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Q60720

- CY561_MOUSE

UniProt

Q60720 - CY561_MOUSE

Protein

Cytochrome b561

Gene

Cyb561

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    Secretory vesicle-specific electron transport protein.

    Cofactori

    Binds 2 heme groups non-covalently.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi52 – 521Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi86 – 861Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi90 – 901Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi120 – 1201Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi159 – 1591Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric-chelate reductase activity Source: HGNC
    2. metal ion binding Source: UniProtKB-KW
    3. transmembrane electron transfer carrier Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Biological processi

    Electron transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome b561
    Alternative name(s):
    Cytochrome b-561
    Gene namesi
    Name:Cyb561
    Synonyms:Mcyt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:103253. Cyb561.

    Subcellular locationi

    Cytoplasmic vesiclesecretory vesicle membrane By similarity; Multi-pass membrane protein By similarity
    Note: Secretory vesicle containing catecholamines and amidated peptides.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250Cytochrome b561PRO_0000151028Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    PTM databases

    PhosphoSiteiQ60720.

    Expressioni

    Tissue specificityi

    Abundantly distributed in a number of neuroendocrine tissues.

    Gene expression databases

    ArrayExpressiQ60720.
    BgeeiQ60720.
    CleanExiMM_CYB561.
    GenevestigatoriQ60720.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60720.
    SMRiQ60720. Positions 20-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25032CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei51 – 7121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 219202Cytochrome b561PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262597.
    GeneTreeiENSGT00390000010986.
    HOGENOMiHOG000231043.
    HOVERGENiHBG054164.
    InParanoidiQ60720.
    KOiK08360.
    OMAiKIPDMYS.
    OrthoDBiEOG7SJD5W.
    PhylomeDBiQ60720.
    TreeFamiTF314222.

    Family and domain databases

    InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    IPR028837. Cytochrome_b561.
    [Graphical view]
    PANTHERiPTHR10106:SF6. PTHR10106:SF6. 1 hit.
    PfamiPF03188. Cytochrom_B561. 1 hit.
    [Graphical view]
    SMARTiSM00665. B561. 1 hit.
    [Graphical view]
    PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN    50
    VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALVG 100
    LVAVFDYHKK KGYADLYSLH SWCGILVFVL YFVQWLVGFS FFLFPGASFS 150
    LRSRYRPQHI FFGATIFLFS VGTALLGLKE ALLFKLGSKY STFEPEGVLA 200
    NVLGLLLVCF GVVVLYILAQ ADWKRPSQAE EQALSMDFKT LTEGDSPSPQ 250
    Length:250
    Mass (Da):27,822
    Last modified:November 25, 2002 - v2
    Checksum:iD0FDE6C9DE5EA09E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 2113PAALP…AFSQL → LLHCRTMWPSPSC in AAA65643. (PubMed:9778036)CuratedAdd
    BLAST
    Sequence conflicti171 – 1744VGTA → AGHS in AAA65643. (PubMed:9778036)Curated
    Sequence conflicti199 – 1991L → V in AAA65643. (PubMed:9778036)Curated
    Sequence conflicti222 – 2265DWKRP → ALERG in AAA65643. (PubMed:9778036)Curated
    Sequence conflicti248 – 2492SP → TS in AAA65643. (PubMed:9778036)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16297 mRNA. Translation: AAA65643.1.
    AK014395 mRNA. Translation: BAB29321.1.
    AK158978 mRNA. Translation: BAE34753.1.
    AK169711 mRNA. Translation: BAE41322.1.
    BC006732 mRNA. Translation: AAH06732.1.
    CCDSiCCDS25542.1.
    RefSeqiNP_031831.2. NM_007805.4.
    XP_006532193.1. XM_006532130.1.
    XP_006532194.1. XM_006532131.1.
    XP_006532195.1. XM_006532132.1.
    UniGeneiMm.149403.

    Genome annotation databases

    EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590.
    GeneIDi13056.
    KEGGimmu:13056.
    UCSCiuc007lxr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U16297 mRNA. Translation: AAA65643.1 .
    AK014395 mRNA. Translation: BAB29321.1 .
    AK158978 mRNA. Translation: BAE34753.1 .
    AK169711 mRNA. Translation: BAE41322.1 .
    BC006732 mRNA. Translation: AAH06732.1 .
    CCDSi CCDS25542.1.
    RefSeqi NP_031831.2. NM_007805.4.
    XP_006532193.1. XM_006532130.1.
    XP_006532194.1. XM_006532131.1.
    XP_006532195.1. XM_006532132.1.
    UniGenei Mm.149403.

    3D structure databases

    ProteinModelPortali Q60720.
    SMRi Q60720. Positions 20-215.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q60720.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019734 ; ENSMUSP00000019734 ; ENSMUSG00000019590 .
    GeneIDi 13056.
    KEGGi mmu:13056.
    UCSCi uc007lxr.1. mouse.

    Organism-specific databases

    CTDi 1534.
    MGIi MGI:103253. Cyb561.

    Phylogenomic databases

    eggNOGi NOG262597.
    GeneTreei ENSGT00390000010986.
    HOGENOMi HOG000231043.
    HOVERGENi HBG054164.
    InParanoidi Q60720.
    KOi K08360.
    OMAi KIPDMYS.
    OrthoDBi EOG7SJD5W.
    PhylomeDBi Q60720.
    TreeFami TF314222.

    Miscellaneous databases

    NextBioi 282978.
    PROi Q60720.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60720.
    Bgeei Q60720.
    CleanExi MM_CYB561.
    Genevestigatori Q60720.

    Family and domain databases

    InterProi IPR006593. Cyt_b561/ferric_Rdtase_TM.
    IPR004877. Cyt_b561_euk.
    IPR028837. Cytochrome_b561.
    [Graphical view ]
    PANTHERi PTHR10106:SF6. PTHR10106:SF6. 1 hit.
    Pfami PF03188. Cytochrom_B561. 1 hit.
    [Graphical view ]
    SMARTi SM00665. B561. 1 hit.
    [Graphical view ]
    PROSITEi PS50939. CYTOCHROME_B561. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse cytochrome b561: cDNA cloning and expression in rat brain, mouse embryos, and human glioma cell lines."
      Srivastava M., Pollard H.B., Fleming P.J.
      DNA Cell Biol. 17:771-777(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain and Visual cortex.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCY561_MOUSE
    AccessioniPrimary (citable) accession number: Q60720
    Secondary accession number(s): Q3TEC6, Q9D6C9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3