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Q60677

- ITAE_MOUSE

UniProt

Q60677 - ITAE_MOUSE

Protein

Integrin alpha-E

Gene

Itgae

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi514 – 5229Sequence Analysis
    Calcium bindingi578 – 5869Sequence Analysis
    Calcium bindingi646 – 6549Sequence Analysis

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. integrin-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Integrin, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin alpha-E
    Alternative name(s):
    Integrin alpha M290
    CD_antigen: CD103
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Itgae
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1298377. Itgae.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integrin complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 11671148Integrin alpha-EPRO_0000016286Add
    BLAST
    Chaini20 – 181162Integrin alpha-E light chainPRO_0000016287Add
    BLAST
    Chaini183 – 1167985Integrin alpha-E heavy chainPRO_0000016288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi72 ↔ 83By similarity
    Disulfide bondi130 ↔ 164By similarity
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi364 – 3641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi418 – 4181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi698 ↔ 754By similarity
    Glycosylationi718 – 7181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi773 – 7731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi814 ↔ 820By similarity
    Glycosylationi829 – 8291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi884 ↔ 898By similarity
    Glycosylationi911 – 9111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi925 – 9251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi968 – 9681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi998 ↔ 1023By similarity
    Glycosylationi1013 – 10131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi1031 ↔ 1047By similarity
    Glycosylationi1055 – 10551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1086 – 10861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60677.

    PTM databases

    PhosphoSiteiQ60677.

    Expressioni

    Gene expression databases

    ArrayExpressiQ60677.
    BgeeiQ60677.
    CleanExiMM_ITGAE.
    GenevestigatoriQ60677.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60677.
    SMRiQ60677. Positions 180-1152.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 11141095ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1138 – 116730CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1115 – 113723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati27 – 8155FG-GAP 1Add
    BLAST
    Repeati84 – 14259FG-GAP 2Add
    BLAST
    Domaini193 – 382190VWFAPROSITE-ProRule annotationAdd
    BLAST
    Repeati383 – 43553FG-GAP 3Add
    BLAST
    Repeati438 – 49255FG-GAP 4Add
    BLAST
    Repeati493 – 55260FG-GAP 5Add
    BLAST
    Repeati555 – 61965FG-GAP 6Add
    BLAST
    Repeati623 – 68361FG-GAP 7Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 19244X-domain (extra domain)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1140 – 11445GFFKR motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi185 – 1917Glu-rich (acidic)

    Domaini

    The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    Sequence similaritiesi

    Belongs to the integrin alpha chain family.Curated
    Contains 7 FG-GAP repeats.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240019.
    GeneTreeiENSGT00750000117471.
    HOGENOMiHOG000049185.
    HOVERGENiHBG006187.
    InParanoidiB1AUD5.
    KOiK06524.
    OMAiNHRTKIT.
    TreeFamiTF105391.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view]
    PRINTSiPR01185. INTEGRINA.
    SMARTiSM00191. Int_alpha. 4 hits.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    PROSITEiPS51470. FG_GAP. 6 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q60677-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN     50
    NQTCLLVARR SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT 100
    LVGNHNGVLV CIQVQARKFR SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG 150
    FLDPGAHVDS GDYCRSKGGS TGEEKKSARR RRTVEEEDEE EDGTEIAIVL 200
    DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG AVIQTEFDLQ 250
    ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM 300
    VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI 350
    ASDPKEAHTF KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS 400
    AQILDKGQVL LGTVGAFNWS GGALLYSTQN GRGCFLNQTA KEDSRTVQYS 450
    YLGYSLAVLH KAHGVSYVAG APRHKLRGAV FELRKEDREE DAFVRRIEGE 500
    QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV YVYQVPEQDA 550
    SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD 600
    GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD 650
    GLADITVGSR DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE 700
    VDSSGVASEP GLREMFLNFT VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG 750
    SFLCEHFWLI STEELCEEDC FSNITIKVTY EFQTSGGRRD YPNPTLDHYK 800
    EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT KEVTMNISLT 850
    NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI 900
    GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ 950
    FRHAFIAVLS RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP 1000
    IKLQDFQIVR VKNLTKTQDH TECTQSQEPA CGSDPVQHVK EWHSVVCAIT 1050
    SNKENVTVAA EISVGHTKQL LRDVSELPIL GEISFNKSLY EGLNAENHRT 1100
    KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG FFKRKYQQLN 1150
    LESTRRAQLK ADSLLQD 1167
    Length:1,167
    Mass (Da):128,906
    Last modified:July 27, 2011 - v2
    Checksum:i7534783B341175E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221L → M in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti46 – 461Q → L in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti207 – 2071E → G in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti337 – 3371A → R in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti378 – 3781H → R in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti465 – 4651V → I in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti696 – 6961K → N in AAC52142. (PubMed:7882170)Curated
    Sequence conflicti705 – 7051G → V in AAC52142. (PubMed:7882170)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12236 mRNA. Translation: AAC52142.1.
    AL670399 Genomic DNA. Translation: CAI24788.1.
    CCDSiCCDS24995.1.
    RefSeqiNP_032425.2. NM_008399.2.
    UniGeneiMm.96.

    Genome annotation databases

    EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
    GeneIDi16407.
    KEGGimmu:16407.
    UCSCiuc007jzy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12236 mRNA. Translation: AAC52142.1 .
    AL670399 Genomic DNA. Translation: CAI24788.1 .
    CCDSi CCDS24995.1.
    RefSeqi NP_032425.2. NM_008399.2.
    UniGenei Mm.96.

    3D structure databases

    ProteinModelPortali Q60677.
    SMRi Q60677. Positions 180-1152.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q60677.

    Proteomic databases

    PRIDEi Q60677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006101 ; ENSMUSP00000006101 ; ENSMUSG00000005947 .
    GeneIDi 16407.
    KEGGi mmu:16407.
    UCSCi uc007jzy.2. mouse.

    Organism-specific databases

    CTDi 3682.
    MGIi MGI:1298377. Itgae.

    Phylogenomic databases

    eggNOGi NOG240019.
    GeneTreei ENSGT00750000117471.
    HOGENOMi HOG000049185.
    HOVERGENi HBG006187.
    InParanoidi B1AUD5.
    KOi K06524.
    OMAi NHRTKIT.
    TreeFami TF105391.

    Enzyme and pathway databases

    Reactomei REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    ChiTaRSi ITGAE. mouse.
    NextBioi 289573.
    PROi Q60677.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q60677.
    Bgeei Q60677.
    CleanExi MM_ITGAE.
    Genevestigatori Q60677.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR013519. Int_alpha_beta-p.
    IPR000413. Integrin_alpha.
    IPR013649. Integrin_alpha-2.
    IPR018184. Integrin_alpha_C_CS.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00357. Integrin_alpha. 1 hit.
    PF08441. Integrin_alpha2. 1 hit.
    PF00092. VWA. 1 hit.
    [Graphical view ]
    PRINTSi PR01185. INTEGRINA.
    SMARTi SM00191. Int_alpha. 4 hits.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    PROSITEi PS51470. FG_GAP. 6 hits.
    PS00242. INTEGRIN_ALPHA. 1 hit.
    PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine M290 integrin expression modulated by mast cell activation."
      Smith T.J., Ducharme L.A., Shaw S.K., Parker C.M., Brenner M.B., Kilshaw P.J., Weis J.H.
      Immunity 1:393-403(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: AKR.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiITAE_MOUSE
    AccessioniPrimary (citable) accession number: Q60677
    Secondary accession number(s): B1AUD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3