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Q60698

- SKI_MOUSE

UniProt

Q60698 - SKI_MOUSE

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Protein

Ski oncogene

Gene

Ski

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. histone deacetylase inhibitor activity Source: MGI
  3. protein domain specific binding Source: BHF-UCL
  4. protein kinase binding Source: BHF-UCL
  5. repressing transcription factor binding Source: BHF-UCL
  6. SMAD binding Source: BHF-UCL
  7. transcription corepressor activity Source: MGI
  8. ubiquitin protein ligase binding Source: BHF-UCL
  9. zinc ion binding Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior axis specification Source: MGI
  2. bone morphogenesis Source: MGI
  3. camera-type eye development Source: MGI
  4. camera-type eye morphogenesis Source: MGI
  5. embryonic limb morphogenesis Source: MGI
  6. face morphogenesis Source: MGI
  7. lens morphogenesis in camera-type eye Source: MGI
  8. myelination in peripheral nervous system Source: MGI
  9. myotube differentiation Source: MGI
  10. negative regulation of activin receptor signaling pathway Source: BHF-UCL
  11. negative regulation of BMP signaling pathway Source: BHF-UCL
  12. negative regulation of cell proliferation Source: BHF-UCL
  13. negative regulation of fibroblast proliferation Source: MGI
  14. negative regulation of histone deacetylation Source: GOC
  15. negative regulation of osteoblast differentiation Source: BHF-UCL
  16. negative regulation of Schwann cell proliferation Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  18. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  19. neural tube closure Source: MGI
  20. nose morphogenesis Source: MGI
  21. olfactory bulb development Source: MGI
  22. palate development Source: MGI
  23. positive regulation of DNA binding Source: BHF-UCL
  24. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  25. protein heterotrimerization Source: BHF-UCL
  26. protein homotrimerization Source: UniProtKB
  27. regulation of apoptotic process Source: RefGenome
  28. retina development in camera-type eye Source: MGI
  29. skeletal muscle fiber development Source: MGI
  30. SMAD protein signal transduction Source: BHF-UCL
  31. somatic stem cell maintenance Source: MGI
  32. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ski oncogene
Alternative name(s):
Proto-oncogene c-Ski
Gene namesi
Name:Ski
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:98310. Ski.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear body Source: BHF-UCL
  3. nucleoplasm Source: BHF-UCL
  4. nucleus Source: MGI
  5. PML body Source: BHF-UCL
  6. protein complex Source: MGI
  7. transcriptional repressor complex Source: MGI
  8. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Ski oncogenePRO_0000129383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei477 – 4771PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ60698.

PTM databases

PhosphoSiteiQ60698.

Expressioni

Developmental stagei

Is expressed in a uniform pattern in all embryonic cells prior to skeletal muscle cell formation in the myotomes of somites. Expression is first up-regulated in skeletal muscle at 12 dpc, this up-regulation is evident first in body wall muscle and one day later in limb muscles. At 13.5 dpc a most prominent expression is seen in all skeletal muscles. At this stage expression is seen in all other cells and tissues but at lower levels than in skeletal muscle.

Gene expression databases

CleanExiMM_SKI.
GenevestigatoriQ60698.

Interactioni

Subunit structurei

Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-60020N.

Structurei

3D structure databases

ProteinModelPortaliQ60698.
SMRiQ60698. Positions 89-190, 216-310, 662-708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili534 – 708175Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG82850.
HOVERGENiHBG006599.
InParanoidiQ60698.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60698 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAAAAGRGG FQQPGLQKTL EQFHLSSMSS LGGPAVSRRA GQEAYKKESA
60 70 80 90 100
KEAGAATVPA PVPTAAEPPP VLHLPAIQPP PPVLPGPFFM PSDRSTERCE
110 120 130 140 150
TVLEGETISC FVVGGEKRLC LPQILNSVLR DFSLQQINSV CDELHIYCSR
160 170 180 190 200
CTADQLEILK VMGILPFSAP SCGLITKTDA ERLCNALLYG GAYPPPCKKE
210 220 230 240 250
LAASLALGLE LSERSVRVYH ECFGKCKGLL VPELYSSPSA ACIQCLDCRL
260 270 280 290 300
MYPPHKFVVH SHKALENRTC HWGFDSANWR AYILLSQDYT GKEEQARLGR
310 320 330 340 350
CLDDVKEKFD YANKYKRRVP RVSEPPASIR PKTDDTSSQS PASSEKDKQS
360 370 380 390 400
TWLRTLAGSS NKSLGCTHPR QRLSAFRPWS PAVSASEKET SPHLPALIRD
410 420 430 440 450
SFYSYKSFET AVAPNVALAP PTQQKVVNSP PCTTVVSRAP EPLTTCIQPR
460 470 480 490 500
KRKLTLDTAG APDMLTPVAA AEEDKDSEAE VEVESREEFT SSLSSLSSPS
510 520 530 540 550
FTSSSSAKDL SSPGMHAPPV VAPDAAAHVD APSGLEAELE HLRQALEGGL
560 570 580 590 600
DTKEAKEKFL HEVVKMRVKQ EEKLTAALQA KRTLHQELEF LRVAKKEKLR
610 620 630 640 650
EATEAKRNLR KEIERLRAEN EKKMKEANES RVRLKRELEQ ARQVRVCDKG
660 670 680 690 700
CEAGRLRAKY SAQVEDLQAK LQHAEADREQ LRADLLRERE AREHLEKVVR
710 720
ELQEQLRPRP RPEHPGGESN AELGP
Length:725
Mass (Da):80,119
Last modified:June 21, 2005 - v2
Checksum:i1BFD05C38519505C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF435852 mRNA. Translation: AAL30825.1.
U14173 Genomic DNA. Translation: AAA99669.1. Sequence problems.
UniGeneiMm.28520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF435852 mRNA. Translation: AAL30825.1 .
U14173 Genomic DNA. Translation: AAA99669.1 . Sequence problems.
UniGenei Mm.28520.

3D structure databases

ProteinModelPortali Q60698.
SMRi Q60698. Positions 89-190, 216-310, 662-708.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60020N.

PTM databases

PhosphoSitei Q60698.

Proteomic databases

PRIDEi Q60698.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98310. Ski.

Phylogenomic databases

eggNOGi NOG82850.
HOVERGENi HBG006599.
InParanoidi Q60698.

Miscellaneous databases

PROi Q60698.
SOURCEi Search...

Gene expression databases

CleanExi MM_SKI.
Genevestigatori Q60698.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Mouse Ski proto-oncogene cDNA."
    Chen Y., Berk M., Chen H., Stavnezer E., Colmenares C.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  2. "Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitro."
    Namciu S., Lyons G.E., Micales B.K., Heyman H.-C., Colmenares C., Stavnezer E.
    Dev. Dyn. 204:291-300(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-324.
    Strain: 129/J.

Entry informationi

Entry nameiSKI_MOUSE
AccessioniPrimary (citable) accession number: Q60698
Secondary accession number(s): Q8VIL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3