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Protein

Killer cell lectin-like receptor 2

Gene

Klra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for class I MHC.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processCell adhesion
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor 2
Alternative name(s):
Lymphocyte antigen 49b
Short name:
Ly-49b
T-cell surface glycoprotein Ly-49B
Gene namesi
Name:Klra2
Synonyms:Ly49-b, Ly49b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:101906. Klra2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 288ExtracellularSequence analysisAdd BLAST222

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466801 – 288Killer cell lectin-like receptor 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi151 ↔ 156PROSITE-ProRule annotation
Disulfide bondi169 ↔ 257PROSITE-ProRule annotation
Disulfide bondi173 ↔ 259PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi238 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ60660.
PRIDEiQ60660.

PTM databases

iPTMnetiQ60660.
PhosphoSitePlusiQ60660.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliQ60660.
SMRiQ60660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 263C-type lectinPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60660.
PhylomeDBiQ60660.

Family and domain databases

CDDicd03593. CLECT_NK_receptors_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR013600. Ly49_N.
IPR033992. NKR-like_CTLD.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q60660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQEVTYTT LRFHKSSGLQ NPVRPEETQR PRDVGHRECS VPWKFIVIVL
60 70 80 90 100
GILCFLLLLT VAVLVIHIFR DGQEKHEQEK TLNNLRQEYQ VMKNDSSLME
110 120 130 140 150
EMLRNKSSEC KALNDSLHYL NREQNRCLRK TKIVLDCSQN KGKQVEGYWF
160 170 180 190 200
CCGMKCYYFI MDDKKWNGCK QICQDYNLTL LKTNDEDELK FLKSQLQRNT
210 220 230 240 250
YWISLTHHKS KEESQQIGDR PSKLDSAARN SVPNRQKCAY LSSFSTEEDD
260 270 280
CARTHGCICE KRLNKFPIPG SCAKGRTQSA LQRDEDES
Length:288
Mass (Da):33,607
Last modified:November 1, 1996 - v1
Checksum:iB3A410A32DF8E82F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10304 mRNA. Translation: AAA19052.1.
CCDSiCCDS20603.1.
PIRiI49058.
UniGeneiMm.4783.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKLRA2_MOUSE
AccessioniPrimary (citable) accession number: Q60660
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot