281. Slc30a1.

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000166089.
HOVERGENi HBG000588.
InParanoidi Q60738.
KOi K14688.
OMAi RACLLEC.
OrthoDBi EOG7034GQ.
PhylomeDBi Q60738.
TreeFami TF313924.

Miscellaneous databases

NextBioi 303351.
PROi Q60738.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60738.
Bgeei Q60738.
Genevestigatori Q60738.

Family and domain databases

Gene3Di 1.20.1510.10. 3 hits.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc."
    Palmiter R.D., Findley S.D.
    EMBO J. 14:639-649(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-502, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNT1_MOUSE
AccessioniPrimary (citable) accession number: Q60738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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