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Q60677

- ITAE_MOUSE

UniProt

Q60677 - ITAE_MOUSE

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Protein

Integrin alpha-E

Gene

Itgae

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi514 – 5229Sequence Analysis
Calcium bindingi578 – 5869Sequence Analysis
Calcium bindingi646 – 6549Sequence Analysis

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
Integrin alpha M290
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:Itgae
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1298377. Itgae.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 11141095ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1115 – 113723HelicalSequence AnalysisAdd
BLAST
Topological domaini1138 – 116730CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 11671148Integrin alpha-EPRO_0000016286Add
BLAST
Chaini20 – 181162Integrin alpha-E light chainPRO_0000016287Add
BLAST
Chaini183 – 1167985Integrin alpha-E heavy chainPRO_0000016288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi72 ↔ 83By similarity
Disulfide bondi130 ↔ 164By similarity
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi698 ↔ 754By similarity
Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi773 – 7731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi814 ↔ 820By similarity
Glycosylationi829 – 8291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi884 ↔ 898By similarity
Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi925 – 9251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi998 ↔ 1023By similarity
Glycosylationi1013 – 10131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1031 ↔ 1047By similarity
Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1086 – 10861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ60677.

PTM databases

PhosphoSiteiQ60677.

Expressioni

Gene expression databases

BgeeiQ60677.
CleanExiMM_ITGAE.
ExpressionAtlasiQ60677. baseline and differential.
GenevestigatoriQ60677.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Structurei

3D structure databases

ProteinModelPortaliQ60677.
SMRiQ60677. Positions 180-1108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 8155FG-GAP 1Add
BLAST
Repeati84 – 14259FG-GAP 2Add
BLAST
Domaini193 – 382190VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati383 – 43553FG-GAP 3Add
BLAST
Repeati438 – 49255FG-GAP 4Add
BLAST
Repeati493 – 55260FG-GAP 5Add
BLAST
Repeati555 – 61965FG-GAP 6Add
BLAST
Repeati623 – 68361FG-GAP 7Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 19244X-domain (extra domain)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1140 – 11445GFFKR motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 1917Glu-rich (acidic)

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240019.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiQ60677.
KOiK06524.
OMAiNHRTKIT.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60677-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN
60 70 80 90 100
NQTCLLVARR SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT
110 120 130 140 150
LVGNHNGVLV CIQVQARKFR SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG
160 170 180 190 200
FLDPGAHVDS GDYCRSKGGS TGEEKKSARR RRTVEEEDEE EDGTEIAIVL
210 220 230 240 250
DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG AVIQTEFDLQ
260 270 280 290 300
ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM
310 320 330 340 350
VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI
360 370 380 390 400
ASDPKEAHTF KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS
410 420 430 440 450
AQILDKGQVL LGTVGAFNWS GGALLYSTQN GRGCFLNQTA KEDSRTVQYS
460 470 480 490 500
YLGYSLAVLH KAHGVSYVAG APRHKLRGAV FELRKEDREE DAFVRRIEGE
510 520 530 540 550
QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV YVYQVPEQDA
560 570 580 590 600
SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD
610 620 630 640 650
GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD
660 670 680 690 700
GLADITVGSR DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE
710 720 730 740 750
VDSSGVASEP GLREMFLNFT VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG
760 770 780 790 800
SFLCEHFWLI STEELCEEDC FSNITIKVTY EFQTSGGRRD YPNPTLDHYK
810 820 830 840 850
EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT KEVTMNISLT
860 870 880 890 900
NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI
910 920 930 940 950
GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ
960 970 980 990 1000
FRHAFIAVLS RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP
1010 1020 1030 1040 1050
IKLQDFQIVR VKNLTKTQDH TECTQSQEPA CGSDPVQHVK EWHSVVCAIT
1060 1070 1080 1090 1100
SNKENVTVAA EISVGHTKQL LRDVSELPIL GEISFNKSLY EGLNAENHRT
1110 1120 1130 1140 1150
KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG FFKRKYQQLN
1160
LESTRRAQLK ADSLLQD
Length:1,167
Mass (Da):128,906
Last modified:July 27, 2011 - v2
Checksum:i7534783B341175E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221L → M in AAC52142. (PubMed:7882170)Curated
Sequence conflicti46 – 461Q → L in AAC52142. (PubMed:7882170)Curated
Sequence conflicti207 – 2071E → G in AAC52142. (PubMed:7882170)Curated
Sequence conflicti337 – 3371A → R in AAC52142. (PubMed:7882170)Curated
Sequence conflicti378 – 3781H → R in AAC52142. (PubMed:7882170)Curated
Sequence conflicti465 – 4651V → I in AAC52142. (PubMed:7882170)Curated
Sequence conflicti696 – 6961K → N in AAC52142. (PubMed:7882170)Curated
Sequence conflicti705 – 7051G → V in AAC52142. (PubMed:7882170)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12236 mRNA. Translation: AAC52142.1.
AL670399 Genomic DNA. Translation: CAI24788.1.
CCDSiCCDS24995.1.
RefSeqiNP_032425.2. NM_008399.2.
UniGeneiMm.96.

Genome annotation databases

EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
GeneIDi16407.
KEGGimmu:16407.
UCSCiuc007jzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12236 mRNA. Translation: AAC52142.1 .
AL670399 Genomic DNA. Translation: CAI24788.1 .
CCDSi CCDS24995.1.
RefSeqi NP_032425.2. NM_008399.2.
UniGenei Mm.96.

3D structure databases

ProteinModelPortali Q60677.
SMRi Q60677. Positions 180-1108.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q60677.

Proteomic databases

PRIDEi Q60677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006101 ; ENSMUSP00000006101 ; ENSMUSG00000005947 .
GeneIDi 16407.
KEGGi mmu:16407.
UCSCi uc007jzy.2. mouse.

Organism-specific databases

CTDi 3682.
MGIi MGI:1298377. Itgae.

Phylogenomic databases

eggNOGi NOG240019.
GeneTreei ENSGT00760000118782.
HOGENOMi HOG000049185.
HOVERGENi HBG006187.
InParanoidi Q60677.
KOi K06524.
OMAi NHRTKIT.
TreeFami TF105391.

Enzyme and pathway databases

Reactomei REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSi Itgae. mouse.
NextBioi 289573.
PROi Q60677.
SOURCEi Search...

Gene expression databases

Bgeei Q60677.
CleanExi MM_ITGAE.
ExpressionAtlasi Q60677. baseline and differential.
Genevestigatori Q60677.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view ]
PRINTSi PR01185. INTEGRINA.
SMARTi SM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
PROSITEi PS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine M290 integrin expression modulated by mast cell activation."
    Smith T.J., Ducharme L.A., Shaw S.K., Parker C.M., Brenner M.B., Kilshaw P.J., Weis J.H.
    Immunity 1:393-403(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: AKR.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiITAE_MOUSE
AccessioniPrimary (citable) accession number: Q60677
Secondary accession number(s): B1AUD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3