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Protein

T-box transcription factor TBX2

Gene

Tbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi109 – 287T-boxPROSITE-ProRule annotationAdd BLAST179

GO - Molecular functioni

GO - Biological processi

  • aorta morphogenesis Source: BHF-UCL
  • atrioventricular canal development Source: BHF-UCL
  • cardiac muscle tissue development Source: MGI
  • cell aging Source: MGI
  • cellular senescence Source: UniProtKB
  • developmental growth involved in morphogenesis Source: MGI
  • embryonic camera-type eye morphogenesis Source: BHF-UCL
  • embryonic digit morphogenesis Source: BHF-UCL
  • embryonic heart tube development Source: UniProtKB
  • endocardial cushion morphogenesis Source: BHF-UCL
  • heart looping Source: UniProtKB
  • heart morphogenesis Source: MGI
  • mammary placode formation Source: MGI
  • muscle cell fate determination Source: MGI
  • negative regulation of cardiac chamber formation Source: BHF-UCL
  • negative regulation of heart looping Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • Notch signaling pathway Source: MGI
  • outflow tract morphogenesis Source: BHF-UCL
  • outflow tract septum morphogenesis Source: BHF-UCL
  • pharynx development Source: BHF-UCL
  • positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  • positive regulation of cell proliferation Source: MGI
  • regulation of heart contraction Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
  • roof of mouth development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX2
Short name:
T-box protein 2
Gene namesi
Name:Tbx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98494 Tbx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844271 – 711T-box transcription factor TBX2Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei652PhosphoserineBy similarity1
Modified residuei656PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60707
PaxDbiQ60707
PRIDEiQ60707

PTM databases

iPTMnetiQ60707
PhosphoSitePlusiQ60707

Expressioni

Tissue specificityi

In adults, highest levels in lung. Also found in heart, kidney, and ovary.

Developmental stagei

Expression first observed at day 9.5 in the otic and optic vesicles and in the facial region. At day 12.5, expressed in the trigeminal ganglia, facial regions, retina and limb bud mesenchyme. In later stages, found in ear pinnae, the milk line, lung mesenchyme, body wall. Genital ridge and developing nervous system.2 Publications

Gene expression databases

BgeeiENSMUSG00000000093
CleanExiMM_TBX2
GenevisibleiQ60707 MM

Interactioni

Subunit structurei

Interacts with PML.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000095

Structurei

3D structure databases

ProteinModelPortaliQ60707
SMRiQ60707
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni518 – 602Repression domain 1 (RD1)By similarityAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 87Ala-richAdd BLAST60
Compositional biasi582 – 604Ala-richAdd BLAST23

Domaini

The repression domain 1 (RD1) is necessary for its interaction with PML.By similarity

Phylogenomic databases

eggNOGiKOG3585 Eukaryota
ENOG410XSTS LUCA
GeneTreeiENSGT00760000118897
HOGENOMiHOG000038046
HOVERGENiHBG000412
InParanoidiQ60707
KOiK10176
OMAiPLFIHPG
OrthoDBiEOG091G0I8R
TreeFamiTF106341

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR022582 TBX
IPR002070 TF_Brachyury
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PF12598 TBX, 1 hit
PRINTSiPR00938 BRACHYURY
PR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q60707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALGK
60 70 80 90 100
PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE
110 120 130 140 150
VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK
160 170 180 190 200
YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM
210 220 230 240 250
AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF
260 270 280 290 300
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT
310 320 330 340 350
LPTLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPSAA PSPLRLHRAR
360 370 380 390 400
AEEKPGAADS DPEPERTGEE RSAAPLGRSP SRDASPARLT EPERSRERRS
410 420 430 440 450
PERCSKEPTE GGGDGPFSLR SLEKERPEAR RKDEGRKDVG EGKEPSLAPL
460 470 480 490 500
VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFAMGP
510 520 530 540 550
GAFSAMGMGH LLASVAGGSG SSGGAGPGTA AGLDAGGLGP AASAASTAAP
560 570 580 590 600
FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA
610 620 630 640 650
AAAAGSLSRS PFLGSARPRL RFSPYQIPVT IPPSTSLLTT GLAAEGSKGG
660 670 680 690 700
NSREPSPLPE LALRKVGGPS RGALSPSGSA KEAASELQSI QRLVSGLESQ
710
RALSPGRESP K
Length:711
Mass (Da):75,081
Last modified:July 27, 2011 - v3
Checksum:i1C38BF1D25E1FF60
GO

Sequence cautioni

The sequence AAC52697 differs from that shown. Reason: Frameshift at position 4.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377G → C in AAC52697 (PubMed:7920656).Curated1
Sequence conflicti377G → C in AAF90050 (PubMed:10770922).Curated1
Sequence conflicti486G → C in AAC52697 (PubMed:7920656).Curated1
Sequence conflicti486G → C in AAF90050 (PubMed:10770922).Curated1
Sequence conflicti689S → R in AAC52697 (PubMed:7920656).Curated1
Sequence conflicti689S → R in AAF90050 (PubMed:10770922).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15566 mRNA Translation: AAC52697.1 Frameshift.
AF244917 Genomic DNA Translation: AAF90050.1
AL596324, AL662910 Genomic DNA Translation: CAI25161.1
AL662910, AL596324 Genomic DNA Translation: CAI25309.1
CH466556 Genomic DNA Translation: EDL15775.1
BC156393 mRNA No translation available.
CCDSiCCDS36266.1
PIRiS46458
RefSeqiNP_033350.2, NM_009324.2
UniGeneiMm.287052

Genome annotation databases

EnsembliENSMUST00000000095; ENSMUSP00000000095; ENSMUSG00000000093
GeneIDi21385
KEGGimmu:21385
UCSCiuc007ksb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTBX2_MOUSE
AccessioniPrimary (citable) accession number: Q60707
Secondary accession number(s): Q5SSP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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