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Q60676 (PPP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 5
Short name=PP5
EC=3.1.3.16
Alternative name(s):
Protein phosphatase T
Short name=PPT
Gene names
Name:Ppp5c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the regulation of RNA biogenesis and/or mitosis.

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Interacts with CDC16 and CDC27 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

Contains 3 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Serine/threonine-protein phosphatase 5
PRO_0000058895

Regions

Repeat28 – 6134TPR 1
Repeat62 – 9534TPR 2
Repeat96 – 12934TPR 3
Region184 – 499316Catalytic

Sites

Active site3041Proton donor By similarity
Metal binding2421Iron By similarity
Metal binding2441Iron By similarity
Metal binding2711Iron By similarity
Metal binding2711Manganese By similarity
Metal binding3031Manganese By similarity
Metal binding3521Manganese By similarity
Metal binding4271Manganese By similarity

Experimental info

Sequence conflict241A → T in AAB18613. Ref.3
Sequence conflict1551D → G in AAB18613. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q60676 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: D2D8FBE52D8CB478

FASTA49956,847
        10         20         30         40         50         60 
MAMAEGERTE CAETPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPG 

        70         80         90        100        110        120 
NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 

       130        140        150        160        170        180 
TVVKVKPNDK DAKMKYQECS KIVKQKAFER AIAGDEHRRS VVDSLDIESM TIEDEYSGPK 

       190        200        210        220        230        240 
LEDGKVTITF MKDLMQWYKD QKKLHRKCAY QILVQVKEVL CKLSTLVETT LKETEKITVC 

       250        260        270        280        290        300 
GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 

       310        320        330        340        350        360 
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 

       370        380        390        400        410        420 
VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENQL 

       430        440        450        460        470        480 
DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 

       490 
HPNVKPMAYA NTLLQLGMM

« Hide

References

« Hide 'large scale' references
[1]Ollendorff V., Donoghue D.J.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Targeting of a distinctive protein-serine phosphatase to the protein kinase-like domain of the atrial natriuretic peptide receptor."
Chinkers M.
Proc. Natl. Acad. Sci. U.S.A. 91:11075-11079(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-155.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF018262 mRNA. Translation: AAB70573.1.
BC003744 mRNA. Translation: AAH03744.1.
U12204 mRNA. Translation: AAB18613.1.
IPIIPI00119180.
RefSeqNP_035285.2. NM_011155.2.
UniGeneMm.3294.
Mm.475000.
Mm.482216.

3D structure databases

ProteinModelPortalQ60676.
SMRQ60676. Positions 19-499.
ModBaseSearch...

Protein-protein interaction databases

IntActQ60676. 2 interactions.
MINTMINT-1353706.

PTM databases

PhosphoSiteQ60676.

Proteomic databases

PaxDbQ60676.
PRIDEQ60676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19060.
KEGGmmu:19060.
UCSCuc009fiq.2. mouse.

Organism-specific databases

CTD5536.
MGIMGI:102666. Ppp5c.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172698.
HOVERGENHBG000216.
InParanoidQ60676.
KOK04460.
OrthoDBEOG4PVNZ1.

Gene expression databases

CleanExMM_PPP5C.
GenevestigatorQ60676.
GermOnlineENSMUSG00000003099. Mus musculus.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR004843. Metallo_PEstase_dom.
IPR013235. PPP_dom.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR001440. TPR-1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR11668:SF12. PTHR11668:SF12. 1 hit.
PfamPF00149. Metallophos. 1 hit.
PF08321. PPP5. 1 hit.
PF00515. TPR_1. 2 hits.
[Graphical view]
PIRSFPIRSF033096. PPPtase_5. 1 hit.
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
SM00028. TPR. 3 hits.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPP5C. mouse.
NextBio295562.
SOURCESearch...

Entry information

Entry namePPP5_MOUSE
AccessionPrimary (citable) accession number: Q60676
Secondary accession number(s): O35299
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 11, 2002
Last modified: April 3, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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