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Protein

Cytochrome b561

Gene

Cyb561

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi86Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi90Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi108Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi120Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi159Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:Cyb561
Synonyms:Mcyt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103253. Cyb561.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 250CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510281 – 250Cytochrome b561Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei246PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ60720.
PaxDbiQ60720.
PRIDEiQ60720.

PTM databases

iPTMnetiQ60720.
PhosphoSitePlusiQ60720.

Expressioni

Tissue specificityi

Abundantly distributed in a number of neuroendocrine tissues.

Gene expression databases

BgeeiENSMUSG00000019590.
CleanExiMM_CYB561.
ExpressionAtlasiQ60720. baseline and differential.
GenevisibleiQ60720. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019734.

Structurei

3D structure databases

ProteinModelPortaliQ60720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 219Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOGENOMiHOG000231043.
HOVERGENiHBG054164.
InParanoidiQ60720.
KOiK08360.
OMAiGSAHEFN.
OrthoDBiEOG091G0GC6.
PhylomeDBiQ60720.
TreeFamiTF314222.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN
60 70 80 90 100
VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALVG
110 120 130 140 150
LVAVFDYHKK KGYADLYSLH SWCGILVFVL YFVQWLVGFS FFLFPGASFS
160 170 180 190 200
LRSRYRPQHI FFGATIFLFS VGTALLGLKE ALLFKLGSKY STFEPEGVLA
210 220 230 240 250
NVLGLLLVCF GVVVLYILAQ ADWKRPSQAE EQALSMDFKT LTEGDSPSPQ
Length:250
Mass (Da):27,822
Last modified:November 25, 2002 - v2
Checksum:iD0FDE6C9DE5EA09E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 21PAALP…AFSQL → LLHCRTMWPSPSC in AAA65643 (PubMed:9778036).CuratedAdd BLAST13
Sequence conflicti171 – 174VGTA → AGHS in AAA65643 (PubMed:9778036).Curated4
Sequence conflicti199L → V in AAA65643 (PubMed:9778036).Curated1
Sequence conflicti222 – 226DWKRP → ALERG in AAA65643 (PubMed:9778036).Curated5
Sequence conflicti248 – 249SP → TS in AAA65643 (PubMed:9778036).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA. Translation: AAA65643.1.
AK014395 mRNA. Translation: BAB29321.1.
AK158978 mRNA. Translation: BAE34753.1.
AK169711 mRNA. Translation: BAE41322.1.
BC006732 mRNA. Translation: AAH06732.1.
CCDSiCCDS25542.1.
RefSeqiNP_031831.2. NM_007805.4.
XP_006532193.1. XM_006532130.3.
XP_006532194.1. XM_006532131.2.
XP_006532195.1. XM_006532132.3.
UniGeneiMm.149403.

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590.
GeneIDi13056.
KEGGimmu:13056.
UCSCiuc007lxr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA. Translation: AAA65643.1.
AK014395 mRNA. Translation: BAB29321.1.
AK158978 mRNA. Translation: BAE34753.1.
AK169711 mRNA. Translation: BAE41322.1.
BC006732 mRNA. Translation: AAH06732.1.
CCDSiCCDS25542.1.
RefSeqiNP_031831.2. NM_007805.4.
XP_006532193.1. XM_006532130.3.
XP_006532194.1. XM_006532131.2.
XP_006532195.1. XM_006532132.3.
UniGeneiMm.149403.

3D structure databases

ProteinModelPortaliQ60720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019734.

PTM databases

iPTMnetiQ60720.
PhosphoSitePlusiQ60720.

Proteomic databases

MaxQBiQ60720.
PaxDbiQ60720.
PRIDEiQ60720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590.
GeneIDi13056.
KEGGimmu:13056.
UCSCiuc007lxr.1. mouse.

Organism-specific databases

CTDi1534.
MGIiMGI:103253. Cyb561.

Phylogenomic databases

eggNOGiKOG1619. Eukaryota.
ENOG4111FKI. LUCA.
GeneTreeiENSGT00390000010986.
HOGENOMiHOG000231043.
HOVERGENiHBG054164.
InParanoidiQ60720.
KOiK08360.
OMAiGSAHEFN.
OrthoDBiEOG091G0GC6.
PhylomeDBiQ60720.
TreeFamiTF314222.

Miscellaneous databases

PROiQ60720.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019590.
CleanExiMM_CYB561.
ExpressionAtlasiQ60720. baseline and differential.
GenevisibleiQ60720. MM.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF14. PTHR10106:SF14. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCY561_MOUSE
AccessioniPrimary (citable) accession number: Q60720
Secondary accession number(s): Q3TEC6, Q9D6C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2002
Last modified: November 2, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.