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Q60660

- KLRA2_MOUSE

UniProt

Q60660 - KLRA2_MOUSE

Protein

Killer cell lectin-like receptor 2

Gene

Klra2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for class I MHC.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell lectin-like receptor 2
    Alternative name(s):
    Lymphocyte antigen 49b
    Short name:
    Ly-49b
    T-cell surface glycoprotein Ly-49B
    Gene namesi
    Name:Klra2
    Synonyms:Ly49-b, Ly49b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:101906. Klra2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Killer cell lectin-like receptor 2PRO_0000046680Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi151 ↔ 156PROSITE-ProRule annotation
    Disulfide bondi169 ↔ 257PROSITE-ProRule annotation
    Disulfide bondi173 ↔ 259PROSITE-ProRule annotation
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi238 ↔ 251PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ60660.

    PTM databases

    PhosphoSiteiQ60660.

    Expressioni

    Gene expression databases

    GenevestigatoriQ60660.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.

    Structurei

    3D structure databases

    ProteinModelPortaliQ60660.
    SMRiQ60660. Positions 109-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini67 – 288222ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini144 – 263120C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258878.
    HOGENOMiHOG000113237.
    HOVERGENiHBG053176.
    PhylomeDBiQ60660.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR013600. Ly49.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    PF08391. Ly49. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q60660-1 [UniParc]FASTAAdd to Basket

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    MSEQEVTYTT LRFHKSSGLQ NPVRPEETQR PRDVGHRECS VPWKFIVIVL    50
    GILCFLLLLT VAVLVIHIFR DGQEKHEQEK TLNNLRQEYQ VMKNDSSLME 100
    EMLRNKSSEC KALNDSLHYL NREQNRCLRK TKIVLDCSQN KGKQVEGYWF 150
    CCGMKCYYFI MDDKKWNGCK QICQDYNLTL LKTNDEDELK FLKSQLQRNT 200
    YWISLTHHKS KEESQQIGDR PSKLDSAARN SVPNRQKCAY LSSFSTEEDD 250
    CARTHGCICE KRLNKFPIPG SCAKGRTQSA LQRDEDES 288
    Length:288
    Mass (Da):33,607
    Last modified:November 1, 1996 - v1
    Checksum:iB3A410A32DF8E82F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10304 mRNA. Translation: AAA19052.1.
    CCDSiCCDS20603.1.
    PIRiI49058.
    UniGeneiMm.4783.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10304 mRNA. Translation: AAA19052.1 .
    CCDSi CCDS20603.1.
    PIRi I49058.
    UniGenei Mm.4783.

    3D structure databases

    ProteinModelPortali Q60660.
    SMRi Q60660. Positions 109-267.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q60660.

    Proteomic databases

    PRIDEi Q60660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:101906. Klra2.

    Phylogenomic databases

    eggNOGi NOG258878.
    HOGENOMi HOG000113237.
    HOVERGENi HBG053176.
    PhylomeDBi Q60660.

    Miscellaneous databases

    PROi Q60660.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q60660.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR013600. Ly49.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    PF08391. Ly49. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ly-49 multigene family. New members of a superfamily of type II membrane proteins with lectin-like domains."
      Wong S., Freeman J.D., Kelleher C., Mager D., Takei F.
      J. Immunol. 147:1417-1423(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Lung.

    Entry informationi

    Entry nameiKLRA2_MOUSE
    AccessioniPrimary (citable) accession number: Q60660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3