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Protein

Long-chain fatty acid transport protein 1

Gene

Slc27a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FatP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.7 Publications

Miscellaneous

Mice deficient for Fatp1 are protected from fat-induced insulin resistance and intramuscular accumulation of fatty acyl-CoA without alteration in whole-body adiposity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi246 – 257AMPCuratedAdd BLAST12

GO - Molecular functioni

  • fatty acid transmembrane transporter activity Source: MGI
  • long-chain fatty acid-CoA ligase activity Source: MGI
  • nucleotide binding Source: UniProtKB-KW
  • protein homodimerization activity Source: MGI
  • very long-chain fatty acid-CoA ligase activity Source: MGI

GO - Biological processi

  • adiponectin-activated signaling pathway Source: MGI
  • cardiolipin biosynthetic process Source: MGI
  • fatty acid transport Source: MGI
  • long-chain fatty acid metabolic process Source: MGI
  • long-chain fatty acid transport Source: MGI
  • medium-chain fatty acid transport Source: MGI
  • negative regulation of phospholipid biosynthetic process Source: MGI
  • phosphatidic acid biosynthetic process Source: MGI
  • phosphatidylcholine biosynthetic process Source: MGI
  • phosphatidylethanolamine biosynthetic process Source: MGI
  • phosphatidylglycerol biosynthetic process Source: MGI
  • phosphatidylinositol biosynthetic process Source: MGI
  • phosphatidylserine biosynthetic process Source: MGI
  • positive regulation of heat generation Source: MGI
  • positive regulation of protein serine/threonine kinase activity Source: MGI
  • response to cold Source: MGI
  • response to insulin Source: MGI

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism, Lipid transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-804914 Transport of fatty acids

Chemistry databases

SwissLipidsiSLP:000000426

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 1 (EC:6.2.1.-)
Short name:
FATP-1
Short name:
Fatty acid transport protein 1
Alternative name(s):
Solute carrier family 27 member 1
Gene namesi
Name:Slc27a1
Synonyms:Fatp, Fatp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347098 Slc27a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13ExtracellularSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 646CytoplasmicSequence analysisAdd BLAST612

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi249 – 254TSGTTG → LEAAA: Abolishes very-long-chain acyl-CoA synthetase activity. 1 Publication6
Mutagenesisi250S → A: Diminishes LCFA import and decreases nucleotide binding. 2 Publications1
Mutagenesisi252T → A: Diminishes LCFA import and decreases nucleotide binding. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2052039

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001932021 – 646Long-chain fatty acid transport protein 1Add BLAST646

Proteomic databases

MaxQBiQ60714
PaxDbiQ60714
PRIDEiQ60714

PTM databases

iPTMnetiQ60714
PhosphoSitePlusiQ60714
SwissPalmiQ60714

Expressioni

Tissue specificityi

Highest expression in skeletal muscle, heart and fat. Lower levels in brain, kidney, lung and liver. No expression in spleen or intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000031808
ExpressionAtlasiQ60714 baseline and differential
GenevisibleiQ60714 MM

Interactioni

Subunit structurei

Self-associates. May function as a homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi205003, 1 interactor
IntActiQ60714, 1 interactor
MINTiQ60714
STRINGi10090.ENSMUSP00000034267

Chemistry databases

BindingDBiQ60714

Structurei

3D structure databases

ProteinModelPortaliQ60714
SMRiQ60714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni191 – 475Sufficient for oligomerizationAdd BLAST285

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00550000074420
HOGENOMiHOG000044189
HOVERGENiHBG005642
InParanoidiQ60714
KOiK08745
OMAiYTRICSG
OrthoDBiEOG091G0B76
PhylomeDBiQ60714
TreeFamiTF313430

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR030308 FATP1
PANTHERiPTHR43107:SF7 PTHR43107:SF7, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q60714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPGAGTAS VASLALLWFL GLPWTWSAAA AFCVYVGGGG WRFLRIVCKT
60 70 80 90 100
ARRDLFGLSV LIRVRLELRR HRRAGDTIPC IFQAVARRQP ERLALVDASS
110 120 130 140 150
GICWTFAQLD TYSNAVANLF RQLGFAPGDV VAVFLEGRPE FVGLWLGLAK
160 170 180 190 200
AGVVAALLNV NLRREPLAFC LGTSAAKALI YGGEMAAAVA EVSEQLGKSL
210 220 230 240 250
LKFCSGDLGP ESILPDTQLL DPMLAEAPTT PLAQAPGKGM DDRLFYIYTS
260 270 280 290 300
GTTGLPKAAI VVHSRYYRIA AFGHHSYSMR AADVLYDCLP LYHSAGNIMG
310 320 330 340 350
VGQCVIYGLT VVLRKKFSAS RFWDDCVKYN CTVVQYIGEI CRYLLRQPVR
360 370 380 390 400
DVEQRHRVRL AVGNGLRPAI WEEFTQRFGV PQIGEFYGAT ECNCSIANMD
410 420 430 440 450
GKVGSCGFNS RILTHVYPIR LVKVNEDTME PLRDSEGLCI PCQPGEPGLL
460 470 480 490 500
VGQINQQDPL RRFDGYVSDS ATNKKIAHSV FRKGDSAYLS GDVLVMDELG
510 520 530 540 550
YMYFRDRSGD TFRWRGENVS TTEVEAVLSR LLGQTDVAVY GVAVPGVEGK
560 570 580 590 600
AGMAAIADPH SQLDPNSMYQ ELQKVLASYA RPIFLRLLPQ VDTTGTFKIQ
610 620 630 640
KTRLQREGFD PRQTSDRLFF LDLKQGRYVP LDERVHARIC AGDFSL
Length:646
Mass (Da):71,276
Last modified:November 1, 1996 - v1
Checksum:i910B92BA8D985B4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15976 mRNA Translation: AAC71060.1
AF023258, AF023256, AF023257 Genomic DNA Translation: AAC69640.1
BC028937 mRNA Translation: AAH28937.1
CCDSiCCDS40386.1
PIRiA55093
RefSeqiNP_036107.1, NM_011977.3
XP_006509736.1, XM_006509673.2
XP_006509737.1, XM_006509674.3
XP_006509738.1, XM_006509675.3
XP_006509739.1, XM_006509676.3
UniGeneiMm.38165

Genome annotation databases

EnsembliENSMUST00000034267; ENSMUSP00000034267; ENSMUSG00000031808
ENSMUST00000212889; ENSMUSP00000148768; ENSMUSG00000031808
GeneIDi26457
KEGGimmu:26457
UCSCiuc009mdw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS27A1_MOUSE
AccessioniPrimary (citable) accession number: Q60714
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health