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Protein

Ral guanine nucleotide dissociation stimulator-like 1

Gene

Rgl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable guanine nucleotide exchange factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 1
Short name:
RalGDS-like 1
Gene namesi
Name:Rgl1
Synonyms:Rgl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:107484. Rgl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 768768Ral guanine nucleotide dissociation stimulator-like 1PRO_0000068886Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei520 – 5201PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ60695.
PaxDbiQ60695.
PRIDEiQ60695.

PTM databases

iPTMnetiQ60695.
PhosphoSiteiQ60695.

Expressioni

Gene expression databases

BgeeiQ60695.
ExpressionAtlasiQ60695. baseline and differential.
GenevisibleiQ60695. MM.

Interactioni

Subunit structurei

Interacts with Ras.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027760.

Structurei

Secondary structure

1
768
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi652 – 6587Combined sources
Helixi676 – 6827Combined sources
Turni683 – 6875Combined sources
Beta strandi692 – 70110Combined sources
Beta strandi703 – 7053Combined sources
Beta strandi708 – 7114Combined sources
Turni716 – 7205Combined sources
Beta strandi726 – 7327Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EF5NMR-A632-734[»]
ProteinModelPortaliQ60695.
SMRiQ60695. Positions 10-499, 647-734.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60695.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 196132N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini232 – 501270Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini648 – 73588Ras-associatingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi541 – 61373Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-associating domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00810000125349.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ60695.
KOiK17635.
OrthoDBiEOG76DTRS.
TreeFamiTF315204.

Family and domain databases

Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLWQAKMS SIQDWGEEVE EGAVYHVTLK RVQIQQAANK GARWLGVEGD
60 70 80 90 100
QLPPGHTVSQ YETCKIRTIK AGTLEKLVEN LLTAFGDNDF TYISIFLSTY
110 120 130 140 150
RGFASTKEVL ELLLDRYGNL TGPNCEDDGS QSSPESKAVI RNAIASILRA
160 170 180 190 200
WLDQCAEDFR EPPHFPCLQK LLEYLKQMMP GSDPERRAQN LLEQFQKQDV
210 220 230 240 250
DSDNGLLNTS SFSLEEEEEL ESGGSAEFTN FSEDLVAEQL TYMDAQLFKK
260 270 280 290 300
VVPHHCLGCI WSQRDKKENK HLAPTIRATI SQFNTLTKCV VSTVLGSKEL
310 320 330 340 350
KTQQRARVIE KWINIAHECR ILKNFSSLRA IVSALQSNSI YRLKKAWAAV
360 370 380 390 400
PKDRMLMFEE LSDIFSDHNN HLTSRELLMK EGTSKFANLD SSVKENQKRT
410 420 430 440 450
QRRLQLQKDM GVMQGTVPYL GTFLTDLTML DTALQDYIEG GLINFEKRRR
460 470 480 490 500
EFEVIAQIKL LQSACNSYCM GPDQKFIQWF QRQQLLSEEE SYALSCEIEA
510 520 530 540 550
AADANTTSPK PRKSMVKRLS LLFLGSDIIP GSTPTKEQPK SAASGSSGES
560 570 580 590 600
MDSVSVSSCE SNHSEAEEGP VTPMDTPDEP QKKLSESSSS CSSIHSMDTN
610 620 630 640 650
SSGMSSLINP LSSPPTCNNN PKIHKRSVSV TSITSTVLPP VYNQQNEDTC
660 670 680 690 700
IIRISVEDNN GNMYKSIMLT SQDKTPAVIQ RAMSKHNLES DPAEEYELVQ
710 720 730 740 750
VISEDKELVI PDSANVFYAM NSQVNFDFIL RKKNSVEEQV KLRSRTSLTL
760
PRTAKRGCWS NRHSKITL
Length:768
Mass (Da):86,324
Last modified:July 27, 2011 - v2
Checksum:iF59853A281DD52F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti662 – 6621N → H in AAA64950 (PubMed:7935463).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14103 mRNA. Translation: AAA64950.1.
AK144218 mRNA. Translation: BAE25780.1.
AK169109 mRNA. Translation: BAE40891.1.
AK169180 mRNA. Translation: BAE40958.1.
CH466520 Genomic DNA. Translation: EDL39452.1.
BC017678 mRNA. Translation: AAH17678.1.
CCDSiCCDS15365.1.
PIRiA56234.
RefSeqiNP_058542.2. NM_016846.3.
UniGeneiMm.245270.

Genome annotation databases

EnsembliENSMUST00000027760; ENSMUSP00000027760; ENSMUSG00000026482.
GeneIDi19731.
KEGGimmu:19731.
UCSCiuc007czh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14103 mRNA. Translation: AAA64950.1.
AK144218 mRNA. Translation: BAE25780.1.
AK169109 mRNA. Translation: BAE40891.1.
AK169180 mRNA. Translation: BAE40958.1.
CH466520 Genomic DNA. Translation: EDL39452.1.
BC017678 mRNA. Translation: AAH17678.1.
CCDSiCCDS15365.1.
PIRiA56234.
RefSeqiNP_058542.2. NM_016846.3.
UniGeneiMm.245270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EF5NMR-A632-734[»]
ProteinModelPortaliQ60695.
SMRiQ60695. Positions 10-499, 647-734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027760.

PTM databases

iPTMnetiQ60695.
PhosphoSiteiQ60695.

Proteomic databases

MaxQBiQ60695.
PaxDbiQ60695.
PRIDEiQ60695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027760; ENSMUSP00000027760; ENSMUSG00000026482.
GeneIDi19731.
KEGGimmu:19731.
UCSCiuc007czh.1. mouse.

Organism-specific databases

CTDi23179.
MGIiMGI:107484. Rgl1.

Phylogenomic databases

eggNOGiKOG3629. Eukaryota.
ENOG410ZUT5. LUCA.
GeneTreeiENSGT00810000125349.
HOGENOMiHOG000231592.
HOVERGENiHBG005864.
InParanoidiQ60695.
KOiK17635.
OrthoDBiEOG76DTRS.
TreeFamiTF315204.

Miscellaneous databases

ChiTaRSiRgl1. mouse.
EvolutionaryTraceiQ60695.
PROiQ60695.
SOURCEiSearch...

Gene expression databases

BgeeiQ60695.
ExpressionAtlasiQ60695. baseline and differential.
GenevisibleiQ60695. MM.

Family and domain databases

Gene3Di1.10.840.10. 2 hits.
InterProiIPR000159. RA_dom.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR030748. RGL1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR23113:SF199. PTHR23113:SF199. 2 hits.
PfamiPF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50200. RA. 1 hit.
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "ralGDS family members interact with the effector loop of ras p21."
    Kikuchi A., Demo S.D., Ye Z.H., Chen Y.W., Williams L.T.
    Mol. Cell. Biol. 14:7483-7491(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-520, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  7. "Solution structure of the Ras-binding domain of RGL."
    Kigawa T., Endo M., Ito Y., Shirouzu M., Kikuchi A., Yokoyama S.
    FEBS Lett. 441:413-418(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 632-734.

Entry informationi

Entry nameiRGL1_MOUSE
AccessioniPrimary (citable) accession number: Q60695
Secondary accession number(s): Q8VD09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.