Q60738 (ZNT1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter 1
Short name=ZnT-1

Alternative name(s):
Solute carrier family 30 member 1

Gene names

Name:	Slc30a1
Synonyms:	Znt1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention.
Subunit structure	Multimer Probable.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Zinc
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cadmium ion transmembrane transport Inferred from electronic annotation. Source: Compara calcium ion import Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from direct assay PubMed 15451416. Source: BHF-UCL cellular zinc ion homeostasis Inferred from direct assay PubMed 15451416. Source: BHF-UCL detoxification of cadmium ion Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from mutant phenotype PubMed 15452870. Source: MGI negative regulation of calcium ion import Inferred from direct assay PubMed 15451416. Source: BHF-UCL negative regulation of neurotransmitter secretion Inferred from electronic annotation. Source: Compara negative regulation of zinc ion transmembrane import Inferred from direct assay PubMed 15451416. Source: BHF-UCL
Cellular_component	T-tubule Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence orthology Ref.1. Source: MGI
Molecular_function	calcium channel inhibitor activity Inferred from direct assay PubMed 15451416. Source: BHF-UCL zinc ion transmembrane transporter activity Inferred from sequence orthology Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Zinc transporter 1		PRO_0000206092
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Topological domain	32 – 35	4	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 78	22	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Topological domain	100 – 113	14	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 243	109	Cytoplasmic Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Topological domain	265 – 303	39	Extracellular Potential
	Transmembrane	304 – 324	21	Helical; Potential
	Topological domain	325 – 503	179	Cytoplasmic Potential
	Region	145 – 156	12	6 X 2 AA approximate repeats of H-G
Amino acid modifications
	Modified residue	502	1	Phosphoserine By similarity
	Glycosylation	294	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q60738 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 7C4FF93FC13CDA22	FASTA	503	54,716
	10 20 30 40 50 60 MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA LVVALVAERF 70 80 90 100 110 120 ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA VERFIEPHEM QQPLVVLSVG 130 140 150 160 170 180 VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH GHGHGHLAKG ARKAGRAGVE AGAPPGRAPD 190 200 210 220 230 240 QEETNTLVAN TSNSNGLKAD QAEPEKLRSD DPVDVQVNGN LIQESDNLEA EDNRAGQLNM 250 260 270 280 290 300 RGVFLHVLGD ALGSVIVVVN ALVFYFNWKG CTEDDFCTNP CFPDPCKSSV EIINSTQAPM 310 320 330 340 350 360 RDAGPCWVLY LDPTLCIIMV CILLYTTYPL LKESALILLQ TVPKQIDIKH LVKELRDVDG 370 380 390 400 410 420 VEEVHELHVW QLAGSRIIAT AHIKCEDPAS YMQVAKTIKD VFHNHGIHAT TIQPEFASVG 430 440 450 460 470 480 SKSSVLPCEL ACRTQCALKQ CCGTRPQVHS GKDAEKAPTV SISCLELSEN LEKKARRTKA 490 500 EGSLPAVVIE IKNVPNKQPE SSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc." Palmiter R.D., Findley S.D. EMBO J. 14:639-649(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U17132 Genomic DNA. Translation: AAA79233.1. BC052166 mRNA. Translation: AAH52166.1.
IPI	IPI00120166.
PIR	S54302.
RefSeq	NP_033605.1. NM_009579.3.
UniGene	Mm.9024.
3D structure databases
ProteinModelPortal	Q60738.
SMR	Q60738. Positions 27-106.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4140673.
PTM databases
PhosphoSite	Q60738.
Proteomic databases
PaxDb	Q60738.
PRIDE	Q60738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000044954; ENSMUSP00000042410; ENSMUSG00000037434.
GeneID	22782.
KEGG	mmu:22782.
UCSC	uc007edc.1. mouse.
Organism-specific databases
CTD	7779.
MGI	MGI:1345281. Slc30a1.
Phylogenomic databases
eggNOG	COG1230.
GeneTree	ENSGT00550000074381.
HOGENOM	HOG000166089.
HOVERGEN	HBG000588.
InParanoid	Q60738.
KO	K14688.
OMA	FMFMVLE.
OrthoDB	EOG4GF3F3.
Gene expression databases
ArrayExpress	Q60738.
Bgee	Q60738.
Genevestigator	Q60738.
GermOnline	ENSMUSG00000037434. Mus musculus.
Family and domain databases
Gene3D	1.20.1510.10. 3 hits.
InterPro	IPR002524. Cation_efflux. IPR027469. Cation_efflux_TMD. [Graphical view]
PANTHER	PTHR11562. PTHR11562. 1 hit.
Pfam	PF01545. Cation_efflux. 1 hit. [Graphical view]
TIGRFAMs	TIGR01297. CDF. 1 hit.
ProtoNet	Search...
Other
NextBio	303351.
SOURCE	Search...

Entry information

Entry name

ZNT1_MOUSE

Accession

Primary (citable) accession number: Q60738

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program