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Protein

Forkhead box protein D4

Gene

Foxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi102 – 19392Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4
Alternative name(s):
Forkhead-related protein FKHL9
Forkhead-related transcription factor 5
Short name:
FREAC-5
Transcription factor FKH-2
Gene namesi
Name:Foxd4
Synonyms:Fkh2, Fkhl9, Freac5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1347467. Foxd4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Forkhead box protein D4PRO_0000091822Add
BLAST

Proteomic databases

PaxDbiQ60688.
PRIDEiQ60688.

PTM databases

PhosphoSiteiQ60688.

Expressioni

Tissue specificityi

Not detected in any adult tissues tested.

Developmental stagei

Expressed in headfold stage embryos in the notochord, the anterior neuroectoderm, and a few cells of the definite endoderm. This expression becomes restricted to the anteriormost portions of the invaginating foregut and the developing midbrain. From day 11.5 of gestation onward, FOXD4 transcripts are restricted to the midbrain and become progressively localized to the red nuclei as the sole site of expression.

Gene expression databases

BgeeiENSMUSG00000051490.
CleanExiMM_FOXD4.
GenevisibleiQ60688. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058575.

Structurei

3D structure databases

ProteinModelPortaliQ60688.
SMRiQ60688. Positions 103-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 4727Asp/Glu-richAdd
BLAST
Compositional biasi204 – 29693Ala/Pro-richAdd
BLAST

Domaini

Contains two potential transactivation domains A and B.

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ60688.
KOiK09397.
OMAiLLQRPSC.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ60688.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSARAGHLR STPPPSPLSS DQDEVEIDVL AEEEDGDQTE EEDDEEESHK
60 70 80 90 100
CLERSLQRPG ARTLAGRSAG DCGDLSNSSG FLRKFRAPRT PATTTADGPQ
110 120 130 140 150
PAKPPYSYIA LITMAILQSP HKRLTLSGIC AFISGRFPYY RRKFPAWQNS
160 170 180 190 200
IRHNLSLNDC FVKIPREPGH PGKGNYWSLD PASQDMFDNG SFLRRRKRFK
210 220 230 240 250
RHHPPSGGHP HCPFPPPAVP ATLHVSQPSL LLRYSAPPQP NLAAHPAAPP
260 270 280 290 300
RSHPCAPLHP HPMRYLLLAA PAYGDNPRKA EGADPATPLA IPALQPVLGS
310 320 330 340 350
QPWERDQSSG TRSGRGCASF TIESIMQGVT GGGTGSAQSP SFAPWSYCHL
360 370 380 390 400
LQHPPCLLHP QAASPLFHMS AGSRTILPQQ PQPPLPLQQE QHHCAISCAP
410 420 430 440
GKGVRLGQHL SAVAALLRQQ PAADDGRLTT LAALSGREGT LPEF
Length:444
Mass (Da):48,047
Last modified:November 1, 1997 - v1
Checksum:iFFDC8EDDC6FC18FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2044RHHP → PTTR in CAA50742 (PubMed:7689224).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86368 Genomic DNA. Translation: CAA60128.1.
BC138432 mRNA. Translation: AAI38433.1.
BC138434 mRNA. Translation: AAI38435.1.
X71940 Genomic DNA. Translation: CAA50742.1.
CCDSiCCDS29715.1.
PIRiB47746.
RefSeqiNP_032048.1. NM_008022.2.
UniGeneiMm.377080.

Genome annotation databases

EnsembliENSMUST00000058600; ENSMUSP00000058575; ENSMUSG00000051490.
GeneIDi14237.
KEGGimmu:14237.
UCSCiuc008hav.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86368 Genomic DNA. Translation: CAA60128.1.
BC138432 mRNA. Translation: AAI38433.1.
BC138434 mRNA. Translation: AAI38435.1.
X71940 Genomic DNA. Translation: CAA50742.1.
CCDSiCCDS29715.1.
PIRiB47746.
RefSeqiNP_032048.1. NM_008022.2.
UniGeneiMm.377080.

3D structure databases

ProteinModelPortaliQ60688.
SMRiQ60688. Positions 103-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058575.

PTM databases

PhosphoSiteiQ60688.

Proteomic databases

PaxDbiQ60688.
PRIDEiQ60688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058600; ENSMUSP00000058575; ENSMUSG00000051490.
GeneIDi14237.
KEGGimmu:14237.
UCSCiuc008hav.1. mouse.

Organism-specific databases

CTDi2298.
MGIiMGI:1347467. Foxd4.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000231285.
HOVERGENiHBG051641.
InParanoidiQ60688.
KOiK09397.
OMAiLLQRPSC.
OrthoDBiEOG091G0HW9.
PhylomeDBiQ60688.
TreeFamiTF316127.

Miscellaneous databases

PROiQ60688.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051490.
CleanExiMM_FOXD4.
GenevisibleiQ60688. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFOXD4_MOUSE
AccessioniPrimary (citable) accession number: Q60688
Secondary accession number(s): B2RRJ0, Q61573
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.