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Protein

Ral guanine nucleotide dissociation stimulator-like 1

Gene

Rgl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable guanine nucleotide exchange factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 1
Short name:
RalGDS-like 1
Gene namesi
Name:Rgl1
Synonyms:Rgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107484. Rgl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688861 – 768Ral guanine nucleotide dissociation stimulator-like 1Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei520PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60695.
PaxDbiQ60695.
PRIDEiQ60695.

PTM databases

iPTMnetiQ60695.
PhosphoSitePlusiQ60695.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026482.
ExpressionAtlasiQ60695. baseline and differential.
GenevisibleiQ60695. MM.

Interactioni

Subunit structurei

Interacts with Ras.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027760.

Structurei

Secondary structure

1768
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi652 – 658Combined sources7
Helixi676 – 682Combined sources7
Turni683 – 687Combined sources5
Beta strandi692 – 701Combined sources10
Beta strandi703 – 705Combined sources3
Beta strandi708 – 711Combined sources4
Turni716 – 720Combined sources5
Beta strandi726 – 732Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EF5NMR-A632-734[»]
ProteinModelPortaliQ60695.
SMRiQ60695.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 196N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST132
Domaini232 – 501Ras-GEFPROSITE-ProRule annotationAdd BLAST270
Domaini648 – 735Ras-associatingPROSITE-ProRule annotationAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi541 – 613Ser-richAdd BLAST73

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00860000133700.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ60695.
KOiK17635.
TreeFamiTF315204.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD
60 70 80 90 100
QLPPGHTVSQ YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY
110 120 130 140 150
RGFASTKEVL ELLLDRYGNL TGPNCEDDGS QSSPESKAVI RNAIASILRA
160 170 180 190 200
WLDQCAEDFR EPPHFPCLQK LLEYLKQMMP GSDPERRAQN LLEQFQKQDV
210 220 230 240 250
DSDNGLLNTS SFSLEEEEEL ESGGSAEFTN FSEDLVAEQL TYMDAQLFKK
260 270 280 290 300
VVPHHCLGCI WSQRDKKENK HLAPTIRATI SQFNTLTKCV VSTVLGSKEL
310 320 330 340 350
KTQQRARVIE KWINIAHECR ILKNFSSLRA IVSALQSNSI YRLKKAWAAV
360 370 380 390 400
PKDRMLMFEE LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT
410 420 430 440 450
QRRLQLQKDM GVMQGTVPYL GTFLTDLTML DTALQDYIEG GLINFEKRRR
460 470 480 490 500
EFEVIAQIKL LQSACNSYCM GPDQKFIQWF QRQQLLSEEE SYALSCEIEA
510 520 530 540 550
AADANTTSPK PRKSMVKRLS LLFLGSDIIP GSTPTKEQPK SAASGSSGES
560 570 580 590 600
MDSVSVSSCE SNHSEAEEGP VTPMDTPDEP QKKLSESSSS CSSIHSMDTN
610 620 630 640 650
SSGMSSLINP LSSPPTCNNN PKIHKRSVSV TSITSTVLPP VYNQQNEDTC
660 670 680 690 700
IIRISVEDNN GNMYKSIMLT SQDKTPAVIQ RAMSKHNLES DPAEEYELVQ
710 720 730 740 750
VISEDKELVI PDSANVFYAM NSQVNFDFIL RKKNSVEEQV KLRSRTSLTL
760
PRTAKRGCWS NRHSKITL
Length:768
Mass (Da):86,324
Last modified:July 27, 2011 - v2
Checksum:iF59853A281DD52F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti662N → H in AAA64950 (PubMed:7935463).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14103 mRNA. Translation: AAA64950.1.
AK144218 mRNA. Translation: BAE25780.1.
AK169109 mRNA. Translation: BAE40891.1.
AK169180 mRNA. Translation: BAE40958.1.
CH466520 Genomic DNA. Translation: EDL39452.1.
BC017678 mRNA. Translation: AAH17678.1.
CCDSiCCDS15365.1.
PIRiA56234.
RefSeqiNP_058542.2. NM_016846.4.
UniGeneiMm.245270.

Genome annotation databases

EnsembliENSMUST00000027760; ENSMUSP00000027760; ENSMUSG00000026482.
GeneIDi19731.
KEGGimmu:19731.
UCSCiuc007czh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14103 mRNA. Translation: AAA64950.1.
AK144218 mRNA. Translation: BAE25780.1.
AK169109 mRNA. Translation: BAE40891.1.
AK169180 mRNA. Translation: BAE40958.1.
CH466520 Genomic DNA. Translation: EDL39452.1.
BC017678 mRNA. Translation: AAH17678.1.
CCDSiCCDS15365.1.
PIRiA56234.
RefSeqiNP_058542.2. NM_016846.4.
UniGeneiMm.245270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EF5NMR-A632-734[»]
ProteinModelPortaliQ60695.
SMRiQ60695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027760.

PTM databases

iPTMnetiQ60695.
PhosphoSitePlusiQ60695.

Proteomic databases

MaxQBiQ60695.
PaxDbiQ60695.
PRIDEiQ60695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027760; ENSMUSP00000027760; ENSMUSG00000026482.
GeneIDi19731.
KEGGimmu:19731.
UCSCiuc007czh.1. mouse.

Organism-specific databases

CTDi23179.
MGIiMGI:107484. Rgl1.

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00860000133700.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ60695.
KOiK17635.
TreeFamiTF315204.

Miscellaneous databases

ChiTaRSiRgl1. mouse.
EvolutionaryTraceiQ60695.
PROiQ60695.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026482.
ExpressionAtlasiQ60695. baseline and differential.
GenevisibleiQ60695. MM.

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRGL1_MOUSE
AccessioniPrimary (citable) accession number: Q60695
Secondary accession number(s): Q8VD09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.