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Protein

Follitropin subunit beta

Gene

Fshb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates development of follicle and spermatogenesis in the reproductive organs.

GO - Molecular functioni

GO - Biological processi

  • follicle-stimulating hormone signaling pathway Source: MGI
  • ovarian follicle development Source: MGI
  • positive regulation of bone resorption Source: MGI
  • positive regulation of gene expression Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • Sertoli cell proliferation Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.
R-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
Gene namesi
Name:Fshb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95582. Fshb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 130110Follitropin subunit betaPRO_0000011713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 70By similarity
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Disulfide bondi36 ↔ 85By similarity
Disulfide bondi39 ↔ 123By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 101By similarity
Disulfide bondi51 ↔ 103By similarity
Disulfide bondi106 ↔ 113By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60687.
PRIDEiQ60687.

PTM databases

PhosphoSiteiQ60687.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027120.
CleanExiMM_FSHB.
ExpressionAtlasiQ60687. baseline and differential.
GenevisibleiQ60687. MM.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028533.

Structurei

3D structure databases

ProteinModelPortaliQ60687.
SMRiQ60687. Positions 22-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWHY. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ60687.
KOiK05250.
OMAiAVEKEEC.
OrthoDBiEOG091G0XFH.
PhylomeDBiQ60687.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKLIQLCIL FWCWRAICCH SCELTNITIS VEKEECRFCI SINTTWCAGY
60 70 80 90 100
CYTRDLVYKD PARPNTQKVC TFKELVYETV RLPGCARHSD SLYTYPVATE
110 120 130
CHCGKCDSDS TDCTVRGLGP SYCSFSEMKE
Length:130
Mass (Da):14,919
Last modified:November 1, 1996 - v1
Checksum:i7F9C28C2E34AC161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA. Translation: AAA92804.1.
AK017593 mRNA. Translation: BAB30827.1.
BC061159 mRNA. Translation: AAH61159.1.
CCDSiCCDS16504.1.
PIRiJC4526.
RefSeqiNP_032071.1. NM_008045.3.
UniGeneiMm.249525.

Genome annotation databases

EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120.
GeneIDi14308.
KEGGimmu:14308.
UCSCiuc008llt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA. Translation: AAA92804.1.
AK017593 mRNA. Translation: BAB30827.1.
BC061159 mRNA. Translation: AAH61159.1.
CCDSiCCDS16504.1.
PIRiJC4526.
RefSeqiNP_032071.1. NM_008045.3.
UniGeneiMm.249525.

3D structure databases

ProteinModelPortaliQ60687.
SMRiQ60687. Positions 22-125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028533.

PTM databases

PhosphoSiteiQ60687.

Proteomic databases

PaxDbiQ60687.
PRIDEiQ60687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120.
GeneIDi14308.
KEGGimmu:14308.
UCSCiuc008llt.1. mouse.

Organism-specific databases

CTDi2488.
MGIiMGI:95582. Fshb.

Phylogenomic databases

eggNOGiENOG410IWHY. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ60687.
KOiK05250.
OMAiAVEKEEC.
OrthoDBiEOG091G0XFH.
PhylomeDBiQ60687.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.
R-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ60687.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027120.
CleanExiMM_FSHB.
ExpressionAtlasiQ60687. baseline and differential.
GenevisibleiQ60687. MM.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSHB_MOUSE
AccessioniPrimary (citable) accession number: Q60687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.