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Q60698

- SKI_MOUSE

UniProt

Q60698 - SKI_MOUSE

Protein

Ski oncogene

Gene

Ski

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. histone deacetylase inhibitor activity Source: MGI
    3. protein binding Source: MGI
    4. protein domain specific binding Source: BHF-UCL
    5. protein kinase binding Source: BHF-UCL
    6. repressing transcription factor binding Source: BHF-UCL
    7. SMAD binding Source: BHF-UCL
    8. transcription corepressor activity Source: MGI
    9. ubiquitin protein ligase binding Source: BHF-UCL
    10. zinc ion binding Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior axis specification Source: MGI
    2. bone morphogenesis Source: MGI
    3. camera-type eye development Source: MGI
    4. camera-type eye morphogenesis Source: MGI
    5. embryonic limb morphogenesis Source: MGI
    6. face morphogenesis Source: MGI
    7. lens morphogenesis in camera-type eye Source: MGI
    8. myelination in peripheral nervous system Source: MGI
    9. myotube differentiation Source: MGI
    10. negative regulation of activin receptor signaling pathway Source: BHF-UCL
    11. negative regulation of BMP signaling pathway Source: BHF-UCL
    12. negative regulation of cell proliferation Source: BHF-UCL
    13. negative regulation of fibroblast proliferation Source: MGI
    14. negative regulation of histone deacetylation Source: GOC
    15. negative regulation of osteoblast differentiation Source: BHF-UCL
    16. negative regulation of Schwann cell proliferation Source: BHF-UCL
    17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    18. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
    19. neural tube closure Source: MGI
    20. nose morphogenesis Source: MGI
    21. olfactory bulb development Source: MGI
    22. palate development Source: MGI
    23. positive regulation of DNA binding Source: BHF-UCL
    24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    25. protein heterotrimerization Source: BHF-UCL
    26. protein homotrimerization Source: UniProtKB
    27. regulation of apoptotic process Source: RefGenome
    28. retina development in camera-type eye Source: MGI
    29. skeletal muscle fiber development Source: MGI
    30. SMAD protein signal transduction Source: BHF-UCL
    31. somatic stem cell maintenance Source: MGI
    32. transcription, DNA-templated Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ski oncogene
    Alternative name(s):
    Proto-oncogene c-Ski
    Gene namesi
    Name:Ski
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:98310. Ski.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nuclear body Source: BHF-UCL
    3. nucleoplasm Source: BHF-UCL
    4. nucleus Source: MGI
    5. PML body Source: BHF-UCL
    6. protein complex Source: MGI
    7. transcriptional repressor complex Source: MGI
    8. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 725725Ski oncogenePRO_0000129383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei477 – 4771PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ60698.

    PTM databases

    PhosphoSiteiQ60698.

    Expressioni

    Developmental stagei

    Is expressed in a uniform pattern in all embryonic cells prior to skeletal muscle cell formation in the myotomes of somites. Expression is first up-regulated in skeletal muscle at 12 dpc, this up-regulation is evident first in body wall muscle and one day later in limb muscles. At 13.5 dpc a most prominent expression is seen in all skeletal muscles. At this stage expression is seen in all other cells and tissues but at lower levels than in skeletal muscle.

    Gene expression databases

    CleanExiMM_SKI.
    GenevestigatoriQ60698.

    Interactioni

    Subunit structurei

    Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes By similarity.By similarity

    Protein-protein interaction databases

    DIPiDIP-60020N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60698.
    SMRiQ60698. Positions 89-190, 216-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili534 – 708175Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SKI family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG82850.
    HOVERGENiHBG006599.
    InParanoidiQ60698.

    Family and domain databases

    Gene3Di3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProiIPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028760. Ski.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view]
    PANTHERiPTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF15. PTHR10005:SF15. 1 hit.
    PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view]
    SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q60698-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAAAGRGG FQQPGLQKTL EQFHLSSMSS LGGPAVSRRA GQEAYKKESA    50
    KEAGAATVPA PVPTAAEPPP VLHLPAIQPP PPVLPGPFFM PSDRSTERCE 100
    TVLEGETISC FVVGGEKRLC LPQILNSVLR DFSLQQINSV CDELHIYCSR 150
    CTADQLEILK VMGILPFSAP SCGLITKTDA ERLCNALLYG GAYPPPCKKE 200
    LAASLALGLE LSERSVRVYH ECFGKCKGLL VPELYSSPSA ACIQCLDCRL 250
    MYPPHKFVVH SHKALENRTC HWGFDSANWR AYILLSQDYT GKEEQARLGR 300
    CLDDVKEKFD YANKYKRRVP RVSEPPASIR PKTDDTSSQS PASSEKDKQS 350
    TWLRTLAGSS NKSLGCTHPR QRLSAFRPWS PAVSASEKET SPHLPALIRD 400
    SFYSYKSFET AVAPNVALAP PTQQKVVNSP PCTTVVSRAP EPLTTCIQPR 450
    KRKLTLDTAG APDMLTPVAA AEEDKDSEAE VEVESREEFT SSLSSLSSPS 500
    FTSSSSAKDL SSPGMHAPPV VAPDAAAHVD APSGLEAELE HLRQALEGGL 550
    DTKEAKEKFL HEVVKMRVKQ EEKLTAALQA KRTLHQELEF LRVAKKEKLR 600
    EATEAKRNLR KEIERLRAEN EKKMKEANES RVRLKRELEQ ARQVRVCDKG 650
    CEAGRLRAKY SAQVEDLQAK LQHAEADREQ LRADLLRERE AREHLEKVVR 700
    ELQEQLRPRP RPEHPGGESN AELGP 725
    Length:725
    Mass (Da):80,119
    Last modified:June 21, 2005 - v2
    Checksum:i1BFD05C38519505C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF435852 mRNA. Translation: AAL30825.1.
    U14173 Genomic DNA. Translation: AAA99669.1. Sequence problems.
    UniGeneiMm.28520.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF435852 mRNA. Translation: AAL30825.1 .
    U14173 Genomic DNA. Translation: AAA99669.1 . Sequence problems.
    UniGenei Mm.28520.

    3D structure databases

    ProteinModelPortali Q60698.
    SMRi Q60698. Positions 89-190, 216-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60020N.

    PTM databases

    PhosphoSitei Q60698.

    Proteomic databases

    PRIDEi Q60698.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98310. Ski.

    Phylogenomic databases

    eggNOGi NOG82850.
    HOVERGENi HBG006599.
    InParanoidi Q60698.

    Miscellaneous databases

    PROi Q60698.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SKI.
    Genevestigatori Q60698.

    Family and domain databases

    Gene3Di 3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProi IPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028760. Ski.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view ]
    PANTHERi PTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF15. PTHR10005:SF15. 1 hit.
    Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view ]
    SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse Ski proto-oncogene cDNA."
      Chen Y., Berk M., Chen H., Stavnezer E., Colmenares C.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    2. "Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitro."
      Namciu S., Lyons G.E., Micales B.K., Heyman H.-C., Colmenares C., Stavnezer E.
      Dev. Dyn. 204:291-300(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-324.
      Strain: 129/J.

    Entry informationi

    Entry nameiSKI_MOUSE
    AccessioniPrimary (citable) accession number: Q60698
    Secondary accession number(s): Q8VIL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3