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Q606Q2

- HISX_METCA

UniProt

Q606Q2 - HISX_METCA

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Protein
Histidinol dehydrogenase
Gene
hisD, MCA1963
Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351NAD By similarity
Binding sitei196 – 1961NAD By similarity
Binding sitei219 – 2191NAD By similarity
Binding sitei242 – 2421Substrate By similarity
Metal bindingi264 – 2641Zinc By similarity
Binding sitei264 – 2641Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Active sitei332 – 3321Proton acceptor By similarity
Active sitei333 – 3331Proton acceptor By similarity
Binding sitei333 – 3331Substrate By similarity
Metal bindingi366 – 3661Zinc By similarity
Binding sitei366 – 3661Substrate By similarity
Binding sitei420 – 4201Substrate By similarity
Metal bindingi425 – 4251Zinc By similarity
Binding sitei425 – 4251Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MCA1963
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
ProteomesiUP000006821: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Histidinol dehydrogenaseUniRule annotation
PRO_0000135794Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA1963.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 104
Helixi16 – 249
Helixi32 – 4817
Helixi50 – 6112
Helixi68 – 714
Helixi75 – 839
Helixi87 – 10721
Beta strandi112 – 1154
Beta strandi121 – 1288
Beta strandi130 – 1356
Helixi144 – 15714
Beta strandi160 – 1656
Helixi169 – 1713
Helixi175 – 18410
Beta strandi188 – 1903
Helixi194 – 20310
Beta strandi206 – 2083
Beta strandi212 – 2154
Helixi220 – 22910
Beta strandi233 – 2353
Beta strandi243 – 2486
Helixi254 – 26512
Beta strandi272 – 2787
Helixi280 – 29314
Helixi294 – 2963
Helixi300 – 31011
Beta strandi312 – 3154
Helixi319 – 32911
Beta strandi332 – 3398
Helixi341 – 3444
Helixi345 – 3473
Beta strandi352 – 3565
Helixi380 – 3823
Helixi389 – 3924
Beta strandi393 – 3997

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GICX-ray2.05A/B2-422[»]
ProteinModelPortaliQ606Q2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q606Q2-1 [UniParc]FASTAAdd to Basket

« Hide

MTEVKIKRLY TGDADFASQL DRLLAWSESE DTDIHQRVTE IIGCIRRDGD    50
AALVELTARF DHFVVDTAAA LELPRDVLEA AWQALPAEQA KALREAAERI 100
RAYAERQKLD SWDYREADGT LLGQKITPLD RVGLYVPGGK AAYPSSVLMN 150
AVPAKVAGVP ELIMAVPAPR GELNALVLAA AYISGVDRVF RIGGAQAVAA 200
LAYGTETVPR VDKIVGPGNI YVATAKKLVF GQVGIDMVAG PSEILVISDG 250
RTDPDWIAMD LFSQAEHDED AQAILISPDA AHLEAVQASI ERLLPGMERA 300
EVIRTSLERR GGMILVDDLE QAAAVANRIA PEHLELSVES PEVLVESIRN 350
AGAIFMGRYT AEALGDYCAG PNHVLPTSGT ARFSSPLGVY DFQKRSSLIY 400
CSPDGADQLG RTASLLAWGE GLGAHARSAE YRIRHH 436
Length:436
Mass (Da):47,045
Last modified:November 23, 2004 - v1
Checksum:i161D3DEAAE8BDE17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92021.1.
RefSeqiYP_114396.1. NC_002977.6.

Genome annotation databases

EnsemblBacteriaiAAU92021; AAU92021; MCA1963.
GeneIDi3102435.
KEGGimca:MCA1963.
PATRICi22607774. VBIMetCap22254_1995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017282 Genomic DNA. Translation: AAU92021.1 .
RefSeqi YP_114396.1. NC_002977.6.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GIC X-ray 2.05 A/B 2-422 [» ]
ProteinModelPortali Q606Q2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243233.MCA1963.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU92021 ; AAU92021 ; MCA1963 .
GeneIDi 3102435.
KEGGi mca:MCA1963.
PATRICi 22607774. VBIMetCap22254_1995.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33009 / NCIMB 11132 / Bath.

Entry informationi

Entry nameiHISX_METCA
AccessioniPrimary (citable) accession number: Q606Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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