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Q60660 (KLRA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell lectin-like receptor 2
Alternative name(s):
Lymphocyte antigen 49b
Short name=Ly-49b
T-cell surface glycoprotein Ly-49B
Gene names
Name:Klra2
Synonyms:Ly49-b, Ly49b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for class I MHC.

Subunit structure

Homodimer; disulfide-linked.

Subcellular location

Membrane; Single-pass type II membrane protein.

Sequence similarities

Contains 1 C-type lectin domain.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandLectin
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement PubMed 11290784. Source: MGI

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Killer cell lectin-like receptor 2
PRO_0000046680

Regions

Topological domain1 – 4545Cytoplasmic Potential
Transmembrane46 – 6621Helical; Signal-anchor for type II membrane protein; Potential
Topological domain67 – 288222Extracellular Potential
Domain144 – 263120C-type lectin

Amino acid modifications

Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1771N-linked (GlcNAc...) Potential
Disulfide bond151 ↔ 156 By similarity
Disulfide bond169 ↔ 257 By similarity
Disulfide bond173 ↔ 259 By similarity
Disulfide bond238 ↔ 251 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q60660 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B3A410A32DF8E82F

FASTA28833,607
        10         20         30         40         50         60 
MSEQEVTYTT LRFHKSSGLQ NPVRPEETQR PRDVGHRECS VPWKFIVIVL GILCFLLLLT 

        70         80         90        100        110        120 
VAVLVIHIFR DGQEKHEQEK TLNNLRQEYQ VMKNDSSLME EMLRNKSSEC KALNDSLHYL 

       130        140        150        160        170        180 
NREQNRCLRK TKIVLDCSQN KGKQVEGYWF CCGMKCYYFI MDDKKWNGCK QICQDYNLTL 

       190        200        210        220        230        240 
LKTNDEDELK FLKSQLQRNT YWISLTHHKS KEESQQIGDR PSKLDSAARN SVPNRQKCAY 

       250        260        270        280 
LSSFSTEEDD CARTHGCICE KRLNKFPIPG SCAKGRTQSA LQRDEDES 

« Hide

References

[1]"Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains."
Wong S., Freeman J.D., Kelleher C., Mager D., Takei F.
J. Immunol. 147:1417-1423(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10304 mRNA. Translation: AAA19052.1.
CCDSCCDS20603.1.
PIRI49058.
UniGeneMm.4783.

3D structure databases

ProteinModelPortalQ60660.
SMRQ60660. Positions 109-267.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ60660.

Proteomic databases

PRIDEQ60660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:101906. Klra2.

Phylogenomic databases

eggNOGNOG258878.
HOGENOMHOG000113237.
HOVERGENHBG053176.
PhylomeDBQ60660.

Gene expression databases

GenevestigatorQ60660.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR013600. Ly49.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
PF08391. Ly49. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ60660.
SOURCESearch...

Entry information

Entry nameKLRA2_MOUSE
AccessionPrimary (citable) accession number: Q60660
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot