##gff-version 3
Q60670	UniProtKB	Chain	1	779	.	.	.	ID=PRO_0000086660;Note=Serine/threonine-protein kinase SIK1	
Q60670	UniProtKB	Domain	27	278	.	.	.	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q60670	UniProtKB	Domain	303	343	.	.	.	Note=UBA;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00212	
Q60670	UniProtKB	Region	350	375	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q60670	UniProtKB	Region	449	472	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q60670	UniProtKB	Region	586	612	.	.	.	Note=RK-rich region	
Q60670	UniProtKB	Region	621	641	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q60670	UniProtKB	Compositional bias	352	375	.	.	.	Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
Q60670	UniProtKB	Active site	149	149	.	.	.	Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10027	
Q60670	UniProtKB	Binding site	33	41	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159	
Q60670	UniProtKB	Binding site	56	56	.	.	.	.	
Q60670	UniProtKB	Modified residue	182	182	.	.	.	Note=Phosphothreonine%3B by LKB1 and GSK3-beta;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16817901;Dbxref=PMID:16817901	
Q60670	UniProtKB	Modified residue	186	186	.	.	.	Note=Phosphoserine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P57059	
Q60670	UniProtKB	Modified residue	322	322	.	.	.	Note=Phosphothreonine%3B by CaMK1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9R1U5	
Q60670	UniProtKB	Modified residue	577	577	.	.	.	Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12200423,ECO:0000269|PubMed:16817901,ECO:0000269|PubMed:17468767;Dbxref=PMID:12200423,PMID:16817901,PMID:17468767	
Q60670	UniProtKB	Mutagenesis	56	56	.	.	.	Note=Loss of kinase activity. K->M;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15177563,ECO:0000269|PubMed:16817901,ECO:0000269|PubMed:17468767;Dbxref=PMID:15177563,PMID:16817901,PMID:17468767	
Q60670	UniProtKB	Mutagenesis	182	182	.	.	.	Note=Loss of kinase activity. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16817901;Dbxref=PMID:16817901	
Q60670	UniProtKB	Mutagenesis	182	182	.	.	.	Note=Low levels of constitutive activity. T->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16817901;Dbxref=PMID:16817901	
Q60670	UniProtKB	Mutagenesis	268	268	.	.	.	Note=Does not affect phosphorylation by PKA and nuclear export following ACTH treatment. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12200423;Dbxref=PMID:12200423	
Q60670	UniProtKB	Mutagenesis	475	475	.	.	.	Note=Does not affect phosphorylation by PKA and nuclear export following ACTH treatment. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12200423;Dbxref=PMID:12200423	
Q60670	UniProtKB	Mutagenesis	577	577	.	.	.	Note=Abolishes phosphorylation by PKA and impairs nuclear export following ACTH treatment. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12200423,ECO:0000269|PubMed:16817901,ECO:0000269|PubMed:17468767;Dbxref=PMID:12200423,PMID:16817901,PMID:17468767	
Q60670	UniProtKB	Mutagenesis	577	577	.	.	.	Note=Constitutively active. S->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12200423,ECO:0000269|PubMed:16817901,ECO:0000269|PubMed:17468767;Dbxref=PMID:12200423,PMID:16817901,PMID:17468767	
Q60670	UniProtKB	Mutagenesis	593	594	.	.	.	Note=Localizes mainly in cytoplasm and not in nucleus. RK->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15511237;Dbxref=PMID:15511237	
Q60670	UniProtKB	Mutagenesis	597	599	.	.	.	Note=Localizes mainly in cytoplasm and not in nucleus. RTK->ATA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15511237;Dbxref=PMID:15511237	
Q60670	UniProtKB	Mutagenesis	606	608	.	.	.	Note=Localizes mainly in cytoplasm and not in nucleus. KIK->AIA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15511237;Dbxref=PMID:15511237	
Q60670	UniProtKB	Mutagenesis	607	607	.	.	.	Note=Localizes mainly in cytoplasm and not in nucleus%3B when associated with D-483 and A-610. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15511237;Dbxref=PMID:15511237	
Q60670	UniProtKB	Mutagenesis	610	610	.	.	.	Note=Localizes mainly in cytoplasm and not in nucleus%3B when associated with D-483 and A-607. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15511237;Dbxref=PMID:15511237	
Q60670	UniProtKB	Sequence conflict	183	184	.	.	.	Note=WC->CV;Ontology_term=ECO:0000305;evidence=ECO:0000305