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Q60687

- FSHB_MOUSE

UniProt

Q60687 - FSHB_MOUSE

Protein

Follitropin subunit beta

Gene

Fshb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates development of follicle and spermatogenesis in the reproductive organs.

    GO - Biological processi

    1. follicle-stimulating hormone signaling pathway Source: MGI
    2. ovarian follicle development Source: MGI
    3. positive regulation of bone resorption Source: MGI
    4. regulation of osteoclast differentiation Source: MGI
    5. Sertoli cell proliferation Source: MGI
    6. transforming growth factor beta receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follitropin subunit beta
    Alternative name(s):
    Follicle-stimulating hormone beta subunit
    Short name:
    FSH-B
    Short name:
    FSH-beta
    Follitropin beta chain
    Gene namesi
    Name:Fshb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:95582. Fshb.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 130110Follitropin subunit betaPRO_0000011713Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi22 ↔ 70By similarity
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi36 ↔ 85By similarity
    Disulfide bondi39 ↔ 123By similarity
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi47 ↔ 101By similarity
    Disulfide bondi51 ↔ 103By similarity
    Disulfide bondi106 ↔ 113By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60687.

    Expressioni

    Gene expression databases

    BgeeiQ60687.
    CleanExiMM_FSHB.
    GenevestigatoriQ60687.

    Interactioni

    Subunit structurei

    Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60687.
    SMRiQ60687. Positions 22-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41629.
    GeneTreeiENSGT00390000010115.
    HOGENOMiHOG000116098.
    HOVERGENiHBG006698.
    InParanoidiQ60687.
    KOiK05250.
    OMAiCFLFCCW.
    OrthoDBiEOG7JQBQF.
    PhylomeDBiQ60687.
    TreeFamiTF332940.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view]
    PANTHERiPTHR11515. PTHR11515. 1 hit.
    PfamiPF00007. Cys_knot. 1 hit.
    [Graphical view]
    SMARTiSM00068. GHB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60687-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMKLIQLCIL FWCWRAICCH SCELTNITIS VEKEECRFCI SINTTWCAGY    50
    CYTRDLVYKD PARPNTQKVC TFKELVYETV RLPGCARHSD SLYTYPVATE 100
    CHCGKCDSDS TDCTVRGLGP SYCSFSEMKE 130
    Length:130
    Mass (Da):14,919
    Last modified:November 1, 1996 - v1
    Checksum:i7F9C28C2E34AC161
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12932 Genomic DNA. Translation: AAA92804.1.
    AK017593 mRNA. Translation: BAB30827.1.
    BC061159 mRNA. Translation: AAH61159.1.
    CCDSiCCDS16504.1.
    PIRiJC4526.
    RefSeqiNP_032071.1. NM_008045.2.
    UniGeneiMm.249525.

    Genome annotation databases

    EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120.
    GeneIDi14308.
    KEGGimmu:14308.
    UCSCiuc008llt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12932 Genomic DNA. Translation: AAA92804.1 .
    AK017593 mRNA. Translation: BAB30827.1 .
    BC061159 mRNA. Translation: AAH61159.1 .
    CCDSi CCDS16504.1.
    PIRi JC4526.
    RefSeqi NP_032071.1. NM_008045.2.
    UniGenei Mm.249525.

    3D structure databases

    ProteinModelPortali Q60687.
    SMRi Q60687. Positions 22-125.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q60687.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028533 ; ENSMUSP00000028533 ; ENSMUSG00000027120 .
    GeneIDi 14308.
    KEGGi mmu:14308.
    UCSCi uc008llt.1. mouse.

    Organism-specific databases

    CTDi 2488.
    MGIi MGI:95582. Fshb.

    Phylogenomic databases

    eggNOGi NOG41629.
    GeneTreei ENSGT00390000010115.
    HOGENOMi HOG000116098.
    HOVERGENi HBG006698.
    InParanoidi Q60687.
    KOi K05250.
    OMAi CFLFCCW.
    OrthoDBi EOG7JQBQF.
    PhylomeDBi Q60687.
    TreeFami TF332940.

    Miscellaneous databases

    NextBioi 285727.
    PROi Q60687.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q60687.
    CleanExi MM_FSHB.
    Genevestigatori Q60687.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR006208. Glyco_hormone_CN.
    IPR001545. Gonadotropin_bsu.
    IPR018245. Gonadotropin_bsu_CS.
    [Graphical view ]
    PANTHERi PTHR11515. PTHR11515. 1 hit.
    Pfami PF00007. Cys_knot. 1 hit.
    [Graphical view ]
    SMARTi SM00068. GHB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
    PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse gonadotropin beta-subunit-encoding genes, I. Structure of the follicle-stimulating hormone beta-subunit-encoding gene."
      Kumar T.R., Kelly M., Mortrud M., Low M.J., Matzuk M.M.
      Gene 166:333-334(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiFSHB_MOUSE
    AccessioniPrimary (citable) accession number: Q60687
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3