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Q60707

- TBX2_MOUSE

UniProt

Q60707 - TBX2_MOUSE

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Protein
T-box transcription factor TBX2
Gene
Tbx2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi109 – 287179T-box
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. aorta morphogenesis Source: BHF-UCL
  2. atrioventricular canal development Source: BHF-UCL
  3. cardiac muscle tissue development Source: MGI
  4. cell aging Source: MGI
  5. cellular senescence Source: UniProtKB
  6. developmental growth involved in morphogenesis Source: MGI
  7. embryonic camera-type eye morphogenesis Source: BHF-UCL
  8. embryonic digit morphogenesis Source: BHF-UCL
  9. endocardial cushion morphogenesis Source: BHF-UCL
  10. heart morphogenesis Source: MGI
  11. mammary placode formation Source: MGI
  12. muscle cell fate determination Source: MGI
  13. negative regulation of cardiac chamber formation Source: BHF-UCL
  14. negative regulation of heart looping Source: BHF-UCL
  15. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  16. negative regulation of transcription, DNA-templated Source: MGI
  17. outflow tract morphogenesis Source: BHF-UCL
  18. outflow tract septum morphogenesis Source: BHF-UCL
  19. palate development Source: MGI
  20. pharynx development Source: BHF-UCL
  21. positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
  22. regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation Source: BHF-UCL
  23. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX2
Short name:
T-box protein 2
Gene namesi
Name:Tbx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98494. Tbx2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711T-box transcription factor TBX2
PRO_0000184427Add
BLAST

Proteomic databases

PRIDEiQ60707.

PTM databases

PhosphoSiteiQ60707.

Expressioni

Tissue specificityi

In adults, highest levels in lung. Also found in heart, kidney, and ovary.

Developmental stagei

Expression first observed at day 9.5 in the otic and optic vesicles and in the facial region. At day 12.5, expressed in the trigeminal ganglia, facial regions, retina and limb bud mesenchyme. In later stages, found in ear pinnae, the milk line, lung mesenchyme, body wall. Genital ridge and developing nervous system.2 Publications

Gene expression databases

ArrayExpressiQ60707.
BgeeiQ60707.
CleanExiMM_TBX2.
GenevestigatoriQ60707.

Interactioni

Subunit structurei

Interacts with PML By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000095.

Structurei

3D structure databases

ProteinModelPortaliQ60707.
SMRiQ60707. Positions 102-287.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni518 – 60285Repression domain 1 (RD1) By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 8760Ala-rich
Add
BLAST
Compositional biasi582 – 60423Ala-rich
Add
BLAST

Domaini

The repression domain 1 (RD1) is necessary for its interaction with PML By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG240293.
GeneTreeiENSGT00750000117325.
HOGENOMiHOG000038046.
HOVERGENiHBG000412.
InParanoidiQ5SSP7.
KOiK10176.
OMAiSPAPEHH.
OrthoDBiEOG7W9RV1.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR022582. TBX.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
PF12598. TBX. 1 hit.
[Graphical view]
PRINTSiPR00938. BRACHYURY.
PR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60707-1 [UniParc]FASTAAdd to Basket

« Hide

MREPALAASA MAYHPFHAPR PADFPMSAFL AAAQPSFFPA LALPPGALGK    50
PLPDPGLAGA AAAAAAAAAA AEAGLHVSAL GPHPPAAHLR SLKSLEPEDE 100
VEDDPKVTLE AKELWDQFHK LGTEMVITKS GRRMFPPFKV RVSGLDKKAK 150
YILLMDIVAA DDCRYKFHNS RWMVAGKADP EMPKRMYIHP DSPATGEQWM 200
AKPVAFHKLK LTNNISDKHG FTILNSMHKY QPRFHIVRAN DILKLPYSTF 250
RTYVFPETDF IAVTAYQNDK ITQLKIDNNP FAKGFRDTGN GRREKRKQLT 300
LPTLRLYEEH CKPERDGAES DASSCDPPPA REPPPSPSAA PSPLRLHRAR 350
AEEKPGAADS DPEPERTGEE RSAAPLGRSP SRDASPARLT EPERSRERRS 400
PERCSKEPTE GGGDGPFSLR SLEKERPEAR RKDEGRKDVG EGKEPSLAPL 450
VVQTDSASPL GAGHLPGLAF SSHLHGQQFF GPLGAGQPLF LHPGQFAMGP 500
GAFSAMGMGH LLASVAGGSG SSGGAGPGTA AGLDAGGLGP AASAASTAAP 550
FPFHLSQHML ASQGIPMPTF GGLFPYPYTY MAAAAAAASA LPATSAAAAA 600
AAAAGSLSRS PFLGSARPRL RFSPYQIPVT IPPSTSLLTT GLAAEGSKGG 650
NSREPSPLPE LALRKVGGPS RGALSPSGSA KEAASELQSI QRLVSGLESQ 700
RALSPGRESP K 711
Length:711
Mass (Da):75,081
Last modified:July 27, 2011 - v3
Checksum:i1C38BF1D25E1FF60
GO

