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Reviewed, UniProtKB/Swiss-Prot Q60737 (CSK21_MOUSE)

Last modified February 9, 2010. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Casein kinase II subunit alpha
      Short name=CK II alpha
    EC=2.7.11.1
Gene names
Name: Csnk2a1
Synonyms: Ckiia
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-389' of p53/TP53 following UV irradiation By similarity. Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Tetramer composed of an alpha chain, an alpha' and two beta chains. Interacts with RNPS1. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Casein kinase II subunit alpha
PRO_0000085884

Regions

Domain39 – 324286Protein kinase
Nucleotide binding45 – 539ATP By similarity

Sites

Active site1561Proton acceptor By similarity
Binding site681ATP By similarity

Amino acid modifications

Modified residue21Phosphoserine By similarity
Modified residue71Phosphoserine By similarity
Modified residue501Phosphotyrosine By similarity
Modified residue1021N6-acetyllysine By similarity
Modified residue1251Phosphotyrosine By similarity
Modified residue1271Phosphothreonine By similarity
Modified residue1941Phosphoserine By similarity
Modified residue2551Phosphotyrosine By similarity
Modified residue2771Phosphoserine By similarity
Modified residue2871Phosphoserine By similarity
Modified residue3621Phosphoserine By similarity
Modified residue3701Phosphoserine By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q60737-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 694A57CC8088320B

FASTA39145,162
        10         20         30         40         50         60 
MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT 

        70         80         90        100        110        120 
NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD 

       130        140        150        160        170        180 
FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE 

       190        200        210        220        230        240 
FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD 

       250        260        270        280        290        300 
QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF 

       310        320        330        340        350        360 
LDKLLRYDHQ SRLTVREAME HPFFYTVVKN QARMSSTSMA GGSTPVSSAN MMSGISSVPS 

       370        380        390 
PSPLGPLAGS PVIAAANSLG IPVQAAAGAQ Q

« Hide

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References

[1]"Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle."
Seldin D.C., Leder P.
Science 267:894-897(1995) [PubMed: 7846532] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N.
Tissue: Spleen.
[2]"Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells."
Song D.H., Sussman D.J., Seldin D.C.
J. Biol. Chem. 275:23790-23797(2000) [PubMed: 10806215] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U17112 mRNA. Translation: AAA64563.1.
IPIIPI00120162.
PIRI49141.
UniGeneMm.23692

3D structure databases

SMRQ60737. Positions 2-334.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-32409N.
STRINGQ60737.

PTM databases

PhosphoSiteQ60737.

Proteomic databases

PRIDEQ60737.

Genome annotation databases

EnsemblENSMUST00000099224; ENSMUSP00000096829; ENSMUSG00000074698; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:88543. Csnk2a1.

Phylogenomic databases

eggNOGroNOG04406.
HOGENOMHBG755340.
HOVERGENQ60737.
InParanoidQ60737.
PhylomeDBQ60737.

Enzyme and pathway databases

BRENDA2.7.11.1. 244.

Gene expression databases

ArrayExpressQ60737.
BgeeQ60737.
CleanExMM_CSNK2A1.
GenevestigatorQ60737.
GermOnlineENSMUSG00000057808. Mus musculus.
ENSMUSG00000074698. Mus musculus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameCSK21_MOUSE
AccessionPrimary (citable) accession number: Q60737
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents