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Protein
Submitted name:

Amyloid-like protein 2

Gene

Aplp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiI02.016.

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid-like protein 2Imported
Submitted name:
Amyloid-like protein 2, isoform 751Imported
Gene namesi
Name:Aplp2Imported
Synonyms:APLP2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88047. Aplp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei682 – 70423HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 751720Sequence analysisPRO_5007707303Add
BLAST

Proteomic databases

PeptideAtlasiQ60709.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072428.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini310 – 36051BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
GeneTreeiENSGT00530000063252.
HOVERGENiHBG000051.
OMAiTLYSYGM.
OrthoDBiEOG7RNJZP.
TreeFamiTF317274.

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP
60 70 80 90 100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI
110 120 130 140 150
TNVMEANQPV NIDSWCRRDK RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ
160 170 180 190 200
FFHQERMEVC EKHQRWHTLV KEACLTEGLT LYSYGMLLPC GVDQFHGTEY
210 220 230 240 250
VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF PTEADLEDFT
260 270 280 290 300
EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
310 320 330 340 350
EIVHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF
360 370 380 390 400
ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR
410 420 430 440 450
HRNRMDRVKK EWEEAELQAK NLPKTERQTL IQHFQAMVKA LEKEAASEKQ
460 470 480 490 500
QLVETHLARV EAMLNDRRRI ALENYLAALQ SDPPRPHRIL QALRRYVRAE
510 520 530 540 550
NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV
560 570 580 590 600
PYVAQEIQEE IDELLQEQRA DMDQFTSSIS ENPVDVRVSS EESEEIPPFH
610 620 630 640 650
PLHPFPSLSE NEGSGMAEQD GGLIGAEEKV INSKNKMDEN MVIDETLDVK
660 670 680 690 700
EMIFNAERVG GLEEEPESVG PLREDFSLSS NALIGLLVIA VAIATVIVIS
710 720 730 740 750
LVMLRKRQYG TISHGIVEVD PMLTPEERHL NKMQNHGYEN PTYKYLEQMQ

I
Length:751
Mass (Da):85,248
Last modified:November 1, 1996 - v1
Checksum:iD183F6A4AD17BC04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114542 Genomic DNA. No translation available.
CT025678 Genomic DNA. No translation available.
U15571 mRNA. Translation: AAA50603.1.
PIRiA49974.
RefSeqiNP_001095925.1. NM_001102455.1.
UniGeneiMm.19133.

Genome annotation databases

EnsembliENSMUST00000072634; ENSMUSP00000072428; ENSMUSG00000031996.
GeneIDi11804.
UCSCiuc009orm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114542 Genomic DNA. No translation available.
CT025678 Genomic DNA. No translation available.
U15571 mRNA. Translation: AAA50603.1.
PIRiA49974.
RefSeqiNP_001095925.1. NM_001102455.1.
UniGeneiMm.19133.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072428.

Protein family/group databases

MEROPSiI02.016.

Proteomic databases

PeptideAtlasiQ60709.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072634; ENSMUSP00000072428; ENSMUSG00000031996.
GeneIDi11804.
UCSCiuc009orm.1. mouse.

Organism-specific databases

CTDi334.
MGIiMGI:88047. Aplp2.

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
GeneTreeiENSGT00530000063252.
HOVERGENiHBG000051.
OMAiTLYSYGM.
OrthoDBiEOG7RNJZP.
TreeFamiTF317274.

Miscellaneous databases

ChiTaRSiAplp2. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.410.10. 1 hit.
InterProiIPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
[Graphical view]
PfamiPF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
[Graphical view]
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
SMARTiSM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
[Graphical view]
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiPS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP)."
    Slunt H.H., Thinakaran G., Von Koch C., Lo A.C., Tanzi R.E., Sisodia S.S.
    J. Biol. Chem. 269:2637-2644(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-229.
    Strain: ICRImported.
  2. "Amyloid precursor-like protein 2 (APLP2) is modified by the addition of chondroitin sulfate glycosaminoglycan at a single site."
    Thinakaran G., Sisodia S.S.
    J. Biol. Chem. 269:22099-22104(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.
  3. "Mouse Amyloid Precursor-Like Protein 2 (APLP2) mRNA, isoform APLP2-751,complete cds."
    Slunt H.H., Von Koch C., Sisodia S.S.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ICRImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ60709_MOUSE
AccessioniPrimary (citable) accession number: Q60709
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.