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Q60687 (FSHB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name=FSH-B
Short name=FSH-beta
Follitropin beta chain
Gene names
Name:Fshb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates development of follicle and spermatogenesis in the reproductive organs.

Subunit structure

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Subcellular location

Secreted.

Sequence similarities

Belongs to the glycoprotein hormones subunit beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 130110Follitropin subunit beta
PRO_0000011713

Amino acid modifications

Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation431N-linked (GlcNAc...) Potential
Disulfide bond22 ↔ 70 By similarity
Disulfide bond36 ↔ 85 By similarity
Disulfide bond39 ↔ 123 By similarity
Disulfide bond47 ↔ 101 By similarity
Disulfide bond51 ↔ 103 By similarity
Disulfide bond106 ↔ 113 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60687 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 7F9C28C2E34AC161

FASTA13014,919
        10         20         30         40         50         60 
MMKLIQLCIL FWCWRAICCH SCELTNITIS VEKEECRFCI SINTTWCAGY CYTRDLVYKD 

        70         80         90        100        110        120 
PARPNTQKVC TFKELVYETV RLPGCARHSD SLYTYPVATE CHCGKCDSDS TDCTVRGLGP 

       130 
SYCSFSEMKE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of the mouse gonadotropin beta-subunit-encoding genes, I. Structure of the follicle-stimulating hormone beta-subunit-encoding gene."
Kumar T.R., Kelly M., Mortrud M., Low M.J., Matzuk M.M.
Gene 166:333-334(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12932 Genomic DNA. Translation: AAA92804.1.
AK017593 mRNA. Translation: BAB30827.1.
BC061159 mRNA. Translation: AAH61159.1.
CCDSCCDS16504.1.
PIRJC4526.
RefSeqNP_032071.1. NM_008045.2.
UniGeneMm.249525.

3D structure databases

ProteinModelPortalQ60687.
SMRQ60687. Positions 22-125.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ60687.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120.
GeneID14308.
KEGGmmu:14308.
UCSCuc008llt.1. mouse.

Organism-specific databases

CTD2488.
MGIMGI:95582. Fshb.

Phylogenomic databases

eggNOGNOG41629.
GeneTreeENSGT00390000010115.
HOGENOMHOG000116098.
HOVERGENHBG006698.
InParanoidQ60687.
KOK05250.
OMACFLFCCW.
OrthoDBEOG7JQBQF.
PhylomeDBQ60687.
TreeFamTF332940.

Gene expression databases

BgeeQ60687.
CleanExMM_FSHB.
GenevestigatorQ60687.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERPTHR11515. PTHR11515. 1 hit.
PfamPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285727.
PROQ60687.
SOURCESearch...

Entry information

Entry nameFSHB_MOUSE
AccessionPrimary (citable) accession number: Q60687
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot