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Protein
Submitted name:

Amyloid-like protein 2

Gene

Aplp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Protein family/group databases

MEROPSiI02.016.

Names & Taxonomyi

Protein namesi
Submitted name:
Amyloid-like protein 2Imported
Submitted name:
Amyloid-like protein 2, isoform 751Imported
Gene namesi
Name:Aplp2Imported
Synonyms:APLP2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88047. Aplp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei682 – 704HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_501121007432 – 751Sequence analysisAdd BLAST720

Expressioni

Gene expression databases

BgeeiENSMUSG00000031996.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini310 – 360BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
GeneTreeiENSGT00530000063252.
HOVERGENiHBG000051.
OMAiIRHRNRM.
OrthoDBiEOG091G0UW4.
TreeFamiTF317274.

Family and domain databases

CDDicd00109. KU. 1 hit.
Gene3Di3.30.1490.140. 1 hit.
3.90.570.10. 1 hit.
4.10.410.10. 1 hit.
InterProiView protein in InterPro
IPR036669. Amyloid_Cu-bd_sf.
IPR008155. Amyloid_glyco.
IPR011178. Amyloid_glyco_Cu-bd.
IPR024329. Amyloid_glyco_E2_domain.
IPR008154. Amyloid_glyco_extra.
IPR019744. Amyloid_glyco_extracell_CS.
IPR015849. Amyloid_glyco_heparin-bd.
IPR036454. Amyloid_glyco_heparin-bd_sf.
IPR019745. Amyloid_glyco_intracell_CS.
IPR019543. APP_amyloid_C.
IPR036176. E2_sf.
IPR002223. Kunitz_BPTI.
IPR036880. Kunitz_BPTI_sf.
IPR020901. Prtase_inh_Kunz-CS.
PANTHERiPTHR23103. PTHR23103. 1 hit.
PfamiView protein in Pfam
PF10515. APP_amyloid. 1 hit.
PF12924. APP_Cu_bd. 1 hit.
PF12925. APP_E2. 1 hit.
PF02177. APP_N. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
PRINTSiPR00203. AMYLOIDA4.
PR00759. BASICPTASE.
SMARTiView protein in SMART
SM00006. A4_EXTRA. 1 hit.
SM00131. KU. 1 hit.
SUPFAMiSSF109843. SSF109843. 1 hit.
SSF56491. SSF56491. 1 hit.
SSF57362. SSF57362. 1 hit.
SSF89811. SSF89811. 1 hit.
PROSITEiView protein in PROSITE
PS00319. A4_EXTRA. 1 hit.
PS00320. A4_INTRA. 1 hit.
PS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATGTAAAA ATGKLLVLLL LGLTAPAAAL AGYIEALAAN AGTGFAVAEP
60 70 80 90 100
QIAMFCGKLN MHVNIQTGKW EPDPTGTKSC LGTKEEVLQY CQEIYPELQI
110 120 130 140 150
TNVMEANQPV NIDSWCRRDK RQCKSHIVIP FKCLVGEFVS DVLLVPDNCQ
160 170 180 190 200
FFHQERMEVC EKHQRWHTLV KEACLTEGLT LYSYGMLLPC GVDQFHGTEY
210 220 230 240 250
VCCPQTKTVD SDSTMSKEEE EEEEDEEDEE EDYDLDKSEF PTEADLEDFT
260 270 280 290 300
EAAADEEEED EEEGEEVVED RDYYYDPFKG DDYNEENPTE PSSEGTISDK
310 320 330 340 350
EIVHDVKAVC SQEAMTGPCR AVMPRWYFDL SKGKCVRFIY GGCGGNRNNF
360 370 380 390 400
ESEDYCMAVC KAMIPPTPLP TNDVDVYFET SADDNEHARF QKAKEQLEIR
410 420 430 440 450
HRNRMDRVKK EWEEAELQAK NLPKTERQTL IQHFQAMVKA LEKEAASEKQ
460 470 480 490 500
QLVETHLARV EAMLNDRRRI ALENYLAALQ SDPPRPHRIL QALRRYVRAE
510 520 530 540 550
NKDRLHTIRH YQHVLAVDPE KAAQMKSQVM THLHVIEERR NQSLSLLYKV
560 570 580 590 600
PYVAQEIQEE IDELLQEQRA DMDQFTSSIS ENPVDVRVSS EESEEIPPFH
610 620 630 640 650
PLHPFPSLSE NEGSGMAEQD GGLIGAEEKV INSKNKMDEN MVIDETLDVK
660 670 680 690 700
EMIFNAERVG GLEEEPESVG PLREDFSLSS NALIGLLVIA VAIATVIVIS
710 720 730 740 750
LVMLRKRQYG TISHGIVEVD PMLTPEERHL NKMQNHGYEN PTYKYLEQMQ

I
Length:751
Mass (Da):85,248
Last modified:November 1, 1996 - v1
Checksum:iD183F6A4AD17BC04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114542 Genomic DNA. No translation available.
CT025678 Genomic DNA. No translation available.
U15571 mRNA. Translation: AAA50603.1.
PIRiA49974.
RefSeqiNP_001095925.1. NM_001102455.1.
UniGeneiMm.19133.

Genome annotation databases

EnsembliENSMUST00000072634; ENSMUSP00000072428; ENSMUSG00000031996.
GeneIDi11804.
UCSCiuc009orm.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ60709_MOUSE
AccessioniPrimary (citable) accession number: Q60709
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 22, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported