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Protein

Integrin alpha-E

Gene

Itgae

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi514 – 522Sequence analysis9
Calcium bindingi578 – 586Sequence analysis9
Calcium bindingi646 – 654Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
Integrin alpha M290
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:Itgae
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1298377. Itgae.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1114ExtracellularSequence analysisAdd BLAST1095
Transmembranei1115 – 1137HelicalSequence analysisAdd BLAST23
Topological domaini1138 – 1167CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integrin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001628620 – 1167Integrin alpha-EAdd BLAST1148
ChainiPRO_000001628720 – 181Integrin alpha-E light chainAdd BLAST162
ChainiPRO_0000016288183 – 1167Integrin alpha-E heavy chainAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi72 ↔ 83By similarity
Disulfide bondi130 ↔ 164By similarity
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Glycosylationi364N-linked (GlcNAc...)Sequence analysis1
Glycosylationi418N-linked (GlcNAc...)Sequence analysis1
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi698 ↔ 754By similarity
Glycosylationi718N-linked (GlcNAc...)Sequence analysis1
Glycosylationi773N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi814 ↔ 820By similarity
Glycosylationi829N-linked (GlcNAc...)Sequence analysis1
Glycosylationi846N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi884 ↔ 898By similarity
Glycosylationi911N-linked (GlcNAc...)Sequence analysis1
Glycosylationi925N-linked (GlcNAc...)Sequence analysis1
Glycosylationi968N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi998 ↔ 1023By similarity
Glycosylationi1013N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1031 ↔ 1047By similarity
Glycosylationi1055N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1086N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ60677.
MaxQBiQ60677.
PaxDbiQ60677.
PRIDEiQ60677.

PTM databases

iPTMnetiQ60677.
PhosphoSitePlusiQ60677.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005947.
CleanExiMM_ITGAE.
ExpressionAtlasiQ60677. baseline and differential.
GenevisibleiQ60677. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006101.

Structurei

3D structure databases

ProteinModelPortaliQ60677.
SMRiQ60677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 81FG-GAP 1Add BLAST55
Repeati84 – 142FG-GAP 2PROSITE-ProRule annotationAdd BLAST59
Domaini193 – 382VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati383 – 435FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati438 – 491FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati492 – 552FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati555 – 619FG-GAP 6PROSITE-ProRule annotationAdd BLAST65
Repeati623 – 683FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 192X-domain (extra domain)Add BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1140 – 1144GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Glu-rich (acidic)7

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPAZ. Eukaryota.
ENOG410XR7I. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiQ60677.
KOiK06524.
OMAiAIFQLPY.
OrthoDBiEOG091G09V5.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
PROSITEiPS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN
60 70 80 90 100
NQTCLLVARR SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT
110 120 130 140 150
LVGNHNGVLV CIQVQARKFR SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG
160 170 180 190 200
FLDPGAHVDS GDYCRSKGGS TGEEKKSARR RRTVEEEDEE EDGTEIAIVL
210 220 230 240 250
DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG AVIQTEFDLQ
260 270 280 290 300
ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM
310 320 330 340 350
VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI
360 370 380 390 400
ASDPKEAHTF KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS
410 420 430 440 450
AQILDKGQVL LGTVGAFNWS GGALLYSTQN GRGCFLNQTA KEDSRTVQYS
460 470 480 490 500
YLGYSLAVLH KAHGVSYVAG APRHKLRGAV FELRKEDREE DAFVRRIEGE
510 520 530 540 550
QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV YVYQVPEQDA
560 570 580 590 600
SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD
610 620 630 640 650
GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD
660 670 680 690 700
GLADITVGSR DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE
710 720 730 740 750
VDSSGVASEP GLREMFLNFT VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG
760 770 780 790 800
SFLCEHFWLI STEELCEEDC FSNITIKVTY EFQTSGGRRD YPNPTLDHYK
810 820 830 840 850
EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT KEVTMNISLT
860 870 880 890 900
NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI
910 920 930 940 950
GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ
960 970 980 990 1000
FRHAFIAVLS RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP
1010 1020 1030 1040 1050
IKLQDFQIVR VKNLTKTQDH TECTQSQEPA CGSDPVQHVK EWHSVVCAIT
1060 1070 1080 1090 1100
SNKENVTVAA EISVGHTKQL LRDVSELPIL GEISFNKSLY EGLNAENHRT
1110 1120 1130 1140 1150
KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG FFKRKYQQLN
1160
LESTRRAQLK ADSLLQD
Length:1,167
Mass (Da):128,906
Last modified:July 27, 2011 - v2
Checksum:i7534783B341175E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22L → M in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti46Q → L in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti207E → G in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti337A → R in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti378H → R in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti465V → I in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti696K → N in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti705G → V in AAC52142 (PubMed:7882170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12236 mRNA. Translation: AAC52142.1.
AL670399 Genomic DNA. Translation: CAI24788.1.
CCDSiCCDS24995.1.
RefSeqiNP_032425.2. NM_008399.2.
UniGeneiMm.96.

Genome annotation databases

EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
GeneIDi16407.
KEGGimmu:16407.
UCSCiuc007jzy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12236 mRNA. Translation: AAC52142.1.
AL670399 Genomic DNA. Translation: CAI24788.1.
CCDSiCCDS24995.1.
RefSeqiNP_032425.2. NM_008399.2.
UniGeneiMm.96.

3D structure databases

ProteinModelPortaliQ60677.
SMRiQ60677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006101.

PTM databases

iPTMnetiQ60677.
PhosphoSitePlusiQ60677.

Proteomic databases

EPDiQ60677.
MaxQBiQ60677.
PaxDbiQ60677.
PRIDEiQ60677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
GeneIDi16407.
KEGGimmu:16407.
UCSCiuc007jzy.2. mouse.

Organism-specific databases

CTDi3682.
MGIiMGI:1298377. Itgae.

Phylogenomic databases

eggNOGiENOG410IPAZ. Eukaryota.
ENOG410XR7I. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000049185.
HOVERGENiHBG006187.
InParanoidiQ60677.
KOiK06524.
OMAiAIFQLPY.
OrthoDBiEOG091G09V5.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

ChiTaRSiItgae. mouse.
PROiQ60677.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005947.
CleanExiMM_ITGAE.
ExpressionAtlasiQ60677. baseline and differential.
GenevisibleiQ60677. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 2 hits.
PROSITEiPS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITAE_MOUSE
AccessioniPrimary (citable) accession number: Q60677
Secondary accession number(s): B1AUD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.