Sequence cautioni

The sequence AAC52697.1 differs from that shown. Reason: Frameshift at position 4.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti377 – 3771G → C in AAC52697. 1 Publication
Sequence conflicti377 – 3771G → C in AAF90050. 1 Publication
Sequence conflicti486 – 4861G → C in AAC52697. 1 Publication
Sequence conflicti486 – 4861G → C in AAF90050. 1 Publication
Sequence conflicti689 – 6891S → R in AAC52697. 1 Publication
Sequence conflicti689 – 6891S → R in AAF90050. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15566 mRNA. Translation: AAC52697.1. Frameshift.
AF244917 Genomic DNA. Translation: AAF90050.1.
AL596324, AL662910 Genomic DNA. Translation: CAI25161.1.
AL662910, AL596324 Genomic DNA. Translation: CAI25309.1.
CH466556 Genomic DNA. Translation: EDL15775.1.
BC156393 mRNA. No translation available.
CCDSiCCDS36266.1.
PIRiS46458.
RefSeqiNP_033350.2. NM_009324.2.
UniGeneiMm.287052.

Genome annotation databases

EnsembliENSMUST00000000095; ENSMUSP00000000095; ENSMUSG00000000093.
GeneIDi21385.
KEGGimmu:21385.
UCSCiuc007ksb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15566 mRNA. Translation: AAC52697.1 . Frameshift.
AF244917 Genomic DNA. Translation: AAF90050.1 .
AL596324 , AL662910 Genomic DNA. Translation: CAI25161.1 .
AL662910 , AL596324 Genomic DNA. Translation: CAI25309.1 .
CH466556 Genomic DNA. Translation: EDL15775.1 .
BC156393 mRNA. No translation available.
CCDSi CCDS36266.1.
PIRi S46458.
RefSeqi NP_033350.2. NM_009324.2.
UniGenei Mm.287052.

3D structure databases

ProteinModelPortali Q60707.
SMRi Q60707. Positions 102-287.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000095.

PTM databases

PhosphoSitei Q60707.

Proteomic databases

PRIDEi Q60707.

Protocols and materials databases

DNASUi 21385.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000095 ; ENSMUSP00000000095 ; ENSMUSG00000000093 .
GeneIDi 21385.
KEGGi mmu:21385.
UCSCi uc007ksb.1. mouse.

Organism-specific databases

CTDi 6909.
MGIi MGI:98494. Tbx2.

Phylogenomic databases

eggNOGi NOG240293.
GeneTreei ENSGT00750000117325.
HOGENOMi HOG000038046.
HOVERGENi HBG000412.
InParanoidi Q5SSP7.
KOi K10176.
OMAi SPAPEHH.
OrthoDBi EOG7W9RV1.
TreeFami TF106341.

Miscellaneous databases

NextBioi 300620.
PROi Q60707.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60707.
Bgeei Q60707.
CleanExi MM_TBX2.
Genevestigatori Q60707.

Family and domain databases

Gene3Di 2.60.40.820. 1 hit.
InterProi IPR008967. p53-like_TF_DNA-bd.
IPR022582. TBX.
IPR002070. TF_Brachyury.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view ]
PANTHERi PTHR11267. PTHR11267. 1 hit.
Pfami PF00907. T-box. 1 hit.
PF12598. TBX. 1 hit.
[Graphical view ]
PRINTSi PR00938. BRACHYURY.
PR00937. TBOX.
SMARTi SM00425. TBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF49417. SSF49417. 1 hit.
PROSITEi PS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus."
    Bollag R.J., Siegfried Z., Cebra-Thomas J.A., Garvey N., Davison E.M., Silver L.M.
    Nat. Genet. 7:383-389(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "The gene encoding the T-box Factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes."
    Carreira S., Liu B., Goding C.R.
    J. Biol. Chem. 275:21920-21927(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTBX2_MOUSE
AccessioniPrimary (citable) accession number: Q60707
Secondary accession number(s): Q5SSP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi