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Q60677

- ITAE_MOUSE

UniProt

Q60677 - ITAE_MOUSE

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Protein

Integrin alpha-E

Gene
Itgae
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi514 – 5229 Reviewed prediction
Calcium bindingi578 – 5869 Reviewed prediction
Calcium bindingi646 – 6549 Reviewed prediction

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
Integrin alpha M290
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:Itgae
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1298377. Itgae.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11141095Extracellular Reviewed predictionAdd
BLAST
Transmembranei1115 – 113723Helical; Reviewed predictionAdd
BLAST
Topological domaini1138 – 116730Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityAdd
BLAST
Chaini20 – 11671148Integrin alpha-EPRO_0000016286Add
BLAST
Chaini20 – 181162Integrin alpha-E light chainPRO_0000016287Add
BLAST
Chaini183 – 1167985Integrin alpha-E heavy chainPRO_0000016288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi72 ↔ 83 By similarity
Disulfide bondi130 ↔ 164 By similarity
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi364 – 3641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi418 – 4181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi698 ↔ 754 By similarity
Glycosylationi718 – 7181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi773 – 7731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi814 ↔ 820 By similarity
Glycosylationi829 – 8291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi846 – 8461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi884 ↔ 898 By similarity
Glycosylationi911 – 9111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi925 – 9251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi968 – 9681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi998 ↔ 1023 By similarity
Glycosylationi1013 – 10131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1031 ↔ 1047 By similarity
Glycosylationi1055 – 10551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1086 – 10861N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60677.

PTM databases

PhosphoSiteiQ60677.

Expressioni

Gene expression databases

ArrayExpressiQ60677.
BgeeiQ60677.
CleanExiMM_ITGAE.
GenevestigatoriQ60677.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Structurei

3D structure databases

ProteinModelPortaliQ60677.
SMRiQ60677. Positions 180-1152.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 8155FG-GAP 1Add
BLAST
Repeati84 – 14259FG-GAP 2Add
BLAST
Domaini193 – 382190VWFAAdd
BLAST
Repeati383 – 43553FG-GAP 3Add
BLAST
Repeati438 – 49255FG-GAP 4Add
BLAST
Repeati493 – 55260FG-GAP 5Add
BLAST
Repeati555 – 61965FG-GAP 6Add
BLAST
Repeati623 – 68361FG-GAP 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 19244X-domain (extra domain)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1140 – 11445GFFKR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1917Glu-rich (acidic)

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240019.
GeneTreeiENSGT00750000117471.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiB1AUD5.
KOiK06524.
OMAiNHRTKIT.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60677-1 [UniParc]FASTAAdd to Basket

« Hide

MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN     50
NQTCLLVARR SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT 100
LVGNHNGVLV CIQVQARKFR SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG 150
FLDPGAHVDS GDYCRSKGGS TGEEKKSARR RRTVEEEDEE EDGTEIAIVL 200
DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG AVIQTEFDLQ 250
ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM 300
VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI 350
ASDPKEAHTF KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS 400
AQILDKGQVL LGTVGAFNWS GGALLYSTQN GRGCFLNQTA KEDSRTVQYS 450
YLGYSLAVLH KAHGVSYVAG APRHKLRGAV FELRKEDREE DAFVRRIEGE 500
QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV YVYQVPEQDA 550
SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD 600
GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD 650
GLADITVGSR DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE 700
VDSSGVASEP GLREMFLNFT VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG 750
SFLCEHFWLI STEELCEEDC FSNITIKVTY EFQTSGGRRD YPNPTLDHYK 800
EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT KEVTMNISLT 850
NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI 900
GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ 950
FRHAFIAVLS RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP 1000
IKLQDFQIVR VKNLTKTQDH TECTQSQEPA CGSDPVQHVK EWHSVVCAIT 1050
SNKENVTVAA EISVGHTKQL LRDVSELPIL GEISFNKSLY EGLNAENHRT 1100
KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG FFKRKYQQLN 1150
LESTRRAQLK ADSLLQD 1167
Length:1,167
Mass (Da):128,906
Last modified:July 27, 2011 - v2
Checksum:i7534783B341175E5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221L → M in AAC52142. 1 Publication
Sequence conflicti46 – 461Q → L in AAC52142. 1 Publication
Sequence conflicti207 – 2071E → G in AAC52142. 1 Publication
Sequence conflicti337 – 3371A → R in AAC52142. 1 Publication
Sequence conflicti378 – 3781H → R in AAC52142. 1 Publication
Sequence conflicti465 – 4651V → I in AAC52142. 1 Publication
Sequence conflicti696 – 6961K → N in AAC52142. 1 Publication
Sequence conflicti705 – 7051G → V in AAC52142. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12236 mRNA. Translation: AAC52142.1.
AL670399 Genomic DNA. Translation: CAI24788.1.
CCDSiCCDS24995.1.
RefSeqiNP_032425.2. NM_008399.2.
UniGeneiMm.96.

Genome annotation databases

EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
GeneIDi16407.
KEGGimmu:16407.
UCSCiuc007jzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12236 mRNA. Translation: AAC52142.1 .
AL670399 Genomic DNA. Translation: CAI24788.1 .
CCDSi CCDS24995.1.
RefSeqi NP_032425.2. NM_008399.2.
UniGenei Mm.96.

3D structure databases

ProteinModelPortali Q60677.
SMRi Q60677. Positions 180-1152.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q60677.

Proteomic databases

PRIDEi Q60677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006101 ; ENSMUSP00000006101 ; ENSMUSG00000005947 .
GeneIDi 16407.
KEGGi mmu:16407.
UCSCi uc007jzy.2. mouse.

Organism-specific databases

CTDi 3682.
MGIi MGI:1298377. Itgae.

Phylogenomic databases

eggNOGi NOG240019.
GeneTreei ENSGT00750000117471.
HOGENOMi HOG000049185.
HOVERGENi HBG006187.
InParanoidi B1AUD5.
KOi K06524.
OMAi NHRTKIT.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi ITGAE. mouse.
NextBioi 289573.
PROi Q60677.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q60677.
Bgeei Q60677.
CleanExi MM_ITGAE.
Genevestigatori Q60677.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine M290 integrin expression modulated by mast cell activation."
    Smith T.J., Ducharme L.A., Shaw S.K., Parker C.M., Brenner M.B., Kilshaw P.J., Weis J.H.
    Immunity 1:393-403(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AKR.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiITAE_MOUSE
AccessioniPrimary (citable) accession number: Q60677
Secondary accession number(s): B1AUD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi