Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q60687

- FSHB_MOUSE

UniProt

Q60687 - FSHB_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Follitropin subunit beta

Gene

Fshb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Stimulates development of follicle and spermatogenesis in the reproductive organs.

GO - Biological processi

  1. follicle-stimulating hormone signaling pathway Source: MGI
  2. ovarian follicle development Source: MGI
  3. positive regulation of bone resorption Source: MGI
  4. regulation of osteoclast differentiation Source: MGI
  5. Sertoli cell proliferation Source: MGI
  6. transforming growth factor beta receptor signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_242871. G alpha (s) signalling events.
REACT_243909. Hormone ligand-binding receptors.
REACT_259994. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
Gene namesi
Name:Fshb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:95582. Fshb.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 130110Follitropin subunit betaPRO_0000011713Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 70By similarity
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 85By similarity
Disulfide bondi39 ↔ 123By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 101By similarity
Disulfide bondi51 ↔ 103By similarity
Disulfide bondi106 ↔ 113By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60687.

Expressioni

Gene expression databases

BgeeiQ60687.
CleanExiMM_FSHB.
GenevestigatoriQ60687.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

Structurei

3D structure databases

ProteinModelPortaliQ60687.
SMRiQ60687. Positions 22-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41629.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiQ60687.
KOiK05250.
OMAiCFLFCCW.
OrthoDBiEOG7JQBQF.
PhylomeDBiQ60687.
TreeFamiTF332940.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60687-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMKLIQLCIL FWCWRAICCH SCELTNITIS VEKEECRFCI SINTTWCAGY
60 70 80 90 100
CYTRDLVYKD PARPNTQKVC TFKELVYETV RLPGCARHSD SLYTYPVATE
110 120 130
CHCGKCDSDS TDCTVRGLGP SYCSFSEMKE
Length:130
Mass (Da):14,919
Last modified:November 1, 1996 - v1
Checksum:i7F9C28C2E34AC161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA. Translation: AAA92804.1.
AK017593 mRNA. Translation: BAB30827.1.
BC061159 mRNA. Translation: AAH61159.1.
CCDSiCCDS16504.1.
PIRiJC4526.
RefSeqiNP_032071.1. NM_008045.2.
UniGeneiMm.249525.

Genome annotation databases

EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120.
GeneIDi14308.
KEGGimmu:14308.
UCSCiuc008llt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA. Translation: AAA92804.1 .
AK017593 mRNA. Translation: BAB30827.1 .
BC061159 mRNA. Translation: AAH61159.1 .
CCDSi CCDS16504.1.
PIRi JC4526.
RefSeqi NP_032071.1. NM_008045.2.
UniGenei Mm.249525.

3D structure databases

ProteinModelPortali Q60687.
SMRi Q60687. Positions 22-125.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q60687.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028533 ; ENSMUSP00000028533 ; ENSMUSG00000027120 .
GeneIDi 14308.
KEGGi mmu:14308.
UCSCi uc008llt.1. mouse.

Organism-specific databases

CTDi 2488.
MGIi MGI:95582. Fshb.

Phylogenomic databases

eggNOGi NOG41629.
GeneTreei ENSGT00390000010115.
HOGENOMi HOG000116098.
HOVERGENi HBG006698.
InParanoidi Q60687.
KOi K05250.
OMAi CFLFCCW.
OrthoDBi EOG7JQBQF.
PhylomeDBi Q60687.
TreeFami TF332940.

Enzyme and pathway databases

Reactomei REACT_242871. G alpha (s) signalling events.
REACT_243909. Hormone ligand-binding receptors.
REACT_259994. Glycoprotein hormones.

Miscellaneous databases

NextBioi 285727.
PROi Q60687.
SOURCEi Search...

Gene expression databases

Bgeei Q60687.
CleanExi MM_FSHB.
Genevestigatori Q60687.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view ]
PANTHERi PTHR11515. PTHR11515. 1 hit.
Pfami PF00007. Cys_knot. 1 hit.
[Graphical view ]
SMARTi SM00068. GHB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse gonadotropin beta-subunit-encoding genes, I. Structure of the follicle-stimulating hormone beta-subunit-encoding gene."
    Kumar T.R., Kelly M., Mortrud M., Low M.J., Matzuk M.M.
    Gene 166:333-334(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiFSHB_MOUSE
AccessioniPrimary (citable) accession number: Q60687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3