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Protein

Cytochrome b561

Gene

Cyb561

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi86 – 861Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi90 – 901Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi108 – 1081Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi120 – 1201Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi159 – 1591Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric-chelate reductase activity Source: HGNC
  2. metal ion binding Source: UniProtKB-KW
  3. transmembrane electron transfer carrier Source: InterPro

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:Cyb561
Synonyms:Mcyt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:103253. Cyb561.

Subcellular locationi

Cytoplasmic vesiclesecretory vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Secretory vesicle containing catecholamines and amidated peptides.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence AnalysisAdd
BLAST
Topological domaini219 – 25032CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Cytochrome b561PRO_0000151028Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ60720.

PTM databases

PhosphoSiteiQ60720.

Expressioni

Tissue specificityi

Abundantly distributed in a number of neuroendocrine tissues.

Gene expression databases

BgeeiQ60720.
CleanExiMM_CYB561.
ExpressionAtlasiQ60720. baseline and differential.
GenevestigatoriQ60720.

Structurei

3D structure databases

ProteinModelPortaliQ60720.
SMRiQ60720. Positions 20-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 219202Cytochrome b561PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cytochrome b561 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262597.
GeneTreeiENSGT00390000010986.
HOGENOMiHOG000231043.
HOVERGENiHBG054164.
InParanoidiQ60720.
KOiK08360.
OMAiAAIMIYK.
OrthoDBiEOG7SJD5W.
PhylomeDBiQ60720.
TreeFamiTF314222.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_euk.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF6. PTHR10106:SF6. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN
60 70 80 90 100
VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALVG
110 120 130 140 150
LVAVFDYHKK KGYADLYSLH SWCGILVFVL YFVQWLVGFS FFLFPGASFS
160 170 180 190 200
LRSRYRPQHI FFGATIFLFS VGTALLGLKE ALLFKLGSKY STFEPEGVLA
210 220 230 240 250
NVLGLLLVCF GVVVLYILAQ ADWKRPSQAE EQALSMDFKT LTEGDSPSPQ
Length:250
Mass (Da):27,822
Last modified:November 25, 2002 - v2
Checksum:iD0FDE6C9DE5EA09E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 2113PAALP…AFSQL → LLHCRTMWPSPSC in AAA65643 (PubMed:9778036).CuratedAdd
BLAST
Sequence conflicti171 – 1744VGTA → AGHS in AAA65643 (PubMed:9778036).Curated
Sequence conflicti199 – 1991L → V in AAA65643 (PubMed:9778036).Curated
Sequence conflicti222 – 2265DWKRP → ALERG in AAA65643 (PubMed:9778036).Curated
Sequence conflicti248 – 2492SP → TS in AAA65643 (PubMed:9778036).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA. Translation: AAA65643.1.
AK014395 mRNA. Translation: BAB29321.1.
AK158978 mRNA. Translation: BAE34753.1.
AK169711 mRNA. Translation: BAE41322.1.
BC006732 mRNA. Translation: AAH06732.1.
CCDSiCCDS25542.1.
RefSeqiNP_031831.2. NM_007805.4.
XP_006532193.1. XM_006532130.1.
XP_006532194.1. XM_006532131.1.
XP_006532195.1. XM_006532132.1.
UniGeneiMm.149403.

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590.
GeneIDi13056.
KEGGimmu:13056.
UCSCiuc007lxr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA. Translation: AAA65643.1.
AK014395 mRNA. Translation: BAB29321.1.
AK158978 mRNA. Translation: BAE34753.1.
AK169711 mRNA. Translation: BAE41322.1.
BC006732 mRNA. Translation: AAH06732.1.
CCDSiCCDS25542.1.
RefSeqiNP_031831.2. NM_007805.4.
XP_006532193.1. XM_006532130.1.
XP_006532194.1. XM_006532131.1.
XP_006532195.1. XM_006532132.1.
UniGeneiMm.149403.

3D structure databases

ProteinModelPortaliQ60720.
SMRiQ60720. Positions 20-215.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ60720.

Proteomic databases

MaxQBiQ60720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590.
GeneIDi13056.
KEGGimmu:13056.
UCSCiuc007lxr.1. mouse.

Organism-specific databases

CTDi1534.
MGIiMGI:103253. Cyb561.

Phylogenomic databases

eggNOGiNOG262597.
GeneTreeiENSGT00390000010986.
HOGENOMiHOG000231043.
HOVERGENiHBG054164.
InParanoidiQ60720.
KOiK08360.
OMAiAAIMIYK.
OrthoDBiEOG7SJD5W.
PhylomeDBiQ60720.
TreeFamiTF314222.

Miscellaneous databases

NextBioi282978.
PROiQ60720.
SOURCEiSearch...

Gene expression databases

BgeeiQ60720.
CleanExiMM_CYB561.
ExpressionAtlasiQ60720. baseline and differential.
GenevestigatoriQ60720.

Family and domain databases

InterProiIPR006593. Cyt_b561/ferric_Rdtase_TM.
IPR004877. Cyt_b561_euk.
IPR028837. Cytochrome_b561.
[Graphical view]
PANTHERiPTHR10106:SF6. PTHR10106:SF6. 1 hit.
PfamiPF03188. Cytochrom_B561. 1 hit.
[Graphical view]
SMARTiSM00665. B561. 1 hit.
[Graphical view]
PROSITEiPS50939. CYTOCHROME_B561. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cytochrome b561: cDNA cloning and expression in rat brain, mouse embryos, and human glioma cell lines."
    Srivastava M., Pollard H.B., Fleming P.J.
    DNA Cell Biol. 17:771-777(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Visual cortex.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCY561_MOUSE
AccessioniPrimary (citable) accession number: Q60720
Secondary accession number(s): Q3TEC6, Q9D6C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2002
Last modified: March 4, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.