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Q60707

- TBX2_MOUSE

UniProt

Q60707 - TBX2_MOUSE

Protein

T-box transcription factor TBX2

Gene

Tbx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi109 – 287179T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. aorta morphogenesis Source: BHF-UCL
    2. atrioventricular canal development Source: BHF-UCL
    3. cardiac muscle tissue development Source: MGI
    4. cell aging Source: MGI
    5. cellular senescence Source: UniProtKB
    6. developmental growth involved in morphogenesis Source: MGI
    7. embryonic camera-type eye morphogenesis Source: BHF-UCL
    8. embryonic digit morphogenesis Source: BHF-UCL
    9. endocardial cushion morphogenesis Source: BHF-UCL
    10. heart morphogenesis Source: MGI
    11. mammary placode formation Source: MGI
    12. muscle cell fate determination Source: MGI
    13. negative regulation of cardiac chamber formation Source: BHF-UCL
    14. negative regulation of heart looping Source: BHF-UCL
    15. negative regulation of transcription, DNA-templated Source: MGI
    16. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    17. outflow tract morphogenesis Source: BHF-UCL
    18. outflow tract septum morphogenesis Source: BHF-UCL
    19. palate development Source: MGI
    20. pharynx development Source: BHF-UCL
    21. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
    22. regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
    23. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX2
    Short name:
    T-box protein 2
    Gene namesi
    Name:Tbx2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98494. Tbx2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711T-box transcription factor TBX2PRO_0000184427Add
    BLAST

    Proteomic databases

    PRIDEiQ60707.

    PTM databases

    PhosphoSiteiQ60707.

    Expressioni

    Tissue specificityi

    In adults, highest levels in lung. Also found in heart, kidney, and ovary.

    Developmental stagei

    Expression first observed at day 9.5 in the otic and optic vesicles and in the facial region. At day 12.5, expressed in the trigeminal ganglia, facial regions, retina and limb bud mesenchyme. In later stages, found in ear pinnae, the milk line, lung mesenchyme, body wall. Genital ridge and developing nervous system.2 Publications

    Gene expression databases

    ArrayExpressiQ60707.
    BgeeiQ60707.
    CleanExiMM_TBX2.
    GenevestigatoriQ60707.

    Interactioni

    Subunit structurei

    Interacts with PML.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000000095.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60707.
    SMRiQ60707. Positions 102-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni518 – 60285Repression domain 1 (RD1)By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi28 – 8760Ala-richAdd
    BLAST
    Compositional biasi582 – 60423Ala-richAdd
    BLAST

    Domaini

    The repression domain 1 (RD1) is necessary for its interaction with PML.By similarity

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG240293.
    GeneTreeiENSGT00750000117325.
    HOGENOMiHOG000038046.
    HOVERGENiHBG000412.
    InParanoidiQ5SSP7.
    KOiK10176.
    OMAiSPAPEHH.
    OrthoDBiEOG7W9RV1.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR022582. TBX.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    PF12598. TBX. 1 hit.
    [Graphical view]
    PRINTSiPR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60707-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALGK    50
    PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE 100
    VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK 150
    YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM 200
    AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF 250
    RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 300
    LPTLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPSAA PSPLRLHRAR 350
    AEEKPGAADS DPEPERTGEE RSAAPLGRSP SRDASPARLT EPERSRERRS 400
    PERCSKEPTE GGGDGPFSLR SLEKERPEAR RKDEGRKDVG EGKEPSLAPL 450
    VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFAMGP 500
    GAFSAMGMGH LLASVAGGSG SSGGAGPGTA AGLDAGGLGP AASAASTAAP 550
    FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA 600
    AAAAGSLSRS PFLGSARPRL RFSPYQIPVT IPPSTSLLTT GLAAEGSKGG 650
    NSREPSPLPE LALRKVGGPS RGALSPSGSA KEAASELQSI QRLVSGLESQ 700
    RALSPGRESP K 711
    Length:711
    Mass (Da):75,081
    Last modified:July 27, 2011 - v3
    Checksum:i1C38BF1D25E1FF60
    GO

