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Q60660

- KLRA2_MOUSE

UniProt

Q60660 - KLRA2_MOUSE

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Protein

Killer cell lectin-like receptor 2

Gene

Klra2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for class I MHC.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor 2
Alternative name(s):
Lymphocyte antigen 49b
Short name:
Ly-49b
T-cell surface glycoprotein Ly-49B
Gene namesi
Name:Klra2
Synonyms:Ly49-b, Ly49b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:101906. Klra2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Killer cell lectin-like receptor 2PRO_0000046680Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi151 ↔ 156PROSITE-ProRule annotation
Disulfide bondi169 ↔ 257PROSITE-ProRule annotation
Disulfide bondi173 ↔ 259PROSITE-ProRule annotation
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi238 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ60660.
PRIDEiQ60660.

PTM databases

PhosphoSiteiQ60660.

Expressioni

Gene expression databases

GenevestigatoriQ60660.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliQ60660.
SMRiQ60660. Positions 109-267.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini67 – 288222ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei46 – 6621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 263120C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258878.
HOGENOMiHOG000113237.
HOVERGENiHBG053176.
InParanoidiQ60660.
PhylomeDBiQ60660.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR013600. Ly49.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q60660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQEVTYTT LRFHKSSGLQ NPVRPEETQR PRDVGHRECS VPWKFIVIVL
60 70 80 90 100
GILCFLLLLT VAVLVIHIFR DGQEKHEQEK TLNNLRQEYQ VMKNDSSLME
110 120 130 140 150
EMLRNKSSEC KALNDSLHYL NREQNRCLRK TKIVLDCSQN KGKQVEGYWF
160 170 180 190 200
CCGMKCYYFI MDDKKWNGCK QICQDYNLTL LKTNDEDELK FLKSQLQRNT
210 220 230 240 250
YWISLTHHKS KEESQQIGDR PSKLDSAARN SVPNRQKCAY LSSFSTEEDD
260 270 280
CARTHGCICE KRLNKFPIPG SCAKGRTQSA LQRDEDES
Length:288
Mass (Da):33,607
Last modified:November 1, 1996 - v1
Checksum:iB3A410A32DF8E82F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10304 mRNA. Translation: AAA19052.1.
CCDSiCCDS20603.1.
PIRiI49058.
UniGeneiMm.4783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10304 mRNA. Translation: AAA19052.1 .
CCDSi CCDS20603.1.
PIRi I49058.
UniGenei Mm.4783.

3D structure databases

ProteinModelPortali Q60660.
SMRi Q60660. Positions 109-267.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q60660.

Proteomic databases

MaxQBi Q60660.
PRIDEi Q60660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:101906. Klra2.

Phylogenomic databases

eggNOGi NOG258878.
HOGENOMi HOG000113237.
HOVERGENi HBG053176.
InParanoidi Q60660.
PhylomeDBi Q60660.

Miscellaneous databases

PROi Q60660.
SOURCEi Search...

Gene expression databases

Genevestigatori Q60660.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR013600. Ly49.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains."
    Wong S., Freeman J.D., Kelleher C., Mager D., Takei F.
    J. Immunol. 147:1417-1423(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Lung.

Entry informationi

Entry nameiKLRA2_MOUSE
AccessioniPrimary (citable) accession number: Q60660
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3