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Q606L3 (FABH_METCA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:MCA2003
OrganismMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) [Complete proteome] [HAMAP]
Taxonomic identifier243233 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Methylococcales › Methylococcaceae › Methylococcus

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3213213-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000088314

Regions

Region249 – 2535ACP-binding By similarity

Sites

Active site1141 By similarity
Active site2481 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q606L3 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 97329C43DCCCE532

FASTA32134,697
        10         20         30         40         50         60 
MSRYSRIAGT GGYLPRQVVT NDDLAMRVET SDEWIVERTG IRRRHIAAAD ETASSMAEIA 

        70         80         90        100        110        120 
SRQALEAAAI DPHDLDLIIL ATSSPDRVFP STACLLQQRL GVRSCAAFDV QAACSGFIFA 

       130        140        150        160        170        180 
LSIADQYISA GNANRVLVVG TEVNSRSVDW DDRSTCILFG DGAGAVVLES ATEPGIMSTH 

       190        200        210        220        230        240 
IHSDGHYQDL LYLPNPASNG EGSDESRTIR MQGSEVFKVA VNTLGRIVDE TLEQNGLQKS 

       250        260        270        280        290        300 
DVDWLVPHQA NIRIIAATAK KLQLPMERVV VTVDEQGNTS SASIPLAFDE AVRDGRIKRG 

       310        320 
QTVLMEAFGG GFAWGSALLR Y

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017282 Genomic DNA. Translation: AAU91776.1.
RefSeqYP_114435.1. NC_002977.6.

3D structure databases

HSSPHSSP built from PDB template 1HNK based on UniProtKB P0A6R0.
ProteinModelPortalQ606L3.
SMRQ606L3. Positions 4-321.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3103003.
GenomeReviewsGene locus MCA2003 in contig AE017282_GR.
KEGGmca:MCA2003.
NMPDRfig|243233.4.peg.1954.
PATRIC22607852. VBIMetCap22254_2033.
TIGRMCA2003.

Phylogenomic databases

HOGENOMHBG649927.
OMARILNFLA.
ProtClustDBPRK09352.

Enzyme and pathway databases

BioCycMCAP243233:MCA_2003-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_METCA
AccessionPrimary (citable) accession number: Q606L3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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