    Sequence cautioni

    The sequence AAC52697.1 differs from that shown. Reason: Frameshift at position 4.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti377 – 3771G → C in AAC52697. (PubMed:7920656)Curated
    Sequence conflicti377 – 3771G → C in AAF90050. (PubMed:10770922)Curated
    Sequence conflicti486 – 4861G → C in AAC52697. (PubMed:7920656)Curated
    Sequence conflicti486 – 4861G → C in AAF90050. (PubMed:10770922)Curated
    Sequence conflicti689 – 6891S → R in AAC52697. (PubMed:7920656)Curated
    Sequence conflicti689 – 6891S → R in AAF90050. (PubMed:10770922)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15566 mRNA. Translation: AAC52697.1. Frameshift.
    AF244917 Genomic DNA. Translation: AAF90050.1.
    AL596324, AL662910 Genomic DNA. Translation: CAI25161.1.
    AL662910, AL596324 Genomic DNA. Translation: CAI25309.1.
    CH466556 Genomic DNA. Translation: EDL15775.1.
    BC156393 mRNA. No translation available.
    CCDSiCCDS36266.1.
    PIRiS46458.
    RefSeqiNP_033350.2. NM_009324.2.
    UniGeneiMm.287052.

    Genome annotation databases

    EnsembliENSMUST00000000095; ENSMUSP00000000095; ENSMUSG00000000093.
    GeneIDi21385.
    KEGGimmu:21385.
    UCSCiuc007ksb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15566 mRNA. Translation: AAC52697.1 . Frameshift.
    AF244917 Genomic DNA. Translation: AAF90050.1 .
    AL596324 , AL662910 Genomic DNA. Translation: CAI25161.1 .
    AL662910 , AL596324 Genomic DNA. Translation: CAI25309.1 .
    CH466556 Genomic DNA. Translation: EDL15775.1 .
    BC156393 mRNA. No translation available.
    CCDSi CCDS36266.1.
    PIRi S46458.
    RefSeqi NP_033350.2. NM_009324.2.
    UniGenei Mm.287052.

    3D structure databases

    ProteinModelPortali Q60707.
    SMRi Q60707. Positions 102-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000000095.

    PTM databases

    PhosphoSitei Q60707.

    Proteomic databases

    PRIDEi Q60707.

    Protocols and materials databases

    DNASUi 21385.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000095 ; ENSMUSP00000000095 ; ENSMUSG00000000093 .
    GeneIDi 21385.
    KEGGi mmu:21385.
    UCSCi uc007ksb.1. mouse.

    Organism-specific databases

    CTDi 6909.
    MGIi MGI:98494. Tbx2.

    Phylogenomic databases

    eggNOGi NOG240293.
    GeneTreei ENSGT00750000117325.
    HOGENOMi HOG000038046.
    HOVERGENi HBG000412.
    InParanoidi Q5SSP7.
    KOi K10176.
    OMAi SPAPEHH.
    OrthoDBi EOG7W9RV1.
    TreeFami TF106341.

    Miscellaneous databases

    NextBioi 300620.
    PROi Q60707.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60707.
    Bgeei Q60707.
    CleanExi MM_TBX2.
    Genevestigatori Q60707.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR022582. TBX.
    IPR002070. TF_Brachyury.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    PF12598. TBX. 1 hit.
    [Graphical view ]
    PRINTSi PR00938. BRACHYURY.
    PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus."
      Bollag R.J., Siegfried Z., Cebra-Thomas J.A., Garvey N., Davison E.M., Silver L.M.
      Nat. Genet. 7:383-389(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
      Tissue: Embryo.
    2. "The gene encoding the T-box Factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes."
      Carreira S., Liu B., Goding C.R.
      J. Biol. Chem. 275:21920-21927(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTBX2_MOUSE
    AccessioniPrimary (citable) accession number: Q60707
    Secondary accession number(s): Q5SSP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3