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Q60677 (ITAE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrin alpha-E
Alternative name(s):
Integrin alpha M290
CD_antigen=CD103
Gene names
Name:Itgae
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 11671148Integrin alpha-E
PRO_0000016286
Chain20 – 181162Integrin alpha-E light chain
PRO_0000016287
Chain183 – 1167985Integrin alpha-E heavy chain
PRO_0000016288

Regions

Topological domain20 – 11141095Extracellular Potential
Transmembrane1115 – 113723Helical; Potential
Topological domain1138 – 116730Cytoplasmic Potential
Repeat27 – 8155FG-GAP 1
Repeat84 – 14259FG-GAP 2
Domain193 – 382190VWFA
Repeat383 – 43553FG-GAP 3
Repeat438 – 49255FG-GAP 4
Repeat493 – 55260FG-GAP 5
Repeat555 – 61965FG-GAP 6
Repeat623 – 68361FG-GAP 7
Calcium binding514 – 5229 Potential
Calcium binding578 – 5869 Potential
Calcium binding646 – 6549 Potential
Region149 – 19244X-domain (extra domain)
Motif1140 – 11445GFFKR motif
Compositional bias185 – 1917Glu-rich (acidic)

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3411N-linked (GlcNAc...) Potential
Glycosylation3641N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation7181N-linked (GlcNAc...) Potential
Glycosylation7731N-linked (GlcNAc...) Potential
Glycosylation8291N-linked (GlcNAc...) Potential
Glycosylation8461N-linked (GlcNAc...) Potential
Glycosylation9111N-linked (GlcNAc...) Potential
Glycosylation9251N-linked (GlcNAc...) Potential
Glycosylation9681N-linked (GlcNAc...) Potential
Glycosylation10131N-linked (GlcNAc...) Potential
Glycosylation10551N-linked (GlcNAc...) Potential
Glycosylation10861N-linked (GlcNAc...) Potential
Disulfide bond72 ↔ 83 By similarity
Disulfide bond130 ↔ 164 By similarity
Disulfide bond698 ↔ 754 By similarity
Disulfide bond814 ↔ 820 By similarity
Disulfide bond884 ↔ 898 By similarity
Disulfide bond998 ↔ 1023 By similarity
Disulfide bond1031 ↔ 1047 By similarity

Experimental info

Sequence conflict221L → M in AAC52142. Ref.1
Sequence conflict461Q → L in AAC52142. Ref.1
Sequence conflict2071E → G in AAC52142. Ref.1
Sequence conflict3371A → R in AAC52142. Ref.1
Sequence conflict3781H → R in AAC52142. Ref.1
Sequence conflict4651V → I in AAC52142. Ref.1
Sequence conflict6961K → N in AAC52142. Ref.1
Sequence conflict7051G → V in AAC52142. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q60677 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7534783B341175E5

FASTA1,167128,906
        10         20         30         40         50         60 
MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN NQTCLLVARR 

        70         80         90        100        110        120 
SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT LVGNHNGVLV CIQVQARKFR 

       130        140        150        160        170        180 
SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG FLDPGAHVDS GDYCRSKGGS TGEEKKSARR 

       190        200        210        220        230        240 
RRTVEEEDEE EDGTEIAIVL DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG 

       250        260        270        280        290        300 
AVIQTEFDLQ ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM 

       310        320        330        340        350        360 
VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI ASDPKEAHTF 

       370        380        390        400        410        420 
KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS AQILDKGQVL LGTVGAFNWS 

       430        440        450        460        470        480 
GGALLYSTQN GRGCFLNQTA KEDSRTVQYS YLGYSLAVLH KAHGVSYVAG APRHKLRGAV 

       490        500        510        520        530        540 
FELRKEDREE DAFVRRIEGE QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV 

       550        560        570        580        590        600 
YVYQVPEQDA SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD 

       610        620        630        640        650        660 
GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD GLADITVGSR 

       670        680        690        700        710        720 
DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE VDSSGVASEP GLREMFLNFT 

       730        740        750        760        770        780 
VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG SFLCEHFWLI STEELCEEDC FSNITIKVTY 

       790        800        810        820        830        840 
EFQTSGGRRD YPNPTLDHYK EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT 

       850        860        870        880        890        900 
KEVTMNISLT NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI 

       910        920        930        940        950        960 
GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ FRHAFIAVLS 

       970        980        990       1000       1010       1020 
RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP IKLQDFQIVR VKNLTKTQDH 

      1030       1040       1050       1060       1070       1080 
TECTQSQEPA CGSDPVQHVK EWHSVVCAIT SNKENVTVAA EISVGHTKQL LRDVSELPIL 

      1090       1100       1110       1120       1130       1140 
GEISFNKSLY EGLNAENHRT KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG 

      1150       1160 
FFKRKYQQLN LESTRRAQLK ADSLLQD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U12236 mRNA. Translation: AAC52142.1.
AL670399 Genomic DNA. Translation: CAI24788.1.
CCDSCCDS24995.1.
RefSeqNP_032425.2. NM_008399.2.
UniGeneMm.96.

3D structure databases

ProteinModelPortalQ60677.
SMRQ60677. Positions 180-1152.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ60677.

Proteomic databases

PRIDEQ60677.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947.
GeneID16407.
KEGGmmu:16407.
UCSCuc007jzy.2. mouse.

Organism-specific databases

CTD3682.
MGIMGI:1298377. Itgae.

Phylogenomic databases

eggNOGNOG240019.
GeneTreeENSGT00750000117471.
HOGENOMHOG000049185.
HOVERGENHBG006187.
InParanoidB1AUD5.
KOK06524.
OMANHRTKIT.
TreeFamTF105391.

Gene expression databases

ArrayExpressQ60677.
BgeeQ60677.
CleanExMM_ITGAE.
GenevestigatorQ60677.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR002035. VWF_A.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 4 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
PROSITEPS51470. FG_GAP. 6 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITGAE. mouse.
NextBio289573.
PROQ60677.
SOURCESearch...

Entry information

Entry nameITAE_MOUSE
AccessionPrimary (citable) accession number: Q60677
Secondary accession number(s): B1AUD5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot