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Q606N2 (NAGZ_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:MCA1984
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000234916

Regions

Region158 – 1592Substrate binding By similarity

Sites

Active site1711Proton donor/acceptor By similarity
Active site2421Nucleophile By similarity
Binding site571Substrate By similarity
Binding site651Substrate By similarity
Binding site1281Substrate By similarity
Site1691Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q606N2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 38423296CB06F04D

FASTA33435,944
        10         20         30         40         50         60 
MFDLVGPRLS ADEREFLCHP AAGGLILFSR NYASPDQMLA LVSEVRSLRP DMLIAVDHEG 

        70         80         90        100        110        120 
GRVQRFREGF TRLPPASAYL EVAGEAGLAA AETAGWLMAA ELRAVGVDFS FAPVLDVDSG 

       130        140        150        160        170        180 
ISTVIGDRAF ARTPEEVTAA ARAFATGMRR AGMAAVGKHF PGHGGVAGDS HLVLPEDRRE 

       190        200        210        220        230        240 
LEELLARDLL PFSALIRENL EGIMPAHVLY SRIDARPPCF SPFWLQTILR ERMNFDGAIF 

       250        260        270        280        290        300 
SDDLSMAGAA VAGDYAARAL AALEAGCDML VVCNTPEATA SILEALENRT ASPGSTRRLA 

       310        320        330 
AMCGRSRIDR DALLASSEWR NAVDRIHSFN DSAQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017282 Genomic DNA. Translation: AAU91985.1.
RefSeqYP_114416.1. NC_002977.6.

3D structure databases

ProteinModelPortalQ606N2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243233.MCA1984.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAU91985; AAU91985; MCA1984.
GeneID3103253.
KEGGmca:MCA1984.
PATRIC22607816. VBIMetCap22254_2015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMALLNGFVW.
OrthoDBEOG6BCT06.

Enzyme and pathway databases

UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAGZ_METCA
AccessionPrimary (citable) accession number: Q606N2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries